Solid dosage forms Filimonova Sofia Mf-303 • Tablets • Drops • Pills • Granules • Powders • Capsules • Caramels • Pencils Solid dosage forms Tablets • solid dosage forms obtained by compression of medicinal substances and intended for internal, sublingual, topical, or parenteral use. Easy to use Easy transportation Positive aspects Easy storage Regulation of sequential absorption of individual medicinal substances of the tablets of complex composition (multi-layer tablets) Prolonged effect of drugs Portability Tablets begin to act more slowly than some another forms Long-term storage of tablets may cause chemical changes Negative aspects In some cases, the tablets lose the ability to disintegrate in the gastrointestinal tract Tablets may cause mechanical or chemical irritation of the mucous membrane of the digestive tract Tablets may not be prescribed to children and people who are unable to swallow them or have lost this ability due to various reasons. Drops • solid dosage forms obtained by repeated layering (pelleting) of medicinal and auxiliary substances on sugar granules (grains). • Drops have a regular spherical shape. Granules • undosed solid form in homogeneous particles (grains) of different shapes (round, cylindrical or irregular) for internal use. Powders • solid dosage form for internal and external use, consisting of one or more crushed substances and having the property of flowability Positive HIGH PHARMACOLOGICAL ACTIVITY PORTABILITY STORAGE STABILITY aspects EASE OF MANUFACTURE ABILITY TO ADJUST THE DEGREE OF DISPERSION Negative aspects Some substances in powders may change their properties under the influence of the external factors Some drugs in the form of powders have an irritating effect on the mucous membrane Drugs that have a bitter taste, odorous and coloring, uncomfortable and unpleasant to receive Powders can acquire a foreign smell by adsorbing vapors of odorous substances Capsules • dosed dosage form consisting of a drug enclosed in a sheath. • Most often, the capsules are intended for oral administration of the drug; less often for rectal, vaginal and parenteral methods of administration. Accuracy of dosing Protection of the drug from exposure to light, air and moisture Positive aspects Elimination of unpleasant taste and smell of the drug Ability to quickly swell, dissolve and absorb High bioavailability Negative aspects HIGH HYGROSCOPICITY OF GELATIN DIFFICULTY SWALLOWING Caramels • solid dosage forms obtained by mixing drugs with sugar and molasses. • Caramels are used to affect the mucous membrane of the oral cavity due to their complete absorption. Pencils • solid dosage form obtained by melting drugs and having the form of cylinders with a pointed end on one side. • Applied to lubricate the skin and mucous membranes in order to obtain astringent and cauterizing action Pills • solid dosage form for internal use in the form of balls prepared from a homogeneous plastic mass. • Pills consist of a medicinal substance, as well as auxiliary substances that give them the necessary mass and volume, plasticity, causing bonding ingredients and prevent them from hardening. Thank you for attention!