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( ) . , , , , , , , : 1. . 2. . 3. . 4 , . я 18 2014 « - » . «South Eastern Society of Toxicology «61st Meeting American Association for the Meeting» (Athens, Georgia, USA, 2010); Study of Liver Diseases» (Boston, Massachusetts, USA, 2010); «Society of Toxicology 50 th Anniversary Meeting and Tox Expo» (Washington, DC, USA, 2011); «Society of Toxicology 51st Annual Meeting and Tox Expo» (San Francisco, California, USA, 2012); «7th Congress of the International Federation of Shock Societies and 35th Annual Conference on Shock » (Miami, Florida, USA 2012). . o8 , 2 . . 52 , , , ( 1 – 2 – , , 4– ), , 121 , . , , . 1 3 . , . . . 2 , . , , , , , , , . . 5 3 – (C57BL6) . (BКr HКrЛШr, ME). 26-28 , 8-10 . « » (CСКrХОsЭШЧ, SC). . 50 / - ( ). ( а а 1. а , а , , я а. 0,1 / ) . , . . , . , . . . 5 30 . , . . 3 . 3 , ( , 10 ). 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[Aharinejad S. et al. 1997, Farrell G.C. et al. 2008, Lee S.H. et al. 2008, McCuscey R.S. et al. 1979, McCuscey R.S. et al. 1990, McCuscey R.S. et al. 2000, McCuscey R.S. et al. 2008, Paxian M. et al. 2004]. . 11 . . . , , . , , . , , , . , . , , з30% – (Visser T. et al. 2008). . / , / . , , , , . / . . , / , ( , 12 ). , Ш . Ш 2+ . Ш , , . ( . 2+ ) , CК 2+ . 2+ CК2+ CК2+ , (Kim J.S. et al. 2003). , , 200 CК 2+ / . CК 2+ , , « ». , Ca2+ (Farber J.L. CК et al. 1982). 2+ , , , , 2+ . . , Ruthenium 360 ( ) . 2+ 1,5 CК2+ (32). , , , . , , , , С . 13 . (vШХЭКРО НОpОЧНОЧЭ КЧТШЧ МСКЧЧОХ, VDAC), (КНОЧТЧО ЧЮМХОШЭТНО ЭrКЧspШrЭОr, ANT) , . MPTVDAC ANT. , . . MPT . , CК , 2+ . , . , CК2+ , - CК2+ . , CК2+ MPT . , CК2+ , MPT. MPT 2+ 23187, CК 2+ Ca , , . 2+ 23187 , . , 623 , , . , , . . ( ) 14 , . . , ( ) ( ) , . , - / . « ». , . , , , , , . , , , , , . , , . , , . , , ApКП-1, НATP - , , . -9, – ( - 3), . , з30% . . , , . , . . 15 , , , , . , , , . , . / , . / . , 1 . 1 , , . . / , . . , . TUNEL , . / TUNEL. TUNEL . , , , . -3. 16 , . -3 , -3 , . , - , . , . . , , , . / . / . , 1 , . , , . / . . / , . , 1 , . . TUNEL , / , TUNEL . TUNEL , , , -3 , 17 . , , . , , 4.5 . , , . 7 4.5 . 62%. , 31 34%, . , , , . , . 2009 . , 2+ . (300 2+ / ) (20 10 / , ). 2+ , . , . , . 2+ , , , 2+ . , . , . , , , . 18 , , . , , . , . , 1. . , 2. . 3. . , 4. . , 1. Kholmukhamedov A, Czerny C, Hu J, Schwartz J, Zhong Z, Lemasters JJ. Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock/resuscitation. Shock. 2014 Sep;42(3):256-63. 2. Kholmukhamedov A, Lemasters JJ. Hemorrhage/Resuscitation-induced liver injury: Protection by Iron Chelation. Shock 2013. 39 (Suppl. 1), 100. 3. Czerny C, Kholmukhamedov A, Theruvath T, Maldonado E, Ramshesh V, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. Minocycline Decreases Liver Injury after Hemorrhagic Shock and Resuscitation in Mice. HPB Surg. 2012; 2012:259512. 4. Kholmukhamedov A, Czerny C, Lemasters JJ. Liver injury following hemorrhagic shock/resuscitation: Mechanisms and targeted therapy with minocycline. Shock 2012. 37 (Suppl. 1), 77. 19 5. Kholmukhamedov A, Zhang X, Schwartz J, Lemasters JJ. Lysosomal iron release promotes hemorrhage/resuscitation-induced liver injury. Toxicol. Sci. 2012. 126 (Suppl. 1), 80-81. 6. Kholmukhamedov A, Czerny C, Hu J, Schwartz J, Zhong Z, Lemasters JJ. Minocycline and doxycycline, but not tetracycline, decrease liver and kidney injury after hemorrhagic shock and resuscitation in mice. Toxicol. Sci 2011. 120 (Suppl. 2), 354-355. 7. Kholmukhamedov A, Czerny C, Hu J, Schwartz J, Lemasters JJ. Minocycline and doxycycline decrease liver and kidney injury after hemorrhagic shock/resuscitation in mice. Hepatology 2010. 52 (Suppl.), 588A. 8. Kholmukhamedov A, Czerny C, Hu J, Schwartz J, Zhong Z, Lemasters JJ. Minocycline decreases liver and kidney injury after hemorrhagic shock and resuscitation in mice: comparison of minocycline pre- and post-treatment. In Program Book and Abstracts: Southeastern Society of Toxicology Fall Meeting, Athens, GA, October 11-12, 2010. 20