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Saunders Company, 1974. - 45. . ., 1976, . 70, . . 44. : .,1995. , . 5, . 74–78. 40. . . , 2007. 41. . . : . 385–388. 42. . . 43. ., 1986, . 91, . The concept of tissues is one of the main categories in histology. This paper describes the evolution of the tissue concept during the last century. The review of different definitions of tissues found in Russian and foreign educational and scientific literature published in XX–XXI centuries, is presented. Special attention is given to the changes of the concept of tissues that due to the appearance of the new approaches and concepts in tissue biology (doctrine of stem cells, differon principle of tissue organization, histione conception). A brief characteristic of different definitions of tissues based on various approaches that were suggested by Russian and foreign histologists, is given. The data are discussed that support the idea that the «tissue» concept belongs to a number of undefinable basic concepts of tissue biology. Key words: tissue, tissue biology, histology, classification of tissues, differon, stem cells Department of Histology, Cytology, and Embryology, Orenburg State Medical Academy