биосенсоры на основе углеродных нанотрубок для выявления

Раздел 4
777
ɍȾɄ 544.653.2:577.323.7
ȻɂɈɋȿɇɋɈɊɕ ɇȺ ɈɋɇɈȼȿ ɍȽɅȿɊɈȾɇɕɏ ɇȺɇɈɌɊɍȻɈɄ
ȾɅə ȼɕəȼɅȿɇɂə ɉɈȼɊȿɀȾȿɇɂɃ ȼ ȾɇɄ1
ɇɢɤɢɬɢɧɚ ɂ.ɂ., Ⱥɛɞɭɥɥɢɧ Ɍ.ɂ.
Ʉɚɡɚɧɫɤɢɣ ɝɨɫɭɞɚɪɫɬɜɟɧɧɵɣ ɭɧɢɜɟɪɫɢɬɟɬ, [email protected]
ȼɚɠɧɨɣ ɡɚɞɚɱɟɣ ɫɨɜɪɟɦɟɧɧɨɣ ɛɢɨɥɨɝɢɢ ɹɜɥɹɟɬɫɹ ɪɚɡɪɚɛɨɬɤɚ
ɧɨɜɵɯ ɦɟɬɨɞɨɜ ɞɟɬɟɤɬɢɪɨɜɚɧɢɹ ɛɢɨɥɨɝɢɱɟɫɤɢ ɚɤɬɢɜɧɵɯ ɫɨɟɞɢɧɟɧɢɣ.
Ⱦɥɹ ɪɟɲɟɧɢɹ ɷɬɨɣ ɡɚɞɚɱɢ ɩɟɪɫɩɟɤɬɢɜɧɵɦ ɹɜɥɹɟɬɫɹ ɢɫɩɨɥɶɡɨɜɚɧɢɟ
ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɢɯ ɛɢɨɫɟɧɫɨɪɨɜ, ɫ ɩɨɦɨɳɶɸ ɤɨɬɨɪɵɯ ɦɨɠɧɨ ɫ ɜɵɫɨɤɨɣ
ɱɭɜɫɬɜɢɬɟɥɶɧɨɫɬɶɸ
ɢ
ɫɟɥɟɤɬɢɜɧɨɫɬɶɸ
ɨɩɪɟɞɟɥɹɬɶ
ɪɚɡɥɢɱɧɵɟ
ɛɢɨɦɨɥɟɤɭɥɵ, ɚ ɬɚɤɠɟ ɯɚɪɚɤɬɟɪɢɡɨɜɚɬɶ ɜɡɚɢɦɨɞɟɣɫɬɜɢɹ ɦɟɠɞɭ ɧɢɦɢ [1].
ɋɪɟɞɢ ɛɢɨɦɨɥɟɤɭɥ ɨɫɨɛɵɣ ɢɧɬɟɪɟɫ ɩɪɟɞɫɬɚɜɥɹɸɬ ɧɨɫɢɬɟɥɢ
ɝɟɧɟɬɢɱɟɫɤɨɣ ɢɧɮɨɪɦɚɰɢɢ – ɧɭɤɥɟɢɧɨɜɵɟ ɤɢɫɥɨɬɵ (ɇɄ). Ʉ ɧɚɫɬɨɹɳɟɦɭ
ɜɪɟɦɟɧɢ ɩɪɟɞɥɨɠɟɧɵ ɪɚɡɥɢɱɧɵɟ ɦɟɬɨɞɵ ɞɟɬɟɤɬɢɪɨɜɚɧɢɹ ɇɄ ɫ
ɩɪɢɦɟɧɟɧɢɟɦ ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɢɯ ɛɢɨɫɟɧɫɨɪɨɜ. Ⱦɥɹ ɷɬɨɝɨ ɨɛɵɱɧɨ
ɢɫɩɨɥɶɡɭɸɬ ɧɢɡɤɨɦɨɥɟɤɭɥɹɪɧɵɟ ɷɥɟɤɬɪɨɚɤɬɢɜɧɵɟ ɢɧɞɢɤɚɬɨɪɵ ɢɥɢ
ɮɟɪɦɟɧɬɧɵɟ ɦɟɬɤɢ. Ⱦɪɭɝɨɣ ɦɟɬɨɞ ɨɫɧɨɜɚɧ ɧɚ ɫɩɨɫɨɛɧɨɫɬɢ ɩɭɪɢɧɨɜɵɯ
ɧɭɤɥɟɨɬɢɞɨɜ ɨɤɢɫɥɹɬɶɫɹ ɧɚ ɷɥɟɤɬɪɨɞɟ. ɉɪɟɢɦɭɳɟɫɬɜɨɦ ɷɬɨɝɨ ɦɟɬɨɞɚ
ɹɜɥɹɟɬɫɹ ɜɨɡɦɨɠɧɨɫɬɶ ɩɪɹɦɨɝɨ ɞɟɬɟɤɬɢɪɨɜɚɧɢɹ ɇɄ ɛɟɡ ɞɨɩɨɥɧɢɬɟɥɶɧɵɯ
ɪɟɚɝɟɧɬɨɜ, ɨɞɧɚɤɨ ɨɧ ɯɚɪɚɤɬɟɪɢɡɭɟɬɫɹ ɨɬɧɨɫɢɬɟɥɶɧɨ ɧɢɡɤɨɣ
ɱɭɜɫɬɜɢɬɟɥɶɧɨɫɬɶɸ [1].
Ⱦɥɹ ɭɜɟɥɢɱɟɧɢɹ ɱɭɜɫɬɜɢɬɟɥɶɧɨɫɬɢ ɩɪɹɦɨɝɨ ɞɟɬɟɤɬɢɪɨɜɚɧɢɹ ɇɄ
ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɢɣ
ɩɪɟɨɛɪɚɡɨɜɚɬɟɥɶ
(ɷɥɟɤɬɪɨɞ)
ɦɨɞɢɮɢɰɢɪɭɸɬ
ɪɚɡɥɢɱɧɵɦɢ ɦɚɬɟɪɢɚɥɚɦɢ. ɉɟɪɫɩɟɤɬɢɜɧɵɦ ɦɨɞɢɮɢɤɚɬɨɪɨɦ ɹɜɥɹɸɬɫɹ
ɭɝɥɟɪɨɞɧɵɟ ɧɚɧɨɬɪɭɛɤɢ (ɍɇɌ), ɤɨɬɨɪɵɟ ɨɛɥɟɝɱɚɸɬ ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɨɟ
ɨɤɢɫɥɟɧɢɟ ɇɄ [2, 3]. ȼ ɧɚɫɬɨɹɳɟɦ ɢɫɫɥɟɞɨɜɚɧɢɢ ɫ ɢɫɩɨɥɶɡɨɜɚɧɢɟɦ
ɷɥɟɤɬɪɨɞɨɜ, ɦɨɞɢɮɢɰɢɪɨɜɚɧɧɵɯ ɍɇɌ, ɪɚɡɪɚɛɨɬɚɧɵ ȾɇɄ-ɫɟɧɫɨɪɵ ɞɥɹ
ɜɵɹɜɥɟɧɢɹ ɩɨɜɪɟɠɞɟɧɢɣ ɜ ȾɇɄ ɩɨɞ ɞɟɣɫɬɜɢɟɦ ɪɚɡɥɢɱɧɵɯ ɮɚɤɬɨɪɨɜ.
ɗɤɫɩɟɪɢɦɟɧɬɚɥɶɧɚɹ ɱɚɫɬɶ
ȼ ɪɚɛɨɬɟ ɢɫɩɨɥɶɡɨɜɚɥɢ ɦɧɨɝɨɫɬɟɧɧɵɟ ɭɝɥɟɪɨɞɧɵɟ ɧɚɧɨɬɪɭɛɤɢ,
ɩɪɨɢɡɜɟɞɟɧɧɵɟ ɮɢɪɦɨɣ Sigma-Aldrich (Ƚɟɪɦɚɧɢɹ), ȾɇɄ ɢɡ ɷɪɢɬɪɨɰɢɬɨɜ
ɰɵɩɥɹɬ
(Reanal,
ȼɟɧɝɪɢɹ).
ɋɬɟɤɥɨɭɝɥɟɪɨɞɧɵɟ
ɷɥɟɤɬɪɨɞɵ
ɦɨɞɢɮɢɰɢɪɨɜɚɥɢ ɍɇɌ, ɤɚɤ ɨɩɢɫɚɧɨ ɜ [2]. ɗɥɟɤɬɪɨɯɢɦɢɱɟɫɤɢɟ
ɷɤɫɩɟɪɢɦɟɧɬɵ ɩɪɨɜɨɞɢɥɢ ɫ ɩɨɦɨɳɶɸ ɚɧɚɥɢɡɚɬɨɪɚ «ɗɤɨɬɟɫɬ ȼȺ»
(«ɗɤɨɧɢɤɫ-ɗɤɫɩɟɪɬ», Ɋɨɫɫɢɹ) ɜ ɪɟɠɢɦɟ ɥɢɧɟɣɧɨɣ ɩɨɫɬɨɹɧɧɨɬɨɤɨɜɨɣ
1
ȼɵɩɨɥɧɟɧɨ ɩɪɢ ɩɨɞɞɟɪɠɤɟ ɝɪɚɧɬɚ Ⱥɇ ɊɌ ʋ 20-35/2007(Ƚ).
778
Структура и динамика молекулярных систем, 2007 г., Выпуск №1
ɜɨɥɶɬɚɦɩɟɪɨɦɟɬɪɢɢ. ȾɇɄ ɤɨɧɰɟɧɬɪɚɰɢɟɣ 1 ɦɝ/ɦɥ ɩɪɟɞɜɚɪɢɬɟɥɶɧɨ
ɚɞɫɨɪɛɢɪɨɜɚɥɢ ɧɚ ɦɨɞɢɮɢɰɢɪɨɜɚɧɧɨɦ ɷɥɟɤɬɪɨɞɟ ɢ ɞɚɥɟɟ ɡɚɩɢɫɵɜɚɥɢ
ɜɨɥɶɬɚɦɩɟɪɨɝɪɚɦɦɵ ɜ ɨɬɫɭɬɫɬɜɢɟ ȾɇɄ ɜ ɪɚɫɬɜɨɪɟ. ȼ ɤɚɱɟɫɬɜɟ ɮɨɧɨɜɨɝɨ
ɷɥɟɤɬɪɨɥɢɬɚ ɢɫɩɨɥɶɡɨɜɚɥɢ ɚɰɟɬɚɬɧɨ-ɮɨɫɮɚɬɧɵɣ ɛɭɮɟɪɧɵɣ ɪɚɫɬɜɨɪ (ɪɇ
5,0). Ƚɢɞɪɨɤɫɢɥ-ɪɚɞɢɤɚɥɵ ɝɟɧɟɪɢɪɨɜɚɥɢ ɩɨ ɪɟɚɤɰɢɢ Ɏɟɧɬɨɧɚ [4].
Ⱦɥɹ ɮɪɚɝɦɟɧɬɚɰɢɢ ȾɇɄ ɪɚɡɪɭɲɚɥɢ ɭɥɶɬɪɚɡɜɭɤɨɦ (ɱɚɫɬɨɬɚ 22ɤȽɰ,
15 ɦɢɧ) ɢ ɩɢɩɟɬɢɪɨɜɚɥɢ ɲɩɪɢɰɟɦ ɫ ɬɨɧɤɨɣ ɢɝɥɨɣ. ɋɬɟɩɟɧɶ
ɮɪɚɝɦɟɧɬɚɰɢɢ ȾɇɄ ɨɰɟɧɢɜɚɥɢ ɷɥɟɤɬɪɨɮɨɪɟɬɢɱɟɫɤɢ ɜ 0.7% ɚɝɚɪɨɡɧɨɦ
ɝɟɥɟ.
Ɋɟɡɭɥɶɬɚɬɵ ɢ ɢɯ ɨɛɫɭɠɞɟɧɢɟ
Ʉɚɤ ɩɨɤɚɡɚɧɨ ɜ ɪɚɛɨɬɟ [2], ɫɬɟɤɥɨɭɝɥɟɪɨɞɧɵɟ ɷɥɟɤɬɪɨɞɵ,
ɦɨɞɢɮɢɰɢɪɨɜɚɧɧɵɟ ɍɇɌ (ɋɍɗ-ɍɇɌ), ɨɛɥɚɞɚɸɬ ɧɚɧɨɫɬɪɭɤɬɭɪɢɪɨɜɚɧɧɨɣ ɩɨɜɟɪɯɧɨɫɬɶɸ, ɤɨɬɨɪɚɹ ɨɛɥɟɝɱɚɟɬ ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɨɟ ɨɤɢɫɥɟɧɢɟ
ɧɭɤɥɟɢɧɨɜɵɯ ɤɢɫɥɨɬ ɢ ɢɯ ɤɨɦɩɨɧɟɧɬɨɜ. ɇɚ ɋɍɗ-ɍɇɌ ȾɇɄ ɨɛɥɚɞɚɥɚ
ɜɵɪɚɠɟɧɧɨɣ ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɨɣ ɚɤɬɢɜɧɨɫɬɶɸ ɩɪɢ ɩɨɬɟɧɰɢɚɥɟ ɨɤɨɥɨ
+1100 ɦȼ (ɪɢɫ.1) ɢ ɧɟ ɨɤɢɫɥɹɥɚɫɶ ɧɚ ɧɟɦɨɞɢɮɢɰɢɪɨɜɚɧɧɨɦ ɋɍɗ.
ɋɢɝɧɚɥ, PȺ
24
ɋɢɝɧɚɥ, PȺ
12
ɇɚɬ.ȾɇɄ + ȺɎɄ
Ʉɨɧɬɪɨɥɶ
18
9
12
ɇɚɬ.ȾɇɄ
Ⱦɟɧ.ȾɇɄ
6
6
3
0
300
600
900
1200
1500
ȿ, ɦȼ ɨɬɧ. Ag/AgCl
Ɋɢɫ. 1. ɍɜɟɥɢɱɟɧɢɟ ɫɢɝɧɚɥɚ ɛɢɨɫɟɧɫɨɪɚ ɩɨɫɥɟ ɨɛɪɚɛɨɬɤɢ ȾɇɄ
ɪɟɚɤɬɢɜɨɦ Ɏɟɧɬɨɧɚ. ɇɚɬɪɢɣɮɨɫɮɚɬɧɵɣ ɛɭɮɟɪɧɵɣ ɪɚɫɬɜɨɪ
(ɪɇ 7.0), ɫɤɨɪɨɫɬɶ ɫɤɚɧɢɪɨɜɚɧɢɹ
100 ɦȼ/ɫ.
ɥɶ
ɪɨ
ɧɬ
ɨ
Ʉ
ɢɟ
ɤɚ
ɚɧ
ɨɬ
ɨɜ
ɚɛ
ɛɪ
ɢɪ
ɨ
ɬ
ɩɟ
ɍɁ
ɉɢ
Ɋɢɫ. 2. ȼɥɢɹɧɢɟ ɮɪɚɝɦɟɧɬɚɰɢɢ
ȾɇɄ ɧɚ ɬɨɤ ɟɟ ɨɤɢɫɥɟɧɢɹ ɧɚ ɋɍɗɍɇɌ.
Ⱦɚɥɟɟ ɦɵ ɢɫɫɥɟɞɨɜɚɥɢ ɜɥɢɹɧɢɟ ɧɚ ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɨɟ ɨɤɢɫɥɟɧɢɟ
ɛɢɨɩɨɥɢɦɟɪɚ ɝɢɞɪɨɤɫɢɥ-ɪɚɞɢɤɚɥɨɜ, ɤɨɬɨɪɵɟ ɩɪɢɜɨɞɹɬ ɤ ɩɨɜɪɟɠɞɟɧɢɹɦ
ȾɇɄ in vivo ɢ, ɤɚɤ ɫɥɟɞɫɬɜɢɟ, ɹɜɥɹɸɬɫɹ ɩɪɢɱɢɧɨɣ ɦɭɬɚɰɢɣ [4, 5].
Ƚɢɞɪɨɤɫɢɥ-ɪɚɞɢɤɚɥ ɝɟɧɟɪɢɪɨɜɚɥɢ ɜ ɪɟɚɤɰɢɢ Ɏɟɧɬɨɧɚ ɫɨɝɥɚɫɧɨ ɫɯɟɦɟ:
Раздел 4
Fe 2+ + H2O2
779
Fe 3+ + OH- + •OH
ɍɫɬɚɧɨɜɥɟɧɨ, ɱɬɨ ɩɨɫɥɟ ɢɧɤɭɛɚɰɢɢ ɛɢɨɫɟɧɫɨɪɚ ɜ ɪɟɚɤɬɢɜɟ
Ɏɟɧɬɨɧɚ ɫɢɝɧɚɥ ɨɤɢɫɥɟɧɢɹ ȾɇɄ ɭɜɟɥɢɱɢɜɚɟɬɫɹ ɫ 11,1 ± 0,7 ɦɤȺ
(ɤɨɧɬɪɨɥɶ) ɞɨ 18,1 ± 3,1 ɦɤȺ (ɪɢɫ.1). ɂɡɜɟɫɬɧɨ, ɱɬɨ ɝɢɞɪɨɤɫɢɥ-ɪɚɞɢɤɚɥ
ɦɨɠɟɬ ɢɧɞɭɰɢɪɨɜɚɬɶ ɪɚɡɥɢɱɧɵɟ ɬɢɩɵ ɩɨɜɪɟɠɞɟɧɢɣ ɜ ȾɇɄ:
ɨɤɢɫɥɢɬɟɥɶɧɭɸ
ɦɨɞɢɮɢɤɚɰɢɸ
ɨɫɧɨɜɚɧɢɣ,
ɞɟɩɭɪɢɧɢɡɚɰɢɸ,
ɞɟɩɢɪɢɦɢɞɢɧɢɡɚɰɢɸ, ɨɤɢɫɥɟɧɢɟ ɞɟɡɨɤɫɢɪɢɛɨɡɢɥɶɧɨɝɨ ɨɫɬɚɬɤɚ ɢ ɞɪ. [5].
ɑɬɨɛɵ ɭɫɬɚɧɨɜɢɬɶ, ɤɚɤɨɣ ɬɢɩ ɩɨɜɪɟɠɞɟɧɢɣ ɩɪɢɜɨɞɢɬ ɤ
ɭɜɟɥɢɱɟɧɢɸ ɫɢɝɧɚɥɚ ɛɢɨɫɟɧɫɨɪɚ, ɧɚɦɢ ɩɪɨɜɟɞɟɧ ɷɤɫɩɟɪɢɦɟɧɬ ɩɨ
ɪɚɡɪɭɲɟɧɢɸ ȾɇɄ ɭɥɶɬɪɚɡɜɭɤɨɦ ɢ ɩɢɩɟɬɢɪɨɜɚɧɢɟɦ. Ʉɚɤ ɩɨɤɚɡɚɧɨ ɧɚ
ɷɥɟɤɬɪɨɮɨɪɟɝɪɚɦɦɟ ɩɪɨɛ ȾɇɄ (ɪɢɫ.3), ɩɢɩɟɬɢɪɨɜɚɧɢɟ ɧɟ ɩɪɢɜɨɞɢɬ ɤ
ɡɚɦɟɬɧɨɦɭ ɭɦɟɧɶɲɟɧɢɸ ɦɨɥɟɤɭɥɹɪɧɨɣ ɦɚɫɫɵ ɛɢɨɩɨɥɢɦɟɪɚ. ȼ ɷɬɨɦ
ɫɥɭɱɚɟ ɧɟ ɧɚɛɥɸɞɚɥɨɫɶ ɢɡɦɟɧɟɧɢɹ ɬɨɤɚ ɨɤɢɫɥɟɧɢɹ ȾɇɄ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ
ɤɨɧɬɪɨɥɟɦ (ɪɢɫ.2). Ɉɛɪɚɛɨɬɤɚ ȾɇɄ ɭɥɶɬɪɚɡɜɭɤɨɦ ɫɩɨɫɨɛɫɬɜɨɜɚɥɚ
ɡɧɚɱɢɬɟɥɶɧɨɣ ɮɪɚɝɦɟɧɬɚɰɢɢ ɛɢɨɩɨɥɢɦɟɪɚ (ɪɢɫ.3) ɢ ɭɜɟɥɢɱɟɧɢɸ ɫɢɝɧɚɥɚ
ɛɢɨɫɟɧɫɨɪɚ (ɪɢɫ.2). Ɋɟɡɭɥɶɬɚɬɵ
ɩɨɤɚɡɚɥɢ,
ɱɬɨ
ɭɦɟɧɶɲɟɧɢɟ
ɦɨɥɟɤɭɥɹɪɧɨɣ ɦɚɫɫɵ ȾɇɄ ɫɨɩɪɨɜɨɠɞɚɟɬɫɹ ɭɫɢɥɟɧɢɟɦ ɬɨɤɚ ɟɟ ɨɤɢɫɥɟɧɢɹ
ɧɚ ɋɍɗ-ɍɇɌ, ɩɪɟɞɩɨɥɨɠɢɬɟɥɶɧɨ, ɜɫɥɟɞɫɬɜɢɟ ɭɜɟɥɢɱɟɧɢɹ ɩɥɨɳɚɞɢ
ɤɨɧɬɚɤɬɚ ɦɟɠɞɭ ɚɞɫɨɪɛɢɪɨɜɚɧɧɵɦ ɛɢɨɩɨɥɢɦɟɪɨɦ ɢ ɷɥɟɤɬɪɨɞɨɦ.
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ɦɚɪɤɟɪɵ ȾɇɄ, ɩ.ɧ.;
ɧȾɇɄ, ɤɨɧɬɪɨɥɶ;
ɩɢɩɟɬɢɪɨɜɚɧɧɚɹ ɧȾɇɄ;
ɧȾɇɄ ɩɨɫɥɟ ɍɁ-ɨɛɪɚɛɨɬɤɢ;
ɞȾɇɄ, ɤɨɧɬɪɨɥɶ;
ɩɢɩɟɬɢɪɨɜɚɧɧɚɹ ɞȾɇɄ;
ɞȾɇɄ ɩɨɫɥɟ ɍɁ-ɨɛɪɚɛɨɬɤɢ.
Ɋɢɫ. 3. ɗɥɟɤɬɪɨɮɨɪɟɝɪɚɦɦɚ ɩɪɨɛ ȾɇɄ, ɩɨɞɜɟɪɝɧɭɬɵɯ ɦɟɯɚɧɢɱɟɫɤɨɦɭ
ɪɚɡɪɭɲɟɧɢɸ.
ɇɚ ɨɫɧɨɜɟ ɷɬɨɝɨ ɦɵ ɩɪɟɞɩɨɥɚɝɚɟɦ, ɱɬɨ ɜɥɢɹɧɢɟ ɝɢɞɪɨɤɫɢɥɪɚɞɢɤɚɥɚ ɧɚ ɷɥɟɤɬɪɨɯɢɦɢɱɟɫɤɨɟ ɨɤɢɫɥɟɧɢɟ ȾɇɄ ɨɛɭɫɥɨɜɥɟɧɨ
ɨɤɢɫɥɟɧɢɟɦ ɨɫɬɚɬɤɚ ɞɟɡɨɤɫɢɪɢɛɨɡɵ, ɤɨɬɨɪɨɟ ɩɪɢɜɨɞɢɬ ɤ ɝɢɞɪɨɥɢɡɭ
ɫɚɯɚɪɨ-ɮɨɫɮɚɬɧɨɣ ɰɟɩɢ ɢ ɮɪɚɝɦɟɧɬɚɰɢɢ ɛɢɨɩɨɥɢɦɟɪɚ. ɉɨɥɭɱɟɧɧɵɟ
ɪɟɡɭɥɶɬɚɬɵ ɩɪɟɞɩɨɥɚɝɚɸɬ ɜɨɡɦɨɠɧɨɫɬɶ ɢɫɩɨɥɶɡɨɜɚɧɢɹ ɛɢɨɫɟɧɫɨɪɨɜ ɧɚ
ɨɫɧɨɜɟ ɍɇɌ ɞɥɹ ɨɰɟɧɤɢ ɩɨɜɪɟɠɞɚɸɳɟɝɨ ɞɟɣɫɬɜɢɹ ɯɢɦɢɱɟɫɤɢɯ ɚɝɟɧɬɨɜ
ɧɚ ȾɇɄ.
780
Структура и динамика молекулярных систем, 2007 г., Выпуск №1
Ʌɢɬɟɪɚɬɭɪɚ
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Ɉ.Ⱥ. Ʉɨɧɨɜɚɥɨɜɚ, Ɇ.ɏ. ɋɚɥɚɯɨɜ // ɀɭɪɧ. ɚɧɚɥɢɬ. ɯɢɦɢɢ. – 2007. –
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