40 ВОСПАЛЕНИЕ

Сульфатированные полисахариды бурых водорослей: влияние на продукцию цитокинов
Effect of sulfated polysaccharides of brown algae on the serum
cytokine dynamics in CBA mice
I.D. Makarenkova
Scientific Research Institute of Epidemiology and Microbiology,
Siberian Branch RAMS, Vladivostok
The effect of sulfated polysaccharides — fucoidans from brown algae Fucus evanescens, Laminaria cichorioides and Laminaria japonica on the dynamics of cytokine production in serum of CBA mice was studied.
It was found that fucoidans induced an increase in the level of pro-inflammatory (TNFα, IL-2, IL-6, IL-17)
and immunoregulatory (IL-12, IFNγ) cytokines, but also inhibit the production of anti-inflammatory
cytokine (TGFβ), indicating that the influence of polysaccharides on the functional activity of innate
immunity effector cells and activation of mechanisms of polarizing the immune response towards Th1
type. (Cytokines and Inflammation. 2012. Vol. 11. № 4. P. 34–40.)
Key words: sulfated polysaccharides, fucoidan, cytokines, immunity.
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Том 11 № 4 2012