СКОРОСТЬ КРОВОТОКА В АРТЕРИОЛАХ У БОЛЬНЫХ

2012. – . 10,
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СКОРОСТЬ КРОВОТОКА В АРТЕРИОЛАХ У БОЛЬНЫХ
АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ
ГБОУ ВПО «Тверская ГМА Минздравсоцразвития РФ»
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BLOOD VELOCITY IN ARTERIOLES IN PATIENTS
WITH ARTERIAL HYPERTENSION
V.C. Volkov, O.B. Poselyugina, E.V. Rudenko
Aim. To study blood velocity in arterioles in patients with arterial hypertension (AH) by means of Dopplerography.
Material and methods. 90 patients with essential AH 83 patients with diabetes mellitus of the 2-nd type (DM-2) who
had associated AH were examind. Blood velocity in arterioles was determined in them with the help of an apparatus
«Miniplax-Doppler-K»: during a systole (Vs cm/s) diastole (Vd cm/s) and during the mean blood flow cycle (Vm cm/s)
Then for 1 min spontaneous changes of blood velocity were recorded the shifts were expressed in percents In patients
with DM-2 blood velocity in relation to the disease duration was studied In 43 patients with AH after their therapy Vs
and Vd values were defined Control group consisted of 102 subjects.
Results. It was established that AH patients had the highest blood velocity, then in this respect healthy persons stand,
DM-2 with AH patients take the 3-rd place. Fluctuations in blood velocity during a systole were the highest in healthy
persons, they were less in AH and the least in DM-2 with AH patients. Variations of blood velocity during a diastole
were the highest in AH patients, less in DM-2 with AH patients and the least in healthy persons. Blood velocity in arterioles decreases with DM-2 duration growth. In AH patients under the influence of hypotensive drugs blood velocity in
arterioles reduces.
Conclusion. The study of blood velocity in arterioles allows to have a clear view about functional condition of these
vessels in AH patients.
Key words: arterial hypertension, type 2 diabetes, mellitus arterioles.
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2012. – . 10,
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. .
1. Ward R., Sparrow D., Landsberg L. et al. The influence of
obesity, insulin and sympathetic nervous system activity on blood
pressure // Clin. Res. – 1993. – Vol. 41. – P. 168–174.
2. Glans R.O., Bilo H.J., Donker A.J. The renal response to
exogenous insulin in non-insulin-dependent diabetes mellitus in
relation to blood pressure and cardiovascular hormonal status //
Dial. Transplant. – 1996. – Vol. 11. – P. 794–802.
3.
. .,
. .,
. .
2-
//
4.
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. – 2006. –
3. – . 34–37.
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. – 2006. – 344 .
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5.
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//
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53-85-65; e-mail: gzyrina@yandex.ru
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