The work program of the academic discipline Microbiology

The work program of the academic discipline Microbiology, Virology and
Immunology" For specialty 560001 "General Medicine" CAIMU for the 20232024 academic year
The work program for microbiology, virology, immunology is compiled in
accordance with the State educational standard of higher professional education
1.Goals of the discipline:
Formation of students as widely educated and qualified medical professionals,
aware of their place in medicine, capable of analyzing and predicting complex
medical problems in the field of microbiology, virology and immunology. To give
students modern knowledge about the role of microorganisms in human life and
society, about the morphology, physiology and ecology of microorganisms, methods
for studying them. Will teach the fundamental principles of their interaction with
the human body, the fundamental algorithms of microbiological, virological and
immunological methods for diagnosing infectious diseases, and able to propose
mechanisms for solving problems in these areas necessary for the acquisition of
professional training and the development of subsequent practical activities of a
doctor
2.Objectives of the discipline:
1. the formation of widely educated and qualified medical professionals who have
the skills to establish the etiological role of microorganisms in normal and
pathological conditions, the interaction of the patterns of structure and functioning
of a microbial cell and a viral particle.
2. the formation of widely educated and qualified medical professionals with the
skills of bacteriological control of the environment, food, compliance with
sterilization regimes and supervision of sources of infection in medical and other
institutions, and monitoring the sensitivity of microorganisms to antibiotics and
other drugs, the state of microbiocenoses of surfaces and body cavities person.
3. microbiological service, its tasks in the health care system and organizational
practical forms of solving these problems.
3. The place of the discipline among the main educational program:
Basic part of the professional cycle
3. Requirement as a result of studying disciplines:
A graduate of specialty 560001 “General Medicine”, in accordance with the goals
and objectives of professional activity, must have the following competencies:
a) general:
OK-4 - is able to analyze economic problems and social processes, use methods
of economic relations in the health care system;
OK-7 - capable of using control methods; organize the work of the team, find
and make responsible management decisions within the framework of their
professional competence;
OK-8 - is able to carry out its activities taking into account the moral and legal
norms accepted in society; comply with the rules of medical ethics, laws and
regulations regarding the handling of confidential information; maintain medical
confidentiality;
b) professional:
PK-4 - is able to apply aseptic and antiseptic methods, use medical instruments,
knows the technique of caring for sick adults and children;
PC-6 - is able to apply modern information on population health indicators at the
health care facility level;
PC-7 - carry out preventive measures to prevent infectious, parasitic and noninfectious diseases, carry out sanitary educational work on hygienic issues;
PK-10 is capable of carrying out anti-epidemic measures, protecting the population
in areas of particularly dangerous infection, in case of deterioration of the
radiological situation and natural disasters;
Know:
- current trends and problems in medical microbiology and other branches of
medicine;
- methods of generalization, analysis, perception of information in the field of
microbiology and other branches of medicine;
- basic patterns and trends in the development of the infectious process;
- know the key concepts of microbiology and how to use them in solving
microbiological and professional problems;
- basic modern research and methods of immuno-chemo- and antiseptic therapy and
prevention of infectious diseases;
- Theoretical foundations of computer science in medical microbiological systems,
the use of computer information systems and periodicals.
- Solving clinical problem-situational tasks; independent preparation of oral abstract
reports on program issues with their subsequent discussion.
Be able to:
- identify the main factors and trends in the development of medical microbiology;
- critically evaluate various theoretical approaches existing in the field of medical
microbiology;
- apply theoretical knowledge to analyze current problems in medical microbiology;
- independently select and analyze pathological materials for laboratory research,
apply the results obtained for the diagnosis of infectious diseases
- use equipment, nutrient media, chemical reagents and conduct microbiological
experiments;
- work with original scientific medical texts, adequately interpret medical texts of
various doctrinal orientations
- use educational, scientific, popular science literature, the Internet and an
educational portal for professional activities.
- collect, process and summarize information in the medical field and apply basic
theoretical and methodological approaches.
Own:
- culture of laboratory thinking in the field of medical microbiology, understanding
of current microbiological realities and challenges of globalization;
- methods of microbiological interaction in public medicine, characterized by the
presence of significant microbiological and general medical differences;
- skills in scientific research and analysis of microbiological problems and processes
related to medical microbiology and other branches of medicine;
- basic theoretical and methodological approaches when approaching medical
microbiology and other branches of medicine in the field of microbiological
forecasting
4.Scope of discipline and types of academic work
4.1.Full-time education
Total
Type of educational work
hours
Classroom lessons (total)
240
Including:
Lectures
Practical exercises (PL)
Seminars (C)
Independent work (total)
Total
Type of intermediate certification (test,
exam)
Semesters
2
3
90
150
15
30
30
45
45
90
75
150
Exam
Exam
5. Thematic plan of lectures in the discipline “Microbiology, Virology and
Immunology” 2nd year III – semester specialty “General Medicine” for the
2023-2024 academic year.
№
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
Lesson topics
Volum
e
hours
Subject and tasks of microbiology, immunology and virology.
2
Research methods in microbiology.
2
Basic principles of classification of microorganisms. Morphology of 2
bacteria.
The structure of a bacterial cell and its elements.
2
Physiology of bacteria.
2
Genetic engineering in medical microbiology. Genetics of
microorganisms. Organization of the genetic apparatus in bacteria and
viruses.
Genetic engineering in medical microbiology.
Microbiological basis of chemotherapy of infectious diseases.
Chemotherapy drugs. Antibiotics.
Drug resistance of bacteria.
General virology
Pathogenic fungi 1, 2
Pathogenic protozoa 1,
Pathogenic protozoa 2
Causative agents of purulent inflammatory processes.
Gram-positive cocci
2
2
2
2
2
2
2
2
2
2
30
Gram-negative cocci
Total:
6. Schedule of lectures in the discipline “Microbiology, Virology and
Immunology” 2nd year IV – semester specialty “General Medicine” for the
2022-2023 academic year
№
1
2
3
Lesson topics
Pathogens of diphtheria, whooping cough and parawhooping cough
Pathogens of tuberculosis and leprosy.
Causative agents of bacterial intestinal infections: Salmonella,
Enterobacteriaceae, Escherichia, Shigella
Volume
hours
2
2
2
4
5
6
7
8
9
10
11
12
13
14
15
Causative agents of cholera.
Causative agents of botulism.
Pathogens of tularemia
Pathogens of zoonotic infections - anthrax.
The causative agents of zoonotic infections are brucellosis.
Causative agents of anaerobic infections. Causative agents of gas
gangrene, tetanus
Pathogens of pathogenic rickettsia.
RNA viruses: Filoviruses. Coronaviruses. Caliciviruses. Reoviruses
RNA viruses: Retroviruses. Pathogens of HIV infection.
DNA viruses: Herpes viruses. Papoviruses.Adenoviruses
DNA viruses: Poxviruses. Vapor viruses. Hepadnoviruses.
RNA viruses: Orthomyxoviruses. Paramyxoviruses. Picarnoviruses.
2
2
2
2
2
2
Total:
30
2
2
2
2
2
2
7. Title of the topic of practical classes in the discipline “Microbiology,
Virology and Immunology” 2nd year III – semester specialty “General
Medicine” for the 2022-2023 academic year
№
1
2
3
4
Lesson topics
Subject and tasks of microbiology, immunology and virology. History
of the development of microbiology. Design and equipment of a
laboratory tank, safety precautions and operating rules.
Research methods in microbiology. Light microscope and rules for
working with it. Microscopic research methods.
Basic principles of classification of microorganisms. Morphology of
bacteria.
Dyes of microorganisms. Preparation of a smear. Simple ways to stain
bacteria.
The structure of a bacterial cell and its elements. Sporulation in bacteria.
Inclusion of microbial cells, volutin grains. Motility of bacteria.
Sophisticated methods for staining microbes. Technique and essence
6
7 Physiology of bacteria. Metabolism of microorganisms. Mechanism of
bacterial nutrition.
8 Nutrient media, their classification. Principle of preparation of nutrient
media.
9 Growth and reproduction of microbes. Principles of microorganism
cultivation
10 Sterilization and disinfection.
11 Bacterial enzymes. Determination of the type of bacteria by enzymatic
activity.
12 Bacterial pigments and their significance. Luminous and aromaforming microorganisms.
5
Volume
hours
2
2
2
2
2
2
2
2
2
2
2
2
13 Genetics of microorganisms. Organization of the genetic apparatus in
bacteria and viruses. Genetic recombination.
14 Methods for selection of recombinants. Bacterial plasmids. Genetic
engineering in medical microbiology.
15 Biological research method.
16 Microbiological basis of chemotherapy of infectious diseases. Chemotherapy
drugs. Antibiotics.
17 Drug resistance of bacteria. Determination of bacterial sensitivity to
antibiotics.
18 General virology. Classification of viruses. Morphology and structural
structure of viruses. Virus-cell interactions. Bacteriophage viruses,
morphological features, significance of bacteriophages.
19 Virological research methods. Methods for growing and displaying viruses
20 Medical mycology, taxonomy of fungi, general characteristics of pathogenic
fungi. Principles of classification. Morphology, mushroom cultivation.
21 Disease caused by fungi. Superficial and deep mycoses morphology, cultural
properties.
22 Pathogenic protozoa. Amoeba. Giardia. Leishmania. Trichomonas.
Trypanosomes.
23 Plasmodium malaria. Toxoplasma. The causative agent of balantidiasis.
2
2
2
2
2
2
2
2
2
2
1
45
Total:
8. Title of the topic of practical classes in the discipline “Microbiology, Virology and
Immunology” 2nd year IV – semester specialty “General Medicine”. for the 2022-2023
academic year
№
1
2
3
4
5
6
7
8
9
10
11
12
Lesson topics
Causative agents of diphtheria.
Causative agents of whooping cough and parawhooping cough.
Pathogens of tuberculosis and leprosy.
Pathogens of actinomycosis.
Causative agents of bacterial intestinal infections: salmonella. The
causative agents of typhoid and paratyphoid A and B.
Bacteriological and serological diagnosis of typhoid-paratyphoid fever,
ethereal bacteria.
Causative agents of bacterial intestinal infections: enterobacteriaceae,
Escherichia, Shigella.
Causative agents of bacterial intestinal infections: Klebsiella, Protea.
Causative agents of cholera.
Causative agents of cholera.
Pathogens of plague.
Pathogens of tularemia
Volume
hours
2
2
2
2
2
2
2
2
2
2
2
2
13
14
15
16
17
18
19
20
21
22
23
Pathogens of zoonotic infections - anthrax.
The causative agents of zoonotic infections are brucellosis.
Causative agents of anaerobic infections. Causative agents of gas
gangrene, tetanus
Causative agents of botulism.
Causative agents of pathogenic rickettsia: causative agents of typhus, BrillZinsser disease, Q fever,
Microbiological diagnosis of rickettsia
Pathogens of pathogenic spirochetes: Borrelia - causative agents of
relapsing fever. Leptospira is the causative agent of leptospirosis.
Treponema pallidum is the causative agent of syphilis. Microbiological
diagnosis of spirochetes.
DNA viruses: Herpes viruses. Papoviruses.Adenoviruses
DNA viruses: Poxviruses. Vapor viruses. Hepadnoviruses.
RNA viruses: Orthomyxoviruses. Paramyxoviruses. Picarnoviruses.
Total:
2
2
2
2
2
2
2
2
2
2
1
45
9.Independent work of students (SWS) in the discipline “Microbiology, virology,
immunology” for students majoring in general medicine, 2nd year, 3rd semester for the
2022-2023 academic year.
№
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
Topic name
Modern principles applied to bacterial taxonomy
Report form
1. Abstract
2.Presentation
3.report
Modern achievements of biotechnology. Transgenic, 1. Abstract
microorganisms, plants, animals.
2.Presentation
3.report
Modern achievements of biotechnology. Transgenic, 1. Abstract
microorganisms, plants, animals.
2.Presentation
3.report
Heat shock proteins in bacteria.
1. Abstract
2.Presentation
3.report
Bacterial toxins. Properties. Application in medicine.
1. Abstract
2.Presentation
3.report
History of vaccination.
1. Abstract
2.Presentation
3.report
Intraspecific methods
1. Abstract
2.Presentation
identification of bacteria..
3.report
Gene therapy. Problem, prospects for application.
1. Abstract
2.Presentation
3.report
Microorganisms as symbiotic partners..
1. Abstract
2.Presentation
3.report
Evolution of microorganisms.
1. Abstract
2.Presentation
3.report
Mechanisms of action of antimicrobial agents.
1. Abstract
2.Presentation
3.report
Compatibility of antibiotics with other drugs.
1. Abstract
2.Presentation
3.report
The role of viruses and plasmids in ontogenesis.
1. Abstract
2.Presentation
3.report
Mechanisms of resistance to antibacterial agents.
1. Abstract
2.Presentation
3.report
Bacteriophage viruses, morphological features,
1. Abstract
significance of bacteriophages
2.Presentation
3.report
Pathogens of systemic or deep mycoses.
1. Abstract
Number
of hour
2
3
2
3
3
2
3
3
2
3
3
3
3
3
3
3
17
Causative agents of subcutaneous and epidermal
superficial mycoses. Conditionally pathogenic fungi and
mycoses caused by them.
18 Ureaplasma urealyticaum. Biological properties, clinical
significance, diagnosis of human diseases..
19
Staphylococcus pylori. Friend or foe...
20 Monitoring of pathogens of purulent-inflammatory
diseases in the hospital.
№
1
2
3
4
2.Presentation
3.report
1. Abstract
2.Presentation
3.report
1. Abstract
2.Presentation
3.report
1. Abstract
2.Presentation
3.report
1. Abstract
2.Presentation
3.report
1. Abstract
2.Presentation
3.report
1. Abstract
2.Presentation
3.report
21
Differential principles of streptococcal species
22
Pathogens
not gonorrheal
urethritis
– chlamydia,
23
Pathogens
1. Abstract
non-gonorrheal
2.Presentation
urethritis
3.report
– mycoplasma
Total
10.Independent work of students (SRS) 2nd year 4th semester
Topic name
Determination of diphtheria toxigenicity in vitro
Report form
1. Abstract
2. Presentation
3. report
Bacteriological and serological studies of whooping 1. Abstract
cough and parapertussis
2. Presentation
3. report
Microbiological
1. Abstract
diagnosis of leprosy.
2. Presentation
3. report
Pathogens of tuberculosis.
1. Abstract
2. Presentation
3. report
Number
of hours
2
3
3
2
3
3
2
2
2
2
2
60
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
Chronic brucellosis. Modern
diagnosis and treatment.
approaches
to 1. Abstract
2. Presentation
3. report
Pathogens of typhoid fever and paratyphoid fever. 1. Abstract
2. Presentation
3. report
Causative agents of salmonellosis.
1. Abstract
2. Presentation
3. report
Causative agents of dysentery.
1. Abstract
2. Presentation
3. report
Pathogens of cholera, Vibrio
1. Abstract
paragemolyticus
2. Presentation
3. report
Microbiological
1. Abstract
diagnostics Y.
2. Presentation
enterocolitica
3. report
Pathogens of gas
1. Abstract
gangrene – Clostridium novy, Clostridium 2. Presentation
oedematiens, Clostridium septicum.
3. report
Particularly dangerous infections.
1. Abstract
2. Presentation
3. report
Pathogens of cholera, Vibrio
1. Abstract
paragemolyticus
2. Presentation
3. report
Brill-Zinsser disease.
1. Abstract
2. Presentation
3. report
Differentiation of epidemic and endemic typhus.
1. Abstract
2. Presentation
3. report
Other treponematoses: yaws, pinta, Bejel.
1. Abstract
2. Presentation
3. report
Lyme disease.
1. Abstract
2. Presentation
3. report
Microbiological
1. Abstract
glanders diagnosis
2. Presentation
3. report
Microbiological
1. Abstract
diagnostics
2. Presentation
3
2
2
2
2
2
3
2
2
2
2
2
2
2
2
melioidosis
20 Pathogens
nocardiosis.
21 Pathogens
yaws, pint.
22 Adenoviruses and rhinoviruses
23
Reviruses and RS - viruses
24
Norwalk virus
25
Caliciviruses
26
The causative agents of Kuru disease, GerstmannStraussler-Scheinker syndrome. Hereditary fatal
insomnia
Causative agents of Scrapie disease (from the
English scrape - scrape), bovine spongiform
encephalopathy, Creutzfeldt-Jakob disease (CJD)
Natural killer cells and proteins of acute
phases. Humoral nonspecific factors
protection.
The role of immunoglobulin classes in immunity
newborns due to their accumulation in
organisms of mother and fetus.
Applied immunology.
Molecular biological methods: NA hybridization,
PCR, DNA scanning.
Vaccines, immune serums, immunoglobulins.
Vaccination calendar.
27
28
29
30
31
32 Immunoserological and immunocytological tests for
the diagnosis of allergies.
33
Delayed hypersensitivity reaction
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
1. Abstract
2. Presentation
3. report
2
2
2
2
2
2
2
2
2
2
3
2
2
2
34
Invasiveness of viruses. Genetic control
factors of pathogenicity and toxigenicity.
35 Evolution of microbial parasitism and
origin of pathogenic microorganisms.
1. Abstract
2. Presentation
3. report
2
1. Abstract
2. Presentation
3. report
2
Total:
75
11.Sections/topics of the discipline and interdisciplinary connections with the
provided (subsequent) disciplines
No. of sections/topics of this discipline
№
Name of the provided (subsequent)
required for studying the provided
п/п disciplines
(subsequent) disciplines
1-6
1-12
12-22
12-30
1.
medical biology, genetics and +
+
parasitology
2.
histology, embryology, cytology
+
3.
infectious diseases
+
+
4.
normal physiology
+
5.
epidemiology
+
+
6.
pathological anatomy
+
7.
general hygiene
+
+
12. Material and technical support of the discipline:
12.1.Textbooks, teaching aids, methodological instructions, lecture notes,
practical materials, reference books, etc.
12.2. TSO
№
Topic name
п/п
Rules for working in bacteriological laboratories.
1.
Ultrastructure of a bacterial cell
2.
Ultrastructure of a bacterial cell
3.
Spirochetes
4.
Rickettsia, chlamydia, viruses
5.
Actinomycetes
6.
Methods for isolating pure cultures of aerobic
7.
bacteria
Methods for isolating pure cultures
8.
Methods for isolating pure cultures
9.
Видео
слайды
+
+
+
+
+
+
+
+
Плакат Схем
ы
ы
+
+
+
+
+
+
+
+
+
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23
24
25
26
Prevalence of microbes in nature
The effect of environmental factors on
microorganisms
Bacteriophages
Doctrine of infection
Pathogens of especially dangerous and zoonotic
infections
Pathogens of zoonotic diseases
Rickettsia. Rickettsia
Clostridia. Clostridium
Escherichia coli. E.coli
Shigella. Shigella
Salmonella. Salmonella typhi, S. paratyphi A and
S.
Staphylococcus Staphylococcus
Streptococci. Streptococcus
Neisseria. Neisseria meningitidis
Corynebacteria
Mycobacteria. Mycobacterium tuberculosis
Hepatitis viruses B, D, C, G, F
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
13. Methodological recommendations for organizing the study of the
discipline: the section includes the following subsections:
13.1.Features and order of studying the discipline.
This course includes both classroom and independent training. Classroom lessons
include:
• lectures;
•
practical lessons.
• seminars;
In the process of studying, the following types of work are expected to be performed
by students:
in practical classes:
 problem solving;
 performing tests;
 making reports; extracurricular:
 doing homework;
 preparation of reports, abstracts;
work with basic and additional literature, work with materials on the Internet.
14.Educational technologies
When studying the discipline, traditional forms of teaching are used using a
module-rating system of training and control of student knowledge. Information
technologies are widely used: multimedia presentation of lectures, student work in
the classroom of the department, electronic textbooks on the discipline.
Active and interactive forms of conducting classes
The following forms of conducting classes are widely used:
- work in small groups;
- analysis of a specific situation;
- discussion;
- defense of an abstract with a multimedia presentation.
15.List of basic and additional educational literature necessary for mastering
the discipline
Main literature
Year,
place
п/
№ Name
Аuthors)
1.
Pozdeev O.K.
publications
M.: GEOTARMedia, 2010.-
*Tsarev V.N.
M.:
Practical
medicine,
2017.-
Medical microbiology.
Textbook
Microbiology, virology and
2. immunology. Textbook
Medical and sanitary
microbiology. Educational
3. allowance
4. Immunology. Textbook
Vorobiev A.A.
Khaitov R.M.
Laboratory workshop
works with illustrated
situational tasks for
microbiology, immunology
5. and virology
* . Vorobiev A.A
General medical
*Goryachkina
6. virology. Tutorial
N.S.
additional literature
п
№/ Name
Medical microbiology.
1. Textbook
Medical microbiology.
2. Textbook
M.: Academy,
2015.M.: GEOTARMedia, 2014.-
M.: MIA,
2016.Rostov n/d.:
Phoenix, 2018.-
Pozdeev O.K.
Year, place
publications
M.: GEOTARMedia, 2010
Pozdeev O.K.
M.: GEOTARMedia, 2010
Authors)
Microbiology. Textbook
M.: Medicine,
3 MZRF
* Vorobiev A.A 2015
Fundamentals of microbiology,
virology and immunology.
4. Textbook MORPH
*. Vorobiev A.A Мастерство, 2013
М.: ГЭОТАР
МЕДИЦИНА,
2016
5. Visual immunology
J. Playfair
Microbiology, immunology,
virology. Methodical
guidelines for practical
*Koltsov I.P.
classes for medical students,
*Nesterenko
ped. and ostomy faculties. In 3 L.Ya.
Khabarovsk:
6. Parts
DVSMU, 2018
Microbiology, immunology,
virology. Guide for
independent work for
medical students, ped. and
*Koltsov I.P.
ostomy
*Nesterenko
Khabarovsk:
7. faculties. In 3 parts
L.Ya.
DVSMU, 2018
Viral diseases
person with fecal-oral
by transfer. Guide to
practical training for
medical students, ped. and
*Kogut E.P.
ostomy
*Koltsov I.P.
Khabarovsk:
8. faculties Ch.11
DVSMU, 2017
Viral diseases
man with air
by droplet transmission.
Guide to practical
classes for medical students,
*Kogut E.P.
Khabarovsk:
9. ped. and ostomy faculties Ch.10 *Koltsov I.P.
DVSMU, 2013
Introduction to Microbiology
oral cavity. Benefit for
*Koltsov I.P.
Khabarovsk:
10. Students
*Nesterenko L.Ya DVSMU, 2014
16. List of resources of the information and telecommunications network
"Internet" (hereinafter referred to as the "Internet") necessary for
mastering the discipline
1.
http: // www. ramld.ru
2.
http: // www.antibiotic.ru
3.
http: // cmr.asm.org
4.
http: // mmbr.asm.org
5.
http: // www.inbi.ras.ru/ pmb.html
6.
http: // www.rusmedserv.com/ microbiology/ articles
7.
http: // www.medlit.ru medrus/vop.vir.htm
8.
http:// www.mycology.ru