Генетика. - labogen.ru

1983.
. XIX,
1. - . 58-63
575.11:599.323.4
tII.
,
(t-
.
),
,
.
Mus musculus L.
,
>50%.
t-
,
. musculus
(t0, t9, t12
.
tw5),
,
t.
– t-
t-
–
(tv – viable),
tv
1
t [3,
:
(lethal – t1) [1, 2].
sl
(semilethal – t )
.
tv
;
,
4].
tsl
2
,
t v-
t
wPa-3
tsl
,
(twPa-2
,
[5].
:
),
tv- [4],
51%
.
,
(tw2)
tsl
51%-
[6]
tsl
tsl
.
t-
«
»
.
tsl
100%-
,
,
10%
.
,
»,
tv
twPa-2 twPa-3),
tsl
,
tsl
,
10-100%.
,
,
-
.
– tl
.
,
,
,
,
-
tl
.
[2, 4, 7, 8].
,
,
.
tl
-
.
[9, 10].
,
. musculus.
tl1/tl2
-
–
t
,
1
,
,
,
-2 [11, 12].
, -
,
t(0,5);
t-
>0,5.
t. musculus,
[8].
t:
«
»
«
11
,
tl
t-
-
» [13, 14].
,
,
tw5).
.
,
(t0, t9, t12
,
,
+/tw
tw –
[2]).
,
,
;
[13] (
. wild
,
,
(T/t)
T/tw.
.
T/tw
(T/t
w
.
+/tw
/tw)
.
tw
t v-, tsl(
[
T/tw (Stw
+/+ ×
-
tw
–
)
Stw
tl
,
+/tw
T/tw
+/tw]),
0 9 12
: t,t,t
tw5 [8].
T/t
.
tw
,
(
,
-
tw
,
T/tw
t/t
-
)
T/tw.
,
,
. tw
[2, 10].
,
tl1/tl2 (n )
)
.
T/t,
(N)
. N=2T/t.
:
0,5 ( .
[2]),
: T/T + tl1/tl2 = T/tl1/ + T/tl2.
(T/t1),
,
)
(
,
.
tl1/tl2
K=n : n ×100%.
-
(K)
)
,
, N=2T/t.
St
: n=N:2×St.
3
(
*
0,01%-
(tw
)
: «+» – 5%;
«—» –
;
«++» – 1%-
; «+++» –
.
.1
tw
tw
,
(T/tw
,
/tw)
(Stw)
-
.
:
(T/tw)
.
,
tv
(2,6-3,8
)
tsl.
-
,
(3,0-3,8
(St 0,80)
).
-
(St 0,80)
.
(1:1)
.
t-
,
[2, 15].
.2
t12-
t0-, t9-,
(t6, twl8, t12, tw5),
.
, . .,
tw5
,
[2, 8, 9].
),
tw
(
tw
.
.
. 2),
,
tw
K
(
,
.
.2
3)
t-
[9].
,
,
,
tw
,
culus
-
. 3).
(
.
,
. mus[2, 4,
),
,
15].
– tw5,
,
.
,
tw5
,
[4, 16, 17].
. musculus
,
,
[18],
,
,
.
– tw73
[4, 16].
twPa-l,
,
tw
: twl (
), tw73
twPa~l
. musculus).
.1
1
t -,
/t
t
sl
tw
,
.
,
tsl
t /t ,
sl
,
sl sl
tsl/tsl
[5].
(T/tw
-
/tw)
.
tw
,
,
,
tw
,
tsl
10%-
.
tsl
2
twM45, twM08, twM010
,
twM024
t1 .
t1-,
,
[2].
twM16, twM17-6, twM41, twM28,
,
twM07, twM017 twM018
-
ts1
.
,
(T/t× /t),
t1-,
ts1
.
tw
. musculus
w
(t )
(1:1).
,
-
,
,
-
,
[6, 15].
tw
. 3).
,
,
,
tw
Kcp
(
tw
,
.
-
,
.
,
,
.
,
,
tw
,
(
.
. 3).
.
,
Kcp
«
,
»
«
»
tl
.
1. Bennett D., Dunn L. . Transmission ratio distorting genes on chromosome IX and their interaction.
–In: Immunogenetics of the H-2 System. Karger, Basel, 1971, p. 90.
2. Bennett D. The T-locus of the mouse. -Cell, 1975, v. 6, p. 441.
3. Braden A. W. H. T-locus in mice: segregation distortion and sterility in the male. – In: The genetics
of the spermatozoon.– Proc. Int. Sympos. Edinburgh, 1972, p. 289.
4. Guenet J.L., Condamine H., Gaillard J., Jacob F. twPa-1, twPa-2, twPa-3: three new t-haplotypes in
the mouse. - Genet. Res., 1980, v. 36. 2, p. 211.
5. Bennett D., Dunn L. C. Genetical and embriological comparisons of semilethal t alleles from wild
mouse populations. – Genetics, 1969, v. 61, 2, p. 411.
6. Lewontin R. C. The effect of differential viability on the population dinamics of t-alleles in the
mouse.- Evolution, 1968, v. 22, 2, p. 262.
7. Artzl K., Rabiarz ., Bennett D. A t-haplotype (tw35) overlapping two complementation groups. Genet. Res., 1979, v. 33, 3, p. 279.
8.
. .,
. .
(Mus musculus L.).–
.:
.
. 9. .:
, 1980, . 97.
9. Silagi S. A genetical and embriological study of partial complementation between lethal alleles at the
T locus of the house mouse. –Develop. Biol., 1962, v. 5, 1, p. 35.
10.
. .
(Mus musculus L.).
–
.
., 1980, . 14, 2, . 73.
11. Hammerberg G., Klein J., Artzt K., Bennett D. Histocompatibility-2-system in wild mice. II. H-2
haplotypes of t-bearing mice. – Transplantation. 1976, v. 21, 3, p. 199.
12. Snell G. D. The H-2 locus of the mouse: observations and speculations concerning its comparative
genetics and its polymorphism. –Folia Biol. (Praha), 1968, v. 14, 5, p. 335.
13.
,
.,
.
t.
I.
tMus musculus L.
.. 1980, . 16, 7, . 1270.
14.
. ,
. .,
. .
(Mus musculus L.).–
.
., 1981, . 16, 12, . 182.
15.
.
:
Mus musculus.–
.:
. .:
, 1977, . 39.
16. Dunn L. , Bennett D., Cookingham J. Polymorphisms for lethal alleles in European populations of
Mus musculus. – J. Mammal., 1973. v. 54, 4, p. 822.
17. Klein J., Hammerberg The control of differentiation by the T complex. – Immunol. Revs, 1977, v.
33, p. 70.
18. Chaline J. Rodents, evolution and prehistory. – Endeavour, 1977, v. 1, 2, p. 44.
29.V.1981
. .
,
25.IX.1984
STUDY OF t-HAPLOTYPES OF NATURAL MOUSE POPULATIONS
(MUS MUSCULUS L.)
II. ANALYSIS OF COMPLEMENTATION GROUPS
DEMIN Yu. S., KRYUKOV V. I.
A. N. Severtzov Institute of Evolutionary Morphology
and Ecology of Animals, Academy of Sciences of the USSR, Moscow
Summar
w
A description of eleven t -haplotypes (T locus, IX linkage group of Mus musculus L.) is presented which
were found in two natural populations of mice from Tajikistan (USSR). These haplotypes are recessive
lethals with the transmission ratio 0.73-1.00. It was shown that they do not belong to the t0, t9, t12 and tw5
complementation groups.
:
,
,
II.
1. – . 58-63
,
.
t//
.
. –1983. – . XIX,