Загрузил Рита Лоторева

Solid Dosage Forms

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Solid dosage forms
Filimonova Sofia Mf-303
• Tablets
• Drops
• Pills
• Granules
• Powders
• Capsules
• Caramels
• Pencils
Solid dosage forms
Tablets
• solid dosage forms obtained by compression
of medicinal substances and intended for
internal, sublingual, topical, or parenteral
use.
Easy to use
Easy transportation
Positive
aspects
Easy storage
Regulation of sequential absorption of individual medicinal
substances of the tablets of complex composition (multi-layer tablets)
Prolonged effect of drugs
Portability
Tablets begin to act more slowly than some another
forms
Long-term storage of tablets may cause chemical
changes
Negative
aspects
In some cases, the tablets lose the ability to
disintegrate in the gastrointestinal tract
Tablets may cause mechanical or chemical irritation of
the mucous membrane of the digestive tract
Tablets may not be prescribed to children and people
who are unable to swallow them or have lost this ability
due to various reasons.
Drops
• solid dosage forms obtained by repeated
layering (pelleting) of medicinal and auxiliary
substances on sugar granules (grains).
• Drops have a regular spherical shape.
Granules
• undosed solid form in homogeneous
particles (grains) of different shapes (round,
cylindrical or irregular) for internal use.
Powders
• solid dosage form for internal and
external use, consisting of one or more
crushed substances and having the
property of flowability
Positive
HIGH
PHARMACOLOGICAL
ACTIVITY
PORTABILITY
STORAGE STABILITY
aspects
EASE OF
MANUFACTURE
ABILITY TO ADJUST THE
DEGREE OF
DISPERSION
Negative
aspects
Some substances in powders may
change their properties under the
influence of the external factors
Some drugs in the form of powders
have an irritating effect on the mucous
membrane
Drugs that have a bitter taste, odorous
and coloring, uncomfortable and
unpleasant to receive
Powders can acquire a foreign smell by
adsorbing vapors of odorous
substances
Capsules
• dosed dosage form consisting of a drug
enclosed in a sheath.
• Most often, the capsules are intended for
oral administration of the drug; less often for
rectal, vaginal and parenteral methods of
administration.
Accuracy of dosing
Protection of the drug from exposure to light, air
and moisture
Positive
aspects
Elimination of unpleasant taste and smell of the
drug
Ability to quickly swell, dissolve and absorb
High bioavailability
Negative
aspects
HIGH HYGROSCOPICITY
OF GELATIN
DIFFICULTY
SWALLOWING
Caramels
• solid dosage forms obtained by mixing drugs
with sugar and molasses.
• Caramels are used to affect the mucous
membrane of the oral cavity due to their
complete absorption.
Pencils
• solid dosage form obtained by melting drugs
and having the form of cylinders with a
pointed end on one side.
• Applied to lubricate the skin and mucous
membranes in order to obtain astringent
and cauterizing action
Pills
• solid dosage form for internal use in the
form of balls prepared from a homogeneous
plastic mass.
• Pills consist of a medicinal substance, as well
as auxiliary substances that give them the
necessary mass and volume, plasticity,
causing bonding ingredients and prevent
them from hardening.
Thank you for
attention!
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