ʓʞʖʜʚʝʒÑʖʜʚÏÐÍÐʝÑÐʛÐÍʖʘÐÐ ʝʚʔʜʖʘʖʙʙØʖʓʝʛʖʒʞØʛʓʞʚʕʖʙʖÏʓ ÍÐʓʕʙʚʝʞÐʒÐÐÑʖÔʖʙÐÜ Ðʔʝʢʥßãʢçäʤ ʓʓʓçíʢåʢʦ ʔʔʒʧʨʡʥìʧä 2017 )3". ÒÍʒ ÌÌʒ ʝ ÒÞʡáʡʢæðʢäʤååʢßãΊ ʔʡíʢæʧÞçãæʡçãóèʥʢàåʡßʡʢéʦôʥʧäʤÞʤàʦéÞʤàåôäåãçãëãʦéʤÞ èʤʦÞôîʢççʤʢ çʡãÝʤåʢʢʡäéʧʡåñçʤʣèʥʤÝåʢæʢʦʤÞʥʢæʢççʤʣæʢàãëãçðąʡéʢʥʤʦäåʢʥʤâʧÒʦèʢíçʤ Ýʤʥʤéñʦô ʦ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðæã âʡÝʤåʢÞʡçãôæã çʢÞʤâæʤáçʤ Ýʢâ âçʡçãʣ ʤèʡéʤßʢçʢâʢʡéʢʥʤʦäåʢʥʤâʡ ʢßʤàãʡßçʤʦéãäʢãåʢìʢçããʜʡâÞãéãʢåʡÝʤʥʡéʤʥçðʨ ã ãçʦéʥʧæʢçéʡåñçðʨ æʢéʤàʤÞ ãʦʦåʢàʤÞʡçãô Þçʢàʥʢçãʢ ßʢçʢéãìʢʦäʤßʤ ʡçʡåãâʡ Þ äåãçãìʢʦäʧó èʥʡäéãäʧ èʤôÞåʢçãʢ çʤÞðʨ ßãèʤåãèãàʢæãìʢʦäãʨ èʥʢèʡʥʡéʤÞ ʤéäʥðÞʡóéçʤÞðʢÞʤâæʤáçʤʦéãÞÝʤʥñÝʢʦòéãæʦʢʥñʢâçðæâʡÝʤåʢÞʡçãʢæʔçʡʦéʤôîʢæʥʧäʤÞʤàʦéÞʢèʥʢàʦéʡÞåʢçðʦʤÞʥʢæʢççðʢàʡççðʢ äʡʦʡóîãʢʦôòèãàʢæãʤåʤßãã èʥʤêãåʡäéãäã àãʡßçʤʦéãäã ã åʢìʢçãô ʡéʢʥʤʦäåʢʥʤâʡ ʘʤçʤßʥʡêãô èʥʢàʦéʡÞåôʢéʦʤÝʤʣäʤæèʡäéçðʣéʥʧà ÞäʤéʤʥðʣÞäåóìʢçʡÞʦôçʢʤÝʨʤàãæʡôãçêʤʥæʡëãô ãèʥʢàçʡâçʡìʢçʡàåôäʡʥàãʤåʤßʤÞ éʢʥʡèʢÞéʤÞãÞʥʡìʢʣàʥʧßãʨʦèʢëãʡåñçʤʦéʢʣ ʕåʡÞçðʣÞçʢíéʡéçðʣʦèʢëãʡåãʦéąäʡʥàãʤåʤß ʘãçãʦéʢʥʦéÞʡâàʥʡÞʤʤʨʥʡçʢçãôʜʟ академик ʜʓʙ èʥʤêʢʦʦʤʥÐʥãçʡʖÞßʢçñʢÞçʡÔʡâʤÞʡ ʚßåʡÞåʢçãʢ ʚʕÑʓʔÑʖʙÐʖ ʝʛÐʝʚʒʝʚʒʜʓÖ ʖʙÐʗ ÚʛÐÍʖʘÐʚÑʚʕÐÜÏʓÌʚÑʖʔʓʙÐʗʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞʚʗʝÐʝʞʖʘØ ʓʞʖʜʚʝʒÑʖʜʚʞÐÔʖʝʒʚʕʚʕʖʙʖÏʓʔʘÐʜʖÐʜʟ ʓʞʖʜʚʝʒÑʖʜʚÏʒʓʒʚʝʙʚʔʙʚʗʟʓʒʞʚʜÐÌʝÐÓʖʜʖÌʜʚʔʓʝʒÒÑÜʜʙʚʗʛʓʞʚÑʚʕÐÐ10 ÚʔʚÑÛÓÐÜʛʜʖÍʝʞʓʔÑʖʙÐʗʚʛʜÐʜʚÍʖʓʞʖʜʚʝʒÑʖʜʚÏʓ 11 ʛʓʞʚʕʖʙʖʞÐÔʖʝʒÐʖʘʖʠʓʙÐÏʘØʓʞʖʜʚʝʒÑʖʜʚÏʓ ʜʚÑÙÑÐʛÐÍʚʔÐÑÐʛʚʛʜʚʞʖÐÍʚʔ ÚäâʤßʢççðʣãòçàʤßʢççðʣæʢéʡÝʤåãâæåãèãàʤÞãåãèʤèʥʤéʢãàʤÞ ʛʚʔʜʖÎÍʖʙÐʖÚʙÍʚʞʖÑÐÜ22 ʚʒÐʝÑʖʙÐʖÑʙʛ ʓʒʞÐʔʓÓÐÜÚʙÍʚʞʖÑÐÜÐʓÍʕʖÏÐÜÑʖʗʒʚÓÐʞʚʔ ʓʒʞÐʔʙʚʝʞÙÑʖʗʒʚÓÐʞʚʔʔÐʙʞÐʘʖ ʘʡäʥʤêʡßã Íʢçàʥãéçðʢäåʢéäã Ñãæêʤëãéð27 ʙʢʣéʥʤêãåð ʞʧìçðʢäåʢéäã ʟʚʜʘÐʜʚʔʓʙÐʖʓʞʖʜʚʝʒÑʖʜʚʞÐÔʖʝʒʚʗÌÑÜÕʒÐ ʘãßʥʡëãôãèʥʤåãêʢʥʡëãôßåʡàäʤæðíʢìçðʨäåʢéʤä ʜʢæʤàʢåãʥʤÞʡçãʢÞçʢäåʢéʤìçʤßʤæʡéʥãäʦʡ ʘʤÝãåãâʡëãôòçàʤéʢåãʡåñçðʨèʥʤßʢçãéʤʥçðʨäåʢéʤä ʙʢʤÞʡʦäʧåôʥãâʡëãô ʒʡåñëãêãäʡëãôÝåôíäã ʓèʤèéʤâ ÍʢʦéʡÝãåãâʡëãôÝåôíäããêʤʥæãʥʤÞʡçãʢéʥʤæÝʡ ʒÑʓʝʝÐʟÐʒʓÓÐÜÍÐʝÑÐʛÐÍʖʘÐʗ ʟʓʒʞʚʜØʜÐʝʒʓʜʓÏʔÐʞÐÜʓʞʖʜʚʝʒÑʖʜʚÏʓ ÐʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞØʠʚʝÑʚÎʙʖʙÐʗ ʘʚÍÐʟÐÓÐʜÒʖʘØʖÐʙʖʘʚÍÐʟÐÓÐʜÒʖʘØʖʟʓʒʞʚʜØʜÐʝʒʓ ʝʞʜʓʞÐʟÐʒʓÓÐÜʜÐʝʒʓʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞØʠʚʝÑʚÎʙʖʙÐʗ ʒʓʞʖʕʚʜÐÐʜÐʝʒʓʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞØʠʚʝÑʚÎʙʖʙÐʗ 3 ʚßåʡÞåʢçãʢ ʒÑÐʙÐÔʖʝʒʓÜʚÓʖʙʒʓʝʚʝʞʚÜʙÐÜʛʜÐʓʞʖʜʚʝʒÑʖʜʚÏʖ ÑʓÌʚʜʓʞʚʜʙʓÜÍÐʓʕʙʚʝʞÐʒʓ ÑÐʛÐÍʙØʗʛʜʚʟÐÑÙ ʔʚʝʛʓÑÐʞʖÑÙʙØʖÌÐʚʘʓʜʒʖʜØ ʝ ʥʢʡäéãÞçðʣÝʢåʤä Ñãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʡôêʤʦêʤåãèʡâʡʓ Ðçéʢʥåʢʣäãçð ÍʥʧßãʢÝãʤæʡʥäʢʥð ÐʙʝʞʜÒʘʖʙʞʓÑÙʙʓÜÍÐʓʕʙʚʝʞÐʒʓ ʙʖÐʙʔʓÏÐʔʙØʖʘʖʞʚÍØ ÒåñéʥʡâÞʧäʤÞðʢæʢéʤàð ʘʧåñéãʦèãʥʡåñçʡôäʤæèñóéʢʥçʡôéʤæʤßʥʡêãô ʘʡßçãéçʤ ʥʢâʤçʡçʦçʡôéʤæʤßʥʡêãô ʜʡàãʤçʧäåãàçʡôàãʡßçʤʦéãäʡ ÐʙʔʓÏÐʔʙØʖʘʖʞʚÍØ ʒʤʥʤçʡʥʤʡçßãʤßʥʡêãô ʔçʧéʥãʦʤʦʧàãʦéʤʢʧåñéʥʡâÞʧäʤÞʤʢãʦʦåʢàʤÞʡçãʢ ʚèéãìʢʦäʡôäʤßʢʥʢçéçʡôéʤæʤßʥʡêãô70 ÍʥʧßãʢãçÞʡâãÞçðʢæʢéʤàð ʛʜʚʟÐÑʓʒʞÐʒʓÐÑʖÔʖʙÐʖʓʞʖʜʚʝʒÑʖʜʚÏʓÐÍÐʝÑÐʛÐÍʖʘÐʗ ʙʖʘʖÍÐʒʓʘʖʙʞʚÏʙʓÜʞʖʜʓʛÐÜ ʘʖÍÐʒʓʘʖʙʞʚÏʙʓÜʕÐʛʚÑÐʛÐÍʖʘÐÔʖʝʒʓÜʞʖʜʓʛÐÜ ʝéʡéãçð ÚâʢéãæãÝ ʓçéãéʢåʡä0#3+ ʟãÝʥʡéð ʚæʢßʡ èʤåãçʢçʡʦðîʢççðʢáãʥçðʢäãʦåʤéð ʝʢäÞʢʦéʥʡçéðáʢåìçðʨäãʦåʤé ʙʤÞðʢåãèʤéʥʤèçðʢèʥʢèʡʥʡéð 4 ʚßåʡÞåʢçãʢ ʔʚÏʘʚÎʙʚʝʞÐʒʚʘÌÐʙÐʜʚʔʓʙʙʚʗʕÐʛʚÑÐʛÐÍʖʘÐÔʖʝʒʚʗʞʖʜʓʛÐÐ ʚʝʚÌʖʙʙʚʝʞÐʞʖʜʓʛÐÐʔʚʞÍʖÑÙʙØʠʕʜÒʛʛʓʠʙʓʝʖÑʖʙÐÜ ʚʝʚÌʖʙʙʚʝʞÐʞʖÔʖʙÐÜÐʞʖʜʓʛÐÐʝʖʘʖʗʙʚʗʕÐʛʖʜʠʚÑʖʝʞʖʜÐʙʖʘÐÐ Úéãʤåʤßãôãʥʡʦèʥʤʦéʥʡçʢççʤʦéñʝʕʠʝ ʓåßʤʥãéæÞðôÞåʢçãôèʡëãʢçéʤÞʦʝʕʠʝ100 Ñʢìʢçãʢʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãã ÚʒʝʞʜʓʒʚʜʛʚʜʓÑÙʙØʖʘʖʞʚÍØʔʞʖʜʓʛÐÐÍÐʝÑÐʛÐÍʖʘÐʗ ÏʓʒÑÛÔʖʙÐʖ ʛʜÐÑʚÎʖʙÐÜ 110 ʛʥãåʤáʢçãʢʚʦçʤÞçðʢßʧæʤʥʡåñçðʢêʡäéʤʥðʡéʢʥʤßʢçʢâʡ 110 ʛʥãåʤáʢçãʢʒåãçãìʢʦäãʢãʦʦåʢàʤÞʡçãôßãèʤåãèãàʢæãìʢʦäʤʣéʢʥʡèãã ʝʛÐʝʚʒÑÐʞʖʜʓʞÒʜØ 5 ʝèãʦʤäʦʤäʥʡîʢçãʣ ʝʛÐʝʚʒʝʚʒʜʓÖ ʖʙÐʗ CETP ą ÝʢåʤäąèʢʥʢçʤʦìãäòêãʥʤÞ ʨʤåʢʦéʢʥãçʡCHOLESTERYLESTER TRANSFERPROTEIN eNOS ą òçàʤéʢåãʡåñçʡô./ ʦãçéʡâʡ ENDOTHELIALNITRICOXIDESYNTHASE FDA ą ʡæʢʥãäʡçʦäãʣäʤæãéʢé èʤäʤçéʥʤåóâʡèãîʢÞðæã èʥʤàʧäéʡæããʦʥʢàʦéÞʡæã æʢàãëãçʦäʤßʤçʡâçʡìʢçãô&OOD AND$RUG!DMINISTRATION FGF ą êʡäéʤʥʥʤʦéʡêãÝʥʤÝåʡʦéʤÞ FIBROBLASTGROWTHFACTOR HIF-1 ą êʡäéʤʥ ãçàʧëãʥʤÞʡççðʣ ßãèʤäʦãʢʣHYPOXIA INDUCIBLE FACTOR ICAM ą æʢáäåʢéʤìçʡôæʤåʢäʧåʡʡàßʢâãã INTERCELLULARADHESIONMOLECULE MCP ą æʤçʤëãéʡʥçðʣ ʨʢæʤʡééʥʡäéʡçéçðʣèʥʤéʢãç MONOCYTECHEMOATTRACTANT PROTEIN NO ą ʤäʦãàʡâʤéʡNITRICOXIDE PCSK9 ą èʥʤèʥʤéʢãçʤÞʡôäʤçÞʢʥéʡâʡ ʦʧÝéãåãâãç äʢäʦãçʤÞʤßʤéãèʡ PROPROTEINCONVERTASESUBTILISIN KEXINTYPE PDGF ą êʡäéʤʥʥʤʦéʡéʥʤæÝʤëãéʤÞ PLATELET DERIVEDGROWTHFACTOR SCORE ą ʦãʦéʢæçʡôʤëʢçäʡ äʤʥʤçʡʥçʤßʤʥãʦäʡSYSTEMIC CORONARYRISKEVALUATION SDF ą êʡäéʤʥÞðʦÞʤÝʤáàʢçãôʦéʥʤæʡåñçðʨäåʢéʤäSTROMAL CELL DERIVEDFACTOR TGF ą éʥʡçʦêʤʥæãʥʧóîãʣêʡäéʤʥ ʥʤʦéʡTRANSFORMINGGROWTHFACTOR VCAM ą ʦʤʦʧàãʦéʡôæʤåʢäʧåʡʡàßʢâãã VASCULARCELLADHESIONMOLECULE 6 VEGF ą ʦʤʦʧàãʦéðʣòçàʤéʢåãʡåñçðʣêʡäéʤʥʥʤʦéʡVASCULAR ENDOTHELIALGROWTHFACTOR ʓʕ ą ʡʥéʢʥãʡåñçʡôßãèʢʥéʤçãô ʓÍ ą ʡʥéʢʥãʡåñçʤʢàʡÞåʢçãʢ ʓÑʞ ą ʡåʡçãçʡæãçʤéʥʡçʦêʢʥʡâʡ ʓʘʟ ą ʡàʢçʤâãçæʤçʤêʤʦêʡé ʓʝÌ ą ʡéʢʥʤʦäåʢʥʤéãìʢʦäʡôÝåôíäʡ ʓʝʞ ą ʡʦèʡʥéʡéʡæãçʤéʥʡçʦêʢʥʡâʡ ʓʞʟ ą ʡàʢçʤâãçéʥãêʤʦêʡé ʓʟʒ ą ʡäéãÞçðʢêʤʥæðäãʦåʤʥʤàʡ ʔʒʘ ą Þçʢäåʢéʤìçðʣæʡéʥãäʦ ʔʚÏ ą ʔʦʢæãʥçʡôʤʥßʡçãâʡëãô âàʥʡÞʤʤʨʥʡçʢçãô ʔʝÒÏÐą Þçʧéʥãʦʤʦʧàãʦéʤʢ ʧåñéʥʡâÞʧäʤÞʤʢãʦʦåʢàʤÞʡçãʢ ʕÑʛ ą ßãèʢʥåãèãàʢæãô ʕʘʕ ʒʤʓ ʥʢàʧäéʡâʡą ßãàʥʤäʦã æʢéãåßåóéʡʥãå äʤêʢʥæʢçé ʓʥʢàʧäéʡâʡ ʕʘʒ ą ßåʡàäʤæðíʢìçʡôäåʢéäʡ ʕʠʝ ą ßãèʢʥʨʤåʢʦéʢʥãçʢæãô ÍÑʛ ą àãʦåãèãàʢæãã Íʙʒ ą àʢâʤäʦãʥãÝʤçʧäåʢãçʤÞʡô äãʦåʤéʡ Íʝ ą àʧèåʢäʦçʤʢʦäʡçãʥʤÞʡçãʢ Îʒ ą áãʥçðʢäãʦåʤéð ÐÌʝ ą ãíʢæãìʢʦäʡôÝʤåʢâçñʦʢʥàëʡ ÐÑ ą ãçéʢʥåʢʣäãçð Ðʘ ą ãçêʡʥäéæãʤäʡʥàʡ Ðʘʞ ą ãçàʢäʦæʡʦʦðéʢåʡ Ðʟ ą ãçéʢʥêʢʥʤç ʒʓ ą äʤʥʤçʡʥçðʢʡʥéʢʥãã ʒʓʕ ą äʤʥʤçʡʥʤʡçßãʤßʥʡêãô ʒʝʟ ą äʤåʤçãʢʦéãæʧåãʥʧóîãʣêʡäéʤʥ ʒʟʒ ą äʥʢʡéãçêʤʦêʤäãçʡâʡ Ñʔʛ ą åãèʤèʥʤéʢãàðÞðʦʤäʤʣ èåʤéçʤʦéã ʝèãʦʤäʦʤäʥʡîʢçãʣ Ñʙʛ ą åãèʤèʥʤéʢãàðçãâäʤʣèåʤéçʤʦéã Ñʚʙʛ ą åãèʤèʥʤéʢãàðʤìʢçñçãâäʤʣ èåʤéçʤʦéã Ñèʡ ą åãèʤèʥʤéʢãàʡ Ñʙʛ 2 ą ʥʢëʢèéʤʥäÑʙʛ Ñʛʛ ą åãèʤèʥʤéʢãàðèʥʤæʢáʧéʤìçʤʣ èåʤéçʤʦéã Ñè ʟÑʓ ąåãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʡôêʤʦêʤåãèʡâʡʓ Ñʟʒ ą åãâʤêʤʦêʡéãàçʡôäãʦåʤéʡ Ñʠʓʞ ą ëãéãçʨʤåʢʦéʢʥãçʡëãåéʥʡçʦ êʢʥʡâʡ ʘʘʛ ą æʡéʥãäʦçðʢæʢéʡååʤèʥʤéʢãçʡâð ʘʛʚ ą æãʢåʤèʢʥʤäʦãàʡâʡ ʘʜʞ ą æʡßçãéçʤ ʥʢâʤçʡçʦçʡô éʤæʤßʥʡêãô ʘʝ ą æʢéʡÝʤåãìʢʦäãʣʦãçàʥʤæ ʘʝʒʞ ą æʧåñéãʦèãʥʡåñçʡô äʤæèñóéʢʥçʡôéʤæʤßʥʡêãô ʤäÑʙʛą ʤäãʦåʢççðʢÑʙʛ ʚʒʝ ą ʤʦéʥðʣäʤʥʤçʡʥçðʣʦãçàʥʤæ ʚʒʞ ą ʤèéãìʢʦäʡôäʤßʢʥʢçéçʡô éʤæʤßʥʡêãô ʚÚʒʞ ą ʤàçʤêʤéʤççʡôòæãʦʦãʤççʡô äʤæèñóéʢʥçʡôéʤæʤßʥʡêãô ʛÑ ą èʢìʢçʤìçʡôåãèʡâʡ ʛʙÎʒ ą èʤåãçʢçʡʦðîʢççðʢáãʥçðʢ äãʦåʤéð ʛÚʞ ą èʤâãéʥʤççʡôòæãʦʦãʤççʡô éʤæʤßʥʡêãô ʜʟʛ ą ʥʡàãʤêʡʥæèʥʢèʡʥʡé ʝʕʠʝ ą ʦʢæʢʣçʡôßãèʢʥʨʤåʢʦéʢʥãçʢæãô ʝÍ ą ʦʡʨʡʥçðʣàãʡÝʢé ʝÎʒ ą ʦʢäÞʢʦéʥʡçéðáʢåìçðʨäãʦåʤé ʝʒʟ ą ʦäʤʥʤʦéñäåʧÝʤìäʤÞʤʣ êãåñéʥʡëãã ʝʜÌ ʝʝÏ ą ʝ ʥʢʡäéãÞçðʣÝʢåʤä ą ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʢ âʡÝʤåʢÞʡçãô ʝʝʚ ą ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʢ ʤʦåʤáçʢçãʢ ʝʝʜ ą ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʣʥãʦä ʝʝʝ ą ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʡôʦæʢʥéçʤʦéñ ʞʕ ą éʥãßåãëʢʥãàð ʟʓʞʒ ą êãÝʥʤʡéʢʥʤæʡʦéʤçäʤʣ äʡèʦʧåʤʣ ʟÍʕ ą êéʤʥàʢâʤäʦãßåóäʤâʡ ʟÑ ą êʤʦêʤåãèãàð ʟʙʚ ą êʡäéʤʥçʢäʥʤâʡʤèʧʨʤåã ʟʜ ą êʡäéʤʥðʥãʦäʡ ʠÌʛ ą ʨʥʤçãìʢʦäʡôÝʤåʢâçñèʤìʢä ʠʘ ą ʨãåʤæãäʥʤçð ʠʛʙ ą ʨʥʤçãìʢʦäʡôèʤìʢìçʡô çʢàʤʦéʡéʤìçʤʦéñ ʠʝ ą ʨʤåʢʦéʢʥãç ʠʝÑʔʛą ʨʤåʢʦéʢʥãçåãèʤèʥʤéʢãàʤÞ Þðʦʤäʤʣèåʤéçʤʦéã ʠʝÑʙʛ ąʨʤåʢʦéʢʥãçåãèʤèʥʤéʢãàʤÞ çãâäʤʣèåʤéçʤʦéã ʠʝçʢ Ñʔʛąʨʤåʢʦéʢʥãç çʢʦÞôâʡççðʣ ʦåãèʤèʥʤéʢãàʡæãÞðʦʤäʤʣ èåʤéçʤʦéã ÓÒ ą ëʢåʢÞʤʣʧʥʤÞʢçñ Ôʝʝ ą ìʡʦéʤéʡʦʢʥàʢìçðʨʦʤäʥʡîʢçãʣ Úʒ ą òçàʤéʢåãʡåñçðʢäåʢéäã Úʛʒ ą òçàʤéʢåãʡåñçðʢèʥʤßʢçãéʤʥçðʢ äåʢéäã 7 ÚèãàʢæãʤåʤßãôâʡÝʤåʢÞʡçãʣʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣʦãʦéʢæðʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤßʢçʢâʡ Þæãʥʢãʜʟ ÚʛÐÍʖʘÐʚÑʚʕÐÜÏʓÌʚÑʖʔʓʙÐʗ ʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞʚʗʝÐʝʞʖʘØ ʓʞʖʜʚʝʒÑʖʜʚʞÐÔʖʝʒʚʕʚʕʖʙʖÏʓʔʘÐʜʖÐʜʟ Ðíʢæãìʢʦäʡô Ýʤåʢâçñ ʦʢʥàëʡ ÐÌʝ ʤʦéʡʢéʦô ßåʡÞçʤʣ èʥãìãçʤʣ ʦæʢʥéã Þʤ ÞʦʢʨʥʡâÞãéðʨʦéʥʡçʡʨʝæʢʥéçʤʦéñʤéʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣʝʝÏ çʡæçʤßʤʤèʢʥʢáʡʢéʦæʢʥéçʤʦéñʤéãçêʢäëãʤççðʨãʤçäʤåʤßãìʢʦäãʨÝʤåʢâçʢʣʛʤ ʤëʢçäʡæʔʦʢæãʥçʤʣʤʥßʡçãâʡëããâàʥʡÞʤʤʨʥʡçʢçãôʔʚÏ ÞßʤéʝʝÏÞʤÞʦʢæ æãʥʢʧæʢʥåʤ æåçìʢåʤÞʢä ìéʤʦʤʦéʡÞãåʤʤéÞʦʢʣæãʥʤÞʤʣʦæʢʥéçʤʦéã;= Ðâòéʤßʤìãʦåʡ æåç ʧæʢʥåãʤéÐÌʝ æåç ąʤéãçʦʧåñéʡʛʤèʤàʦìʢéʡæʔʚÏ äßʤéʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣʢáʢßʤàçʤÝʧàʧéʧæãʥʡéñ ʤäʤåʤ æåçìʢåʤÞʢäʜʡʦèʥʤʦéʥʡçʢççʤʦéñÐÌʝèʤʦʤʦéʤôçãóçʡßʧåãë ąåʢéʦʤʦéʡÞåôåʡąʧáʢçîãç ąąʧæʧáìãç ʧåãëąåʢéąą ʧáʢçîãç ąąʧæʧáìãç;=ʜʡʦèʥʤʦéʥʡçʢççʤʦéñÐÌʝʧæʧáìãçãáʢçîãç èʤʦåʢåʢéâçʡìãæʤçʢʥʡâåãìʡʢéʦô èʤòéʤæʧÞòéʤʣÞʤâʥʡʦéçʤʣßʥʧèèʢʥãʦäʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʧæʧáìãçãáʢçîãçʤàãçʡäʤÞ;ą=ʖáʢßʤàçʡô ʤÝîʡô ʦæʢʥéçʤʦéñ çʡʦʢåʢçãô ʦʤʦéʡÞåôʢé èʤ ʥʡâçðæ àʡççðæ ą èʥãòéʤæʦʢʥàʢìçʤ ʦʤʦʧàãʦéʡôʦæʢʥéçʤʦéñʝʝʝ ą ą ìʡʦéʤéʡçʢêʡéʡåñçʤßʤÐʘąʤé èʤàʡççðæãʦʦåʢàʤÞʡçãô2)4! àʤ èʤàʡççðæ#/52!'% ; ą=ʛʥãòéʤæʧÝʤåñçðʨʤìʢçñÞðʦʤäʤßʤʥãʦäʡʢáʢßʤàçʡôʦæʢʥéçʤʦéñʧÞʢåãìãÞʡʢéʦôàʤ ÞéʤÞʥʢæôäʡäʧÝʤåñçðʨʦßʢæʤàãçʡæãìʢʦäãçʢâçʡìãæðæʡéʢʥʤʦäåʢʥʤâʤæäʤʥʤçʡʥçðʨʡʥéʢʥãʣʦæʢʥéçʤʦéñçʡʨʤàãéʦôçʡʧʥʤÞçʢ àʡççðʢ ʥʢßãʦéʥʡ2%!#( ;= ÐâæåçʦåʧìʡʢÞʦæʢʥéãʤéçʢãçêʢäëãʤççðʨâʡÝʤåʢÞʡçãʣÞæãʥʢÞß ʧåãëÞÞʤâʥʡʦéʢàʤåʢéʦåʧìʡʢÞèʥãíåʤʦñçʡàʤåóʦéʥʡçʦçãâäãæãʦʥʢàçãæʧʥʤÞçʢæàʤʨʤàʡ ÞäʤéʤʥðʢÞʨʤàãéãʜʟʝʝÏąÞʢàʧîʡôèʥãìãçʡʦæʢʥéãçʡʦʢåʢçãôÞʜʟʦÞäåʡàʤæÞʤÝîʧóʦæʢʥéçʤʦéñ;=ʝʝÏąéʡäáʢçʡãÝʤåʢʢìʡʦéʡô èʥãìãçʡßʤʦèãéʡåãâʡëãʣãèʤéʢʥñéʥʧàʤʦèʤʦʤÝçʤʦéãçʡʦʢåʢçãôʜʟÚäʤçʤæãìʢʦäãʣʧîʢʥÝʤéʝʝÏÞʜʟʦʤʦéʡÞåôʢéèʤʥôàäʡÞçʧéʥʢççʢßʤÞʡåʤÞʤßʤèʥʤàʧäéʡ ʦéʥʡçð;=ʒʥãÞʡôʦæʢʥéçʤʦéãʤéʝʝÏÞʜʟãæʢʢéÞʤåçʤʤÝʥʡâçʧóêʤʥæʧąʦ èʤßʤçʡÞʤâʥʡʦéʡåʡʦàʤʦåʧìʡʢÞçʡéðʦçʡʦʢåʢçãô âʡéʢæʤéæʢìʡåʦôʦèʡààʤʦåʧìʡʢÞÞß èʤʦåʢìʢßʤʦæʢʥéçʤʦéñʦçʤÞʡÞʤâʥʡʦéʡåʡ àʤʦåʧìʡʢÞÞßʝòéʤßʤæʤæʢçéʡãèʤçʡʦéʤôîʢʢÞʥʢæôʤéæʢìʡʢéʦôʤéçʤʦãéʢåñçʤʧʦéʤʣìãÞʡôéʢçàʢçëãôäʦçãáʢçãóʦæʢʥéçʤʦéãʤéʝʝÏ äʤéʤʥʡôÞß ʦʤʦéʡÞãåʡ ʦåʧìʡô Þ ß ą ʦåʧìʡô çʡ éðʦ çʡʦʢåʢçãô ;= ʚàçʡäʤ òéã èʤäʡâʡéʢåã èʤ èʥʢáçʢæʧ ôÞåôóéʦô ʤàçãæã ãâ ʦʡæðʨ Þðʦʤäãʨ Þ æãʥʢ èʥʢÞðíʡôʡçʡåʤßãìçðʢâçʡìʢçãôÞʥʡâÞãéðʨʦéʥʡçʡʨÞąʥʡâ;=ʞʥʢÞʤáçðæ êʡäéʤʥʤæ ôÞåôʢéʦô ʦʤʨʥʡçʢçãʢ ìʥʢâÞðìʡʣçʤ Þðʦʤäʤʣ àʤåã åãë éʥʧàʤʦèʤʦʤÝçʤßʤ Þʤâʥʡʦéʡ Þ ʦéʡéãʦéãäʢ ʦæʢʥéçʤʦéã ʤé ʝʝÏ Þ ʜʟ ʛʥã òéʤæ ʤʦçʤÞçʤʣ Þäåʡà 8 ÚèãàʢæãʤåʤßãôâʡÝʤåʢÞʡçãʣʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣʦãʦéʢæðʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤßʢçʢâʡ Þæãʥʢãʜʟ ÞʦæʢʥéçʤʦéñåãëéʥʧàʤʦèʤʦʤÝçʤßʤÞʤâʥʡʦéʡÞß Þçʤʦôéæʧáìãçðʚáãàʡʢæʡô èʥʤàʤåáãéʢåñçʤʦéñ áãâçã æʧáìãç çʢʦæʤéʥô çʡ ʢʢ èʤʦéʢèʢççðʣ ʥʤʦé ʤʦéʡʢéʦô äʥʡʣçʢ çãâäʤʣ åʢé Þ ß ʞʡäʧó ʦéʡéãʦéãäʧ æʤáçʤ éʥʡäéʤÞʡéñ äʡäiʦÞʢʥʨʦæʢʥéçʤʦéñxåãëéʥʧàʤʦèʤʦʤÝçʤßʤÞʤâʥʡʦéʡ èʥãìʢæèʥʢãæʧîʢʦéÞʢççʤ æʧáʦäʤßʤèʤåʡéʡÝå ;= ʞʡÝåãëʡ Íãçʡæãäʡèʥʤàʤåáãéʢåñçʤʦéãáãâçã ʤÝîʢʣʦæʢʥéçʤʦéã ʦæʢʥéçʤʦéãʤéʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣ ß ß ß ß ß ʔëʢåʤæ ʘʧáìãçð Îʢçîãçð ʔëʢåʤæ ʚÝîʡôʦæʢʥéçʤʦéñ äʤòêêãëãʢçé ʘʧáìãçð çʡéðʦçʡʦʢåʢçãô Îʢçîãçð ʔëʢåʤæ 170 ʘʧáìãçð Îʢçîãçð ʔëʢåʤæ ʘʧáìãçð Îʢçîãçð ʔëʢåʤæ ʚáãàʡʢæʡôèʥʤàʤåáãéʢåñçʤʦéñáãâçã èʥãʥʤáàʢçããåʢé ʔëʢåʤæ ÐâçãʨÞéʥʧàʤʦèʤʦʤÝʘʧáìãçð çʤæÞʤâʥʡʦéʢ Îʢçîãçð ÐâçãʨʤéʝʝÏ ʔéʤæìãʦåʢÐÌʝ ÓʢʥʢÝʥʤÞʡʦäʧåôʥçðʢ ʘʧáìãçð âʡÝʤåʢÞʡçãô Îʢçîãçð 9 ʓéʢʥʤʦäåʢʥʤâäʡäʤʦçʤÞçʤʣêʡäéʤʥÐÌʝãëʢʥʢÝʥʤÞʡʦäʧåôʥçʤʣèʡéʤåʤßãã ʓʞʖʜʚʝʒÑʖʜʚÏʒʓʒʚʝʙʚʔʙʚʗʟʓʒʞʚʜÐÌʝ ÐÓʖʜʖÌʜʚʔʓʝʒÒÑÜʜʙʚʗʛʓʞʚÑʚʕÐÐ ʚʦçʤÞçʤʣ èʥãìãçʤʣ ʥʡâÞãéãô ãíʢæãìʢʦäãʨ âʡÝʤåʢÞʡçãʣ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣʦãʦéʢæðôÞåôʢéʦôʡéʢʥʤʦäåʢʥʤâʒàʥʧßãæ æʢçʢʢʥʡʦèʥʤʦéʥʡçʢççðæèʥãìãçʡæÞʤâçãäçʤÞʢçãôãíʢæãìʢʦäʤʣÝʤåʢâçãʦʢʥàëʡʤéçʤʦôéèʡéʤåʤßãóæãäʥʤëãʥäʧåôéʤʥçʤßʤʥʧʦåʡæãʤäʡʥàʡãäʤʥʤçʡʥçðʣÞʡâʤʦèʡâæ;= ʝʤßåʡʦçʤʤèʥʢàʢåʢçãóʔʚÏ ʡéʢʥʤʦäåʢʥʤâąòéʤÞʡʥãʡÝʢåñçʡôäʤæÝãçʡëãôãâæʢçʢçãʣÞçʧéʥʢççʢʣʤÝʤåʤìäããçéãæð ʡʥéʢʥãʣ ÞäåóìʡóîʡôçʡäʤèåʢçãʢåãèãàʤÞ ʦåʤáçðʨ ʧßåʢÞʤàʤÞ êãÝʥʤâçʤʣ éäʡçã äʤæèʤçʢçéʤÞ äʥʤÞã äʡåñëãêãäʡëãó ã ʦʤèʧéʦéÞʧóîãʢãâæʢçʢçãôʦʥʢàçʢʣʤÝʤåʤìäãæʢàãã ʔéʢìʢçãʢàåãéʢåñçʤßʤÞʥʢæʢçã ʡéʢʥʤʦäåʢʥʤâæʤáʢéèʥʤéʢäʡéñÝʢʦʦãæèéʤæçʤ åãíñʦʤÞʥʢæʢçʢæèʥãÞʤàôäèʤôÞåʢçãóʦéʢçʤäʡʥàãã ʨʥʤçãìʢʦäʤʣëʢʥʢÝʥʤÞʡʦäʧåôʥçʤʣçʢàʤʦéʡéʤìçʤʦéã èʢʥʢæʢáʡóîʢʣʦôʨʥʤæʤéʢãåãáʢäçʢèʤʦʥʢàʦéÞʢççʤʣæʡçãêʢʦéʡëãããçêʡʥäéʤææãʤäʡʥàʡ ãíʢæãìʢʦäãæ ãçʦʧåñéʤæ Þçʢâʡèçʤʣ ʦæʢʥéñó ʔ ʥʢâʧåñéʡéʢ ʤÝʥʡâʤÞʡçãô ã ʥʤʦéʡ ʓʝÌ èʥʤãʦʨʤàãé èʤʦéʢèʢççʤʢ ʦéʢçʤâãʥʤÞʡçãʢ äʤʥʤçʡʥçðʨ æʤâßʤÞðʨ ã àʥʧßãʨ ʡʥéʢʥãʣʚàçʡäʤìʡʦéʤèʢʥÞðæèʥʤôÞåʢçãʢæÐÌʝʦéʡçʤÞãéʦôãçêʡʥäéæãʤäʡʥàʡãåã ÞçʢâʡèçʡôʦæʢʥéñÞʦåʢàʦéÞãʢʥʡâʥðÞʡʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäã çʢʤÝéʧʥãʥʧóîʢʣèʥʤʦÞʢéʡʥéʢʥããʔéʡäãʨʦåʧìʡôʨèʥãìãçʤʣéʥʤæÝʤâʡʡʥéʢʥããôÞåôʢéʦôʥʡâʥðÞãʦéʤçìʢççʤʣèʤäʥðíäãʓʝÌʦʤÝçʡáʢçãʢæʢʢéʥʤæÝʤßʢççʤßʤåãèãàçʤßʤôàʥʡ ʜãʦÍʡççðʢãʦʦåʢàʤÞʡçãô-2&)4ʝʧÞʢåãìʢçãʢæäʤçëʢçéʥʡëããʨʤåʢʦéʢʥãçʡ ʧÞʢåãìãÞʡʢéʦôʥãʦäʦæʢʥéãʤéʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ;= ʛʤæãæʤ ßãèʢʥʨʤåʢʦéʢʥãçʢæãã èʥãÞʤàôîʢʣ ä ʥʡâÞãéãó ʡéʢʥʤʦäåʢʥʤâʡ ʥãʦ ä êʡäéʤʥʡæ ʥãʦäʡ ʥʡâÞãéãô ÐÌʝ ʤéçʤʦôéʦô ʡʥéʢʥãʡåñçʡô ßãèʢʥéʢçâãô ʦʡʨʡʥçðʣàãʡÝʢé ßãèʤàãçʡæãô ʤáãʥʢçãʢ äʧʥʢçãʢ ʤéôßʤîʢççðʣʦʢæʢʣçðʣʡçʡæçʢâ;ą=ʛʥʤêãåʡäéãìʢʦäãʢãéʢʥʡèʢÞéãìʢʦäãʢæʢʥʤèʥãôéãô çʡèʥʡÞåʢççðʢ çʡäʤʥʥʢäëãóêʡäéʤʥʤÞʥãʦäʡ èʤâÞʤåôóéʦçãâãéñÞʢʥʤôéçʤʦéñʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʢßʤʤʦåʤáçʢçãʣ; = 10 ÚÞʤåóëãôèʥʢàʦéʡÞåʢçãʣʤèʥãʥʤàʢʡéʢʥʤʦäåʢʥʤâʡ ÚʔʚÑÛÓÐÜʛʜʖÍʝʞʓʔÑʖʙÐʗʚʛʜÐʜʚÍʖ ʓʞʖʜʚʝʒÑʖʜʚÏʓ ʛʤãʦäòéãʤåʤßãìʢʦäãʨãèʡéʤßʢçʢéãìʢʦäãʨêʡäéʤʥʤÞʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡ çʡʦìãéðÞʡʢéÝʤåʢʢåʢéʔß!(ALLERàåôʤÝʤâçʡìʢçãôʤìʡßʤÞʤéåʤáʢçãô áãʥʤÞðʨæʡʦʦÞʦéʢçäʢʡʥéʢʥãʣèʥʢàåʤáãåéʢʥæãçiʡéʢʥʤæʡx'-ORGAGNI ʡ âʡéʢæ * #RUVEILHER ʤèãʦʡåã èʡéʤåʤßãìʢʦäãʢ ãâæʢçʢçãô ʡʥéʢʥãʣ Þ Þãàʢ ʧèåʤéçʢçãôãʨʦéʢçʤäʔß*,OBSTEINÞÞʢåèʤçôéãʢiʡʥéʢʥãʤʦäåʢʥʤâx ÞäåóìʡÞíʢʢʥʡâåãìçðʢèʤʦÞʤʢʣòéãʤåʤßãããèʡéʤßʢçʢâʧèʥʤëʢʦʦð ʤÝîãæãàåôäʤéʤʥðʨ Ýðåã ʦäåʢʥʤéãìʢʦäãʢ ãâæʢçʢçãô ʧéʤåîʢçãʢ ã àʢâʤʥßʡçãâʡëãô ʦʤʦʧàãʦéʤʣ ʦéʢçäãʞʢʥæãçiʡéʢʥʤʦäåʢʥʤâxßʥʢìATHEREąäʡíãëʡSKLEROSISąʧèåʤéçʢçãʢ Ýðå èʥʢàåʤáʢç&-ARCHANDÞß ãʤçèʤåʧìãåèʥãâçʡçãʢ èʤʦäʤåñäʧʧàʡìçʤèʤàìʢʥäãÞʡåʦÞʤʣʦéÞʢççʤʢâʡÝʤåʢÞʡçãóʦʤìʢéʡçãʢãâæʢçʢçãʣÞʦéʢçäʡʨʡʥéʢʥãʣʤéåʤáʢçãʢäʡíãëʢÞãàçðʨáãʥʤÞðʨæʡʦʦãʥʡâÞãéãʢʦʤʢàãçãéʢåñçʤʣéäʡçãÞʦéʢçäʢ ʡʥéʢʥãʣ ʙʡèʥʤéôáʢçããÝʤåʢʢåʢéèʥʢàåʡßʡåãʦñʥʡâåãìçðʢéʢʤʥããʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡ ʛʤ éʢʤʥãã àãʦäʥʡâãã + 2OKITANSKY ʡéʢʥʤʦäåʢʥʤâʧ èʥʢàíʢʦéÞʧʢéʤÝʥʡâʤÞʡçãʢéʥʤæÝʤÞçʡèʤÞʢʥʨçʤʦéããçéãæðʡʥéʢʥããʦèʤʦåʢàʧóîãæʢʢ èʤÞʥʢáàʢçãʢæ ʔ òéʤ áʢ Þʥʢæô 2 6IRCHOW èʥʢàåʤáãå iÞʤʦèʡåãéʢåñçʧóx éʢʤʥãóʡéʢʥʤʦäåʢʥʤâʡ ÞʦʤʤéÞʢéʦéÞããʦäʤéʤʥʤʣèʢʥÞʤèʥãìãçʤʣèʡéʤåʤßããʦìãéʡåʤʦñ æʢʨʡçãìʢʦäʤʢ èʤÞʥʢáàʢçãʢ ãçéãæð ʦ ʥʡâÞãéãʢæ ʢʢ èʥʤçãëʡʢæʤʦéã àåô äåʢéʤìçðʨ òåʢæʢçéʤÞ äʥʤÞã ã Þʤʦèʡåʢçãʢæ Þ ʦéʢçäʢ ʦʤʦʧàʡ éʥãʡàʡ 6IRCHOW ʞʢʤʥãô 2 4HOMA ʥʡʦʦæʡéʥãÞʡåʡ ʡéʢʥʤʦäåʢʥʤâ äʡä äʤæèʢçʦʡéʤʥçʤ ʥʢèʡʥʡéãÞçʤʢôÞåʢçãʢÞʤéÞʢéçʡʧéʥʡéʧʡʥéʢʥãôæãæðíʢìçʤßʤéʤçʧʦʡãòåʡʦéãìʢʦäãʨʦÞʤʣʦéÞ ʔßèʡéʤæʤʥêʤåʤßʡæãʙʙʓçãìäʤÞðæãʝʝʠʡåʡéʤÞðæÝðåʡÞðàÞãçʧéʡiʨʤåʢʦéʢʥãçʤÞʡôxéʢʤʥãôʡéʢʥʤʦäåʢʥʤâʡʝʤßåʡʦçʤʢʣ èʧʦäʤÞðææʤæʢçéʤæ ÞʥʡâÞãéããʡéʢʥʤʦäåʢʥʤâʡôÞåôʢéʦôãçêãåñéʥʡëãôʦéʢçäãʦʤʦʧàʡʨʤåʢʦéʢʥãçʤæ ʔòäʦèʢʥãæʢçéʡåñçðʨãʦʦåʢàʤÞʡçãôʨãæãÝðåʤèʤäʡâʡçʤ ìéʤàʤÝʡÞåʢçãʢʨʤåʢʦéʢʥãçʡ Þ ʥʡëãʤç äʥʤåãäʤÞ èʥãÞʤàãåʤ ä ʥʡâÞãéãó ʧ çãʨ ʡéʢʥʤʦäåʢʥʤâʡ Ð ʨʤéô ʤéæʤæʢçéʡʤäʤçìʡçãôʥʡÝʤéʙʙʓçãìäʤÞʡàʤèʤôÞåʢçãôʦéʡéãçʤÞèʥʤíåʤèʤìéã åʢé ãæʢççʤòéããʦʦåʢàʤÞʡçãôèʤâÞʤåãåãÞʤâàʢʣʦéÞʤÞʡéñçʡäåóìʢÞʤʢâÞʢçʤ èʡéʤßʢçʢâʡʡéʢʥʤʦäåʢʥʤâʡąʨʤåʢʦéʢʥãç ʡçʢéʤåñäʤèʥʤÞʤàãéñ ʦãæèéʤæʡéãìʢʦäʤʢåʢìʢçãʢ ʚàçʡäʤʥʤåñʨʤåʢʦéʢʥãçʡÞʥʡâÞãéããʡéʢʥʤʦäåʢʥʤâʡʧìʢåʤÞʢäʡàʤåßʤʢÞʥʢæô ʦéʡÞãåʡʦñèʤàʦʤæçʢçãʢ èʤäʡÞʦʢʥʢàãçʢ88Þçʢçʡìʡåʡʦñ èʤʦʧéã òèãàʢæãô ãçʦʧåñéʤÞ ã ãçêʡʥäéʤÞ æãʤäʡʥàʡ ʛʥãìãçð éʡäʤßʤ ôÞåʢçãô çʡìʡåã ãçéʢçʦãÞçʤ ãâʧìʡéñʦôÞòèãàʢæãʤåʤßãìʢʦäãʨãʦʦåʢàʤÞʡçãôʨʛʢʥÞðæãâ çãʨʦéʡåʤçʡìʡéʤʢ Þ ß ʟʥʡæãçßʢæʦäʤʢ ãʦʦåʢàʤÞʡçãʢ Þ äʤéʤʥʤʢ Ýðåã Þäåóìʢçð Þʦʢ áãéʢåã 11 ÚÞʤåóëãôèʥʢàʦéʡÞåʢçãʣʤèʥãʥʤàʢʡéʢʥʤʦäåʢʥʤâʡ çʢÝʤåñíʤßʤʡæʢʥãäʡçʦäʤßʤßʤʥʤàʡʟʥʡæãçßʢæÐʦʦåʢàʤÞʡçãʢàʡåʤÞʤâæʤáçʤʦéñ ÞðôÞãéñçʢéʤåñäʤʤʦçʤÞçðʢêʡäéʤʥðʥãʦäʡéʢʨãåããçðʨâʡÝʤåʢÞʡçãʣ çʤéʡäáʢ èʥʤʦåʢàãéñ äʡäãâæʢçôʢéʦôʦãéʧʡëãôʦéʢìʢçãʢæÞʥʢæʢçã ʦèʤôÞåʢçãʢæçʤÞðʨ æʢéʤàʤÞèʥʤêãåʡäéãäããåʢìʢçãôʔʥʢâʧåñéʡéʢòéʤßʤãʦʦåʢàʤÞʡçãôäßʦéʡåʤôʦçʤ ìéʤéʡäãʢêʡäéʤʥð äʡäßãèʢʥʨʤåʢʦéʢʥãçʢæãôʥãʦ èʤÞðíʢççʤʢʓÍ ãäʧʥʢçãʢ ʦʧîʢʦéÞʢççʤèʤÞðíʡóéʥãʦäʥʡâÞãéãôʝʝÏʒßèʤôÞãåãʦñàʡççðʢ ʦÞãàʢéʢåñʦéÞʧóîãʢʤéʤæ ìéʤÞʡáçʧóʥʤåñÞʡéʢʥʤßʢçʢâʢæʤßʧéãßʥʡéñçʢ éʤåñäʤʧʥʤÞʢçñʨʤåʢʦéʢʥãçʡ çʤãʧʥʤÞçãéʥãßåãëʢʥãàʤÞʞʕ ʨʤåʢʦéʢʥãçʡåãèʤèʥʤéʢãàʤÞçãâäʤʣãÞðʦʤäʤʣèåʤéçʤʦéãÑʙʛãÑʔʛ ʒßÞäʡìʢʦéÞʢèʥʤʡéʢʥʤßʢççðʨêʡäéʤʥʤÞàʤÝʡÞãåãʦñåãèʤèʥʤéʢãàʡ ãʡèʤèʥʤéʢãàʖ ʜãʦʔâʡãæʤʦÞôâñʧʥʤÞçôʠʝÑʙʛʦìʡʦéʤéʤʣʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ 0ąèåʡëʢÝʤ 3ąʦéʡéãçðʡàʡèéãʥʤÞʡçʤãâ"ALLANTYNEETAL ʛʡʥʡååʢåñçʤʦòéãæãʦʤÝðéãôæã7-EYER ʡâʡéʢæʙ"REDT ÞçʤÞñ èʥãÞåʢäåãÞçãæʡçãʢäéʢʤʥããʡéʢʥʤʦäåʢʥʤâʡ6IRCHOWÐʨãʦʦåʢàʤÞʡçãôèʤäʡâʡåã ìéʤ ãçêãåñéʥʡëãã åãèãàʡæã ʦʤʦʧàãʦéʤʣ ʦéʢçäã èʥʢàíʢʦéÞʧóé ãâæʢçʢçãô Þʢàʧîãʢ ä èʤÞðíʢçãó ʢʢ èʥʤçãëʡʢæʤʦéã Ñãèãàð èʥã òéʤæ ʥʡʦʦæʡéʥãÞʡåãʦñ çʢäʡäèʥãìãçʡ ʡåãíñäʡäãçàãäʡéʤʥðʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʥʤëʢʦʦʡÞʦéʢçäʢ ʡʥéʢʥãʣʔàʡåñçʢʣíʢæ22OSSã*'LOMSETèʥʢàåʤáãåãßãèʤéʢâʧʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡäʡäʤéÞʢéçʡèʤÞʥʢáàʢçãʢòçàʤéʢåãʡåñçʤʣÞðʦéãåäãʡʥéʢʥãʣ;=ʝʤßåʡʦçʤãʨéʢʤʥãã èʤÞʥʢáàʢçãʢòçàʤéʢåãôʦʤèʥʤÞʤáàʡʢéʦôèʤÞðíʢççʤʣʡàßʢâãʢʣ éʥʤæÝʤëãéʤÞ ÞðʦÞʤÝʤáàʢçãʢæéʥʤæÝʤëãéʡʥçʤßʤêʡäéʤʥʡʥʤʦéʡ èʥʤåãêʢʥʡëãʢʣ ã æãßʥʡëãʢʣ ßåʡàäʤæðíʢìçðʨ äåʢéʤä ʤÝʥʡâʤÞʡçãʢæ äåʡʦéʢʥʤÞ æʤçʤëãéʤÞ ʒ ʤʦçʤÞçðæ êʡäéʤʥʡæ ÞðâðÞʡóîãæ èʤÞʥʢáàʢçãʢ òçàʤéʢåãô Ýðåã ʤéçʢʦʢçð ʤäãʦñʧßåʢʥʤàʡ èʤʦéʧèʡóîʡôÞäʥʤÞñèʥãäʧʥʢçãã èʤÞðíʢçãʢʓÍ ìʥʢâæʢʥçðʢ êãâãìʢʦäãʢãåãòæʤëãʤçʡåñçðʢçʡßʥʧâäãÍãʦåãèãàʢæãôÝðåʡéʡäáʢʤéçʢʦʢçʡ 12 ÚÞʤåóëãôèʥʢàʦéʡÞåʢçãʣʤèʥãʥʤàʢʡéʢʥʤʦäåʢʥʤâʡ äèʤÞʥʢáàʡóîãæêʡäéʤʥʡæ äʡäãÝʡäéʢʥãããÞãʥʧʦðʨåʡæãàããèçʢÞæʤçãã ëãéʤæʢßʡåʤÞãʥʧʦ æʤàãêãëãʥʤÞʡççðʢ ʤäãʦåʢççðʢ àʢʦãʡåãʥʤÞʡççðʢ åãèʤèʥʤéʢãàðãʥôààʥʧßãʨêʡäéʤʥʤÞ ʛʤæʢʥʢçʡäʤèåʢçãôçʤÞðʨàʡççðʨʤèʥãʥʤàʢʡéʢʥʤʦäåʢʥʤâʡéʢʤʥãã ʧàʢåôóîãʢÞçãæʡçãʢåãíñäʡäʤæʧ åãÝʤʤàçʤæʧêʡäéʤʥʧ ʧʦéʧèʡåãæʢʦéʤäʤçëʢèëãôæ ʥʡʦʦæʡéʥãÞʡóîãæ æçʤßʤêʡäéʤʥçʤʢ ÞʤâàʢʣʦéÞãʢ çʡ ʦʤʦʧàãʦéʧó ʦéʢçäʧ ʓÑ ʘôʦçãäʤÞ ʦìãéʡå ìéʤ Þ ʤʦçʤÞʢ ʥʡâÞãéãô ʡéʢʥʤʦäåʢʥʤâʡ åʢáãé çʢʦäʤåñäʤ êʡäéʤʥʤÞ ʙʢ ʤéʥãëʡô ʥʤåã èãîʢÞʤßʤ ʨʤåʢʦéʢʥãçʡ ʤç ʤʦʤÝʤ èʤàìʢʥäãÞʡå Þʡáçʤʦéñ çʢʥÞçʤ ßʧæʤʥʡåñçðʨ ʥʡʦʦéʥʤʣʦéÞ Þʢàʧîãʨ ä çʡʥʧíʢçãôæ åãèãàçʤßʤ ãÝʢåäʤÞʤßʤæʢéʡÝʤåãâæʡÞʤʥßʡçãâæʢìʢåʤÞʢäʡ;=ʔéʤÞʥʢæôãææʧçʤåʤßãìʢʦäãʢãʦʦåʢàʤÞʡçãôéʤåñäʤçʡìãçʡåãÞçʢàʥôéñʦôÞäåãçãìʢʦäʧóèʥʡäéãäʧ èʤòéʤæʧâçʡìʢçãʢÞʥʡâÞãéããèʡéʤåʤßãìʢʦäʤßʤèʥʤëʢʦʦʡæʡʥäʢʥʤÞÞʤʦèʡåʢçãô èʥʤÞʤʦèʡåãéʢåñçðʨëãéʤäãçʤÞãʥʤʦéʤÞðʨêʡäéʤʥʤÞʦéʡåʤèʤçôéçðæßʤʥʡâàʤèʤâàçʢʢ ʘçʤßʤåʢéʦèʧʦéôèʤʦåʢʤéäʥðéãôʙʙʓçãìäʤÞʡãʝʝʠʡåʡéʤÞʡèʥʢàʦéʡÞåʢçãô ʤèʥãʥʤàʢʡéʢʥʤʦäåʢʥʤâʡãêʡäéʤʥʡʨʡéʢʥʤßʢçʢâʡÝðåãâçʡìãéʢåñçʤʥʡʦíãʥʢçð ÝåʡßʤàʡʥôæçʤßʤìãʦåʢççðæãʦʦåʢàʤÞʡçãôæʔʡáçʢʣíãæãâçãʨʦéʡåʤʤéäʥðéãʢ Þ ʨßßʥʢëʢèéʤʥʤÞäÑʙʛ-3"ROWN *,'OLDSTEIN ãæʢʨʡçãâæʤÞʦÞôâðÞʡçãôʠʝÑʙʛʦòéãæãʥʢëʢèéʤʥʡæãÌðåʡʤÝïôʦçʢçʡæʤåʢäʧåôʥçʤ ßʢçʢéãìʢʦäʡô èʥãʥʤàʡʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæããʝʕʠʝ ąâʡÝʤåʢÞʡçãô ʦʤèʥʤÞʤáàʡÞíʢßʤʦôèʥʢáàʢÞʥʢæʢççðæʥʡâÞãéãʢæʡéʢʥʤʦäåʢʥʤâʡãʦæʢʥéñóÞæʤåʤàʤæÞʤâʥʡʦéʢ ;=ÍʥʧßãæÞʡáçʢʣíãæʦʤÝðéãʢæçʡìʡåʡ ʨßßʦéʡåʤʤéäʥðéãʢôèʤçʦäãæÝãʤåʤßʤæ!%NDOäʤæèʡäéãçʡąÞʢîʢʦéÞʡ äʤçäʧʥʢçéçʤèʤàʡÞåôóîʢßʤàʢʣʦéÞãʢêʢʥæʢçéʡʕʘʕ ʒʤʓ ʥʢàʧäéʡâðąʤʦçʤÞçʤßʤʥʢßʧåôéʤʥʡÝãʤʦãçéʢâʡʠʝÚéʤʤéäʥðéãʢ èʥãÞʢåʤäʦʤâàʡçãóçʤÞʤßʤäåʡʦʦʡèʥʢèʡʥʡéʤÞąʦéʡéãçʤÞ òêêʢäéãÞçʤʦçãáʡóîãʨäʤçëʢçéʥʡëãóʠʝÑʙʛÞäʥʤÞãʛʥʤÞʢàʢççðʢÞèʤʦåʢàʦéÞããæçʤßʤìãʦåʢççðʢäåãçãìʢʦäãʢãʦʦåʢàʤÞʡçãôʦèʥãæʢçʢçãʢæʦéʡéãçʤÞʧÝʢàãéʢåñçʤèʤäʡâʡåã ìéʤʦçãáʢçãʢʧʥʤÞçôʠʝÑʙʛèʥãÞʤàãéäʧæʢçñíʢçãóçʤÞðʨʦåʧìʡʢÞãçêʡʥäéʡ æãʤäʡʥàʡ ãçʦʧåñéʡ ʡéʡäáʢʦçãáʢçãóèʤéʥʢÝçʤʦéãÞèʥʤÞʢàʢçããʤèʢʥʡéãÞçðʨ ÞæʢíʡéʢåñʦéÞçʡäʤʥʤçʡʥçðʨʡʥéʢʥãôʨ;=ʝʡæðæÞʡáçðæʥʢâʧåñéʡéʤæäåãçãìʢʦäãʨ ãʦʦåʢàʤÞʡçãʣ ʦéʡéãçʤÞ Ýðåʤ ʦçãáʢçãʢ çʢ éʤåñäʤ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ çʤãʤÝîʢʣʦæʢʥéçʤʦéãÍʡåñçʢʣíãʢãʦʦåʢàʤÞʡçãôèʤäʡâʡåã ìéʤéʢʥʡèãôʦéʡéãçʡæãÞÞðʦʤäãʨàʤâʡʨÞʢàʢéäʦéʡÝãåãâʡëãããàʡáʢʥʢßʥʢʦʦããʓʝÌ; = ʞʡäãæʤÝʥʡâʤæ ÞçʡʦéʤôîʢʢÞʥʢæôʡéʢʥʤʦäåʢʥʤâʥʡʦʦæʡéʥãÞʡʢéʦôäʡäæçʤßʤêʡäéʤʥçʤʢâʡÝʤåʢÞʡçãʢ ÞʤʦçʤÞʢäʤéʤʥʤßʤåʢáãéʦʤìʢéʡçãʢçʡʥʧíʢçãʣåãèãàçʤßʤʤÝæʢçʡ ÞʤâàʢʣʦéÞãʢèʤʥʡáʡóîãʨòçàʤéʢåãʣêʡäéʤʥʤÞãÞäåóìʢçãʢãææʧçʤåʤßãìʢʦäãʨæʢʨʡçãâæʤÞʦäåʢéʤìçðæãßʧæʤʥʡåñçðæʤéÞʢéʤæ 13 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʛʓʞʚʕʖʙʖʞÐÔʖʝʒÐʖʘʖʠʓʙÐÏʘØʓʞʖʜʚʝʒÑʖʜʚÏʓ ʚʦçʤÞçðæ òåʢæʢçéʤæ ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤ èʤʥʡáʢçãô ôÞåôʢéʦô ʓʝÌ ʛʤ æʢʥʢʧÞʢåãìʢçãôʢʢʤÝïʢæʡʤçʡÞðâðÞʡʢéʦʧáʢçãʢèʥʤʦÞʢéʡʡʥéʢʥãããʦèʤʦʤÝʦéÞʧʢéçʡʥʧíʢçãóäʥʤÞʤéʤäʡʙʡäʤèåʢçãʢåãèãàʤÞÞʦʢʥàëʢÞãçʢÝåôíäãʦʤèʥʤÞʤáàʡʢéʦô ʧÞʢåãìʢçãʢæ ʢʢ ʥʡâæʢʥʤÞ Þ ʥʢâʧåñéʡéʢ ìʢßʤ êãÝʥʤâçʡô èʤäʥðíäʡ Ýåôíäã èʤà àʢʣʦéÞãʢæ ʦèʢëãêãìʢʦäãʨ òçâãæʤÞ òåʡʦéʡâ æʢéʡååʤèʥʤéʢãçʡâ ãʦéʤçìʡʢéʦô ã èʥã ʤèʥʢàʢåʢççðʨ ʧʦåʤÞãôʨ æʤáʢé ʥʡâʤʥÞʡéñʦô ʜʡâʥðÞ Ýåôíäã ʦʤèʥʤÞʤáàʡʢéʦô ʡäéãÞʡëãʢʣ äʤʡßʧåôëãʤççʤßʤ äʡʦäʡàʡ äʥʤÞã ʡßʥʢßʡëãʢʣ éʥʤæÝʤëãéʤÞ ʦ ʤÝʥʡâʤÞʡçãʢæ éʥʤæÝʡ Ýåʤäãʥʧóîʢßʤ èʥʤʦÞʢé ʦʤʦʧàʡ ã èʤôÞåʢçãʢæ ʨʡʥʡäéʢʥçðʨäåãçãìʢʦäãʨèʥʤôÞåʢçãʣãíʢæããʤʥßʡçʡ äʥʤÞʤʦçʡÝáʡʢæʤßʤèʤʥʡáʢççʤʣʡʥéʢʥãʢʣ ʓʝÌæʤßʧéÝðéñʦéʡÝãåñçðæããçʢʦéʡÝãåñçðæãʞʡäʡôàãêêʢʥʢçëãʡëãôàåô äåãçãëãʦéʡ àʡáʢ Ýʤåʢʢ Þʡáçʡ çʢáʢåã ʦéʢèʢçñ ʦéʢçʤâãʥʤÞʡçãô ʡʥéʢʥãã ʝéʡÝãåñçʤʦéñÝåôíäãâʡÞãʦãéʤéʢʢʦéʥʤʢçãô ʥʡâæʢʥʤÞãäʤçêãßʧʥʡëããʝéʡÝãåñçðʢÝåôíäãʨʡʥʡäéʢʥãâʧóéʦôéʤåʦéʤʣ èåʤéçʤʣêãÝʥʤâçʤʣèʤäʥðíäʤʣ Ýʤßʡéʤʣ äʤååʡßʢçʤæ;=ʞʡäãʢʓʝÌʨʡʥʡäéʢʥãâʧóéʦôæʢàåʢççðæʥʤʦéʤæÞéʢìʢçãʢæçʤßãʨåʢé ʤçãæʤßʧéçʢʤäʡâðÞʡéñâçʡìãæʤßʤÞåãôçãôçʡäʥʤÞʤʦçʡÝáʢçãʢʤʥßʡçʤÞ ʙʢʦéʡÝãåñçðʢÝåôíäãʨʡʥʡäéʢʥãâʧóéʦôéʤçäʤʣæäæ êãÝʥʤâçʤʣäʡèʦʧåʤʣ èʥãâçʡäʡæãʡäéãÞçʤßʤÞʤʦèʡåʢçãôãçêãåñéʥʡëãôêãÝʥʤâçʤʣèʤäʥðíäãäåʢéäʡæãÞʤʦèʡåʢçãô ÞʤʦçʤÞçʤææʡäʥʤêʡßʡæã ʡäéãÞãʥʤÞʡççðæãʞ äåʢéäʡæããéʧìçðæã äåʢéäʡæã äʥʧèçðæ åãèãàçðæ ôàʥʤæ ʤé ʤÝïʢæʡ ʓʝÌ ʧìʡʦéäʡæã æãäʥʤäʡåñëãçʤâʡãäʥʤÞʤãâåãôçãôæãÞôàʥʤʥãʦ ;= ʜãʦʟãÝʥʤʡéʢʥʤæʡʦéʤçäʤʣ èʤäʥðíäʤʣ%&ALK 14 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʜʡççãæéʥãßßʢʥʤæʡéʢʥʤßʢçʢâʡôÞåôʢéʦôèʤÞʥʢáàʢçãʢòçàʤéʢåãôʥʡâåãìçðæã êʡäéʤʥʡæã ÞʤâàʢʣʦéÞʧóîãæã ʦʤ ʦéʤʥʤçð èʥʤʦÞʢéʡ ʡʥéʢʥãã Úéã áʢ êʡäéʤʥð ʤÝʧʦåʤÞåãÞʡóé ÞðʦÞʤÝʤáàʢçãʢ ʦãçßåʢéçʤßʤ äãʦåʤʥʤàʡ ìéʤ ʦʤèʥʤÞʤáàʡʢéʦô ʤäãʦåʢçãʢæ Ñʙʛ ʚäãʦåʢççðʢ Ñʙʛ èʥʤçãäʡóé Þ ʦʧÝãçéãæʡåñçʤʢ èʥʤʦéʥʡçʦéÞʤ ãâʡʨÞʡéðÞʡóéʦôæʡäʥʤêʡßʡæã;=ʓäéãÞçðʢêʤʥæðäãʦåʤʥʤàʡʓʟʒ ÞʤâàʢʣʦéÞʧóéçʡòçàʤéʢåãʡåñçðʢäåʢéäãÚʒ ãÞðâðÞʡóéãʨʡäéãÞʡëãóʓäéãÞãʥʤÞʡççðʢÚʒèʥʤàʧëãʥʧóéæʤåʢäʧåðäåʢéʤìçʤʣʡàßʢâãããʨʢæʤäãçðÚéʤʦèʤʦʤÝʦéÞʧʢé ʡàßʢâãã åʢʣäʤëãéʤÞ Þ ʤʦʤÝʢççʤʦéã æʤçʤëãéʤÞ äʤéʤʥðʢ èʥʤçãäʡóé Þ ãçéãæʧ êʡßʤëãéãʥʧóéʤäãʦåʢççðʢÑʙʛãèʤéʢçëãʥʧóéÞʤʦèʡåʢçãʢÞʦʤʦʧàãʦéʤʣʦéʢçäʢ ʘʡäʥʤêʡßãèʤæʢʥʢçʡäʤèåʢçãôÞçãʨåãèãàʤÞèʥʢÞʥʡîʡóéʦôÞèʢçãʦéðʢäåʢéäã ÚéãäåʢéäãçʡèʢʥÞʤæòéʡèʢêʤʥæãʥʤÞʡçãôʡéʢʥʤʦäåʢʥʤâʡ çʡäʡèåãÞʡôʦñÞãçéãæʢ ʤÝʥʡâʧóéåãèãàçðʢèôéçʡãèʤåʤʦäãʦéʡàãôåãèʤãàʤâʡ ãʦéʡçʤÞôéʦôʤʦçʤÞʤʣåãèãàçʤßʤôàʥʡÝʧàʧîʢʣÝåôíäã;= ʛʤ æʢʥʢ èʥʤßʥʢʦʦãʥʤÞʡçãô ʡéʢʥʤʦäåʢʥʤâʡ Þ ʧìʡʦéäʡʨ ʤéåʤáʢçãô åãèãàʤÞ ʥʡâʥʡʦéʡʢéʦôʦʤʢàãçãéʢåñçʡôéäʡçñ ìʢæʧʦèʤʦʤÝʦéÞʧʢéʧÞʢåãìʢçãʢäʤåãìʢʦéÞʡ åãèãàʤÞ ÞðʦÞʤÝʤáàʡóîãʨʦô Þ ʥʢâʧåñéʡéʢ ßãÝʢåã ʡèʤèéʤâʡ ßåʡÞçðæ ʤÝʥʡâʤæ èʢçãʦéðʨäåʢéʤä èʢʥʢßʥʧáʢççðʨåãèãàʡæãʒʥʤæʢéʤßʤ æʤßʧéÝðéñʡäéãÞãʥʤÞʡçðèʥʤëʢʦʦð ÞʢàʧîãʢäçʢʤÞʡʦäʧåôʥãâʡëããôàʥʡʓʝÌʛʥãòéʤæÞçʤÞñʤÝʥʡâʤÞʡççðʢʦʤʦʧàðʤÝåʡàʡóéèʤÞðíʢççʤʣèʥʤçãëʡʢæʤʦéñóãåʤæäʤʦéñó ìéʤÞʢàʢé ä äʥʤÞʤãâåãôçãó Þ ôàʥʤ Ýåôíäã ã ʥʡâÞãéãó åʤäʡåñçʤßʤ Þʤʦèʡåʢçãô ʛʥã òéʤæ ÞçʤÞñ ʤÝʥʡâʤÞʡççðʢ ʦʤʦʧàð ôÞåôóéʦô çʢèʤåçʤëʢççðæã ìéʤ èʥʤôÞåôʢéʦô ãʨ èʤÞðíʢççʤʣèʥʤçãëʡʢæʤʦéñóʚàçʤÞʥʢæʢççʤʦòéãæèʥʤãʦʨʤàãéʥʤʦéʦʤʢàãçãéʢåñçʤʣéäʡçãÞʥʡʣʤçʢʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʤʥʡáʢçãôʒʤåãìʢʦéÞʤäåʢéʤìçðʨ òåʢæʢçéʤÞÞçʢʣʧæʢçñíʡʢéʦô ʡäʤååʡßʢçʤÞðʢÞʤåʤäçʡʧéʤåîʡóéʦô êʤʥæãʥʧô ʦʤʢàãçãéʢåñçʤéäʡççðʣ äʡʥäʡʦ èʤäʥðíäʧ ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣ Ýåôíäã äʤéʤʥðʣʤéàʢåôʢéåãèãàçʤʢôàʥʤʤéèʥʤʦÞʢéʡʦʤʦʧàʡʞʡäêʤʥæãʥʧʢéʦôéãèãìçʡôêãÝʥʤâçʡôÝåôíäʡ ÞðʦéʧèʡóîʡôÞèʥʤʦÞʢéʦʤʦʧàʡãèʤæʢʥʢʧÞʢåãìʢçãôÞʤÝïʢæʢ çʡʥʧíʡóîʡôäʥʤÞʤéʤäÞçʢæ;= ʒåãçãìʢʦäʤʢãèʥʤßçʤʦéãìʢʦäʤʢâçʡìʢçãʢʦêʤʥæãʥʤÞʡÞíʢʣʦôʓʝÌÞʤæçʤßʤæ âʡÞãʦãé ãæʢççʤ ʤé ʦéʥʧäéʧʥð ʢʢ êãÝʥʤâçʤʣ èʤäʥðíäã ã ʥʡâæʢʥʤÞ åãèãàçʤßʤ ôàʥʡ ʛʥã àåãéʢåñçʤæ êʤʥæãʥʤÞʡçãã Ýåôíäã ʢʢ êãÝʥʤâçʡô èʤäʥðíäʡ ʤÝðìçʤ ʨʤʥʤíʤÞðʥʡáʢçʡ æʢçñíʢèʤàÞʢʥáʢçʡèʤÞʥʢáàʢçãóãʥʡâʥðÞʡæʛʥãòéʤæʤéæʢìʡʢéʦôèʤʦéʢèʢççʤʢʦʧáʢçãʢèʥʤʦÞʢéʡʡʥéʢʥãã äʤéʤʥʡôèʤàÞʢʥßʡʢéʦôäʤæèʢçʦʡéʤʥçʤæʧ ʥʢæʤàʢåãʥʤÞʡçãó ʛʥã éʡäʤæ éʢìʢçãã èʥʤëʢʦʦʡ äʥʤÞʤéʤä Þ ʧìʡʦéäʢ ʡéʢʥʤʦäåʢʥʤâʡæʤáʢéçʢãâæʢçôéñʦôÞéʢìʢçãʢàåãéʢåñçʤßʤÞʥʢæʢçã ãèʥãâçʡäã ãíʢæããʧèʡëãʢçéʡÝʧàʧéʤéʦʧéʦéÞʤÞʡéñʚàçʡäʤèʤæʢʥʢʥʤʦéʡÝåôíäãäʤæèʢçʦʡéʤʥçðʢʥʢâʢʥÞðʡʥéʢʥããäʥʢæʤàʢåãʥʤÞʡçãóʤʦåʡÝʢÞʡóé ãÝåôíäʡÞðʦéʧèʡʢé ÞèʥʤʦÞʢéʦʤʦʧàʡ èʤʦéʢèʢççʤÝåʤäãʥʧôäʥʤÞʤéʤäʔʦåʧìʡʢèʤʥʡáʢçãôäʤʥʤçʡʥçðʨʡʥéʢʥãʣèʥʤãʦʨʤàãéèʤʦéʢèʢççʤʢèʥʤßʥʢʦʦãʥʤÞʡçãʢʦéʢçʤäʡʥàãã;= 15 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʔçʢäʤéʤʥðʨʦåʧìʡôʨ ʤÝðìçʤçʡʤéçʤʦãéʢåñçʤʥʡççãʨʦéʡàãôʨêʤʥæãʥʤÞʡçãô Ýåôíäã ʢʢåãèãàçʤʢôàʥʤʨʤʥʤíʤÞðʥʡáʢçʤàʤãÝʤåʢʢʤéʤÝîʢßʤʤÝïʢæʡ Ýåôíäã ʡ ʦʤʢàãçãéʢåñçʤéäʡççʡô äʡèʦʧåʡ ʦʥʡÞçãéʢåñçʤ éʤçäʡô ã æʤáʢé åʢßäʤ èʤÞʥʢáàʡéñʦôèʤààʢʣʦéÞãʢæʥʡâåãìçðʨêʡäéʤʥʤÞʞʡäãʢʓʝÌæʤßʧéʦéʡéñãʦéʤìçãäʤæ êʤʥæãʥʤÞʡçãô òæÝʤåʤÞ æãäʥʤéʥʤæÝð ìʡʦéãëð ʦʡæʤʣ ʓʝÌ ʡ ʡéʢʥʤæʡéʤâçʤʢãâïôâÞåʢçãʢʦåʧáãéʤʦçʤÞʤʣàåôʤÝʥʡâʤÞʡçãôéʥʤæÝʡÚæÝʤåãôìʡʦéãëʡæãçʢʦéʡÝãåñçʤʣʓʝÌæʤáʢéÞʤâçãäʡéñäʡäʤʦåʤáçʢçãʢʨãʥʧʥßãìʢʦäãʨʤèʢʥʡëãʣ çʡʡʤʥéʢ èʥãèʥʤÞʢàʢçããʡçßãʤßʥʡêãã éʥʤæÝʤåãéãìʢʦäʤʣéʢʥʡèãã;= ÏʡÞʢʥíʡóîʢʣ ʦéʡàãʢʣ ʡéʢʥʤʦäåʢʥʤâʡ ôÞåôʢéʦô ʡéʢʥʤäʡåñëãçʤâ ą ʤéåʤáʢçãʢʦʤåʢʣäʡåñëãôÞʡéʢʥʤæʡéʤâçðʢæʡʦʦð æʢáʧéʤìçʤʢÞʢîʢʦéÞʤãêãÝʥʤâçʧó éäʡçñ ìéʤʦʧîʢʦéÞʢççʤʧÞʢåãìãÞʡʢéèåʤéçʤʦéñʓʝÌʝåʢàʧʢéʤéæʢéãéñ ìéʤèʥã ʥʡÞçʤæʢʥçʤæ ʤéåʤáʢçãã äʡåñëãçʤâ çʢ ʧÞʢåãìãÞʡʢé ʥãʦä ʥʡâÞãéãô ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ éʤßàʡäʡäßʢéʢʥʤßʢççʡôäʡåñëãêãäʡëãôʓʝÌʧÞʢåãìãÞʡʢéʥãʦäèʤàʤÝçðʨʤʦåʤáçʢçãʣ;= ʜʚÑÙÑÐʛÐÍʚʔÐÑÐʛʚʛʜʚʞʖÐÍʚʔ ʒåãèãàʡæäʥʤÞãʤéçʤʦôéʨʤåʢʦéʢʥãç éʥãßåãëʢʥãàðʞʕ êʤʦêʤåãèãàðʟÑ ã ʦÞʤÝʤàçðʢ áãʥçðʢ äãʦåʤéð Îʒ ʔʦʢ ʤçã ãæʢóé Þʡáçʤʢ Ýãʤåʤßãìʢʦäʤʢ âçʡìʢçãʢʠʤåʢʦéʢʥãçąʤÝôâʡéʢåñçðʣäʤæèʤçʢçéÞʦʢʨäåʢéʤìçðʨæʢæÝʥʡç ʤçéʡäáʢʧìʡʦéÞʧʢéÞʦãçéʢâʢʦéʢʥʤãàçðʨèʤåʤÞðʨßʤʥæʤçʤÞ ÞʤÝʥʡâʤÞʡçããáʢåìçðʨ äãʦåʤéÚêãʥðʨʤåʢʦéʢʥãçʡ äʤéʤʥðʢʤÝʥʡâʧóéʦôèʥãòéʢʥãêãäʡëããʦÞʤÝʤàçʤßʤ ʨʤåʢʦéʢʥãçʡ ʦ èʥãʦʤʢàãçʢçãʢæ ʥʡàãäʡåʡ áãʥçʤʣ äãʦåʤéð èʤà àʢʣʦéÞãʢæ êʢʥæʢçéʡåʢëãéãçʨʤåʢʦéʢʥãçʡëãåéʥʡçʦêʢʥʡâðÑʠʓʞ èʥʢàʦéʡÞåôóéçʡãÝʤåʢʢʡäéãÞçʧó æʢéʡÝʤåãìʢʦäʧó ìʡʦéñ ʨʤåʢʦéʢʥãçʡ ʚçã ʦʢäʥʢéãʥʧóéʦô ßʢèʡéʤëãéʡæã ÞäʥʤÞʤéʤäÞʦʤʦéʡÞʢÑʚʙʛ;= ʛʥãæʢʥçʤéʥʢéñʦʧéʤìçʤʣèʤéʥʢÝçʤʦéãÞʨʤåʢʦéʢʥãçʢąæß ʤÝʢʦèʢìãÞʡʢéʦôâʡʦìʢéèʤʦéʧèʡóîʢʣÞʤʥßʡçãâæèãîãʨʤåʢʦéʢʥãçÞʦʡʦðÞʡʢéʦôÞéʤçäʤæ äãíʢìçãäʢ ʧìʡʦéÞʧô Þ ʤÝʥʡâʤÞʡçãã ʨãåʤæãäʥʤçʤÞ ʠʘ ʚʦéʡÞíãʢʦô àÞʢ éʥʢéã çʢʤÝʨʤàãæʤßʤ ʨʤåʢʦéʢʥãçʡ ą æß ʦãçéʢâãʥʧóéʦô Þ ßʢèʡéʤëãéʡʨ ãâ ʡëʢéãå ʒʤʓ èʧéʢæ çʢʦäʤåñäãʨ èʤʦåʢàʤÞʡéʢåñçðʨ ʥʢʡäëãʣ ʙʡ èʢʥÞʤæ òéʡèʢ ʡëʢéãå ʒʤʓèʥʢÞʥʡîʡʢéʦôÞʕʘʕ ʒʤʓ äʤéʤʥðʣèʤàÞʤâàʢʣʦéÞãʢæʕʘʕ ʒʤʓ ʥʢàʧäéʡâðèʥʢÞʥʡîʡʢéʦôÞæʢÞʡåʤçʡé;=ÍʡåʢʢæʢÞʡåʤçʡé æãçʧôʥôàèʥʤæʢáʧéʤìçðʨ æʢéʡÝʤåãéʤÞ æʢÞʡåʤçʡé èãʥʤêʤʦêʡé ãâʤèʢçéʢçãå èãʥʤêʤʦêʡé ßʢʥʡçãåèãʥʤêʤʦêʡé êʡʥçʢâãåèãʥʤêʤʦêʡé ʦäÞʡåʢç åʡçʤʦéʢʥʤå èʥʢʤÝʥʡâʧʢéʦô Þ ʨʤåʢʦéʢʥãçʛʥʤàʧäéʡæãäʡéʡÝʤåãâæʡʨʤåʢʦéʢʥãçʡôÞåôóéʦôçʢʣéʥʡåñçðʢʦéʢʥãçð ãáʢåìñÎʢåìçðʢäãʦåʤéðçʢéʤåñäʤãßʥʡóéÞʡáçʧóʥʤåñÞèʥʤëʢʦʦʢèãîʢÞʡʥʢçãô ʤçãÞʦʡʦðÞʡóéʦôÞéʤçäʤæäãíʢìçãäʢʤÝʥʡéçʤÞäʥʤÞñãèʤʦéʧèʡóéÞèʢìʢçñ èʥʢàʦéʡÞåôôʦʤÝʤʣàʤèʤåçãéʢåñçðʣæʡéʢʥãʡåàåôʥʢʦãçéʢâʡʨʤåʢʦéʢʥãçʡ;= 16 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʞʥãßåãëʢʥãàðʞʕ èʥʢàʦéʡÞåôóéʦʤÝʤʣʦåʤáçðʢòêãʥðßåãëʢʥãçʡãáãʥçðʨ äãʦåʤé ʔ çʤʥæʢ ʤçã àʢèʤçãʥʧóéʦô Þ áãʥʤÞʤʣ äåʢéìʡéäʢ Þãʦëʢʥʡåñçʤʣ ã èʤàäʤáçʤʣ ʛʥã òæʤëãʤçʡåñçʤæ ʦéʥʢʦʦʢ âçʡìãéʢåñçʤʣ êãâãìʢʦäʤʣ çʡßʥʧâäʢ ʤçã èʤàÞʢʥßʡóéʦô åãèʤåãâʧ Þ ʥʢâʧåñéʡéʢ ìʢßʤ ʤÝʥʡâʧóéʦô ʦÞʤÝʤàçðʢ áãʥçðʢ äãʦåʤéð äʤéʤʥðʢèʤßåʤîʡóéʦôäåʢéäʡæãæðíʢìçʤʣéäʡçãÞäʡìʢʦéÞʢʦʧÝʦéʥʡéʡàåô ʤäãʦåʢçãôÞæãéʤʨʤçàʥãôʨãÞðʥʡÝʤéäãòçʢʥßããʦãçéʢâʡʓʞʟ ʔʦäʤʥʢèʤʦåʢèʥãʢæʡèãîãäʤçëʢçéʥʡëãôʞʕÞäʥʤÞãʦéʡçʤÞãéʦôæʡäʦãæʡåñçʤʣ ʡìʢʥʢâąì ÞʤâÞʥʡîʡʢéʦôäãʦʨʤàçʤæʧʧʥʤÞçóʚàçʡäʤèʥãèʡéʤåʤßãìʢʦäãʨʦʤʦéʤôçãôʨ çʡèʥãæʢʥèʥãàʢêʢäéʢßʢçʡèʤʦéßʢèʡʥãçʤÞʤʣåãèʤèʥʤéʢãàåãèʡâðãåãèʥãʦʡʨʡʥçʤæ àãʡÝʢéʢ ßãèʢʥéʥãßåãëʢʥãàʢæãôʦʤʨʥʡçôʢéʦôàåãéʢåñçʤʢÞʥʢæôãæʤáʢéʦèʤʦʤÝʦéÞʤÞʡéñʥʡâÞãéãóʡéʢʥʤʦäåʢʥʤâʡ;= ʟʤʦêʤåãèãàðôÞåôóéʦôʦʤʦéʡÞçʤʣìʡʦéñóäåʢéʤìçðʨæʢæÝʥʡçãʥʡâåãìçðʨ åãèʤèʥʤéʢãàʤÞʒêʤʦêʤåãèãàʡæéʡäáʢʤéçʤʦôéʦôéʡäãʢèʤåôʥçðʢåãèãàð äʡä êʤʦêʡéãàãåʨʤåãç ã ʦêãçßʤæãʢåãç ʔ èʤʦåʢàçʢʢ Þʥʢæô ãçéʢçʦãÞçʤ ãâʧìʡʢéʦô êʢʥæʢçéåãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʡôêʤʦêʤåãèʡâʡʓÑè ʟÑʓ ;=ʚçʡʦʢäʥʢéãʥʧʢéʦôåʢʣäʤëãéʡæããèʥʤôÞåôʢéʦÞʤʢàʢʣʦéÞãʢÞʦʤʦéʡÞʢëãʥäʧåãʥʧóîãʨ ÞäʥʤÞãåãèʤèʥʤéʢãàʤÞÑè ʟÑʓßãàʥʤåãâʧʢéêʤʦêʤåãèãàðèʤÞʢʥʨçʤʦéçʤßʤæʤçʤʦåʤôʤäãʦåʢççðʨÑʙʛ ʤÝʥʡâʧôèʥãòéʤæòçàʤßʢççðʢæʢàãʡéʤʥðÞʤʦèʡåʢçãôą åãâʤêʤʦêʡéãàãåʨʤåãç ã ʤäãʦåʢççðʢ çʢòéʢʥãêãëãʥʤÞʡççðʢ áãʥçðʢ äãʦåʤéð äʤéʤʥðʢâʡàʢʣʦéÞʤÞʡçðÞèʡéʤßʢçʢâʢʡéʢʥʤʦäåʢʥʤâʡ;= ÑãèãàðôÞåôóéʦôßãàʥʤêʤÝçðæãÞʢîʢʦéÞʡæããçʢæʤßʧéèʢʥʢçʤʦãéñʦôäʥʤÞñó Þ ʥʡʦéÞʤʥʢççʤæ Þãàʢ ʔ äʥʤÞã ã æʢáäåʢéʤìçʤʣ ʦʥʢàʢ ãʨ èʢʥʢçʤʦôé ʦèʢëãêãìçðʢ éʥʡçʦèʤʥéçðʢ æʡäʥʤæʤåʢäʧåð ą åãèʤèʥʤéʢãàð ą Þ êʤʥæʢ åãèãàçʤ ÝʢåäʤÞðʨ äʤæèåʢäʦʤÞ ʦêʢʥãìʢʦäʤʣ êʤʥæð ʦêʤʥæãʥʤÞʡççðʨ èʤ ʢàãçʤæʧ èʥãçëãèʧ çʤãæʢóîãʨʥʡâçʧóʦéʥʧäéʧʥʧʔëʢçéʥʢåãèʤèʥʤéʢãàʤÞʥʡʦèʤåʡßʡóéʦôßãàʥʤêʤÝçðʢæʤåʢäʧåðòêãʥʤÞʠʝãʞʕ ʦçʡʥʧáã ÞÞãàʢæʤçʤʦåʤô ąʦÞʤÝʤàçðʣçʢòéʢʥãêãëãʥʤÞʡççðʣ ʨʤåʢʦéʢʥãç êʤʦêʤåãèãàðãʡèʤÝʢåäãʥãʦ Ñãèʤèʥʤéʢãàçðʢìʡʦéãëðʥʡâåãìʡóéʦôèʤʥʡâæʢʥʡæ èåʤéçʤʦéã äʤåãìʢʦéÞʧ ÞʨʤàôîãʨÞãʨʦʤʦéʡÞʠʝãʞʕʒʤæèʤçʢçéʡæãåãèʤèʥʤéʢãàçʤʣìʡʦéãëðôÞåôóéʦôʦèʢëãêãìʢʦäãʢʡèʤÝʢåäãʡèʤèʥʤéʢãàð äʤéʤʥðʢÞðèʤåçôóéàÞʤôäʧóʥʤåñ ʦʤàçʤʣʦéʤʥʤçð ʤÝʢʦèʢìãÞʡóéÞâʡãæʤàʢʣʦéÞãʢåãèʤèʥʤéʢãàʤÞʦʦʤʤéÞʢéʦéÞʧóîãæãʥʢëʢèéʤʥʡæãÞèʢìʢçããàʥʧßãʨéäʡçôʨ ʦàʥʧßʤʣąʥʢßʧåãʥʧóéʦäʤʥʤʦéñ ʥʢʡäëãʣåãèʤåãâʡåãèʤèʥʤéʢãàçðʨìʡʦéãë Ýʤßʡéðʨʞʕ ʚʦçʤÞçðæãåãèʤèʥʤéʢãàʡæãèåʡâæðÞèʤʥôàäʢÞʤâʥʡʦéʡçãôãʨßãàʥʡéãʥʤÞʡççʤʣèåʤéçʤʦéããʧæʢçñíʢçãôʥʡâæʢʥʤÞôÞåôóéʦôʨãåʤæãäʥʤçðʠʘ åãèʤèʥʤéʢãàð ʤìʢçñ çãâäʤʣ èåʤéçʤʦéã Ñʚʙʛ åãèʤèʥʤéʢãàð èʥʤæʢáʧéʤìçʤʣ èåʤéçʤʦéã Ñʛʛ åãèʤèʥʤéʢãàðçãâäʤʣèåʤéçʤʦéãÑʙʛ åãèʤèʥʤéʢãàðÞðʦʤäʤʣèåʤéçʤʦéã Ñʔʛ ʦʥʢàãèʤʦåʢàçãʨÞðàʢåôóéàÞʢèʤàêʥʡäëããÑʔʛ2ãÑʔʛ;= 17 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʜãʦʝéʥʤʢçãʢÑʙʛʠʝąʨʤåʢʦéʢʥãç ʞʕąéʥãßåãëʢʥãàð Ñè ʟÑʓąåãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʡôêʤʦêʤåãèʡâʡʓ ʚʦʤÝʤʢæʢʦéʤèʥãçʡàåʢáãéåãèʤèʥʤéʢãàʧʡ Ñèʡ Ñèʡ èʥʢàʦéʡÞåôʢéʦʤÝʤʣäʤçïóßʡéÑʙʛʦʤʦèʢëãêãìʢʦäãæʡèʤèʥʤéʢãàʤæʡ äʤéʤʥðʣèʤʦÞʤʢʣʦéʥʧäéʧʥʢãæʢʢéʦʨʤàʦéÞʤʦèåʡâæãçʤßʢçʤæã ʦåʢàʤÞʡéʢåñçʤ æʤáʢéÞåãôéñçʡèʥʤëʢʦʦêãÝʥãçʤåãâʡ èʤàʡÞåôôʢßʤ;=ÒʥʤÞʢçñÑèʡ ʥʢäʤæʢçàʧʢéʦôʤèʥʢàʢåôéñ ʧåãëʦʦʢæʢʣçðæʡçʡæçʢâʤæ ʤéôßʤîʢççðæèʤâʡÝʤåʢÞʡçãôæ ʦÞôâʡççðæʦʡéʢʥʤéʥʤæÝʤâʤæ Íʤ çʡʦéʤôîʢßʤ Þʥʢæʢçã âʡ ãʦäåóìʢçãʢæ çãäʤéãçʤÞʤʣ äãʦåʤéð ãʡçéãéʢåäèʥʤèʥʤéʢãçʤÞʤʣäʤçÞʢʥéʡâʢʦʧÝéãåãâãç äʢäʦãçʤÞʤßʤéãèʡ0#3+ çʢéèʥʢèʡʥʡéʤÞ äʤéʤʥðʢòêêʢäéãÞçʤʦçãáʡåãÝðʧʥʤÞʢçñÑèʡ ʚèéãæʡåñçðʣ ʧʥʤÞʢçñÑèʡ èʤàʡççðæʖÞʥʤèʢʣʦäʤßʤäʤçʦʢçʦʧʦʡ çʢàʤåáʢçèʥʢÞðíʡéñ æßàå;= ʜʡâåãìçðʢåãèʤèʥʤéʢãàðʦʤàʢʥáʡéèʥãʦʧîãʢéʤåñäʤãæʦèʢëãêãìʢʦäãʢÝʢåäã ą ʡèʤèʥʤéʢãàð ʚʦçʤÞçðʢ ʡèʤèʥʤéʢãàð ʠʘ ą ʡèʤʔ ʡèʤʖ ã ʡèʤ#)) ʛʢʥÞðʢ àÞʡôÞåôóéʦôåãßʡçàʡæã ʤÝʢʦèʢìãÞʡóîãæãʦÞôâðÞʡçãʢʥʢæçʡçéʤÞʠʘʦʤʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥʡæã ßʢèʡéʤëãéʤÞ ʓèʤ#)) ôÞåôʢéʦô äʤêʡäéʤʥʤæ ʡäéãÞãʥʧóîãæåãèʤèʥʤéʢãàåãèʡâʧèåʡâæðąêʢʥæʢçéʡ ßãàʥʤåãâʧóîʢßʤåãèʤèʥʤéʢãàçðʢ ìʡʦéãëðʦÞðʦʤäãæʦʤàʢʥáʡçãʢæʞʕ ʔÑʚʙʛãÑʛʛʤʦçʤÞçðæãʡèʤèʥʤéʢãàʡæãôÞåôóéʦôʡèʤʔãʡèʤʖ äʤéʤʥðʢ Þðèʤåçôóé êʧçäëãó åãßʡçàʤÞ èʥã ʦÞôâðÞʡçãã òéãʨ ìʡʦéãë ʦ ʥʢëʢèéʤʥʡæã èʢìʢçãʔÑʚʙʛ èʤʦäʤåñäʧʤçã äʡäãʨãåʤæãäʥʤçð èʤàÞʢʥßʡóéʦôßãàʥʤåãâʧèʤà àʢʣʦéÞãʢæåãèʤèʥʤéʢãàåãèʡâð èʥãʦʧéʦéÞʧʢéäʤêʡäéʤʥʡèʤ#))ʔÑʙʛʤʦçʤÞçðæ ãʢàãçʦéÞʢççðæʡèʤÝʢåäʤæôÞåôʢéʦôʡèʤʔ Ýåʡßʤàʡʥôäʤéʤʥʤæʧåãèʤèʥʤéʢãàð çãâäʤʣèåʤéçʤʦéãâʡʨÞʡéðÞʡóéʦôãÞðÞʤàôéʦôãâäʥʤÞʤéʤäʡÑʙʛ ʥʢëʢèéʤʥʡæã ßʢèʡéʤëãéʤÞ;= 18 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ Ñãèʤèʥʤéʢãàð Þðʦʤäʤʣ èåʤéçʤʦéã ʦʤàʢʥáʡé ʡèʤÝʢåäã ʡèʤ!) ã ʓ)) ʚÝʡ ʡèʤèʥʤéʢãàʡôÞåôóéʦôåãßʡçàʡæãàåôʦÞôâðÞʡçãôÑʔʛäʡäʦäåʢéäʡæãèʢʥãêʢʥãìʢʦäãʨéäʡçʢʣèʤʦʥʢàʦéÞʤæʦèʢëãêãìʢʦäãʨʥʢëʢèéʤʥʤÞäʡʦʦʢéçðʨéʥʡçʦèʤʥéʢʥʤÞ ʓʔʝʓ éʡä ã ʦʤ ʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥʡæã ʔ Þ èʢìʢçã ʚʦçʤÞçʡô êʧçäëãô òéʤßʤ äåʡʦʦʡ åãèʤèʥʤéʢãàʤÞ ą ʤÝʥʡéçðʣ éʥʡçʦèʤʥé ʠʝ ãâ èʢʥãêʢʥãìʢʦäãʨ éäʡçʢʣ Þéʤæìãʦåʢãâʦʤʦʧàãʦéʤʣʦéʢçäã äßʢèʡéʤëãéʡæʔäåãçãìʢʦäʤʣèʥʡäéãäʢãÞòèãàʢæãʤåʤßãìʢʦäãʨãʦʦåʢàʤÞʡçãôʨàåôʤëʢçäãʦéʢèʢçãʥãʦäʡʤèʥʢàʢåôóéʧʥʤÞçã ÞäʥʤÞãʤÝîʢßʤʠʝ ʠʝÑʙʛãÑʔʛ ʡéʡäáʢʞʕʔʦʤæçãéʢåñçðʨʦåʧìʡôʨ çʡèʥãæʢʥ èʥãçʤʥæʡåñçðʨâçʡìʢçãôʨèʢʥʢìãʦåʢççðʨèʤäʡâʡéʢåʢʣʧÝʤåñçʤßʤʦÐÌʝ ʤèʥʢàʢåôóéʧʥʤÞçãÑèʡ ãʡèʤèʥʤéʢãàʤÞ äʤéʤʥðʢæʤßʧéÝʤåʢʢéʤìçʤʤʨʡʥʡäéʢʥãâʤÞʡéñʡéʢʥʤßʢççʧóàãʦåãèãàʢæãóʔäåãçãìʢʦäʤʣèʥʡäéãäʢàåôàʤèʤåçãéʢåñçʤʣ ʤëʢçäãʡéʢʥʤßʢççʤʦéãåãèʤèʥʤéʢãàçʤßʤèʥʤêãåôèåʡâæðʤèʥʢàʢåôóéʦʤʤéçʤíʢçãʢʠʝ çʢʦÞôâʡççʤßʤʦÑʔʛ äʠʝÑʔʛãçàʢäʦʡéʢʥʤßʢççʤʦéãʓʙʒåãæʤÞʡ ;= KXC = XCˈÝîãˇ – XCÑʿʸʿ ˄ˁÑʿʸʿ ʝʤʤéçʤíʢçãʢ Ħ ʦìãéʡʢéʦô ʤèéãæʡåñçðæ èʥã âçʡìʢçãôʨ ʥãʦä ʥʡâÞãéãô ʡéʢʥʤʦäåʢʥʤâʡʦʧîʢʦéÞʢççʤÞʤâʥʡʦéʡʢé ʞʡÝåãëʡ ʠʡʥʡäéʢʥãʦéãäãåãèʤèʥʤéʢãàʤÞ ʠʘ ʓéʢʥʤßʢççʤʦéñ ʛåʤéçʤʦéñ ßæå Íãʡæʢéʥçæ ʓèʤåãèʤèʥʤéʢãàð Ýʢåäʡ ʠʝ ʟÑ ʞʕ Ñʚʙʛ Ñʛʛ Òæʢʥʢççʡô ą ą ą ą 1000 ʓèʤ" ʓèʤ" ʓèʤ#) #)) #))) % 10 22 7 ą Ñʙʛ Ñʔʛ Ñʔʛ ʔðʦʤäʡô ą ą ʓçéãʡéʢʥʤßʢççðʢ ą ą ą ą ʓèʤʖ " 22 Ñèʡ 21 ą ą ʓèʤ" ʓèʤ!) !)) !)6 #) ʡèʤʡ #)) #))) $ % ą ą ą ą 10 ÚʒÏʚʕʖʙʙØʗÐÚʙÍʚʕʖʙʙØʗʘʖʞʓÌʚÑÐÏʘÑÐʛÐÍʚʔÐÑÐʛʚʛʜʚʞʖÐÍʚʔ Íåô Ýʤåʢʢ çʡßåôàçʤßʤ èʥʢàʦéʡÞåʢçãô æʢʨʡçãâæʤÞ ʥʡâÞãéãô àãʦåãèãàʢæãʣ ʥʡʦʦæʤéʥãæàÞʡʤʦçʤÞçðʨèʧéãæʢéʡÝʤåãâæʡåãèãàʤÞãåãèʤèʥʤéʢãàʤÞòäâʤßʢççðʣʥãʦ ãòçàʤßʢççðʣʥãʦ 19 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʜãʦÚäâʤßʢççðʣʤÝæʢçʨʤåʢʦéʢʥãçʡÑʛÑąåãèʤèʥʤéʢãàåãèʡâʡ 32 "ąʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥäåʡʦʦʡ"éãèʡ ʜãʦÚçàʤßʢççðʣʤÝæʢçʨʤåʢʦéʢʥãçʡʛÑąèʢìʢçʤìçʡôåãèʡâʡ ÑʛÑą åãèʤèʥʤéʢãàåãèʡâʡ Ñʙʛ 2ąʥʢëʢèéʤʥäÑʙʛ Ñʙʛąåãèʤèʥʤéʢãàðçãâäʤʣèåʤéçʤʦéã ÑʔʛąåãèʤèʥʤéʢãàðÞðʦʤäʤʣèåʤéçʤʦéã Ñʚʙʛąåãèʤèʥʤéʢãàðʤìʢçñçãâäʤʣèåʤéçʤʦéã ʝʖʞʜąCHOLESTERYLESTERTRANSFERPROTEIN ʔéʤçäʤæäãíʢìçãäʢáãʥðèãîãèʤàÞʢʥßʡóéʦôßãàʥʤåãâʧãÞʦʡʦðÞʡóéʦôòèãéʢåãʡåñçðæãäåʢéäʡæãÞÞãàʢʦÞʤÝʤàçðʨáãʥçðʨäãʦåʤé ʠʝãæʤçʤʡëãåßåãëʢʥãàʤÞʞʡæáʢ Þòèãéʢåãʡåñçðʨäåʢéäʡʨ èʥʤãʦʨʤàãéʥʢʦãçéʢâʞʕ ãâäãíʢìçãäʡ ʠʘìʢʥʢâåãæêʡéãìʢʦäʧóʦãʦéʢæʧèʤèʡàʡóéÞßʥʧàçʤʣåãæêʡéãìʢʦäãʣèʥʤéʤä ʚàçʤÞʥʢæʢççʤ òçéʢʥʤëãéð êʤʥæãʥʧóé Ñʔʛ äʤéʤʥðʢ ʦʤàʢʥáʡé ʡèʤèʥʤéʢãàð ʡèʤ!)ãʡèʤʓ))ʠãåʤæãäʥʤçðÞäʡìʢʦéÞʢʡèʤèʥʤéʢãàʤÞʦʤàʢʥáʡééʤåñäʤʡèʤʔ 20 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʔ åãæêʡéãìʢʦäʤʣ ʦãʦéʢæʢ èʥʤãʦʨʤàãé ʤÝæʢç ʡèʤèʥʤéʢãàʤÞ ą Þ ìʡʦéçʤʦéã ʠʘ èʤæãæʤʡèʤʔ èʥãʤÝʥʢéʡóééʡäáʢʡèʤèʥʤéʢãàðʡèʤ#))ãʡèʤʖ àʤçʤʥʡæãäʤéʤʥðʨʦåʧáʡéÑʔʛʛʥʤëʢʦʦßãàʥʤåãâʡʠʘèʥʤãʦʨʤàãéçʡèʤÞʢʥʨçʤʦéãäʡèãååôʥʤÞ ʡʥéʢʥãʡåñçʤßʤʥʧʦåʡèʤààʢʣʦéÞãʢæåãèʤèʥʤéʢãàåãèʡâðʦʧìʡʦéãʢæʡèʤ#))ÞäʡìʢʦéÞʢ äʤêʡäéʤʥʡ ʔ ʥʢâʧåñéʡéʢ ʤÝʥʡâʧóéʦô Ýʤåʢʢ æʢåäãʢ ìʡʦéãëð ʥʢæçʡçéð ʠʘ ãʦÞʤÝʤàçðʢáãʥçðʢäãʦåʤéð äʤéʤʥðʢʦÞôâðÞʡóéʦôʦʡåñÝʧæãçʤæÎãʥçðʢ äãʦåʤéðʤéäåʡàðÞʡóéʦôÞÞãʦëʢʥʡåñçʤʣãèʤàäʤáçʤʣáãʥʤÞʤʣäåʢéìʡéäʢʜʢæçʡçéð èʤʦéʧèʡóé Þ èʢìʢçñ ʦÞôâðÞʡôʦñ ʦ ʥʢëʢèéʤʥʡæã ßʢèʡéʤëãéʡæã ä ʡèʤʔ ãʡèʤʖ ãèʤàÞʢʥßʡóéʦôàʡåñçʢʣíʢæʧßãàʥʤåãâʧàʤáãʥçðʨäãʦåʤéãʠʝ ãâäʤéʤʥðʨßʢèʡéʤëãéðʦãçéʢâãʥʧóéòçàʤßʢççðʢÑʚʙʛ;= ÒʥʤÞʢçñ ʠʘ Þ äʥʤÞã àʤʦéãßʡʢé ʦÞʤʢßʤ æʡäʦãæʧæʡ ʦʥʡâʧ èʤʦåʢ èʥãʢæʡ èãîã ãâʡÞãʦãéʤéʢʢʦʤʦéʡÞʡʛãîʡʦÞðʦʤäãæʦʤàʢʥáʡçãʢæçʡʦðîʢççðʨáãʥçðʨäãʦåʤé ʥʡêãçãʥʤÞʡççðʨʧßåʢÞʤàʤÞÞʢàʢéäâçʡìãéʢåñçʤæʧèʤÞðíʢçãóʧʥʤÞçôʠʘ ʤàçʡäʤÞêãâãʤåʤßãìʢʦäãʨʧʦåʤÞãôʨʤçìʢʥʢâąìÞʤâÞʥʡîʡʢéʦôäãʦʨʤàçʤæʧ ʛãîʡʦçãâäãæʦʤàʢʥáʡçãʢæáãʥʤÞ ÝʤßʡéʡôäåʢéìʡéäʤʣãʦåʤáçðæãʧßåʢÞʤàʡæã çʢÞðâðÞʡʢéʦʧîʢʦéÞʢççʤßʤèʤÞðíʢçãôʧʥʤÞçôʠʘÒÝʤåñçðʨʦàãʦåãèãàʢæãʢʣ ÍÑʛ ÞðÞʢàʢçãʢʠʘãâäʥʤÞãâʡæʢàåôʢéʦôããʨʧʥʤÞʢçñÞéʢìʢçãʢàåãéʢåñçʤßʤ Þʥʢæʢçã ʤʦéʡʢéʦô èʤÞðíʢççðæ Úéʤ ʨʡʥʡäéʢʥçʤ àåô èʡëãʢçéʤÞ ʦ æʢéʡÝʤåãìʢʦäãæʦãçàʥʤæʤæ ʤáãʥʢçãʢæ ʦʡʨʡʥçðæàãʡÝʢéʤæ ÒʥʤÞʢçñ ʠʝ äʥʤÞã âʡÞãʦãé ʤé éʥʢʨ êʡäéʤʥʤÞ ʡÝʦʤʥÝëãô ʠʝ èãîã ʦãçéʢâ òçàʤßʢççʤßʤ ʠʝ ã òäʦäʥʢëãôʥʢʡÝʦʤʥÝëãô Ýãåãʡʥçʤßʤ ʠʝ ʔ åóÝʤæ ʦåʧìʡʢ èʥã èʤÞðíʢçããʦãçéʢâʡããåãʦçãáʢçããäʡéʡÝʤåãâæʡʠʝʢßʤʧʥʤÞʢçñÞäʥʤÞãÞʤâʥʡʦéʡʢé;= ʔʦʡʦðÞʡçãʢʠʝÞòèãéʢåããéʤçäʤßʤäãíʢìçãäʡʤÝʢʦèʢìãÞʡʢéʦôʤʦʤÝðæéʥʡçʦèʤʥéçðæÝʢåäʤæ èʤàʤÝçðæÝʢåäʧʙãæʡççąʛãäʡ.0#, .IEMANN 0ICK#L LIKE ʛʤçãæʡçãʢʤʦʤÝʢççʤʦéʢʣòäâʤßʢççʤßʤæʢéʡÝʤåãâæʡʠʝèʥãÞʢåʤãʦʦåʢàʤÞʡéʢåʢʣ äʥʡâʥʡÝʤéäʢéʡäʤßʤèʥʢèʡʥʡéʡ äʡäòâʢéãæãÝ ąãçßãÝãéʤʥʡÞʦʡʦðÞʡçãôʠʝÞäãíʢìçãäʢ ʔäåʢéäʡʨèʢìʢçãèʥʤãʦʨʤàãéʦãçéʢâÑʚʙʛ Ýʤßʡéðʨʞʕ ÞʦʤʦéʡÞäʤéʤʥðʨÞʨʤàôé ʡèʤèʥʤéʢãàð ʡèʤʔ ã ʡèʤʖ ʤÝʢʦèʢìãÞʡóîãʢ êʧçäëãã åãßʡçàʤÞ ʛʤèʡÞ ÞäʥʤÞʤéʤä Ñʚʙʛ äʡäãʠʘ èʤàÞʢʥßʡóéʦôßãàʥʤåãéãìʢʦäʤæʧʥʡʦîʢèåʢçãóèʤà àʢʣʦéÞãʢæ èʤʦéßʢèʡʥãçʤÞʤʣ åãèʤèʥʤéʢãàåãèʡâð ʔ ʥʢâʧåñéʡéʢ Ñʚʙʛ éʢʥôóé ìʡʦéñʞʕãèʥʢÞʥʡîʡóéʦôÞÝʤåʢʢæʢåäãʢãèåʤéçðʢåãèãàçðʢìʡʦéãëðąåãèʤèʥʤéʢãàð èʥʤæʢáʧéʤìçʤʣ èåʤéçʤʦéã Ñʛʛ ìʡʦéñ ãâ äʤéʤʥðʨ Þ ʦÞʤó ʤìʢʥʢàñ èʤàÞʢʥßʡʢéʦô ßãàʥʤåãâʧ ʡ àʥʧßʡô ìʡʦéñ âʡʨÞʡéðÞʡʢéʦô ßʢèʡéʤëãéʡæã èʤʦʥʢàʦéÞʤæʡèʤʔ ãʡèʤʖ ʥʢëʢèéʤʥʤÞʕãàʥʤåãâʤÞʡççðʢÑʛʛéʢʥôóéìʡʦéñʞʕ äʤéʤʥðʢéʥʡçʦèʤʥéãʥʧóéʦôäÑʔʛÞʤÝæʢççʡòêãʥðʠʝÚéʤéèʥʤëʢʦʦʤʦʧîʢʦéÞåôʢéʦô èʥã èʤæʤîã ʦèʢëãêãìʢʦäʤßʤ Ýʢåäʡ ą èʢʥʢçʤʦìãäʡ òêãʥʤÞ ʠʝ ʝʖʞʜ CHOLESTERYL ESTERTRANSFERPROTEIN ʕãàʥʤåãâʤÞʡççðʢÑʛʛ éʢʥôôʞʕãáãʥçðʢäãʦåʤéð èʥʢÞʥʡîʡóéʦôÞÑʙʛ ʦʤàʢʥáʡîãʢàʤòêãʥʤÞʠʝ ʡʡèʤèʥʤéʢãàðʦʤàʢʥáʡéãʦäåóìãéʢåñçʤʡèʤʔÐâäʥʤÞʤéʤäʡÑʙʛÞðÞʤàôéʦôÞʦʢæãäåʢéäʡæã ʦʤàʢʥáʡîãæã 21 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ çʡèåʡâæʡéãìʢʦäʤʣæʢæÝʥʡçʢʥʢëʢèéʤʥðäʡèʤʔÑʙʛ ʥʢëʢèéʤʥð çʤèʥʢãæʧîʢʦéÞʢççʤßʢèʡéʤëãéʡæã;= ʛʚʔʜʖÎÍʖʙÐʖÚʙÍʚʞʖÑÐÜ ʛʢʥÞãìçðæèʥʤëʢʦʦʤæàåôåʤäʡåñçʤßʤʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʤʥʡáʢçãôÞʦéʢçäʢʦʤʦʧàʡôÞåôʢéʦôòçàʤéʢåãʡåñçʡôàãʦêʧçäëãôÚçàʤéʢåãʣʥʢßʧåãʥʧʢéʦʤʦʧàãʦéðʣéʤçʧʦìʢʥʢâÞðʦÞʤÝʤáàʢçãʢÞʡâʤàãåʡéʡéʤʥçðʨãäʤçʦéʥãäéʤʥçðʨêʡäéʤʥʤÞ æʤàʧåãʥʧʢéʦʤäʥʡéãéʢåñçʧóʡäéãÞçʤʦéñßåʡàäʤæðíʢìçðʨäåʢéʤä ʦʤʦʧàʡ; =ʔçʤʥæʢèʥʢʤÝåʡàʡʢéÞðʦÞʤÝʤáàʢçãʢÞʡâʤàãåʡéʡéʤʥçðʨêʡäéʤʥʤÞ ääʤéʤʥðæʤéçʤʦôéʦô ą æʤçʤʤäʦãà ʡâʤéʡ ./ ą æʤåʢäʧåʡ ʥʢßʧåãʥʧóîʡô ʦʤʦʧàãʦéðʣ ßʤæʢʤʦéʡâ ãèʤààʢʥáãÞʡóîʡôÝʡâʡåñçðʣéʤçʧʦʦʤʦʧàʤÞ çʤʥæʡåãâʧôãʨʥʢʡäéãÞçʤʦéñ ʦèʤʦʤÝçʤʦéñäàãåʡéʡëãã ʧʥʤÞʢçñʓÍʚÝåʡàʡʢéʡçéãʡßʥʢßʡëãʤççðæã ʡçéãʡàßʢâãÞçðæã ʡçéãéʥʤæÝʤßʢççðæã èʥʤéãÞʤÞʤʦèʡåãéʢåñçðæã ã ãçßãÝãʥʧóîãæãçʢʤʡçßãʤßʢçʢâʦÞʤʣʦéÞʡæã ą òçàʤéʢåãʡåñçðʣêʡäéʤʥßãèʢʥèʤåôʥãâʡëãã%$(& ąʦʧÝʦéʡçëãô Ýãʤʨãæãìʢʦäã ãàʢçéãìçʡôÝʥʡàãäãçãçʧʚçʡʦèʤʦʤÝçʡÞðâðÞʡéñßãèʢʥèʤåôʥãâʡëãóʕʘʒ èʥã òéʤæèʥʤãʦʨʤàãéʦçãáʢçãʢãʨìʧÞʦéÞãéʢåñçʤʦéãäÞʡâʤäʤçʦéʥãäéʤʥçðæêʡäéʤʥʡæãèʤÞðíʢçãʢÞʡâʤàãåʡéʡëããìʢʥʢâãçàʧäëãóʦãçéʢâʡ./ãèʥʤʦéʡëãäåãçʡ ą èʥʤʦéʡëãäåãç )2 0')2 ą èʥʤʦéʡßåʡçàãç ʤÝʥʡâʧóîãʣʦô ãâ êʤʦêʤåãèãàʤÞ ÍʢʣʦéÞʧʢéäʡäʡçéãʡßʥʢßʡçéãèʥʤéãÞʤʦÞʢʥéðÞʡóîãʣêʡäéʤʥ ą çʡéʥãʣʧʥʢéãìʢʦäãʣèʢèéãàʝ éãèʡãʡàʥʢçʤæʢàʧååãç àʢʣʦéÞʧóîãʢäʡäèʥôæðʢÞʡâʤàãåʡéʡéʤʥðâʡʦìʢéʧÞʢåãìʢçãôèʥʤàʧäëããëʓʘʟÞʥʢâʧåñéʡéʢʡäéãÞʡëããʡàʢçãåʡéëãäåʡâð;= ʒÞʡâʤäʤçʦéʥãäéʤʥçðæèʤÞʥʢáàʡóîãæʦéʢçäʧʦʤʦʧàʡ êʡäéʤʥʡæʤéçʤʦôéʦô òçàʤéʢåãç %4 éʥʤæÝʤäʦʡçʓ2 èʥʤʦéʡßåʡçàãç&² ʦʧèʢʥʤäʦãà ʡçãʤç;= ʒʥʤæʢ éʤßʤ òçàʤéʢåãʤëãéð ʦãçéʢâãʥʧóé æçʤáʢʦéÞʤ àʥʧßãʨ êʡäéʤʥʤÞ ʔʦʧÝòçàʤéʢåãʡåñçʤʢèʥʤʦéʥʡçʦéÞʤèʤèʡàʡóéäʤæèʤçʢçéðÝʡâʡåñçʤʣæʢæÝʥʡçð äʤååʡßʢç òåʡʦéãç åʡæãçãç èʥʤéʢʡâðããʨãçßãÝãéʤʥð éʥʤæÝʤʦèʤçàãç æʧäʤèʤåãʦʡʨʡʥãàð Þãéʥʤçʢäéãç êãÝʥʤçʢäéãç êʡäéʤʥ ʔãååʢÝʥʡçàʡ ã àʥʧßãʢ Ýʢåäã ʒʥʤæʢ éʤßʤ Þ èʥʤʦÞʢé ʦʤʦʧàʡ òçàʤéʢåãʤëãéð èʥʤãâÞʤàôé êʡäéʤʥð ʥʢßʧåãʥʧóîãʢ ʥʢʡäéãÞçʤʦéñ éʥʤæÝʤëãéʤÞ ã éʢäʧìʢʦéñ äʥʤÞã Úéʤ ßåãäʤâʡæãçʤßåãäʡçð '!' äʤæèåʢäʦð ßʢèʡʥãç ą ʡçéãéʥʤæÝãç ))) éʥʤæÝãç ą éʥʤæÝʤæʤàʧåãç ą èʥʤéʢãç# èåʡâæãçʤßʢçʕʢèʡʥãçôÞåôʢéʦôʢʦéʢʦéÞʢççðæèʥôæðæʡçéãäʤʡßʧåôçéʤæ ʤç ʡäéãÞãʥʧʢé ʡçéãéʥʤæÝãç ))) äʤéʤʥðʣ Þ ʦÞʤó ʤìʢʥʢàñ ãçßãÝãʥʧʢé éäʡçʢÞðʢ ʡäéãÞʡéʤʥð èåʡâæãçʤßʢçʡ ʔ çʤʥæʢ Úʒ èʥʤãâÞʤàôé àʤʦéʡéʤìçðʣ ʤÝïʢæ ßʢèʡʥãçʡàåôèʤààʢʥáʡçãôçʤʥæʡåñçʤßʤʡçéãäʤʡßʧåôëãʤççʤßʤÝʡåʡçʦʡÞçʧéʥãʦʤʦʧàʡ éʤʢʦéñòçàʤéʢåãʣàʢʣʦéÞʧʢéäʡäæʤîçʡôʡçéãäʤʡßʧåôçéçʡôʦãʦéʢæʡ Þäʤéʤʥʤʣ Ýʢåäã ʦÞʢʥéðÞʡçãô äʥʤÞã çʢ ʡäéãÞãʥʧóéʦô ʡ äåʢéʤìçðʢ äʤæèʤçʢçéð äʥʤÞã çʢ ʤÝʥʡâʧóéäʤçßåʤæʢʥʡéʤÞ 22 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʛʤàÞʤâàʢʣʦéÞãʢæêʡäéʤʥʤÞʥãʦäʡʦèʤʦʤÝçʤʦéñòçàʤéʢåãʡåñçðʨäåʢéʤäÞðàʢåôéñÞʡâʤàãåʡéʡéʤʥðʧæʢçñíʡʢéʦô éʤßàʡäʡäʤÝʥʡâʤÞʡçãʢÞʡâʤäʤçʦéʥãäéʤʥʤÞ ʦʤʨʥʡçôʢéʦôãåãʧÞʢåãìãÞʡʢéʦôʞʡäãʢêʡäéʤʥðʥãʦäʡ äʡäßãèʢʥʨʤåʢʦéʢʥãçʢæãô ßãèʢʥßåãäʢæãô ʓʕ òçàʤéʤäʦãçð ʤäʡâðÞʡóéèʤÞʥʢáàʡóîʢʢàʢʣʦéÞãʢçʡʦéʥʧäéʧʥʧßåãäʤäʡåãäʦʡ èʤäʥðÞʡóîʢßʤæʤçʤʦåʤʣòçàʤéʢåãôʒʥʤæʢéʤßʤ äêʡäéʤʥʡæ èʤÞʥʢáàʢçãôòçàʤéʢåãôʤéçʤʦôéʦôßʤæʤëãʦéʢãç Ñèʡ ʝʜÌãʡçéãéʢåʡäʤäÑʙʛ ʒʤæèåʢäʦçʤʢÞʤâàʢʣʦéÞãʢÞʥʢàʤçʤʦçðʨêʡäéʤʥʤÞÞʢàʢéäàãʦêʧçäëããòçàʤéʢåãô äʤéʤʥʡôʨʡʥʡäéʢʥãâʧʢéʦôʦåʢàʧóîʢʣëʢèñóèʡéʤåʤßãìʢʦäãʨèʥʤëʢʦʦʤÞ ąçʡʥʧíʢçãʢëʢåʤʦéçʤʦéãßåãäʤäʡåãäʦʡ ąèʤÞðíʢçãʢèʥʤçãëʡʢæʤʦéãòçàʤéʢåãô ąʡèʤèéʤâòçàʤéʢåãʤëãéʤÞ ʥʡâʥðÞʦÞôâʢʣæʢáàʧçãæãʡçʤãäʤâ ʦʤÝʥʡâʤÞʡçãʢæàʢêʢäéʤÞÞæʤçʤʦåʤʢ;= ʔçʤʥæʢòçàʤéʢåãʣèʥʢèôéʦéÞʧʢéèʥʤçãäçʤÞʢçãóÞãçéãæʧéʡäãʨäʥʧèçðʨæʤåʢäʧå äʡäÑʙʛãÑèʡ ʚàçʡäʤèʥãèʤÞðíʢçããèʥʤçãëʡʢæʤʦéãòçàʤéʢåãôÞʦʤìʢéʡçããʦèʤÞðíʢççðæʦʤàʢʥáʡçãʢæÑʙʛÞäʥʤÞʤéʤäʢèʥʤãʦʨʤàãéâʡʨÞʡéÑʙʛ òçàʤéʢåãʤëãéʡæã ʦ èʤʦåʢàʧóîãæ ãʨ èʥʤçãäçʤÞʢçãʢæ Þ ãçéãæʧ ʦʧÝòçàʤéʢåãʡåñçʤʢèʥʤʦéʥʡçʦéÞʤ ʛʥʤçãäçʤÞʢçãʢÑʙʛãÑʚʙʛÞãçéãæʧèʥʤãʦʨʤàãéâʡʦìʢé ʦÞôâðÞʡçãôʡèʤʔʦßåãäʤâʡæãçʤßåãäʡçʡæããòåʡʦéãçʤæãçéãæð;=ʝåʢàʧʢé ʤéæʢéãéñ ìéʤæʡåðʢèåʤéçðʢìʡʦéãëðÑʙʛʤÝʥʡâʧóîãʢʦô çʡèʥãæʢʥ èʥãʦʡʨʡʥçʤæàãʡÝʢéʢ æʤßʧéèʥʤçãäʡéñÞãçéãæʧìʢʥʢâæʢáäåʢéʤìçðʢèʥʤæʢáʧéäãʛʥã àʡåñçʢʣíʢæ èʤÞʥʢáàʢçãã òçàʤéʢåãô èʥʤçãäçʤÞʢçãʢ Ñʙʛ Þ ãçéãæʧ ʦéʡçʤÞãéʦô çʢʥʢßʧåãʥʧʢæðæÍʤèʤåçãéʢåñçðʣʥãʦäʝʝʚʦÞôâʡçʦèʥʤçãäçʤÞʢçãʢæÞãçéãæʧ Ñèʡ ʤÝåʡàʡóîʢßʤèʥʤéʥʤæÝʤéãìʢʦäãæʦÞʤʣʦéÞʤæ;= ʚʒÐʝÑʖʙÐʖÑʙʛ ʒʡäʧáʢßʤÞʤʥãåʤʦñ òçàʤéʢåãʣʦèʤʦʤÝʢçʥʢßʧåãʥʤÞʡéñéʤçʧʦßåʡàäʤʣæʧʦäʧåʡéʧʥðʦéʢçäãʦʤʦʧàʤÞèʧéʢæÞðàʢåʢçãô./ʜʢʡäëãóʤÝʥʡâʤÞʡçãô./ãâéʢʥæãçʡåñçʤßʤ ßʧʡçãàãçʤÞʤßʤ ʡéʤæʡ ʡâʤéʡ , ʡʥßãçãçʡ äʡéʡåãâãʥʧóé êʢʥæʢçéð ʦʢæʢʣʦéÞʡ ./ ʦãçéʡâ ./3S ʚàãç ãâ òéãʨ êʢʥæʢçéʤÞ òçàʤéʢåãʡåñçʡô ./ ʦãçéʡâʡ E./3 #A2+ âʡÞãʦãæʚçèʤʦéʤôççʤçʡʨʤàãéʦôÞäåʢéäʡʨʥʡâåãìçðʨéãèʤÞ Þäåóìʡôäåʢéäã òçàʤéʢåãô ʓäéãÞçʤʦéñ èʥʢÞʥʡîʢçãô , ʡʥßãçãçʡ Þ ./ ʤèʥʢàʢåôʢéʦô Ýʡåʡçʦʤæ æʢáàʧʦãçéʢâʤæãʥʡʦèʡàʤæ./èʧéʢæʢßʤʥʢʡäëããʦʦʧèʢʥʤäʦãàʤæ ʡçãʤçʤæ/2- ʔêãâãʤåʤßãìʢʦäãʨʧʦåʤÞãôʨ/2-âʡæʢéçʤçʢÞåãôʢéçʡäʤçëʢçéʥʡëãó./ʚàçʡäʤ èʥãçʡåãìããêʡäéʤʥʤÞʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤßʤʥãʦäʡèʥʤàʧäëãô/2-ÝðʦéʥʤʦéʡçʤÞãéʦô ãâÝðéʤìçʤʣ Ðʦéʤìçãäʤæ /2- Þ òéãʨ ʧʦåʤÞãôʨ ʦéʡçʤÞôéʦô ÞʤʦʦéʡçʤÞåʢççʡô Ýʢéʡ ʙʓÍʟ(+ ʤäʦãàʡâʡ./8 ãçàʧëãʥʧʢæʡô./ ʦãçéʡâʡ./3)) ʡéʡäáʢʦãçéʢâãʥʧʢæðʢåʢʣäʤëãéʡæãæãʢåʤèʢʥʤäʦãàʡâʡʘʛʚ ãåãèʤäʦãßʢçʡâʡʛʥãèʤÞðíʢççðʨäʤçëʢçéʥʡëãôʨ/2-ʥʡâʥʧíʡʢé./ʦʤÝʥʡâʤÞʡçãʢæèʢʥʤäʦãçãéʥãéʡ/.//- äʤéʤʥðʣôÞåôʢéʦôæʤîçðæʤäʦãàʡçéʤæ;=ʚÝʡʡçãʤçʡʧìʡʦéÞʧóéÞêʤʥæãʥʤÞʡçãã ʤäãʦåʢççðʨêʤʥæÑʙʛʤäÑʙʛ ʒàʥʧßãæÞʡʥãʡçéʡææʤàãêãäʡëããÑʙʛÞãçéãæʢ 23 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʤéçʤʦôéʦôãʨʡßʥʢßʡëãô ßåãäãʥʤÞʡçãʢ àʢßʥʡàʡëãôêʥʡßæʢçéʡëãô ʡèʤèʥʤéʢãàʡ" ßãàʥʤåãâêʤʦêʤåãèãàʤÞʘʤàãêãëãʥʤÞʡççðʢÑʙʛʦéãæʧåãʥʧóéʦãçéʢâæʤåʢäʧå ʡàßʢâãã ʨʢæʤäãçʤÞ êʡäéʤʥʤÞʥʤʦéʡ ʧÞʢåãìãÞʡóéèʥʤåãêʢʥʡëãóʕʘʒãàʢßʥʡàʡëãóäʤååʡßʢçʡ èʤÞðíʡóéʡäéãÞçʤʦéñäʤʡßʧåôëãʤççðʨêʡäéʤʥʤÞÞäʥʤÞã âʡèʧʦäʡô éʡäãæʤÝʥʡâʤæãææʧçʤÞʤʦèʡåãéʢåñçðʢèʥʤëʢʦʦðÞʦʤʦʧàãʦéʤʣʦéʢçäʢ;= ʓʒʞÐʔʓÓÐÜÚʙÍʚʞʖÑÐÜÐʓÍʕʖÏÐÜÑʖʗʒʚÓÐʞʚʔ ʔʤʦçʤÞʢÞʤʦèʡåãéʢåñçʤʣʥʢʡäëããÞʦʤʦʧàãʦéʤʣʦéʢçäʢåʢáʡéèʥʤëʢʦʦðàʡåñçʢʣíʢßʤ èʤÞʥʢáàʢçãô òçàʤéʢåãô ʡäéãÞçðæã êʤʥæʡæã äãʦåʤʥʤàʡ ʓʟʒ ʡçßå REACTIVEOXYGENSPECIES 2/3 ʛʤààʢʣʦéÞãʢæʤäʦãàʡéãÞçʤßʤʦéʥʢʦʦʡ èʥãèʥʤàʤåáʡóîʢæʦôèʤÞʥʢáàʡóîʢæÞʤâàʢʣʦéÞããçʡòçàʤéʢåãʣʓʟʒ ÞâʤçʢèʤÞʥʢáàʢçãô èʥʤãʦʨʤàãéʡäéãÞʡëãôòçàʤéʢåãôãòäʦèʥʢʦʦãôãææʤåʢäʧåʡàßʢâãããëãéʤäãçʤÞ Þ ìʡʦéçʤʦéã ʨʢæʤäãçʤÞ ìéʤ Þʢàʢé ä èʥʤçãäçʤÞʢçãó åʢʣäʤëãéʤÞ Þ ʦʤʦʧàãʦéʧó ʦéʢçäʧ ʙʡãÝʤåñíʧó ʥʤåñ Þ òéʤæ èʥʤëʢʦʦʢ ãßʥʡóé æʤçʤëãéð ʤàçʡäʤ èʤäʡâʡçʡ Þʡáçʡô ʥʤåñ çʢʣéʥʤêãåʤÞ ã ʞ åãæêʤëãéʤÞ ;= ʘʢʨʡçãâæ èʥãÞåʢìʢçãô ã èʥʤçãäçʤÞʢçãô ìʢʥʢâ òçàʤéʢåãʣ ʥʡâçðʨ éãèʤÞ åʢʣäʤëãéʤÞ ãæʢʢé ʤÝîãʢ èʥãçëãèð ãòéʡèð ʤàçʡäʤʤçʥʢʡåãâʧʢéʦôÞʥʡâåãìçðʢʦʥʤäããèʥãèʤæʤîãʥʡâåãìçðʨäʤæÝãçʡëãʣ æʤåʢäʧå ʡàßʢâãã ãçéʢßʥãçʤÞ ʦʢåʢäéãçʤÞ ʡàßʢâãÞçðʨ ʥʢëʢèéʤʥʤÞ ʦʧèʢʥʦʢæʢʣʦéÞʡãææʧçʤßåʤÝʧåãçʤÞ ʨʢæʤäãçʤÞããʨʥʢëʢèéʤʥʤÞçʡåʢʣäʤëãéʡʨʞʡäʡôÞʡʥãʡÝʢåñçʤʦéñʤʦçʤÞçʤßʤæʢʨʡçãâæʡÞʢàʢéäèʥãÞåʢìʢçãóʦèʢëãêãìʢʦäãʨ èʤèʧåôëãʣåʢʣäʤëãéʤÞçʡʥʡâçðʨʦéʡàãôʨèʤʥʡáʢçãô;= ʔ äʡìʢʦéÞʢ çʡãÝʤåʢʢ ʤÝîʢßʤ èʥãæʢʥʡ æʢʨʡçãâæʡ ÞâʡãæʤàʢʣʦéÞãô òçàʤéʢåãô ã åʢʣäʤëãéʤÞ æʤáçʤ èʥãÞʢʦéã æʢʨʡçãâæ èʥãÞåʢìʢçãô æʤçʤëãéʡ èʤàäåʡʦʦʡ ,Y#HIGH'R+ ʧæðíʢʣ;=ʚçʦʤʦéʤãéãâʦåʢàʧóîãʨòéʡèʤÞ ÏʡʨÞʡéʙʡòéʤæòéʡèʢëãʥäʧåãʥʧóîãʣÞäʥʤÞãæʤçʤëãé ãæʢóîãʣçʡʦÞʤʢʣ æʢæÝʥʡçʢ ßåãäʤèʥʤéʢãçʤÞðʣ åãßʡçà 0 ʦʢåʢäéãçʡ 03', 3%,0,' #$ ʤÝʥʡâʧʢéʦÞôâñʦ0 ʦʢåʢäéãçʤæąæʤåʢäʧåʤʣʡàßʢâãã èʤʦéʤôççʤʦãçéʢâãʥʧʢæʤʣòçàʤéʢåãʤëãéʤæÍʤèʤåçãéʢåñçðʣʦãçéʢâʦʢåʢäéãçʤÞã6#!- ʡäéãÞãʥʧʢéʦôéʥʡçʦäʥãèëãʤççðæôàʢʥçðæêʡäéʤʥʤæ.& ʀ";= ʛʢʥʢäʡéðÞʡçãʢ ÏʡʨÞʡìʢççðʣ æʤçʤëãé çʡìãçʡʢé ʦÞôâðÞʡéñʦô éʡäáʢ ʦ % ʦʢåʢäéãçʤæìʢʥʢâåãßʡçà03', ãʥʢëʢèéʤʥ#$ ãèʥʤàÞãßʡéñʦôèʤèʤÞʢʥʨçʤʦéãòçàʤéʢåãôʙʡæʤçʤëãéìʢʥʢâʦʤʤéÞʢéʦéÞʧóîãʢʥʢëʢèéʤʥðçʡìãçʡóéʤäʡâðÞʡéñÞåãôçãʢʨʢæʤäãçð Þʡáçʢʣíãæããâäʤéʤʥðʨʦìãéʡóéʦô##,-#0 ʥʢëʢèéʤʥ çʡ æʤçʤëãéʢ ą ##2 #8#, ãçéʢʥåʢʣäãç ÐÑ ʥʢëʢèéʤʥ ą #8#2 ã#8#,êʥʡäéʡåäãç ʥʢëʢèéʤʥą#8#2 ʙʡàʡççʤæòéʡèʢìʡʦéñ ʨʢæʤäãçʤÞ ãææʤÝãåãâʤÞʡççðʨ çʡ èʤÞʢʥʨçʤʦéã ʡäéãÞãʥʤÞʡççʤßʤ òçàʤéʢåãô ʦèʤæʤîñóßåãäʤâʡæãçʤßåãäʡçʤÞ'!' ÞâʡãæʤàʢʣʦéÞʧʢéìʢʥʢâʥʢëʢèéʤʥð ʦʤèʥôáʢççðʢʦ' Ýʢåäʤæ '0#2 ʦæʤçʤëãéʡʥçðæãçéʢßʥãçʤæ6,! ²³1 ãçéʢßʥãçʡ ããâæʢçôʢéʢßʤäʤçêãßʧʥʡëãó 24 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʓàßʢâãôʓäéãÞãʥʤÞʡççðʣãçéʢßʥãç6,! èʥãʤÝʥʢéʡʢéÞðʦʤäʧóʡêêãççʤʦéñ äòçàʤéʢåãʡåñçðææʤåʢäʧåʡæʡàßʢâãã6#!- ã)#!- âʡʦìʢéìʢßʤâʡæʢàåôʢéàÞãáʢçãʢãêãäʦãʥʧʢéʦôçʡòçàʤéʢåãã;= ÍãʡèʢàʢâãéʥʡçʦæãßʥʡëãôʛʥʤçãäçʤÞʢçãʢæʤçʤëãéʤÞìʢʥʢâòçàʤéʢåãʣæʤáʢé ʤʦʧîʢʦéÞåôéñʦô äʡä èʡʥʡëʢååóåôʥçʤ æʢáàʧ òçàʤéʢåãʤëãéʡæã éʡä ã éʥʡçʦëʢååóåôʥçʤ ʦäÞʤâñ æʢæÝʥʡçʧ òçàʤéʢåãʤëãéʡ ʔ òéʤæ èʥʤëʢʦʦʢ ʤʦçʤÞçʧó ʥʤåñ ãßʥʡóé òçàʤéʢåãʡåñçðʢ æʤåʢäʧåð ʡàßʢâãã )#!- 6#!- *!- "# 6% äʡàßʢʥãç ʥʡâåãìçðʢ æʤçʤëãéʡʥçðʢ ãçéʢßʥãçð %3!- ʡ éʡäáʢ 0%#!-#$ #$ *!- ! ÞðʥʡÝʡéðÞʡʢæðʢäʡäòçàʤéʢåãʢæ éʡäãæʤçʤëãéʡæã ʛʥʤàʧäëãô ʧäʡâʡççðʨ ʦʤʢàãçʢçãʣ èʥʤãʦʨʤàãé èʥã çʢèʤʦʥʢàʦéÞʢççʤæ äʤçéʥʤåʢ ʨʢæʤäãçʤÞ ʔ ʥʢâʧåñéʡéʢ æʤçʤëãé ʤäʡâðÞʡʢéʦô Þ ʦʧÝòçàʤéʢåãʡåñçʤæèʥʤʦéʥʡçʦéÞʢ ʓàßʢâãô4 åãæêʤëãéʤÞèʥʤãʦʨʤàãéÞʤʦçʤÞçʤæâʡʦìʢéÞʤâàʢʣʦéÞãôãçéʢßʥãçʡ ²,³2,&! ìʢʥʢâ)#!- ʚʦçʤÞçðʢʥʢëʢèéʤʥðʞ åãæêʤëãéʤÞą#8#2ã##2 ʦäʤéʤʥðæãʦÞôâðÞʡóéʦôʨʢæʤäãçð#8#,ã##,2!.4%3 ÍåôæʤçʤëãéʤÞèʤàäåʡʦʦʡ,Y#LOWêʥʡäéʡåäãçãßʥʡʢéÝʤåñíʧóʥʤåñÞãʨÞðáãÞʡçãã ;= ʡ ãʨ èʢʥʢæʢîʢçãʢ èʤ òçàʤéʢåãó èʥʤãʦʨʤàãé æʢàåʢççʢʢ ã æʤáʢé ÝðéñàʤʦéʡéʤìçʤàåãéʢåñçðæéʡäçʡâðÞʡʢæʤʢèʡéʥʧåãʥʤÞʡçãʢòçàʤéʢåãô Úéã æʤçʤëãéð äʡäã4 åãæêʤëãéð çʢʦʧéʥʢëʢèéʤʥ##2 ʙʢʣéʥʤêãåð äʡä ã iÞʤʦèʡåãéʢåñçðʢx æʤçʤëãéð ,Y#HIGH çʢʦʧé ʥʢëʢèéʤʥð #8#2ã##2 ʦäʤéʤʥðæãʦÞôâðÞʡóéʦôʨʢæʤäãçð#8#, #8#,), ##, -#0 ã##, #8#, ʤèʤʦʥʢàʤÞʡççʡôʡàßʢâãôæʤçʤëãéʤÞèʥʢàʦéʡÞåôʢéʦʤÝʤʣʤéàʢåñçðʣæʢʨʡçãâæ ʥʢʡåãâʧʢæðʣèʥãÞðʦÞʤÝʤáàʢçãããâʤäÑʙʛåãâʤêʤʦêʡéãàãåʨʤåãçʡåãâʤʟʠ ʡçßå,0# ʤÝʥʡâʧóîʢßʤʦôèʥãʤäãʦåʢçããêʤʦêʡéãàãåʨʤåãçʡèʥãʧìʡʦéãã åãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʤʣ êʤʦêʤåãèʡâð ʓ Ñè ʟÑʓ ʡçßå ,P 0,! ,0# èʥãÞʤâàʢʣʦéÞããʤäãʦåʢççðʨáãʥçðʨäãʦåʤéèʥʢʤÝʥʡâʧʢéʦôÞåãâʤêʤʦêʡéãàçʧó äãʦåʤéʧÑʟʒ ʡçßå,0! ʙʢçʡʦðîʢççʡôÑʟʒ ʦÞôâðÞʡôʦñʦʥʢëʢèéʤʥʡæã,0! çʡ òçàʤéʢåãʤëãéʡʨ ÞðâðÞʡʢé ʡäéãÞʡëãó ʦãçéʢâʡ ãæã ʨʢæʤäãçʡ #8#, äʤéʤʥðʣ ʧìʡʦéÞʧʢéÞʡàßʢâããæʤçʤëãéʤÞʡçʡåʤßãìçʤàʥʧßãæ'!' ʦÞôâʡççðæʨʢæʤäãçʡæ;= ʞʡäãæʤÝʥʡâʤæ ʡäéãÞãʥʧʢéʦôßʧæʤʥʡåñçðʣãäåʢéʤìçðʣæʢʨʡçãâæʦÞʤÞåʢìʢçãʢæ ʞ åãæêʤëãéʤÞ èʧʦäʤÞðææʤæʢçéʤæäʤéʤʥʤßʤôÞåôʢéʦôèʤÞʥʢáàʢçãʢòçàʤéʢåãô ʓʒʞÐʔʙʚʝʞÙÑʖʗʒʚÓÐʞʚʔʔÐʙʞÐʘʖ ʘʓʒʜʚʟʓʕÐ ʜʤåñæʡäʥʤêʡßʤÞÞʡéʢʥʤßʢçʢâʢãâʧìʢçʡçʡãÝʤåʢʢèʤåçʤʛʤàÞʤâàʢʣʦéÞãʢæʤäÑʙʛÞòçàʤéʢåãʤëãéʡʨʧÞʢåãìãÞʡʢéʦôòäʦèʥʢʦʦãôëãéʤäãçʤÞãêʡäéʤʥʤÞʥʤʦéʡ Þìʡʦéçʤʦéã æʤçʤëãéʡʥçʤßʤ ʘ ʒʝʟ - #3& ã ßʥʡçʧåʤëãéʡʥçʤ æʤçʤëãéʡʥçʤßʤ ʕʘ ʒʝʟ 25 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ '- #3& äʤåʤçãʢʦéãæʧåãʥʧóîãʨ êʡäéʤʥʤÞ ʛʤà ÞʤâàʢʣʦéÞãʢæ òéãʨ êʡäéʤʥʤÞ ʡéʡäáʢÞðʥʡÝʡéðÞʡʢæʤßʤåʢʣäʤëãéʡæãåʢʣäʤéʥãʢçʡ",4" ÝʤåñíʡôìʡʦéñèʥʤçãäíãʨÞãçéãæʧæʤçʤëãéʤÞ,Y#HIGHàãêêʢʥʢçëãʥʧʢéʦôÞæʡäʥʤêʡßã;= ʓäéãÞʡëãôæʡäʥʤêʡßʤÞèʥʤãʦʨʤàãéèʤàÞʧæʤʦçʤÞçðæèʧéôæʛʤàÞʤâàʢʣʦéÞãʢæëãéʤäãçʤÞ èʥʤãâÞʤàãæðʨ4HÐʟ ´ æʡäʥʤêʡßʡäéãÞãʥʧʢéʦôèʤäåʡʦʦãìʢʦäʤæʧ èʢʥÞʤæʧéãèʧ- ; =ʙʡèʤÞʢʥʨçʤʦéãéʡäãʨiÞʤʦèʡåãéʢåñçðʨxæʡäʥʤêʡßʤÞ ʘ òäʦèʥʢʦʦãʥʧóéʦô ʤèʥʢàʢåʢççðʢ éãèð ʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥʤÞ ìʧÞʦéÞãéʢåñçðʢäʤäÑʙʛ Þìʡʦéçʤʦéã#$ 4,2éʤåå ʥʢëʢèéʤʥð -32æʡäʥʤêʡßʡåñçðʣ ʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥ 32 ! #$ ã/,2ʤäÑʙʛ ʥʢëʢèéʤʥ ,/8 ʟʡßʤëãéʤâ ʤäÑʙʛ ʤèʤʦʥʢàʤÞʡççðʣ òéãæã éãèʡæã ʥʢëʢèéʤʥʤÞ ʡäéãÞãâãʥʧʢé ÞðʥʡÝʤéäʧ æʡäʥʤêʡßʡæã ëʢåʤßʤ ʥôàʡ ʡäéãÞçðʨ ʨãæãìʢʦäãʨ ʦʤʢàãçʢçãʣ ʦʥʢàã äʤéʤʥðʨ ʤʦçʤÞçʧóʥʤåñãßʥʡóéèʥʤÞʤʦèʡåãéʢåñçðʢëãéʤäãçðÐÑ ³ ÐÑ êʡäéʤʥçʢäʥʤâʡ ʤèʧʨʤåã²ʟʙʚ ² 4.& ² æʡéʥãäʦçðʢæʢéʡååʤèʥʤéʢãçʡâð ʨʢæʤäãçð ʓʟʒãéʥʤæÝʤëãéʡʥçðʣêʡäéʤʥʥʤʦéʡʞʟʜ 0$'& ʠʢæʤäãçðʦéãæʧåãʥʧóéèʥãÞåʢìʢçãʢçʤÞðʨ æʤçʤëãéʤÞÞʦʤʦʧàãʦéʧóʦéʢçäʧ ʦʤâàʡÞʡôéʡäãæʤÝʥʡâʤæèʤʥʤìçðʣäʥʧßʘʡäʥʤêʡßã âʡʨÞʡéãÞíãʢ Ýʤåñíʤʢ äʤåãìʢʦéÞʤ ʤäÑʙʛ éʥʡçʦêʤʥæãʥʧóéʦô Þ éʡä çʡâðÞʡʢæðʢèʢçãʦéðʢäʦʡçéʤæçðʢ ʡçßåFOAM äåʢéäãÚéãäåʢéäãèʤʦéʢèʢççʤéʢʥôóé ʦèʤʦʤÝçʤʦéñäæãßʥʡëãããçʡäʡèåãÞʡóéʦôÞãçéãæʢ ôÞåôôʦñʤʦçʤÞʤʣàåôêʤʥæãʥʤÞʡçãôåãèãàçʤßʤôàʥʡʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäã ʔéʤʥʤʣéãèæʡäʥʤêʡßʤÞʘ ÞʤâçãäʡʢéèʥãʡåñéʢʥçʡéãÞçʤʣʡäéãÞʡëããæʡäʥʤêʡßʤÞèʥʤéãÞʤÞʤʦèʡåãéʢåñçðæãëãéʤäãçʡæãÐÑ ÐÑ ÐÑ 4'& ³ ; = ʞʡäãʢæʡäʥʤêʡßãçʡìãçʡóéòäʦèʥʢʦʦãʥʤÞʡéñÐÑ ʜʓ ÐÑ ' #3&;=ʛʤ Þãàãæʤæʧ ʤʦçʤÞçʡôʥʤåñ- æʡäʥʤêʡßʤÞąäåãʥʢçʦʡèʤèéʤéãìʢʦäãʨäåʢéʤä ʦéãæʧåôëãôʕʘʒãêãÝʥʤÝåʡʦéʤÞäèʥʤåãêʢʥʡëãããʦãçéʢâʧÞçʢäåʢéʤìçʤßʤæʡéʥãäʦʡ ìéʤ ʦèʤʦʤÝʦéÞʧʢéʤÝʥʡâʤÞʡçãóêãÝʥʤâçʤʣéäʡçã;= ÍʖʙÍʜÐʞʙØʖʒÑʖʞʒÐ Íʢçàʥãéçðʢäåʢéäãàʢçàʥʤëãéð òäʦèʥʢʦʦãʥʧóéçʡÝʤʥèʤÞʢʥʨçʤʦéçðʨæʤåʢäʧå ʨʡʥʡäéʢʥçðʣàåôàʥʧßãʨʡçéãßʢçèʥʢàʦéʡÞåôóîãʨäåʢéʤäʚʦçʤÞçðæãéãèʡæãàʢçàʥãéçðʨäåʢéʤäôÞåôóéʦôæãʢåʤãàçðʢãèåʡâæʤëãéʤãàçðʢʘãʢåʤãàçðʢ àʢçàʥʤëãéðʤÝʥʡâʧóéʦôÞʥʢâʧåñéʡéʢæãʢåʤãàçʤßʤßʢæʤèʤòâʡ ʤçããçãëããʥʧóé ãʦéãæʧåãʥʧóéãææʧççðʣʤéÞʢéʛåʡâæʤëãéʤãàçðʢàʢçàʥʤëãéðôÞåôóéʦôäåʢéäʡæãåãæêʤãàçʤßʤèʥʤãʦʨʤáàʢçãôʚçãôÞåôóéʦôʤʦçʤÞçðæããçéʢʥêʢʥʤç èʥʤàʧëãʥʧóîãæãäåʢéäʡæãäʥʤÞã ÞʤʦçʤÞçʤæ)éãèʡ ʡéʡäáʢÐÑ ãÐÑ äʤéʤʥðʢ èʢʥʢäåóìʡóéàãêêʢʥʢçëãʥʤÞäʧçʧåʢÞðʨʞ ʨʢåèʢʥʤÞÞʞ ʨʢåèʢʥð ßʤéãèʡ;= Íʢçàʥãéçðæ äåʢéäʡæ Þ çʡʦéʤôîʢʢ Þʥʢæô ʤéÞʤàãéʦô ʥʤåñ ʥʢßʧåãʥʤÞîãäʤÞ ʢʦéʢʦéÞʢççʤßʤ ã ʡàʡèéãÞçʤßʤ ãææʧççʤßʤ ʤéÞʢéʡ èʥã ʡéʢʥʤßʢçʢâʢ #$C+ èʤèʧåôëãô àʢçàʥʤëãéʤÞ ʥʢßʧåãʥʧʢæʡô êʥʡäéʡåäãçʤæ èʥãʦʧéʦéÞʧʢé Þ ʢîʢ çʢ èʤÞʥʢáàʢççðʨ çʤèʤàÞʢʥáʢççðʨʡéʢʥʤʦäåʢʥʤâʧʧìʡʦéäʡʨʦʤʦʧàãʦéʤʣʦéʢçäã;= ʙʡ çʡìʡåñçðʨ òéʡèʡʨ ʡéʢʥʤßʢçʢâʡ ìʡʦéñ æʤçʤëãéʤÞ àãêêʢʥʢçëãʥʧʢéʦô Þ ãçéã26 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ æʢ Þ #$C+ àʢçàʥʤëãéð äʤéʤʥðʢ Þʤ æçʤßʤæ ʦʨʤáã ʦ æʡäʥʤêʡßʡæã ʤçã éʡäáʢ èʤßåʤîʡóé åãèãàð ã èʥʤàʧëãʥʧóé èʥʤÞʤʦèʡåãéʢåñçðʢ ëãéʤäãçð ʝìãéʡʢéʦô ìéʤ #$C+ ôÞåôʢéʦô ʤʦçʤÞçʤʣ ʡçéãßʢçèʥʢàʦéʡÞåôóîʢʣ èʤèʧåôëãʢʣ äåʢéʤä àåô ʞ åãæêʤëãéʤÞ ʦéãæʧåãʥʧóîʢʣ àãêêʢʥʢçëãʡëãó ʞ åãæêʤëãéʤÞ ã âʡèʧʦä ãæã ʡàʡèéãÞçʤßʤãææʧççʤßʤʤéÞʢéʡÍʥʧßʡôèʤèʧåôëãôàʢçàʥʤëãéʤÞ òäʦèʥʢʦʦãʥʧóîʡôʨʢæʤäãç##,##,+ àʢçàʥʤëãéð èʤàʡÞåôʢéêʧçäëãóʞREGãʦèʤʦʤÝʦéÞʧʢé èʥãÞåʢìʢçãóʞ ʨʢåèʢʥʤÞ;=ʙʡÝʤåʢʢèʤâàçãʨòéʡèʡʨʡéʢʥʤßʢçʢâʡʡäéãÞçʡôèʤèʧåôëãôèåʡâæʤëãéʤãàçðʨàʢçàʥʤëãéʤÞP$# ãæʢóîʡôéʤåå ʥʢëʢèéʤʥð4,2 àåôʡäéãÞʡëããêʡßʤëãéʤâʡêʥʡßæʢçéʤÞãÍʙʒʡèʤèéʤéãìʢʦäãʨäåʢéʤä ÞðʥʡÝʡéðÞʡʢéÐʟ² äʤéʤʥðʣʦéãæʧåãʥʧʢéʞ ʨʢåèʢʥðäÞðʥʡÝʤéäʢ42!),ąèʥʤʡèʤèéʤéãìʢʦäʤßʤëãéʤäãçʡʦʢæʢʣʦéÞʡʟʙʚãÐʟ ´ ÑÐʘʟʚÓÐʞØ ʚʦçʤÞçʧó ʥʤåñ Þ ʡàʡèéãÞçʤæ ãææʧçʤÞʤʦèʡåãéʢåñçʤæ ʤéÞʢéʢ èʥã ʡéʢʥʤßʢçʢâʢãßʥʡóéʞ ʨʢåèʢʥð#$+ ãʥʢßʧåôéʤʥçðʢʞ åãæêʤëãéðʞREG ʞ ʦʧèʥʢʦʦʤʥð ʤäʡâðÞʡóîãʢ èʥʤéãÞʤèʤåʤáçðʢ òêêʢäéð ÍãʦÝʡåʡçʦ æʢáàʧ òéãæã àÞʧæô èʤèʧåôëãôæã 4 åãæêʤëãéʤÞ Þ èʤåñâʧ 4 ʨʢåèʢʥʤÞ ãßʥʡʢé Þʡáçʧó ʥʤåñ Þ ʧʦʧßʧÝåʢçããʡéʢʥʤßʢççʤßʤèʥʤëʢʦʦʡʛʥʤçãäíãʢÞãçéãæʧiçʡãÞçðʢx4 ʨʢåèʢʥð4H èʤʦʥʢàʦéÞʤæ 4#2 4 CELL RECEPTOR ʥʡʦèʤâçʡóé ʡçéãßʢçð Þ ìʡʦéçʤʦéã ʤäÑʙʛ èʥʢàʦéʡÞåʢççðʢ -(# )) ßåʡÞçðæ äʤæèåʢäʦʤæ ßãʦéʤʦʤÞæʢʦéãæʤʦéã äåʡʦʦʡ )) çʡ èʤÞʢʥʨçʤʦéã æʡäʥʤêʡßʡ ʜʢʡäëãô ʦ ʡçéãßʢçʤæ èʥã ʧìʡʦéãã ÐÑ ã ÐÑ ÞðʥʡÝʡéðÞʡʢæðʨ æʡäʥʤêʡßʡæã èʥãÞʤàãé ä àãêêʢʥʢçëãʥʤÞʡçãó ʡäéãÞʡëãã 4H ʨʢåèʢʥʤÞ Þ èʥʤʡéʢʥʤßʢççðʢ 4H åãæêʤëãéð ʥʢʡåãâʧóîãʢ äåʢéʤìçðʣ ãææʧççðʣʤéÞʢé;=ʓäéãÞçðʢ4H åãæêʤëãéðèʥʤàʧëãʥʧóéãçéʢʥêʢʥʤç ´Ðʟ ´ )&. ´ ʟʙʚ ² ÐÑ ÐÑ ÐÑ ãòäʦèʥʢʦʦãʥʧóé#$ åãßʡçà#$, #$ ʤʦçʤÞçðæ ãʦéʤìçãäʤæ äʤéʤʥʤßʤ ôÞåôóéʦô éʥʤæÝʤëãéð ;= ʔâʡãæʤàʢʣʦéÞãʢ #$,ʦʤʦÞʤãæʥʢëʢèéʤʥʤæ#$ èʥʢàʦéʡÞåôʢæðæçʡʦÞʤʢʣèʤÞʢʥʨçʤʦéãàʢçàʥʤëãéʡæã æʡäʥʤêʡßʡæã Úʒ ã ʕʘʒ ôÞåôʢéʦô èʧʦäʤÞðæ æʢʨʡçãâæʤæ àåô ʡäéãÞçʤßʤ Þʤʦèʡåãéʢåñçʤßʤ ʤéÞʢéʡ äʤéʤʥðʣ ʨʡʥʡäéʢʥãâʧʢéʦô àʡåñçʢʣíʢʣ ßãèʢʥèʥʤàʧäëãʢʣæʡäʥʤêʡßʡæãëãéʤäãçʤÞ ʨʢæʤäãçʤÞ êʡäéʤʥʤÞʥʤʦéʡãæʡéʥãäʦçðʨ æʢéʡååʤèʥʤéʢãçʡâʘʘʛ ; = 4H åãæêʤëãéð ʥʢʡåãâʧóîãʢ ʡçéãéʢåñçðʣ ʤéÞʢé àãêêʢʥʢçëãʥʧóéʦô èʤà ÞʤâàʢʣʦéÞãʢæ ÐÑ ʚʦçʤÞçʤʣ èʥʤãâÞʤàãæðʣ ãæã ëãéʤäãç ÐÑ èʤàʡÞåôʢé ʤäÑʙʛ ãçàʧëãʥʤÞʡççʧó ÞðʥʡÝʤéäʧ ÐÑ æʤçʤëãéʡæã ʦçãáʡʢé ʧʥʤÞʢçñ Ðʟ ´ ãèʢʥʢäåóìʡʢéàãêêʢʥʢçëãʡëãó4H äåʢéʤäʦ4H çʡ4H èʧéñ; = ʜʢßʧåôéʤʥçðʢ ʞ åãæêʤëãéð ʞREG ʞ ʦʧèʥʢʦʦʤʥð ʥʢʡåãâʧóé ʡéʢʥʤèʥʤéʢäéãÞçðʢ òêêʢäéð ìʢʥʢâ èʥʤàʧäëãó ÐÑ ã éʥʡçʦêʤʥæãʥʧóîãʣ ʥʤʦéʤÞʤʣ êʡäéʤʥ ³4'& ³ ;=ʕʤæʢʤʦéʡâʞREGèʤàʡÞåôʢéʦôʨʢæʤäãçʤæ##,ãÐʟ ´;=" åãæêʤëãéð èʤ Þãàãæʤæʧ éʡäáʢ ʤäʡâðÞʡóé Þ ʤʦçʤÞçʤæ èʥʤéʢäéãÞçðʢ òêêʢäéð äʤéʤʥðʢʦéãæʧåãʥʧóéʦôÐÑ èʥʤãâÞʤàãæðæ4H äåʢéäʡæã;= 27 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʙʖʗʞʜʚʟÐÑØ ʛʥãßãèʢʥåãèãàʢæããʧÞʢåãìãÞʡʢéʦôìãʦåʤëãʥäʧåãʥʧóîãʨçʢʣéʥʤêãåʤÞ äʤéʤʥðʢéʡäáʢèʥãÞåʢäʡóéʦôÞʦʤʦʧàãʦéʧóʦéʢçäʧèʤʦʥʢàʦéÞʤæʦèʢëãêãìçðʨʥʢëʢèéʤʥʤÞ ä ʨʢæʤäãçʡæ ;= ʙʢʣéʥʤêãåð ãßʥʡóé Þʡáçʧó ʥʤåñ çʡ ʦʡæðʨ ʥʡççãʨ òéʡèʡʨʡéʢʥʤßʢçʢâʡ èʤʦäʤåñäʧʦʡæãèʥʤãâÞʤàôéʓʟʒ ʡéʡäáʢèʥʤéʢʡâʧäʡéʢèʦãç 'ãäʡéʢåãëãàãç,, åãßʡçààåô#8#2 äʤéʤʥðʢôÞåôóéʦôæʤîçðæãʡßʢçéʡæã ʨʢæʤéʡäʦãʦʡ æʤçʤëãéʤÞ ; = ʔ àʡåñçʢʣíʢæ äʡéʢèʦãç ' ʡ éʡäáʢ çʢʣéʥʤêãåñçðʢòåʡʦéʡâðÝåʤäãʥʧóéàʢʣʦéÞãʢãçßãÝãéʤʥʡÞçʢíçʢßʤèʧéãʦÞʢʥéðÞʡçãô 4&0) ìéʤ ôÞåôʢéʦô âÞʢçʤæ êʤʥæãʥʤÞʡçãô éʥʤæÝʡ ;= ʙʢʣéʥʤêãåð ôÞåôôʦñ äʤʥʤéäʤáãÞʧîãæãäåʢéäʡæã ÝðʦéʥʤèʤàÞʢʥßʡóéʦôʡèʤèéʤâʧʙʢʦæʤéʥôçʡéʤìéʤ ʤçããßʥʡóéÞʡáçʧóʥʤåñÞèʤààʢʥáʡçããʨʥʤçãìʢʦäʤßʤÞʤʦèʡåʢçãôèʥãʡéʢʥʤʦäåʢʥʤâʢ ʤçãéʡäáʢʦèʤʦʤÝçðʤäʡâðÞʡéñèʥʤéãÞʤÞʤʦèʡåãéʢåñçðʢòêêʢäéðèʤʦʥʢàʦéÞʤæéʤåå ʥʢëʢèéʤʥʡ 4,2 #$ ;= ʞÒÔʙØʖʒÑʖʞʒÐ ʞʧìçðʢäåʢéäã ãææʧççðʢäåʢéäãʦʤʢàãçãéʢåñçʤʣéäʡçã ʧìʡʦéÞʧóéÞʡàʡèéãÞçʤæ ãææʧçãéʢéʢ ã ôÞåôóéʦô ʡçʡåʤßʡæã ëãʥäʧåãʥʧóîãʨ ÝʡâʤêãåʤÞ äʥʤÞã Ðʨ ʤʦçʤÞçʡô ʥʤåñ Þ ʡéʢʥʤßʢçʢâʢ ʦʤʦéʤãé Þ àʤèʤåçãéʢåñçʤʣ èʥʤàʧäëãã ÐÑ Ðʟ ´ ã ʟʙʚ ² ʛʥã ʡäéãÞʡëãã éʧìçðʨ äåʢéʤä èʤʦʥʢàʦéÞʤæ )G% ãåã èʥã ʧìʡʦéãã ÐÑ ʤçã éʡäáʢ ÞðʥʡÝʡéðÞʡóé éʥãèéʡâð ʦéãæʧåãʥʧóîãʢ ʦãçéʢâ -#0 ã ÐÑ ;= ʒʥʤæʢ éʤßʤ ßʢèʡʥãç ã éʥãèéʡâð éʡä áʢ äʡä ã àʥʧßãʢ èʥʤàʧëãʥʧʢæðʢ éʧìçðæã äåʢéäʡæã êʢʥæʢçéð ʨãæʡâð èʤéʢçëãʥʧóé èʥʢʤÝʥʡâʤÞʡçãʢ æʤçʤëãéʤÞ Þ éʧìçðʢ äåʢéäã ʡ ßãʦéʡæãç ʦéãæʧåãʥʧʢé ãʨ ʡèʤèéʤâ ʞʧìçðʢ äåʢéäã ÞðʥʡÝʡéðÞʡóé êʡäéʤʥ ʥʤʦéʡ êãÝʥʤÝåʡʦéʤÞ B&'& ʦèʤʦʤÝʦéÞʧóîãʣ çʢʤÞʡʦäʧåôʥãâʡëãã ʓʝÌ ʤàçʡäʤʤàçʤÞʥʢæʢççʤèʥʤéʢʡâðãßãʦéʡæãçʦçãáʡóéèʥʤìçʤʦéñçʤÞðʨʦʤʦʧàʤÞ ìéʤ èʤÞðíʡʢé ʥãʦä ßʢæʤʥʥʡßãìʢʦäʤßʤ èʤÞʥʢáàʢçãô Ýåôíäã ʛʥʤéʢʡâð éʧìçðʨ äåʢéʤäʤèʤʦʥʢàʧóéàʢßʥʡàʡëãóÞçʢäåʢéʤìçʤßʤæʡéʥãäʦʡ ʦéãæʧåãʥʧóéʡèʤèéʤâ Úʒãäʤååʡßʢçʦãçéʢâãʥʧóîãʨʕʘʒã äʡäʦåʢàʦéÞãʢ ôÞåôóéʦôêʡäéʤʥʤæêʤʥæãʥʤÞʡçãôʧìʡʦéäʤÞòçàʤéʢåãʡåñçðʨèʤÞʥʢáàʢçãʣãàʢʦéʡÝãåãâʡëããʓʝÌ;ą= ʟʚʜʘÐʜʚʔʓʙÐʖʓʞʖʜʚʝʒÑʖʜʚʞÐÔʖʝʒʚʗÌÑÜÕʒÐ ÍʡåñçʢʣíʢʢʥʡâÞãéãʢʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʥʤëʢʦʦʡôÞåôʢéʦôʥʢâʧåñéʡéʤæ èʤʦéʤôççʤßʤ ÞâʡãæʤèʤéʢçëãʥʤÞʡçãô èʥʤëʢʦʦʤÞ èʥʤéʢäʡóîãʨ Þ ʡʥéʢʥãʡåñçʤʣ ʦéʢçäʢ ʦ ʧìʡʦéãʢæ äåʢéʤìçðʨ ã ßʧæʤʥʡåñçðʨ êʡäéʤʥʤÞ ;= ʔ ʧʦåʤÞãôʨ äʤßàʡ ÞãçéãæʢçʡʨʤàãéʦôÝʤåñíʤʢäʤåãìʢʦéÞʤʤäÑʙʛ ʡåʢʣäʤëãéðãòçàʤéʢåãʤëãéð èʥʤàʧëãʥʧóéëãéʤäãçð äʤéʤʥðʢçʢéʤåñäʤʤÝåʡàʡóéʦʤÝʦéÞʢççðæéʤäʦãìʢʦäãæ òêêʢäéʤæ çʤ ã ãçßãÝãʥʧóé ʡçéãʡéʢʥʤßʢççðʢ æʢʨʡçãâæð ʡéʢʥʤßʢççðʣ äʡʦäʡà æʤáʢé ʦéʡéñ çʢʧèʥʡÞåôʢæðæ ʥãʦ ʛʤʦåʢàʧóîãʢ òéʡèð ʡéʢʥʤßʢçʢâʡ êʡäéãìʢʦäã èʥʤéʢäʡóé èʡʥʡååʢåñçʤ ʡ àåãéʢåñçʤʦéñ êʤʥæãʥʤÞʡçãô Ýåôíäã ã ʢʢ 28 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ àʢʦéʡÝãåãâʡëãôâʡÞãʦôéʤéèʥʢʤÝåʡàʡçãôçʢäʤéʤʥðʨãâèʥãÞʢàʢççðʨæʢʨʡçãâæʤÞçʡàʤʦéʡåñçðæã;= ʜãʦʝʨʢæʡʥʤʦéʡʓʝÌ7ILLIAMS+* 4ABAS) ; =ʕʘʒąßåʡàäʤæðíʢìçðʢ äåʢéäã Ñʙʛąåãèʤèʥʤéʢãàðçãâäʤʣèåʤéçʤʦéã ʘÐʕʜʓÓÐÜÐʛʜʚÑÐʟʖʜʓÓÐÜʕÑʓÍʒʚʘØÕʖÔʙØʠʒÑʖʞʚʒ ʔ çʤʥæʢ ʕʘʒ ʥʡʦèʤåʡßʡóéʦô Þ ʦʥʢàçʢʣ ʤÝʤåʤìäʢ ʡʥéʢʥãʣ ã Þðèʤåçôóé ʦʤäʥʡéãéʢåñçʧóêʧçäëãó ʥʢßʧåãʥʧôéʤçʧʦʦʤʦʧàʡʛʤàÞåãôçãʢæêʡäéʤʥʤÞʥʤʦéʡ èʥʢãæʧîʢʦéÞʢççʤ0$'& èʥʤãʦʨʤàãéæãßʥʡëãôʕʘʒÞãçéãæʧìʢʥʢâÞçʧéʥʢççóó òåʡʦéãìʢʦäʧóæʢæÝʥʡçʧʛʤʦåʢòéʤßʤèʤàÞʤâàʢʣʦéÞãʢæ&'& ÐÑ ãʟʙʚ ²èʥʤãʦʨʤàãéèʥʤåãêʢʥʡëãôʕʘʒÞãçéãæʢ ßàʢʤçãʧìʡʦéÞʧóéÞêʤʥæãʥʤÞʡçããÞçʢäåʢéʤìçʤßʤʦʤʢàãçãéʢåñçʤßʤæʡéʥãäʦʡÝʧàʧîʢʣʓʝÌ;=ʛʥãòéʤæʕʘʒçʡìãçʡóéʦʢäʥʢéãʥʤÞʡéñÐÑ ÐÑ -#0 - #3& &'&ã4'& ³ʙʢäʤéʤʥðʢʕʘʒéʡäáʢ èʥãʤÝʥʢéʡóé ʦèʤʦʤÝçʤʦéñ ä çʢʥʢßʧåãʥʧʢæʤæʧ âʡʨÞʡéʧ ʤäÑʙʛ èʧéʢæ èʥôæʤßʤ òçàʤëãéʤâʡ éʡä äʡä çʢ ãæʢóé ʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥʤÞ ʞʡäãʢ ʕʘʒ Ýʧàʧìã èʢʥʢßʥʧáʢçðåãèãàʡæã éʥʡçʦêʤʥæãʥʧóéʦôÞʦÞʤʢʤÝʥʡâçðʢæʡäʥʤêʡßʤèʤàʤÝçðʢ æãʤëãéʡʥçðʢ èʢçãʦéðʢ äåʢéäã êʤʥæãʥʧô éʡäãæ ʤÝʥʡâʤæ êãÝʥʤâçʤ åãèãàçðʣ äʡʥäʡʦÝåôíäã;= ʜʖʘʚÍʖÑÐʜʚʔʓʙÐʖʔʙʖʒÑʖʞʚÔʙʚʕʚʘʓʞʜÐʒʝʓ ʔçʢäåʢéʤìçðʣ æʡéʥãäʦ ʔʒʘ ʦʤʦéʤãé ãâ ßåãäʤèʥʤéʢãçʤÞ èʥʤéʢʤßåãäʡçʤÞ Þʢʥʦãäʡç Ýãßåãäʡç ʡßßʥʢäʡç àʢäʤʥãç êãÝʥãçʡ òåʡʦéãçʡ êãÝʥʤçʢäéãçʤÞ 29 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʜãʦʒåʢéʤìçðʣãßʧæʤʥʡåñçðʣæʢʨʡçãâæðêʤʥæãʥʤÞʡçãôʓʝÌ Ñʟʒąåãâʤêʤʦêʡéãàçʡôäãʦåʤéʡ ʟʠąêʤʦêʡéãàãåʨʤåãç ʤÎʒąʤäãʦåʢççðʢáãʥçðʢäãʦåʤéð (30ąÝʢåäãéʢèåʤÞʤßʤíʤäʡ ʘʛʚąæãʢåʤèʢʥʤäʦãàʡâʡ 30 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ !4))ąʡçßãʤéʢçâãç)) '- #3&ąßʥʡçʧåʤëãéʡʥçʤ æʡäʥʤêʡßʡåñçðʣäʤåʤçãʢʦéãæʧåãʥʧóîãʣêʡäéʤʥ - #3&ąæʡäʥʤêʡßʡåñçðʣäʤåʤçãʢʦéãæʧåãʥʧóîãʣêʡäéʤʥ 0$'&ąéʥʤæÝʤëãéʡʥçðʣêʡäéʤʥʥʤʦéʡ &'&ąêʡäéʤʥʥʤʦéʡêãÝʥʤÝåʡʦéʤÞ 6%'&ąêʡäéʤʥʥʤʦéʡòçàʤéʢåãôʦʤʦʧàʤÞ ,4"ąåʢʣäʤéʥãʢç" -(#))ąßåʡÞçðʣäʤæèåʢäʦßãʦéʤʦʤÞæʢʦéãæʤʦéãäåʡʦʦʡ)) 4#2ąʞ äåʢéʤìçðʢʥʢëʢèéʤʥð 0$#ąèåʡâæʤëãéʤãàçðʢàʢçàʥʤëãéð 31 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ʔʦʢòéãäʤæèʤçʢçéðèʥʤàʧëãʥʧóéʦôßåʡàäʤæðíʢìçðæãäåʢéäʡæãèʤàÞåãôçãʢæ 0$'& ã 4'& ³ ʛʤà àʢʣʦéÞãʢæ ëãéʤäãçʤÞ èʥʤãʦʨʤàãé âçʡìãéʢåñçʤʢ ãâæʢçʢçãʢ ʦéʥʧäéʧʥð ʔʒʘ ʞʡä Ðʟ ´ ãçßãÝãʥʧʢé ʦãçéʢâ äʤååʡßʢçʡ ʡ èʥʤÞʤʦèʡåãéʢåñçðʢ ëãéʤäãçðÐÑ ãʟʙʚ ²ʦéãæʧåãʥʧóéÞðʥʡÝʤéäʧæʡéʥãäʦçðʨæʢéʡååʤèʥʤéʢãçʡâ ʘʘʛ çʢʦäʤåñäãʨéãèʤÞ;=ʘʘ0Þåãôóéçʢéʤåñäʤçʡʔʒʘ çʤãçʡʦãçéʢâëãéʤäãçʤÞ ʘʘʛ ʡäéãÞãʥʧóé èʥʤàʧäëãó ʟʙʚ ² ʡ ʘʘʛ ã éʡäáʢʡäéãÞãʥʧóéʦãçéʢâÐÑ ³ ʘʘʛ ʦèʤʦʤÝʦéÞʧʢéæãßʥʡëããæʤçʤëãéʤÞ;=ÐæʢóéʦôàʡççðʢãʤèʥʤéãÞʤÞʤʦèʡåãéʢåñçʤæòêêʢäéʢʘʘʛ èʤʦʥʢàʦéÞʤæʡäéãÞʡëãã4'& ³ãÐÑ ʜʓ;=ʛʤ Þãàãæʤæʧ àÞʤʣʦéÞʢççʤʦéñòêêʢäéʤÞʘʘʛʤÝʧʦåʤÞåʢçʡÝʡåʡçʦʤæʤʦéʡåñçðʨʡéʢʥʤßʢççðʨãʡçéãʡéʢʥʤßʢççðʨ æʢʨʡçãâæʤÞ èʥʤéʢäʡóîãʨÞʓʝÌʔäʤçʢìçʤæãéʤßʢʤìʡßʤÞʤʢçʡʥʧíʢçãʢʦãçéʢâʡ ʔʒʘãʢßʤàʢßʥʡàʡëãôôÞåôóéʦôêʡäéʤʥʡæã ÞðâðÞʡóîãæãåʤäʡåñçʤʢãʦéʤçìʢçãʢèʤäʥðíäãʓʝÌ ʘʚÌÐÑÐÏʓÓÐÜÚʙÍʚʞʖÑÐʓÑÙʙØʠʛʜʚʕʖʙÐʞʚʜʙØʠʒÑʖʞʚʒ ʛʤÞʥʢáàʢçãʢòçàʤéʢåãôãêʤʥæãʥʤÞʡçãʢʓʝÌÞðâðÞʡóéèʥʤàʧäëãóëãéʤäãçʤÞ äʤéʤʥðʢèʥãÞåʢäʡóéòçàʤéʢåãʡåñçðʢèʥʤßʢçãéʤʥçðʢäåʢéäãÚʛʒ äʦʤʦʧàãʦéʤʣʦéʢçäʢ;=ʔʥʢèʡʥʡëããòçàʤéʢåãô èʤæãæʤÚʛʒ èʥãçãæʡóéʧìʡʦéãʢãʡäéãÞãʥʤÞʡççðʢ ʘ æʡäʥʤêʡßã èʤʦʥʢàʦéÞʤæ ÞðʥʡÝʤéäã ãæã ' #3& ;= äʤéʤʥðʣ ʤÝåʢßìʡʢéÞðʨʤàÚʛʒÞäʥʤÞʢçʤʦçʤʢʥʧʦåʤʝéãæʧåãʥʤÞʡççʤʢëãéʤäãçʡæãÞðʦÞʤÝʤáàʢçãʢèʥʤéʢʡâ éʡäãʨäʡäòåʡʦéʡâʡ äʡéʢèʦãç'ãæʡéʥãäʦçʡôæʢéʡååʤèʥʤéʢãçʡâʡ ʘʘʜ èʥʢàʤéÞʥʡîʡʢé ʡàßʢâãÞçʤʢ ÞâʡãæʤàʢʣʦéÞãʢ Úʛʒ ʦ äåʢéäʡæã ʦéʥʤæð; =ÍʡåʢʢÚʛʒèʥãÞåʢäʡóéʦôãæʤÝãåãâʧóéʦôÞâʤçʧèʤÞʥʢáàʢçãô ʔʡáçðæ çʡèʥʡÞåôóîãæ ʦãßçʡåʤæ ôÞåôʢéʦô êʡäéʤʥ 3$& STROMAL CELL DERIVED FACTOR äʤéʤʥðʣÞðʥʡÝʡéðÞʡʢéʦôäʤʦéçðææʤâßʤæãæçʤßãæãàʥʧßãæãéäʡçôæã Ò âàʤʥʤÞðʨ åãë 3$& çʢ Þðʨʤàãé ãâ äʤʦéçʤßʤ æʤâßʡ ʔ ʧʦåʤÞãôʨ ãíʢæãã Þʤʦèʡåʢçãô ã ßãèʤäʦãã èʤà ÞʤâàʢʣʦéÞãʢæ ãçàʧëãʥʤÞʡççʤßʤ ßãèʤäʦãʢʣ êʡäéʤʥʡ ()& èʥʤãʦʨʤàãé Þðʨʤà 3$& ;ą= ʚäʦãà ʡâʤéʡ òʦéʥʤßʢçð åãèʤèʥʤéʢãàðÞðʦʤäʤʣèåʤéçʤʦéãÑʔʛ ʦʤʦʧàãʦéðʣòçàʤéʢåãʡåñçðʣêʡäéʤʥʥʤʦéʡ6%'& ãòʥãéʥʤèʤòéãçéʡäáʢʦèʤʦʤÝʦéÞʧóéèʤÞðíʢçãóèåʡâæʢççʤßʤéãéʥʡÚʛʒãèʥãÞåʢìʢçãó Úʛʒ Þ ʤÝåʡʦéñ èʤÞʥʢáàʢçãô ìʢʥʢâ ʥʡʦíãʥʢçãʢ êʤʦêʡéãàãåãçʤâãéʤå êʤʦêʡé0)0 !KT èʧéã;ą=ʝÞôâðÞʡçãʢÚʛʒʦèʤÞʥʢáàʢççðæòçàʤéʢåãʢæʤʦʧîʢʦéÞåôʢéʦôʦèʤæʤîñóæʤåʢäʧåäåʢéʤìçʤʣʡàßʢâããʜ ʖ ʦʢåʢäéãç )#!- ;= ʛʥã èʤÞʥʢáàʢçãã òçàʤéʢåãô èʥʤãʦʨʤàãé ʡäéãÞʡëãô éʥʤæÝʤëãéʤÞ òäʦèʤçãʥʤÞʡççðæãÝʢåäʡæãæʡéʥãäʦʡʦʡàßʢâãʢʣéʥʤæÝʤëãéʤÞäåãíʢççʤʣòçàʤéʢåãôèʤÞʥʢáàʢççʤʣʤÝåʡʦéãʦʤʦʧàãʦéʤʣʦéʢçäãʓäéãÞʡëãôéʥʤæÝʤëãéʤÞÞʢàʢé ä êʤʥæãʥʤÞʡçãó æãäʥʤéʥʤæÝʤÞ ã òäʦèʥʢʦʦãã 3$& ìéʤ çʡèʥʡÞåôʢé Úʛʒ ä èʤÞʥʢáàʢççʤæʧ òçàʤéʢåãó Ìʤåʢʢ éʤßʤ Úʛʒ ʦèʤʦʤÝçð ʡàßʢâãʥʤÞʡéñʦô çʢ éʤåñäʤ ä òçàʤéʢåãó çʤ éʡäáʢ ä éʥʤæÝʤëãéʡæ ìʢʥʢâ ÞâʡãæʤàʢʣʦéÞãʢ ʦ ʜ ʦʢåʢäéãçʤæ ã'0))B ãçéʢßʥãçʤæ;ą=ʛʤàÞʤâàʢʣʦéÞãʢæçʡèʥôáʢçãôʦàÞãßʡåʡæãçʡʥçʤßʤ 32 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ äʥʤÞʤéʤäʡʡàßʢâãʥʤÞʡççðʢÚʛʒçʡìãçʡóéàãêêʢʥʢçëãʥʤÞʡéñʦôÞòçàʤéʢåãʡåñçðʢäåʢéäã; = ʙʖʚʔʓʝʒÒÑÜʜÐÏʓÓÐÜ ʔʡʦäʧåôʥãâʡëãôʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäãæʤáʢéèʥãÞʢʦéãäʢʢàʢʦéʡÝãåãâʡëãããʧÞʢåãìãÞʡʢéʤèʡʦçʤʦéñʥʡâʥðÞʡ ìéʤèʤÞðíʡʢéÞʢʥʤôéçʤʦéñéʥʤæÝʤâʡ ã ʦåʢàʤÞʡéʢåñçʤ ãçêʡʥäéʡæãʤäʡʥàʡ ãçʦʧåñéʡ; =ÏʤçðçʢʤÞʡʦäʧåôʥãâʡëããÞçʧéʥãÝåôíäãìʡʦéʤãçêãåñéʥãʥʧóéʦô4 åãæêʤëãéʡæã;=ʔéʤáʢÞʥʢæô ÞèʥʤëʢʦʦʢçʢʤÞʡʦäʧåôʥãâʡëããʧìʡʦéÞʧóéèʥʡäéãìʢʦäãÞʦʢäåʢéʤìçðʢòåʢæʢçéð òäʦèʥʢʦʦãʥʧóîãʢëãéʤäãçðʛʥãòéʤæèʥʤÞʤʦèʡåãéʢåñçðʢëãéʤäãçðãêʡäéʤʥð ʥʤʦéʡʦéãæʧåãʥʧóéèʤôÞåʢçãʢçʤÞðʨʦʤʦʧàʤÞÞÝåôíäʢ ʡèʥʤéãÞʤÞʤʦèʡåãéʢåñçðʢ ëãéʤäãçð èʥʢèôéʦéÞʧóé òéʤæʧ èʥʤëʢʦʦʧ ʦʤʨʥʡçôô ʦéʡÝãåñçʤʦéñ Ýåôíäã êʢçʤæʢçÜçʧʦʡ ; =ÐâòéʤßʤèʥʡÞãåʡʢʦéñãʦäåóìʢçãôʔìʡʦéçʤʦéã ÐÑ èʤàʡÞåôʢé èʤʦéãíʢæãìʢʦäʧó çʢʤÞʡʦäʧåôʥãâʡëãó ;= ʡ E./3 ãæʢʢé èʤéʢçëãʡåñçʤèʥʤʡçßãʤßʢççðʢʦÞʤʣʦéÞʡ ʤÝåʡàʡôʡçéãʡéʢʥʤßʢççðæãòêêʢäéʡæãÞʦåʧìʡʢçʤʥæʡåñçʤʣèʥʤàʧäëãã./ ʡçʢèʡéʤåʤßãìʢʦäʤʣèʥʤàʧäëããʦʧèʢʥʤäʦãà ʡçãʤçʡ ; = ʒʓÑÙÓÐʟÐʒʓÓÐÜÌÑÜÕʒÐ ʒʡåñëãêãäʡëãô ʓʝÌ çʡìãçʡʢéʦô ʧáʢ çʡ ʦéʡàãã êʤʥæãʥʤÞʡçãô åãèãàçðʨ èʤåʤʦ ã èʥʤàʤåáʡʢéʦô çʡ èʥʤéôáʢçãã Þʦʢʨ òéʡèʤÞ ʡéʢʥʤßʢçʢâʡ Ðçéʢʥʢʦ ä òéʤæʧèʥʤëʢʦʦʧÞçʡʦéʤôîʢʢÞʥʢæôʤÝʧʦåʤÞåʢçéʢæ ìéʤàʡççðʣäʤæèʤçʢçéÝåôíäã æʤáçʤàʤʦéʤÞʢʥçʤÞãâʧʡåãâãʥʤÞʡéñçʢãçÞʡâãÞçʤ æʢéʤàʤæʘʝʒʞʔʦÞôâãʦòéãæ ʤéäʥðé Þʤèʥʤʦ ʤ éʤæ ôÞåôʢéʦô åã äʡåñëãçʤâ ʓʝÌ êʡäéʤʥʤæ ʢʢ ʦéʡÝãåñçʤʦéã ãåãáʢçʢʦéʡÝãåñçʤʦéãʟʤʥæʡåñçʤäʡåñëãçʤâæʤáçʤʦìãéʡéñâʡîãéçðææʢʨʡçãâæʤæ èʤʦäʤåñäʧ ʤç ʧÞʢåãìãÞʡʢé èʥʤìçʤʦéñ Ýåôíäã ʓʝÌ ãæʢóîʡô èåʤéçʧó äʡåñëãçãʥʤÞʡççʧóèʤäʥðíäʧ çʡæçʤßʤÝʤåʢʢʧʦéʤʣìãÞʡäʥʡâʥðÞʧ ìʢæçʤʥæʡåñçʡôʦʤʦʧàãʦéʡôʦéʢçäʡãåãæôßäʡôÝåôíäʡʚàçʡäʤòéʤäʡʦʡʢéʦôéʤåñäʤßʤæʤßʢççʤʣ äʡåñëãêãäʡëãã ʓçʡåãâ ʦéʥʧäéʧʥð äʡåñëãçãʥʤÞʡççðʨ Ýåôíʢä ʧ èʡëãʢçéʤÞ ʦçʢʦéʡÝãåñçʤʣʦéʢçʤäʡʥàãʢʣãʚʒʝÞðôÞãåæçʤáʢʦéÞʢççðʢæʢåäãʢÞäåóìʢçãô äʡåñëãô ʧèʡëãʢçéʤÞʦʠÐÌʝąÝʤåʢʢäʥʧèçðʢãʥʡÞçʤæʢʥçðʢäʡåñëãçʡéð;= ʛʤ Þãàãæʤæʧ âʤçðʦʤʢàãçʢçãôæʢáàʧäʡåñëãçãʥʤÞʡççðæããæôßäãæãʧìʡʦéäʡæãʓʝÌÝʤåʢʢÞʤʦèʥããæìãÞðäèʤÞðíʢççʤæʧàʡÞåʢçãóãâ âʡʥʡâåãìãʣÞáʢʦéäʤʦéããÞëʢåʤæÝʤåʢʢʧôâÞãæðʞʡäãʢèʤʥʡáʢçãôʦêʤäʧʦçðæʤÝðâÞʢʦéÞåʢçãʢæÝʤåʢʢèʤàÞʢʥáʢçðàãʦʦʢäëãããʥʡâʥðÞʧÞèʥʤëʢʦʦʢÝʡååʤççʤʣʡçßãʤèåʡʦéãäã;= ʘʢʨʡçãâæʦʤʦʧàãʦéʤßʤäʡåñëãçʤâʡ èʤ Þãàãæʤæʧ ʡçʡåʤßãìʢçèʥʤëʢʦʦʧæãçʢʥʡåãâʡëããäʤʦéçʤʣéäʡçã èʤʦäʤåñäʧʧòéãʨèʥʤëʢʦʦʤÞʤàãçãéʤéáʢʦʧÝʦéʥʡéą êʤʦêʡéð ã ßãàʥʤäʦãʡèʡéãéð äʡåñëãô ; = ʘʢʨʡçãâæ ʥʡâÞãéãô ʤÝðâÞʢʦéÞåʢçãô ʓʝÌ ʦÞôâðÞʡóé ʦ çʡåãìãʢæ ʤʦʤÝðʨ èʤèʧåôëãʣ ʕʘʒ äʤéʤʥðʢ ʦèʤʦʤÝçð äʧʦãåʢççʤæʧâʡʨÞʡéʧãʤçʤÞäʡåñëãô ìéʤèʥãÞʤàãéäæãçʢʥʡåãâʡëããæʡéʥãäʦʡ 33 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ ; =ʔʓʝÌèʥãʦʧéʦéÞʧʢééʡäáʢ´ äʡʥÝʤäʦãßåʧéʡæãçʤÞʡôäãʦåʤéʡ ʦÞôâðÞʡóîʡôãʤçðäʡåñëãôãʧʦãåãÞʡóîʡôæãçʢʥʡåãâʡëãóÝåôíäãʒʥʤæʢéʤßʤ èʥãʡéʢʥʤʦäåʢʥʤâʢ èʥʤãʦʨʤàãé ʡàßʢâãô ʦéʥʤæʡåñçðʨ äåʢéʤä äʤʦéçʤßʤ æʤâßʡ Þ ʓʝÌ ßàʢ ʤçãéʥʡçʦêʤʥæãʥʧóéʦôÞäåʢéäãäʤʦéçʤʣéäʡçã ʒæʡʥäʢʥʡæäʡåñëãçʤâʡʤéçʤʦôéʦôʤʦéʢʤèʤçéãç/0. ʤʦéʢʤèʥʤéʢßʢʥãç/0' 2!.+,åãßʡçàʥʢëʢèéʤʥʡąʡäéãÞʡéʤʥʡ.& ʀ" ãʤʦéʢʤçʢäéãçʚ. ʔʦʢʤçãÞðʥʡÝʡéðÞʡóéʦôʥʡâåãìçðæãäåʢéäʡæã èʥãʦʧéʦéÞʧóîãæãÞʦʤʦʧàãʦéʤʣʦéʢçäʢèʥã èʥʤßʥʢʦʦãʥʤÞʡçããʡéʢʥʤʦäåʢʥʤâʡ ãʥʢßʧåãʥʧóéäʡåñëãêãäʡëãóÝåôíäã ʡéʡäáʢ ʦèʤʦʤÝçðʥʢßʧåãʥʤÞʡéñÞðʥʡÝʤéäʧëãéʤäãçʤÞãêʡäéʤʥʤÞʡàßʢâãã; = ʓʛʚʛʞʚÏ ʓèʤèéʤéãìʢʦäãʢäåʢéäãʓʒ ÞʤâçãäʡóéÞèʥʤëʢʦʦʢʥʡâÞãéãôãèʥʤßʥʢʦʦãʥʤÞʡçãôʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäãèʥʡäéãìʢʦäããâÞʦʢʨéãèʤÞäåʢéʤä çʤʤʦçʤÞçʤʣÞäåʡàÞçʤʦôéæʡäʥʤêʡßããèʢçãʦéðʢäåʢéäã çʡʨʤàôîãʢʦôÞåãèãàçʤæôàʥʢ ʛʥãòéʤæʡèʤèéʤâæʡäʥʤêʡßʤÞèʥãÞʤàãéäʧÞʢåãìʢçãóåãèãàçʤßʤôàʥʡ ÞéʤÞʥʢæôäʡäʡèʤèéʤéãìʢʦäãʢʕʘʒʤéÞʢìʡóéâʡãʦéʤçìʢçãʢêãÝʥʤâçʤʣäʡèʦʧåðʦʥãʦäʤæʢʢʥʡâʥðÞʡ; =ʜʡʦèʥʢàʢåʢçãʢʓʒçʢʤàçʤʥʤàçʤÞèʥʢàʢåʡʨʓʝÌ ʤçã ìʡîʢÞʤâçãäʡóéÞâʤçʡʨÝʤåʢʢÞðʥʡáʢççʤßʤÞåãôçãôèʥʤÞʤʦèʡåãéʢåñçðʨäåʢéʤäãëãéʤäãçʤÞ çʡæçʤßʤʥʢáʢąÞâʤçʡʨèʤÞðíʢççʤßʤʦãçéʢâʡèʥʤéãÞʤÞʤʦèʡåãéʢåñçðʨëãéʤäãçʤÞ;=ʚʦçʤÞçðʢêʡäéʤʥðʡèʤèéʤâʡʕʘʒãæʡäʥʤêʡßʤÞąÐÑ ʟʙʚ ²ãÐʟ ´ âʡèʧʦäʡóîãʢʥʢëʢèéʤʥ âʡÞãʦãæðʣ&AS&AS, æʢʨʡçãâæʡèʤèéʤâʡ ʡéʡäáʢäʡʦèʡâʡ äʤéʤʥʡôéʡäáʢʦéãæʧåãʥʧʢéʦãçéʢâÐÑ ãÐÑ ; =ʔéʤ áʢÞʥʢæôæʡäʥʤêʡßãʦéãæʧåãʥʧóéʡèʤèéʤâʕʘʒ;=ʙʢʦæʤéʥôçʡéʤìéʤêãâãʤåʤßãìʢʦäãʡèʤèéʤâçʢôÞåôʢéʦôÞʤʦèʡåãéʢåñçðæèʥʤëʢʦʦʤæ èʥãʡéʢʥʤʦäåʢʥʤâʢ ʡèʤèéʤâãæʢʢéèʥʤÞʤʦèʡåãéʢåñçðʣèʤéʢçëãʡåãôÞåôʢéʦôêʡäéʤʥʤæàʢʦéʡÝãåãâʡëãã Ýåôíäã ʓèʤèéʤéãìʢʦäãʢ äåʢéäã ʥʡâʥʧíʡôʦñ ÞðʦÞʤÝʤáàʡóé ʦʤÝʦéÞʢççʧó Íʙʒ äʤéʤʥʡô éʡäáʢ èʤßåʤîʡʢéʦô - æʡäʥʤêʡßʡæã èʤʦʥʢàʦéÞʤæ ʦäʡÞʢçàáʢʥ ʥʢëʢèéʤʥʤÞʛʥãòéʤæʦéãæʧåãʥʧʢéʦôÞðʥʡÝʤéäʡæʡäʥʤêʡßʡæãʨʢæʤäãçʤÞ èʥãÞåʢäʡóîãʨçʢʣéʥʤêãåð ãàʥʧßãʨëãéʤäãçʤÞʔéʤáʢÞʥʢæôʡèʤèéʤéãìʢʦäãʢ çʢʣéʥʤêãåðèʤààʢʥáãÞʡóéèʥãÞåʢìʢçãʢæʤçʤëãéʤÞÝåʡßʤàʡʥô!C!-0 ʦãßçʡåãâʡëãã; = ÍʖʝʞʓÌÐÑÐÏʓÓÐÜÌÑÜÕʒÐÐʟʚʜʘÐʜʚʔʓʙÐʖʞʜʚʘÌʓ ʟãâãʤåʤßãìʢʦäãʢ ʡçéãéʥʤæÝʤéãìʢʦäãʢ ʦÞʤʣʦéÞʡ òçàʤéʢåãô çʡʥʧíʡóéʦô èʥã ÞʤâàʢʣʦéÞãã ÐÑ ʟʙʚ ² ã òçàʤéʤäʦãçʤÞ ;= ʛʥã òéʤæ Þʤâʥʡʦéʡʢé èʥʤäʤʡßʧåôçéçʡôʡäéãÞçʤʦéñòçàʤéʢåãôãèʤàʡÞåôʢéʦôʡçéãäʤʡßʧåôçéçʡô ʤèʤʦʥʢàʤÞʡççʡô ʦãʦéʢæʤʣéʥʤæÝʤæʤàʧåãçąèʥʤéʢãç#êʡäéʤʥʦÞʢʥéðÞʡçãô8)6 ÝåʡßʤàʡʥôʦçãáʢçãóéʥʡçʦäʥãèëããßʢçʡãʨʥʢëʢèéʤʥʡʚßʥʡçãìʢçãʢʡäéãÞʡëããèʥʤéʢãçʡʝÞðâðÞʡʢéêʤʥæãʥʤÞʡçãʢéʥʤæÝʡʒʥʤæʢéʤßʤ èʥʤÞʤʦèʡåãéʢåñçðʢëãéʤäãçðèʤàʡÞåôóé ʡäéãÞçʤʦéñ ʦʤʦʧàãʦéðʨ ßʢèʡʥãçʤèʤàʤÝçðʨ ÞʢîʢʦéÞ ;= ʔ éʤ áʢ Þʥʢæô 34 ʛʡéʤßʢçʢéãìʢʦäãʢæʢʨʡçãâæðʡéʢʥʤʦäåʢʥʤâʡ èʤàʡÞåʢçãʢ ʡçéãäʤʡßʧåôçéçðʨ æʢàãʡéʤʥʤÞ æʤáʢé Þåãôéñ çʡ Þʤʦèʡåãéʢåñçðʣ èʥʤëʢʦʦʞʥʤæÝʤæʤàʧåãçʤäʡâðÞʡʢéèʥʤéãÞʤÞʤʦèʡåãéʢåñçðʣòêêʢäé èʤàʡÞåôô -!0+ ã.& ʀ" èʧéãʓäéãÞãʥʤÞʡççðʣèʥʤéʢãç#èʤàʡÞåôʢé.& ʀ" èʧéñæʤçʤëãéʤÞ;=ʛʥãòéʤæèʥʤÞʤʦèʡåãéʢåñçðʢëãéʤäãçðãâæʢçôóéêãÝʥãçʤåãéãìʢʦäãʢ ʦÞʤʣʦéÞʡ Úʒ ʤçã ʧæʢçñíʡóé èʥʤàʧäëãó éäʡçʢÞʤßʤ ʡäéãÞʡéʤʥʡ èåʡâæãçʤßʢçʡ ãʧÞʢåãìãÞʡóéèʥʤàʧäëãóʢßʤãçßãÝãéʤʥʡ0!) ìéʤÞʢàʢéäʦçãáʢçãóéʥʤæÝʤåãéãìʢʦäʤʣʡäéãÞçʤʦéãòçàʤéʢåãô;=ʒʥʤæʢéʤßʤ ÐÑ ôÞåôʢéʦôéʥʤæÝʤßʢççðæ êʡäéʤʥʤæ èʤÞðíʡôìãʦåʤéʥʤæÝʤëãéʤÞÞʤìʡßʢʡéʢʥʤʦäåʢʥʤâʡ;= 35 ʒåʡʦʦãêãäʡëãôàãʦåãèãàʢæãʣ ʒÑʓʝʝÐʟÐʒʓÓÐÜÍÐʝÑÐʛÐÍʖʘÐʗ ÍãʦåãèãàʢæããÍÑʛ éʤʢʦéñʦʤʦéʤôçãô äʤßàʡäʤçëʢçéʥʡëããåãèãàʤÞã åãèʤèʥʤéʢãàʤÞ äʥʤÞã Þðʨʤàôé âʡ èʥʢàʢåð çʤʥæð æʤßʧé Ýðéñ ÞðâÞʡçð äʡä èʥãʤÝʥʢéʢççðæãÞéʤʥãìçðæã éʡäãçʡʦåʢàʦéÞʢççðæãèʢʥÞãìçðæã ʦʤʦéʤôçãôæã ;=ÍãʦåãèãàʢæããäåʡʦʦãêãëãʥʧóéÞâʡÞãʦãæʤʦéãʤééʤßʤ ʧʥʤÞʢçñäʡäãʨãæʢççʤ åãèãàʤÞ ã åãèʤèʥʤéʢãàʤÞ Þðʨʤàãé âʡ èʥʢàʢåð çʤʥæð ʒʥʡʣçʢ Þʡáçʤ àãêêʢʥʢçëãʥʤÞʡéñ èʢʥÞãìçðʢ ã Þéʤʥãìçðʢ àãʦåãèãàʢæãã éʡä äʡä Þ òéãʨ ʦåʧìʡôʨ èʥãçëãèãʡåñçʤ ʤéåãìʡʢéʦô éʡäéãäʡ åʢìʢçãô ʚʦçʤÞçðæã èʥãìãçʡæã Þéʤʥãìçðʨ àãʦåãèãàʢæãʣôÞåôóéʦôàãʦåãèãàʢæããÞʦåʢàʦéÞãʢʝÍ ßãèʤéãʥʢʤâʡ ʠʛʙʔçʡʦéʤôîʢʢÞʥʢæôʔʚÏèʥãçôéʡäåʡʦʦãêãäʡëãô&REDRICKSON ʦʤßåʡʦçʤäʤéʤʥʤʣ Þðàʢåôóé çʢʦäʤåñäʤ ʢʢ êʢçʤéãèʤÞ éʡÝå ʝåʢàʧʢé èʤàìʢʥäçʧéñ ìéʤ àʡççʡô äåʡʦʦãêãäʡëãôçʢʧʦéʡçʡÞåãÞʡʢéàãʡßçʤâ ʡåãíñêãäʦãʥʧʢééãèàãʦåãèãàʢæãã ÞçʢâʡÞãʦãæʤʦéãʤééʤßʤ ôÞåôʢéʦôåãʤçʡèʥãʤÝʥʢéʢççʤʣãåãçʡʦåʢàʦéÞʢççʤʣ ʛʥãÍÑʛ)éãèʡʨʡʥʡäéʢʥçʤèʤÞðíʢçãʢäʤçëʢçéʥʡëãôʠʘã ʦʤʤéÞʢéʦéÞʢççʤ ʞʕ ʝʧîʢʦéÞʧʢé èʥʤʦéʤʣ éʢʦé àåô ʤèʥʢàʢåʢçãô ÍÑʛ ) éãèʡ ʖʦåã èʤʦéʡÞãéñ èʥʤÝãʥäʧʦʦðÞʤʥʤéäʤʣÞʨʤåʤàãåñçãä éʤìʢʥʢâìʡʦʤÞÞʦʢʠʘÞʦèåðÞʡóéçʡèʤÞʢʥʨçʤʦéñèʤʦäʤåñäʧãʨèåʤéçʤʦéñçãáʢèåʤéçʤʦéãÞʤàð ʤÝʥʡâʧôʨʡʥʡäéʢʥçðʣ ʦåãÞäʤʤÝʥʡâçðʣ ʦåʤʣ ʝðÞʤʥʤéäʡ çãáʢ èʤÞʢʥʨçʤʦéçʤßʤ ʦåʤô Ýʧàʢé ʡÝʦʤåóéçʤ èʥʤâʥʡìçʤʣ ) éãè ÍÑʛ Þʦéʥʢìʡʢéʦô æʢçʢʢ ìʢæ Þ ʦåʧìʡʢÞ Þʦʢʨ ßãèʢʥåãèãàʢæãʣ ã äʡä èʥʡÞãåʤ ʤÝʧʦåʤÞåʢç çʡʦåʢàʦéÞʢççðæ àʢêʢäéʤæ ßʢçʡ äʤàãʥʧóîʢßʤ åãèʤèʥʤéʢãàåãèʡâʧèåʡâæð)éãèÍÑʛʦìãéʡʢéʦôʧʦåʤÞçʤʡéʢʥʤßʢççðæÍåãéʢåñçʡôëãʥäʧåôëãôÞäʥʤÞãʥʢæçʡçéʤÞʠʘæʤáʢéʦʤèʥʤÞʤáàʡéñʦôãʨçʡäʤèåʢçãʢæ Þʦéʢçäʡʨʡʥéʢʥãʣ ìéʤèʥʤÞʤëãʥʧʢéʥʡâÞãéãʢʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäã ÍÑʛ))ʡéãèʡʨʡʥʡäéʢʥãâʧʢéʦôãâʤåãʥʤÞʡççðæèʤÞðíʢçãʢæÞäʥʤÞãʧʥʤÞçʢʣ ÑʙʛãʠʝÔʡʦéʤéʡʥʡʦèʥʤʦéʥʡçʢçãô))AéãèʡʦʤʦéʡÞåôʢéÚéʤééãèßãèʢʥåãèãàʢæããôÞåôʢéʦôçʡãÝʤåʢʢʡéʢʥʤßʢççðæʚçìʡîʢÞʦʢßʤÞʦéʥʢìʡʢéʦôʧÝʤåñçðʨ ʦÐÌʝãʧåãëʦèʤåãßʢççʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣ))AéãèÍÑʛçʡÝåóàʡʢéʦôéʡäáʢ ʧÝʤåñçðʨʦʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣ èʥãäʤéʤʥʤʣäʤçëʢçéʥʡëãôʠʝÑʙʛ æʤáʢéÞąʥʡâèʥʢÞðíʡéñâçʡìʢçãôçʤʥæð ÍÑʛ))BéãèʡʨʡʥʡäéʢʥãâʧʢéʦôèʤÞðíʢçãʢæÞèåʡâæʢʧʥʤÞçôʠʝãʞʕâʡʦìʢé èʤÞðíʢççʤʣäʤçëʢçéʥʡëããÑʙʛãÑʚʙʛÚéʤééãèÍÑʛÞʦéʥʢìʡʢéʦôʧåãëʦßãèʢʥåãèãàʢæãʢʣãʤÝʧʦåʤÞåʢçßãèʢʥèʥʤàʧäëãʢʣʡèʤʔʔäåãçãìʢʦäʤʣèʥʡäéãäʢ ))BéãèìʡîʢçʤçʢÞʦʢßàʡ çʡÝåóàʡʢéʦôʧÝʤåñçðʨʦäʤæÝãçãʥʤÞʡççʤʣʦʢæʢʣçʤʣ ßãèʢʥåãèãàʢæãʢʣ ʦæʢéʡÝʤåãìʢʦäãæʦãçàʥʤæʤæãʦʡʨʡʥçðæàãʡÝʢéʤæ))éãèʡ ÍÑʛ)))éãèʡąʥʢàäʡôêʤʥæʡàãʦåãèãàʢæãã äʤéʤʥʡôÞʦéʥʢìʡʢéʦôʧèʡëãʢçéʤÞ ʦ ʡèʤʖʖ êʢçʤéãèʤæ Ò éʡäãʨ Ýʤåñçðʨ âʡʨÞʡé Ñʛʛ ßʢèʡéʤëãéʡæã çʡʥʧíʡʢéʦô ÞßʤʥʡâàʤÝʤåñíʢʣʦéʢèʢçã ìʢæʧåãëʦãçðæêʢçʤéãèʤæʡèʤèʥʤéʢãàʡʖÍÑʛ))) 36 ʒåʡʦʦãêãäʡëãôàãʦåãèãàʢæãʣ éãèʡʨʡʥʡäéʢʥãâʧʢéʦôÞðʥʡáʢççʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣãßãèʢʥéʥãßåãëʢʥãàʢæãʢʣʚàçʡäʤàåôäåãçãìʢʦäãʨèʥʤôÞåʢçãʣòéʤßʤʦʤʦéʤôçãôçʢʤÝʨʤàãæðʦʤèʧéʦéÞʧóîãʢ æʢéʡÝʤåãìʢʦäãʢ çʡʥʧíʢçãô éʡäãʢ äʡä æʢéʡÝʤåãìʢʦäãʣ ʦãçàʥʤæ ãåã ʝÍèʤèʧåôëããôÞåôʢéʦôßʤæʤâãßʤéçðæèʤʡèʤʖ çʤäåãçãìʢʦäãʢèʥʤôÞåʢçãô çʡÝåóàʡóéʦôåãíñʧãâ ʒåãçãìʢʦäã)))éãèÍÑʛèʥʤôÞåôʢéʦôòʥʧèéãÞçðæ äʦʡçéʤæʡéʤâʤæãÞʢʦñæʡʨʡʥʡäéʢʥçðæèʥãâçʡäʤæąôʥäʤ áʢåéðæʤäʥʡíãÞʡçãʢæ åʡàʤççðʨʦéʥãʣʔʢʥʤôéçʤʦéñʥʡâÞãéãôÐÌʝãàʥʧßãʨèʥʤôÞåʢçãʣʡéʢʥʤʦäåʢʥʤâʡ èʥãÍÑʛ)))éãèʡʤìʢçñÞðʦʤäʡ ʞʡÝåãëʡ ʟʢçʤéãè A B I C A II B III )6 6 ʒåʡʦʦãêãäʡëãôàãʦåãèãàʢæãʣʔʚÏ ʡàʡèéãʥʤÞʡçʤ ãâäåʡʦʦãêãäʡëãã&REDRICKSON ʝãçʤçãæ ʛʤÞðíʢʛʤÞðíʢçãʢʧʥʤÞçô çãʢʧʥʤÞçô åãèʤèʥʤåãèãàʤÞ éʢãàʤÞ èåʡâæð èåʡâæð ʙʡʦåʢàʦéÞʢççʡôßãèʢʥʨãåʤæãäʥʤçʢæãô àʢêãëãéåãèʤèʥʤéʢãàåãèʡâð ʙʡʦåʢàʦéÞʢççðʣ àʢêãëãéʡèʤèʥʤéʢãàʡ ʠʘ #)) ʕãèʢʥʨãåʤæãäʥʤçʢæãôèʥãëãʥäʧåôëãã ãçßãÝãéʤʥʡ åãèʤèʥʤéʢãàåãèʡâð ʛʤåãßʢççʡôçʡʦåʢàÑʙʛ ʦéÞʢççʡôßãèʢʥʨʤåʢʦéʢʥãçʢæãô ʒʤæÝãçãʥʤÞʡççʡô Ñʙʛ Ñʚʙʛ ßãèʢʥåãèãàʢæãô ʙʡʦåʢàʦéÞʢççʡô àãʦ ³ åãèʤèʥʤéʢãàʢÑʛʛ æãô ʙʡʦåʢàʦéÞʢççʡô Ñʚʙʛ ßãèʢʥéʥãßåãëʢʥãàʢæãô ʝæʢíʡççʡô ʠʘ Ñʚʙʛ ßãèʢʥåãèãàʢæãô ʓéʢʥʤßʢççʤʦéñ Ôʡʦéʤéʡ Þʦéʥʧäéʧʥʢ ßãèʢʥåãèãàʢæãʣ ʞʕ ? ʠʝ +++ 10 ʠʝãʞʕ +++ ʞʕãʠʝ +++ ʞʕ + ʞʕãʠʝ + ÍÑʛ)6éãèʡèʥʤôÞåôʢéʦôßãèʢʥéʥãßåãëʢʥãàʢæãʢʣãèʤÞðíʢççðæʦʤàʢʥáʡçãʢæÞäʥʤÞãÑʚʙʛʜʡʦèʥʤʦéʥʡçʢççʤʦéñ)6éãèʡʦʤʦéʡÞåôʢéèʥãÝåãâãéʢåñçʤ 37 ʒåʡʦʦãêãäʡëãôàãʦåãèãàʢæãʣ Þ ʤÝîʢʣ èʤèʧåôëãã ìʡîʢ çʡÝåóàʡʢéʦô ʧ åãë èʥãàʢʥáãÞʡóîãʨʦô àåãéʢåñçʤʢ ÞʥʢæôʧßåʢÞʤàçʤʣàãʢéð ãâÝðéʤìçʤʧèʤéʥʢÝåôóîãʨʡåäʤßʤåñ ʦéʥʡàʡóîãʨʝÍ ))éãèʡãʤáãʥʢçãʢæ ʨʥʤçãìʢʦäãæâʡÝʤåʢÞʡçãʢæèʤìʢä àåãéʢåñçʤèʥãçãæʡóîãʨ çʢʦʢåʢäéãÞçðʢÝʢéʡ Ýåʤäʡéʤʥðããåãéãʡâãàçðʢàãʧʥʢéãäãʒʥʤæʢéʤßʤ )6éãè ÍÑʛæʤáʢéÝðéñèʥʤôÞåʢçãʢæçʡʦåʢàʦéÞʢççʤʣßãèʢʥéʥãßåãëʢʥãàʢæãã ÞʤʦçʤÞʢ äʤéʤʥʤʣ åʢáãé àʢêʢäé ßʢçʤÞ äʤàãʥʧóîãʨ åãÝʤ êʢʥæʢçé åãèʤèʥʤéʢãàåãèʡâʧ åãÝʤʢʢäʤêʡäéʤʥąʡèʤèʥʤéʢãàʡèʤ#))ÒʥʤÞʢçñʞʕèʥã)6êʢçʤéãèʢäʤåʢÝåʢéʦô Þèʥʢàʢåʡʨ ą ææʤåñå ʠʝÑʔʛìʡʦéʤʦçãáʢçʚÝʡòéãêʡäéʤʥʡãßʥʡóéçʢæʡåʤÞʡáçʧóʥʤåñÞʥʡâÞãéããʡéʢʥʤʦäåʢʥʤâʡ ÍÑʛ 6 éãèʡ ʦʤʦéʡÞåôʢé ʤäʤåʤ ʤé Þʦʢʨ ʦåʧìʡʢÞ ÍÑʛ ʔ ʤʦçʤÞʢ òéʤßʤ éãèʡ ÍÑʛìʡîʢÞʦʢßʤåʢáãéçʡʦåʢàʦéÞʢççðʣàʢêʢäéßʢçʡʡèʤʝ)) ìéʤèʥʤôÞåôʢéʦôÞðʦʤäãæãʧʥʤÞçôæãʞʕ ÑʚʙʛãʠʘÒʥʤÞʢçñʞʕæʤáʢéàʤʦéãßʡéñææʤåñå ìéʤæʤáʢéèʥãÞʤàãéñäʥʡâÞãéãóʤʦéʥʤßʤèʡçäʥʢʡéãéʡʛʤòéʤæʧèʥãÞðôÞåʢçãã6éãèʡ ÍÑʛèʢʥÞʤʦéʢèʢççʤʣâʡàʡìʢʣàåôÞʥʡìʡôÞåôʢéʦôʦçãáʢçãʢʧʥʤÞçôʞʕãèʥʢàʤéÞʥʡîʢçãʢèʡçäʥʢʡéãéʡèʤʦʥʢàʦéÞʤæàãʢéðãæʢàãäʡæʢçéʤâçʤʣéʢʥʡèãã ʛʥãæʢçôôäåʡʦʦãêãäʡëãóÍÑʛʦëʢåñóÞðʥʡÝʤéäãéʢʥʡèʢÞéãìʢʦäʤʣʦéʥʡéʢßãã çʢʤÝʨʤàãæʤʧìãéðÞʡéñâçʡìʢçãôàʥʧßãʨåãèãàçðʨèʡʥʡæʢéʥʤÞ çʢÞäåóìʢççðʨÞäåʡʦʦãêãäʡëãóʔʚÏ ÞèʢʥÞʧóʤìʢʥʢàñʠʝÑʔʛÚèãàʢæãʤåʤßãìʢʦäãʢãʦʦåʢàʤÞʡçãôèʤäʡâʡåã ìéʤʧåãëʦèʤÞðíʢççðæʦʤàʢʥáʡçãʢæʠʝÑʔʛ( ææʤåñå ʥãʦäʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʦÞôâʡççðʨʦʡéʢʥʤʦäåʢʥʤâʤæ ʦʧîʢʦéÞʢççʤçãáʢèʤʦʥʡÞçʢçãóʦéʢæã ʧäʤßʤäʤçëʢçéʥʡëãôòéʤßʤåãèʤèʥʤéʢãàʡ ʦçãáʢçʡ ææʤåñå ʔʦʤʤéÞʢéʦéÞããʦʜʤʦʦãʣʦäãæãʥʢäʤæʢçàʡëãôæãèʤäʤʥʥʢäëãã àãʦåãèãàʢæãʣ 6 èʢʥʢʦæʤéʥ ʦåʢàʧóîãʢ åãèãàçðʢ èʡʥʡæʢéʥð ʥʡʦʦæʡéʥãÞʡóéʦô äʡä ʤèéãæʡåñçðʢ àåô èʥʢàʧèʥʢáàʢçãô ÐÌʝ ã àʥʧßãʨ âʡÝʤåʢÞʡçãʣ ʤÝʧʦåʤÞåʢççðʨ ʡéʢʥʤʦäåʢʥʤâʤæ çʡ èʤèʧåôëãʤççʤæ ʧʥʤÞçʢ éʡÝå ʛʥã òéʤæ ßʥʡçãëð çʤʥæʡåñçðʨ èʤäʡâʡéʢåʢʣ åãèãàçʤßʤ ʦèʢäéʥʡ âʡÞãʦôé ʤé ʥʢßãʤçʡ ʤʦʤÝʢççʤʦéʢʣèãéʡçãô çʡåãìãôàʥʧßãʨêʡäéʤʥʤÞʥãʦäʡ;= ʞʡÝåãëʡʚèéãæʡåñçðʢâçʡìʢçãôåãèãàçðʨèʡʥʡæʢéʥʤÞÞèʤèʧåôëãã;= ʛʡʥʡæʢéʥ 38 Ïçʡìʢçãʢ ʚʠʝ Ħ ææʤåñå ʠʝÑʙʛ Ħ ææʤåñå ʠʝÑʔʛ ħ ææʤåñåàåôæʧáìãç ħ ææʤåñåàåôáʢçîãç ʞʕ Ħ ææʤåñå ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʟʓʒʞʚʜØʜÐʝʒʓʜʓÏʔÐʞÐÜʓʞʖʜʚʝʒÑʖʜʚÏʓ ÐʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞØʠʚʝÑʚÎʙʖʙÐʗ ʘʚÍÐʟÐÓÐʜÒʖʘØʖÐʙʖʘʚÍÐʟÐÓÐʜÒʖʘØʖʟʓʒʞʚʜØʜÐʝʒʓ ʝʥʢàãèʥãìãçʝʝÏʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤßʢçʢâʡÞðàʢåôóéæʤàãêãëãʥʧʢæðʢ ã çʢæʤàãêãëãʥʧʢæðʢ êʡäéʤʥð ʥãʦäʡ ʒ çʢæʤàãêãëãʥʧʢæðæ êʡäéʤʥʡæ ʥãʦäʡ ʤéçʤʦôéʦôÞʤâʥʡʦé èʤå ʤéôßʤîʢççʡôçʡʦåʢàʦéÞʢççʤʦéñéʡÝå ;= ʔʤâʥʡʦéÐâÞʢʦéçʤ ìéʤèʢʥÞðʢèʥʤôÞåʢçãôʡéʢʥʤʦäåʢʥʤâʡåãèãàçðʢèʤåʤʦð èʤôÞåôóéʦôÞàʢéʦäʤæÞʤâʥʡʦéʢʛʤʦåʢåʢéèʥʤëʢʦʦçʡìãçʡʢéèʥʤßʥʢʦʦãʥʤÞʡéñ èʥãìʢæʧæʧáìãçʤçèʥʤéʢäʡʢéßʤʥʡâàʤÝðʦéʥʢʢ çʢáʢåãʧáʢçîãç ʧäʤéʤʥðʨʡéʢʥʤʦäåʢʥʤâçʡìãçʡʢéʥʡâÞãÞʡéñʦô äʡäèʥʡÞãåʤ èʤʦåʢåʢé ʛʤåÚʦéʥʤßʢçðâʡîãîʡóéáʢçʦäãʣʤʥßʡçãâæʤéʡéʢʥʤʦäåʢʥʤâʡ Þìʡʦéçʤʦéã ʤçãèʤÞðíʡóéʧʥʤÞʢçñʠʝÑʔʛʚàçʡäʤèʤʦåʢæʢçʤèʡʧâðâʡîãéçʤʢàʢʣʦéÞãʢßʤʥæʤçʤÞèʥʢäʥʡîʡʢéʦôãʧáʢçîãçʡéʢʥʤʦäåʢʥʤâʥʡâÞãÞʡʢéʦôéʡäáʢ äʡäãʧæʧáìãç Ò æʧáìãç ʦ Þʤâʥʡʦéʤæ çʡʥʡʦéʡóé äʤçëʢçéʥʡëãã ʠʝÑʙʛ ã Ñʚʙʛ ʝʥʢàã æʧáìãçìʡîʢʥʡʦèʥʤʦéʥʡçʢçðãàʥʧßãʢêʡäéʤʥðʥãʦäʡäʧʥʢçãʢ ÝʤåʢʢÞðʦʤäʡô èʤàÞʢʥáʢççʤʦéñʦéʥʢʦʦʡæ âåʤʧèʤéʥʢÝåʢçãʢʡåäʤßʤåʢæÚéãêʡäéʤʥðÞçʡãÝʤåñíʢʣæʢʥʢçʡìãçʡóéèʥʤôÞåôéñʦôèʤʦåʢåʢé ããæʢççʤòéʡÞʤâʥʡʦéçʡôìʢʥéʡʦìãéʡʢéʦôèʤßʥʡçãìçʤʣ âʡäʤéʤʥʤʣʥãʦäʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡÝðʦéʥʤçʡʥʡʦéʡʢé ʙʡʦåʢàʦéÞʢççʤʦéñ ʜãʦä ʥʡâÞãéãô ʡéʢʥʤʦäåʢʥʤâʡ ã ÐÌʝ Þʤâʥʡʦéʡʢé ʧ åãë ʦ ʤéôßʤîʢççðæ ʦʢæʢʣçðæ ʡçʡæçʢâʤæ éʤ ʢʦéñ Þ ʦåʧìʡôʨ äʤßàʡ ʧ Ýåãáʡʣíãʨ ʥʤàʦéÞʢççãäʤÞÐÌʝʥʡâÞãåʡʦñʥʡçʤʧæʧáìãçæʤåʤáʢåʢé ʧáʢçîãçæʤåʤáʢ åʢé ʙʡʦåʢàʦéÞʢççðʣêʡäéʤʥãßʥʡʢéÞʡáçʧóʥʤåñÞʦåʧìʡôʨʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãã äʤæÝãçãʥʤÞʡççʤʣ ʦʢæʢʣçʤʣ ßãèʢʥåãèãàʢæãã èʤåãßʢççʤʣ ßãèʢʥʨʤåʢʦéʢʥãçʢæããÚéãçʡʦåʢàʦéÞʢççðʢçʡʥʧíʢçãôåãèãàçʤßʤʤÝæʢçʡʦʤèʥʤÞʤáàʡóéʦôÞðʦʤäʤʣÞʢʥʤôéçʤʦéñóʥʡâÞãéãôÐÌʝÞæʤåʤàʤæÞʤâʥʡʦéʢ ʒæʤàãêãëãʥʧʢæðæêʡäéʤʥʡæʥãʦäʡ éʤʢʦéñéʡäãæ çʡäʤéʤʥðʢæʤáçʤãçʢʤÝʨʤàãæʤÞåãôéñ ʤéçʤʦôéʦôàãʦåãèãàʢæããÍÑʛ äʧʥʢçãʢ ʡʥéʢʥãʡåñçʡôßãèʢʥéʤçãôʓʕ ʦʡʨʡʥçðʣàãʡÝʢéʝÍ ))éãèʡ ʡÝàʤæãçʡåñçʤʢʤáãʥʢçãʢ ßãèʤàãçʡæãô ʨʥʤçãìʢʦäãʢâʡÝʤåʢÞʡçãôèʤìʢä ʒʧʥʢçãʢ Þʢàʢé ä ʧÞʢåãìʢçãó ʡéʢʥʤßʢççʤʣ êʥʡäëãã åãèʤèʥʤéʢãàʤÞ Ò ʨʥʤçãìʢʦäãʨ äʧʥãåñîãäʤÞ ʦçãáʡʢéʦô ʧʥʤÞʢçñ ʠʝ Ñʔʛ èʤÞðíʡʢéʦô ʧʥʤÞʢçñ ʠʝ Ñʚʙʛ ã Ñʙʛ ʧʦãåãÞʡʢéʦô èʥʤëʢʦʦ èʢʥʢäãʦçʤßʤ ʤäãʦåʢçãô åãèãàʤÞ ìéʤ ʦʤèʥʤÞʤáàʡʢéʦô çʡʥʧíʢçãʢæ êʧçäëãã òçàʤéʢåãô ã ʦéʤʣäãæ ʦèʡâæʤæ ʡʥéʢʥãʡåñçðʨ ʦʤʦʧàʤÞ ʛʢʥʢìãʦåʢççðʢ çʡʥʧíʢçãô àʤèʤåçôóéʦô ʤéʥãëʡéʢåñçðæã ʦàÞãßʡæã ÞʦÞʢʥéðÞʡóîʢʣʦãʦéʢæʢäʥʤÞãąʦçãáʡʢéʦôʢʢêãÝʥãçʤåãéãìʢʦäʡôʡäéãÞçʤʦéñ 39 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ èʤÞðíʡʢéʦô ʡßʥʢßʡëãʤççʡô ʦèʤʦʤÝçʤʦéñ éʥʤæÝʤëãéʤÞ ʛʥʢäʥʡîʢçãʢ äʧʥʢçãô ą ʤàãçãâÞʡáçðʨèʥãçëãèʤÞèʢʥÞãìçʤʣãÞéʤʥãìçʤʣèʥʤêãåʡäéãäãʡéʢʥʤʦäåʢʥʤâʡ çʢéʤåñäʤäʤʥʤçʡʥçðʨ çʤãèʢʥãêʢʥãìʢʦäãʨʡʥéʢʥãʣ ʓʥéʢʥãʡåñçʡô ßãèʢʥéʤçãô ʟʥʡæãçßʢæʦäʤʢ ãʦʦåʢàʤÞʡçãʢ ʧÝʢàãéʢåñçʤ èʥʤàʢæʤçʦéʥãʥʤÞʡåʤ ʦÞôâñ ʥãʦäʡ äʤʥʤçʡʥçʤßʤ ʡéʢʥʤʦäåʢʥʤâʡ ʦ èʤÞðíʢççðæ ʓÍ ʓʥéʢʥãʡåñçʡôßãèʢʥéʤçãôèʤÞðíʡʢéìʡʦéʤéʧʥʡâÞãéãôãçêʡʥäéʡæãʤäʡʥàʡ Þçʢâʡèçʤʣäʤʥʤçʡʥçʤʣʦæʢʥéã ìʡʦéʤéʧßʢæʤʥʥʡßãìʢʦäãʨããíʢæãìʢʦäãʨãçʦʧåñéʤÞ ÐʦʦåʢàʤÞʡçãʢ -2&)4 -ULTIPLE 2ISK &ACTOR )NTERVENTION 4RIAL èʤäʡâʡåʤ ʤéìʢéåãÞʧó ÞâʡãæʤʦÞôâñ ʦæʢʥéʢåñçðʨ ʦåʧìʡʢÞ ʤé ÐÌʝ ʦ ʧʥʤÞçôæã äʡä ʦãʦéʤåãìʢʦäʤßʤ éʡä ãàãʡʦéʤåãìʢʦäʤßʤʡʥéʢʥãʡåñçʤßʤàʡÞåʢçãôʓʥéʢʥãʡåñçʡôßãèʢʥéʤçãôôÞåôʢéʦô êʡäéʤʥʤæ èʤÞʥʢáàʡóîãæëʢåʤʦéçʤʦéñòçàʤéʢåãôãçʡʥʧíʡóîãæʢßʤêʧçäëãó ʔäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãôʨʙʚʞ 3(%0 ʓ,,(!4 ,)&%Ýðåʤèʤäʡâʡçʤʦçãáʢçãʢ ìʡʦéʤéðäʤʥʤçʡʥçðʨʤʦåʤáçʢçãʣÞʥʡâåãìçðʨÞʤâʥʡʦéçðʨßʥʧèèʡʨÞʥʢâʧåñéʡéʢ ʡàʢäÞʡéçʤèʥʤÞʤàãæʤʣßãèʤéʢçâãÞçʤʣéʢʥʡèããÒìãéðÞʡôÞðʦʤäʧóʥʡʦèʥʤʦéʥʡçʢççʤʦéñʡʥéʢʥãʡåñçʤʣßãèʢʥéʤçããʦʥʢàãçʡʦʢåʢçãôʜʤʦʦãʣʦäʤʣʟʢàʢʥʡëããÝʤåʢʢçʡʦʢåʢçãôʦéʡʥíʢåʢéʦéʥʡàʡʢéʓʕ ÞäåʡàòéʤßʤêʡäéʤʥʡÞʥʡâÞãéãʢ ÐÌʝ ã âʡÝʤåʢÞʡçãʣ ʦʤʦʧàʤÞ ßʤåʤÞçʤßʤ æʤâßʡ Þʢʦñæʡ âçʡìãéʢåʢç ã ʡàʢäÞʡéçʡô ßãèʤéʢçâãÞçʡôéʢʥʡèãôôÞåôʢéʦôÞʡáçʢʣíãæêʡäéʤʥʤæèʥʤêãåʡäéãäããçêʡʥäéʡ æãʤäʡʥàʡããçʦʧåñéʡ ʝʡʨʡʥçðʣ àãʡÝʢé ʦʤèʥôáʢç ʦ ʥʡâÞãéãʢæ äʡä æãäʥʤʦʤʦʧàãʦéðʨ àãʡÝʢéãìʢʦäʡô ʥʢéãçʤèʡéãô çʢêʥʤèʡéãô èʤåãçʢʣʥʤèʡéãô éʡä ã æʡäʥʤʦʤʦʧàãʦéðʨ Ðʘ ʘÐ èʢʥãêʢʥãìʢʦäãʣʡéʢʥʤʦäåʢʥʤâ ʤʦåʤáçʢçãʣʙʡãÝʤåʢʢʥʡʦèʥʤʦéʥʡçʢçʝÍ)) éãèʡ ÞʜʤʦʦããçʡʦìãéðÞʡʢéʦôèʥãæʢʥçʤæåçÝʤåñçðʨʦʝÍʒʦʤáʡåʢçãó ãæʢʢé æʢʦéʤ éʢçàʢçëãô ä ʥʡʦèʥʤʦéʥʡçʢçãó ʝÍ ã ìéʤ ʤʦʤÝʢççʤ çʡʦéʤʥʡáãÞʡʢé ʦʥʢàã åãëæʤåʤàʤßʤãʦʥʢàçʢßʤÞʤâʥʡʦéʡÒèʡëãʢçéʤÞʦʝÍ))éãèʡìʡʦéʤʥʡâÞãÞʡʢéʦô ʤʦʤÝðʣ éãè àãʦåãèãàʢæãã ãæʢóîãʣ Þðʦʤäʧó ʡéʢʥʤßʢççʤʦéñ ã ʨʡʥʡäéʢʥãâʧóîãʣʦôÞðʦʤäãæʧʥʤÞçʢæʞʕ çãâäãæʧʥʤÞçʢæÑʔʛãèʤÞðíʢççðæʧʥʤÞçʢææʢåäãʨèåʤéçðʨÑʙʛÔʡʦéʤéʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣèʥʢÞðíʡʢééʡäʤÞʧó ʧåãëÝʢâàãʡÝʢéʡèʥãæʢʥçʤÞąʥʡâʡʛʤòéʤʣèʥãìãçʢÝʤåñçðʢʦʝÍʤéçʤʦôéʦôääʡéʢßʤʥããÞðʦʤäʤßʤÝʢâʦʤèʧéʦéÞʧóîʢʣÐÌʝ ãʤìʢçñÞðʦʤäʤßʤʦçʡåãìãʢæ ÐÌʝãåãäåãçãìʢʦäãæãèʥʤôÞåʢçãôæãʡéʢʥʤʦäåʢʥʤâʡàʥʧßʤʣåʤäʡåãâʡëãã ʥãʦäʡ Ìʤåñçðʢ ʦ ʝÍ éʥʢÝʧóé ʤʦʤÝʤßʤ Þçãæʡçãô èʥã èʥʤÞʢàʢçãã åʢìʢÝçðʨ ã èʥʤêãåʡäéãìʢʦäãʨæʢʥʤèʥãôéãʣ äʤéʤʥðʢàʤåáçðÝðéñçʡèʥʡÞåʢçðÞʥʡÞçʤʣʦéʢèʢçã çʡäʤʥʥʢäëãóßãèʢʥßåãäʢæãããàãʦåãèãàʢæããßãèʢʥéʥãßåãëʢʥãàʢæãô ßãèʤʡåñêʡåãèʤèʥʤéʢãàʢæãô ʒʤʥʥʢäëãô àãʦåãèãàʢæãʣ ʦ èʤæʤîñó ßãèʤåãèãàʢæãìʢʦäãʨèʥʢèʡʥʡéʤÞʧÝʤåñçðʨʦʝÍ)ã))éãèʡÞʢàʢéäʦçãáʢçãóìʡʦéʤéðæʡäʥʤ ãæãäʥʤʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣÞʥʡÞçʤʣæʢʥʢ;= ʓÝàʤæãçʡåñçʤʢ ʤáãʥʢçãʢ ʤáãʥʢçãʢ àãʡßçʤʦéãʥʧʢéʦô çʡ ʤʦçʤÞʡçãã ʤëʢçäã ãçàʢäʦʡæʡʦʦðéʢåʡÐʘʞ ãçàʢäʦʒʢéåʢ äʤéʤʥðʣʥʡʦʦìãéðÞʡʢéʦôèʤêʤʥæʧåʢ 40 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ M ; )???? H ßàʢMąæʡʦʦʡéʢåʡ äßHąʥʤʦé æ ʞʡÝåãëʡʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡ;= ʟʡäéʤʥðʥãʦäʡ ʒåʡʦʦ ÒʥʤÞʢçñ àʤäʡâʡççʤʦéã ʔʤâʥʡʦé ʘʧáìãçðåʢé áʢçîãçðåʢé ãåãʦʥʡççʢʣæʢçʤèʡʧâʤʣ I # ʒʧʥʢçãʢ ʔçʢâʡÞãʦãæʤʦéãʤéäʤåãìʢʦéÞʡ I # ʓʥéʢʥãʡåñçʡô ßãèʢʥéʤçãô ʓÍħææʥéʦéãåãèʤʦéʤôççðʣèʥãʢæʡçéãßãèʢʥéʢçâãÞçðʨ èʥʢèʡʥʡéʤÞ I # ʝʡʨʡʥçðʣàãʡÝʢé ))éãèʡ ʕåóäʤâʡçʡéʤîʡä ææʤåñå æßàå I # ʜʡççʢʢçʡìʡåʤ ÐÌʝʧÝåãáʡʣíãʨ ʥʤàʦéÞʢççãäʤÞ ʤéôßʤîʢççʡô çʡʦåʢàʦéÞʢççʤʦéñ Ðçêʡʥäéæãʤäʡʥàʡ ãåãçʢʦéʡÝãåñçʡôʦéʢçʤäʡʥàãô ʧæʧáìãçÞÞʤâʥʡʦéʢåʢé ʧáʢçîãçą I # ʙʡʥʧíʢçãʢåãèãàçʤßʤʤÝæʢçʡ ))ʡ ))Bã)))éãèðÍÑʛ I # ʓÝàʤæãçʡåñçʤʢ ʤáãʥʢçãʢ ʚÝïʢæéʡåããʧæʧáìãçąʦæ ʧáʢçîãçąʦæãåããçàʢäʦæʡʦʦðéʢåʡħäßæ2 I # ʠʥʤçãìʢʦäʤʢ âʡÝʤåʢÞʡçãʢèʤìʢä ʠʛʙʦʤʦçãáʢçãʢæʝʒʟ àʤæåæãçãåãßåʤæʢʥʧåʤçʢêʥãé éʧÝʧåʤãçéʢʥʦéãëãʡåñçðʣ çʢêʥãé èãʢåʤçʢêʥãé ʦéʥʧäéʧʥçðʢ èʡéʤåʤßããèʤìʢä ))B # ʜãʦä ʥʡâÞãéãô ÐÌʝ Þ ą ʥʡâʡ Þðíʢ èʥã ʝʒʟ æåæãç æ Þ ą ʥʡâ ą èʥã ʝʒʟ ąæåæãç æÞąʥʡâąèʥãʝʒʟæåæãç æãåãèʥãèʥãæʢçʢçããßʢæʤàãʡåãâʡ;= ʛʡëãʢçéʤÞʦʝʒʟħæåæãç æʦåʢàʧʢéʥʡʦʦæʡéʥãÞʡéñäʡäâàʤʥʤÞðʨèʥãʤéʦʧéʦéÞããʦåʢàʧ óîãʨâʡÝʤåʢÞʡçãʣèʤìʢäèʢʥʦãʦéãʥʧóîʡôèʥʤéʢãçʧʥãôãåãßʢæʡéʧʥãôãåãʤÝʢ æãäʥʤʡåñÝʧæãçʧʥãô ʧ èʡëãʢçéʤÞ ʦ àãʡÝʢéʤæ ʦéʥʧäéʧʥçðʢ âʡÝʤåʢÞʡçãô èʤìʢä éʡäãʢ äʡä èʤåãäãʦéʤâçʡô Ýʤåʢâçñ èʤìʢä ʧÞâʥʤʦåðʨãåãʥʢêåóäʦçʡôçʢêʥʤèʡéãô ʔ ʦʤʤéÞʢéʦéÞãã ʦ ʥʤʦʦãʣʦäãæã ʥʢäʤæʢçàʡëãôæã ʤáãʥʢçãʢ ) ʦéʢèʢçã àãʡßçʤʦéãʥʧóé èʥã Ðʘʞ ą äßæo )) ʦéʢèʢçã ą ą äßæo ))) ʦéʢèʢçã ą äßæo ʓÝàʤæãçʡåñçʤʢ ëʢçéʥʡåñçʤʢ ʤáãʥʢçãʢ ôÞåôʢéʦô ʦʡæʤʦéʤôéʢåñçðæ 41 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ çʢâʡÞãʦãæðæêʡäéʤʥʤæʥãʦäʡʝʝÏ âçʡìʢçãʢäʤéʤʥʤßʤʦʧîʢʦéÞʢççʤÞʤâʥʡʦéʡʢé èʥãʢßʤʦʤìʢéʡçããʦàãʡÝʢéʤæ ßãèʢʥéʤçãʢʣ ßãèʢʥåãèãàʢæãʢʣ ʙʡʥʧíʢçãôåãèãàçʤßʤʤÝæʢçʡôÞåôóéʦôêʡäéʤʥʤæʥãʦäʡ äʤʥʥʢäëãôäʤéʤʥʤßʤ åʢáãéÞʤʦçʤÞʢèʥʤêãåʡäéãäãʝʝÏʝʡæʤèʤçôéãʢiçʡʥʧíʢçãʢåãèãàçʤßʤʤÝæʢçʡx ãåã iàãʦåãèãàʢæãôx ÍÑʛ Þäåóìʡʢé íãʥʤäãʣ ʦèʢäéʥ çʡʥʧíʢçãʣ åãèãàçʤßʤ ʤÝæʢçʡʔçʡʦéʤôîʢʢÞʥʢæôʤʦçʤÞçʤʢâçʡìʢçãʢàåôʤëʢçäãèʥʤßçʤâʡãòêêʢäéãÞçʤʦéãåʢìʢçãôÍÑʛèʥãàʡóéʧʥʤÞçôæʤÝîʢßʤʨʤåʢʦéʢʥãçʡʚʠʝ ãʨʤåʢʦéʢʥãçʡåãèʤèʥʤéʢãàʤÞ çãâäʤʣ èåʤéçʤʦéã ʠʝÑʙʛ ʒʥʤæʢ éʤßʤ Þ ʤëʢçäʢ ʝʝʜ ãæʢʢé âçʡìʢçãʢ ʧʥʤÞʢçñʨʤåʢʦéʢʥãçʡåãèʤèʥʤéʢãàʤÞÞðʦʤäʤʣèåʤéçʤʦéãʠʝÑʔʛ Úéʤéèʤäʡâʡéʢåñ ÞÞʢàʢçÞèʤʦåʢàçãʨʖÞʥʤèʢʣʦäãʨãʜʤʦʦãʣʦäãʨʥʢäʤæʢçàʡëãôʨÞíäʡåʧ3#/2%;= ÐâàʥʧßãʨçʡʥʧíʢçãʣåãèãàçʤßʤʤÝæʢçʡʦåʢàʧʢéʤéæʢéãéñÞʡáçʧóʥʤåñèʤÞðíʢççʤßʤʧʥʤÞçôéʥãßåãëʢʥãàʤÞʞʕ ÞʥʡâÞãéããʡéʢʥʤʦäåʢʥʤâʡ Þìʡʦéçʤʦéãèʥã ʝÍ ã æʢéʡÝʤåãìʢʦäʤæ ʦãçàʥʤæʢ ʘʝ ʕãèʢʥéʥãßåãëʢʥãàʢæãô æʤáʢé Ýðéñ èʢʥÞãìçʤʣ ʥãʦ ã Þéʤʥãìçʤʣ ʛʥãìãçʤʣ Þéʤʥãìçʤʣ ßãèʢʥéʥãßåãëʢʥãàʢæãã ôÞåôóéʦô ʦʡʨʡʥçðʣ àãʡÝʢé ʠʛʙ æʢéʡÝʤåãìʢʦäãʣ ʦãçàʥʤæ ʡåäʤßʤåãâæ æãʢåʤæçʡô Ýʤåʢâçñ åãæêʤæʡ ʦãʦéʢæçʡôäʥʡʦçʡôÞʤåìʡçäʡ ʡçéãʥʢéʥʤÞãʥʧʦçʡôéʢʥʡèãô ʜãʦʘʢʨʡçãâæðèʢʥÞãìçʤʣßãèʢʥéʥãßåãëʢʥãàʢæããʕãèʢʥèʥʤàʧäëãôÑʚʙʛÍʢêʢäé ßãàʥʤåãâʡʞʕÍʢêʢäéäåãʥʢçʦʡʥʢæçʡçéʤÞʞʕÞèʢìʢçãʡàʡèéãʥʤÞʡçʤãâ*#HAPMAN ÑʛÑąåãèʤèʥʤéʢãàåãèʡâʡʛÑąèʢìʢçʤìçʡôåãèʡâʡ ʒʥʤæʢòéʤßʤ ÞäʡìʢʦéÞʢêʡäéʤʥʤÞʥãʦäʡʥʡʦʦæʡéʥãÞʡóéʦôãàʥʧßãʢÝãʤʨãæãìʢʦäãʢæʡʥäʢʥðÞðʦʤäʤìʧÞʦéÞãéʢåñçðʣʝ ʥʢʡäéãÞçðʣÝʢåʤäÞìʝʜÌ åãèʤèʥʤéʢãà 42 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʡʦʦʤëããʥʤÞʡççʡôêʤʦêʤåãèʡâʡʓÑè ʟÑʓ ʡèʤèʥʤéʢãàʓ)ʡèʤ!) ʡèʤåãèʤèʥʤéʢãàʔʡèʤʔ Ñèʡ ʝʞʜʓʞÐʟÐʒʓÓÐÜʜÐʝʒʓʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞØʠʚʝÑʚÎʙʖʙÐʗ ʔðôÞåʢçãʢêʡäéʤʥʤÞʥãʦäʡʟʜ ãæʢʢéÞʡáçʤʢâçʡìʢçãʢ èʤʦäʤåñäʧàʡʢéÞʤâæʤáçʤʦéñʤèʥʢàʢåãéñÞʢʥʤôéçʤʦéñʥʡâÞãéãôãåãèʥʤßʥʢʦʦãʥʤÞʡçãôÝʤåʢâçãÞéʢìʢçãʢ Ýåãáʡʣíãʨ åʢé ʧ äʤçäʥʢéçʤßʤ Ýʤåñçʤßʤ ʔ ʦéʥʡçʡʨ ʖÞʥʤèð àåô ʤëʢçäã ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤßʤʥãʦäʡãʥʡâÞãéãôʦæʢʥéʢåñçʤßʤãʦʨʤàʡʤéʝʝÏèʥãæʢçôʢéʦôíäʡåʡ3#/2%ʡçßå3YSTEMIC#/RONARY2ISK%VALUATION ʚçʡʧìãéðÞʡʢééʡäãʢèʡʥʡæʢéʥð äʡäèʤå Þʤâʥʡʦé ʦéʡéʧʦäʧʥʢçãô ʦãʦéʤåãìʢʦäʤʢʓÍ ʧʥʤÞʢçñʤÝîʢßʤʠʝ Õäʡåð3#/2%ʥʡâåãìʡóéʦôàåôʦéʥʡçʦÞðʦʤäʤʣãçãâäʤʣʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦæʢʥéçʤʦéñó àåôáãéʢåʢʣʜʟçʢʤÝʨʤàãæʤãʦèʤåñâʤÞʡéñíäʡåʧàåôʦéʥʡçʦÞðʦʤäãæʥãʦäʤæÕäʡåʡ3#/2%èʤâÞʤåôʢéʤëʢçãéñèʥãæʢʥçðʣʥãʦäʦæʢʥéʢåñçʤßʤ ãʦʨʤàʡʤéʝʝÏÞéʢìʢçãʢÝåãáʡʣíãʨåʢéʔʦʤʤéÞʢéʦéÞããʦèʤʦåʢàçãæããâæʢçʢçãôæã ÞçʢʦʢççðæãÞʖÞʥʤèʢʣʦäãʢʥʢäʤæʢçàʡëããèʤäʤʥʥʢäëããàãʦåãèãàʢæãʣ íäʡåʡ3#/2%èʤâÞʤåôʢéʤëʢçãéñçʢéʤåñäʤÞʢʥʤôéçʤʦéñʦæʢʥéãʤéʝʝÏ çʤéʡäáʢ ãʥãʦäʥʡâÞãéãôÐÌʝ äʤéʤʥðʣʧæʧáìãçèʥãæʢʥçʤÞʥʡâʡ ʡʧáʢçîãçÞʥʡâʡ Þðíʢ ìʢæʥãʦäʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣʦæʢʥéãÚéããâæʢçʢçãôʦàʢåʡçð ʦ ëʢåñó Þʤâæʤáçʤʦéã ʦʤèʤʦéʡÞåʢçãô ʤëʢçäã ʥãʦäʡ èʤ íäʡåʢ 3#/2% ʦ àʥʧßãæã æʢáàʧçʡʥʤàçðæãíäʡåʡæã ãèʥʢáàʢÞʦʢßʤʦʟʥʡæãçßʢæʦäʤʣíäʡåʤʣ Þäʤéʤʥʤʣ ʤëʢçãÞʡʢéʦô ʥãʦä ʥʡâÞãéãô ÐÌʝ Þ éʢìʢçãʢ Ýåãáʡʣíãʨ åʢé ʝåʢàʤÞʡéʢåñçʤ ʥãʦä ʤëʢçãÞʡʢæðʣÞʦæʢʥéʢåñçʤßʤãʦʨʤàʡèʤíäʡåʢ3#/2% éʥʡçʦêʤʥæãʥʧʢéʦôÞʥãʦäʥʡâÞãéãôÐÌʝèʧéʢæʧæçʤáʢçãôçʡàåôæʧáìãçãçʡàåôáʢçîãç ìéʤ ʦʤʦéʡÞãéãʦʤʤéÞʢéʦéÞʢççʤ;= Õäʡåʡ3#/2%èʥʢàçʡâçʡìʢçʡàåôʦéʥʡéãêãäʡëããʝʝʜʧåãëÝʢâäåãçãìʢʦäãʨ èʥʤôÞåʢçãʣ ʡéʢʥʤʦäåʢʥʤâʡ Ò Ýʤåñçðʨ ʦ äåãçãìʢʦäãæã èʥʤôÞåʢçãôæã ʡéʢʥʤʦäåʢʥʤâʡ èʥã çʡåãìãã èʥãâçʡäʤÞ Ýʢʦʦãæèéʤæçʤßʤ ʡéʢʥʤʦäåʢʥʤâʡ èʤ àʡççðæ ãçʦéʥʧæʢçéʡåñçðʨ æʢéʤàʤÞ ʤÝʦåʢàʤÞʡçãô ʧ åãë ʦ èʤàéÞʢʥáàʢççðæ ʝʝÏ çʡèʥãæʢʥ Ðʘ ãçʦʧåñéÞʡçʡæçʢâʢ ʦʝÍ))éãèʡãåã)éãèʡʦæãäʥʤʡåñÝʧæãçʧʥãʢʣ ʦʦʢæʢʣçʤʣßãèʢʥåãèãàʢæãʢʣ ʦéôáʢåʤʣʓʕ ʦʠʛʙʤëʢçäʧʥãʦäʡèʤíäʡåʢ3#/2% èʥʤÞʤàãéñçʢʦåʢàʧʢé èʤʦäʤåñäʧéʡäãʢÝʤåñçðʢʡÞéʤæʡéãìʢʦäãʤéçʤʦôéʦôäßʥʧèèʢʤìʢçñÞðʦʤäʤßʤãÞðʦʤäʤßʤʥãʦäʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣãéʥʢÝʧóéãçéʢçʦãÞçʤʣéʢʥʡèãã çʡèʥʡÞåʢççʤʣçʡäʤʥʥʢäëãóʟʜ;=ʛʥãçʡåãìããʝÍ ))éãèʡíäʡåʧæʤáçʤãʦèʤåñâʤÞʡéñ çʤèʤåʧìʢççðʢâçʡìʢçãôçʡàʤʧæçʤáãéñçʡ àåôæʧáìãçãçʡàåôáʢçîãçʙʡåãìãʢàʤèʤåçãéʢåñçðʨʟʜʧÞʢåãìãÞʡʢéʤÝîãʣ ʝʝʜçʡèʥãæʢʥ çãâäãʣʧʥʤÞʢçñʠʝÑʔʛ ʙãáʢèʥãÞʢàʢçʡíäʡåʡ3#/2%Ýʢâʧìʢéʡ äʤçëʢçéʥʡëãã ʠʝ Ñʔʛ ʥãʦ àʤèʤåçãéʢåñçðʢ àʡççðʢ àʤʦéʧèçð Þ èʤåçʤéʢäʦéʤÞʤʣÞʢʥʦããʥʢäʤæʢçàʡëãʣ%3#%!3;= 43 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʜãʦÕäʡåʡ3#/2%ʥãʦäʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣʦæʢʥéãÞÝåãáʡʣíãʢåʢé àåôʦéʥʡç ʦÞðʦʤäãæʧʥʤÞçʢæʦæʢʥéçʤʦéãʤéʝʝÏÞäåóìʡôʜʤʦʦãó çʡʤʦçʤÞʡçããʦåʢàʧóîãʨ êʡäéʤʥʤÞÞʤâʥʡʦé èʤå äʧʥʢçãʢ ʧʥʤÞʢçñʦãʦéʤåãìʢʦäʤßʤʓÍãʚʠʝʧʥʤÞʢçñʠʝÑʔʛ çʢʧìãéðÞʡʢéʦô ʔ ʥʢäʤæʢçàʡëãôʨ éʡäáʢ ÞÞʤàãéʦô íäʡåʡ ʤéçʤʦãéʢåñçʤßʤ ʥãʦäʡ äʤéʤʥʡô èʤâÞʤåôʢéèʤåʧìãéñèʥʢàʦéʡÞåʢçãʢʤʥãʦäʢʧåãëæʤåʤàʤßʤÞʤâʥʡʦéʡʦçãâäãæʡÝʦʤåóéçðæʥãʦäʤæèʤíäʡåʢ3#/2%; =ʝʤßåʡʦçʤʢʣ ʥãʦäʝʝÏʧäʧʥôîʢßʤèʡëãʢçéʡʦÞðʦʤäãæʧʥʤÞçʢæʓÍãʚʠʝÞʥʡâÞðíʢ ìʢæʧçʢäʧʥôîʢßʤʦçʤʥæʡåñçðæã 44 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʧʥʤÞçôæãʓÍãʚʠʝʚëʢçäʡʤéçʤʦãéʢåñçʤßʤʥãʦäʡèʤåʢâçʡÞèʢʥÞʧóʤìʢʥʢàñàåô èʡëãʢçéʤÞ çʢàʤʦéãßíãʨåʢé ʡãæʢççʤʦëʢåñóãʨæʤéãÞʡëããÞðèʤåçôéñçʡâçʡìʢçãôÞʥʡìʡèʤãâæʢçʢçãóʤÝʥʡâʡáãâçããæʢàãäʡæʢçéʤâçʤʣéʢʥʡèãã ʙʢàʤʤëʢçäʡʥãʦäʡʝʝÏèʥããʦèʤåñâʤÞʡçããíäʡåð3#/2%ÞʢʥʤôéçʡÞʦåʢàʧóîãʨʦåʧìʡôʨ ʝʤëãʡåñçʤçʢâʡîãîʢççðʢʦåʤãçʡʦʢåʢçãô ʙʡåãìãʢʤáãʥʢçãô ʙãâäãʣʧʥʤÞʢçñʠʝÑʔʛãåãʡèʤʓ) èʤÞðíʢççðʣʧʥʤÞʢçñʞʕ êãÝʥãçʤßʢçʡ ßʤæʤëãʦéʢãçʡ ʡèʤʔ ã Ñèʡ ʦʢæʢʣçʡô ßãèʢʥʨʤåʢʦéʢʥãçʢæãô ʝʕʠʝ ãåã èʤÞðíʢççðʣʧʥʤÞʢçñÞìʝʜÌ Ìʢʦʦãæèéʤæçðʢèʡëãʢçéðʦàʤäåãçãìʢʦäãæãèʥãâçʡäʡæãʡéʢʥʤʦäåʢʥʤâʡ çʡèʥãæʢʥʦçʡåãìãʢæʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäãèʥãàʧèåʢäʦçʤæʦäʡçãʥʤÞʡçããÝʥʡʨãʤëʢêʡåñçðʨãʦʤççðʨʡʥéʢʥãʣ ʝçãáʢççʡôêʧçäëãôèʤìʢä ʝʢæʢʣçðʣʡçʡæçʢâʥʡççʢßʤçʡìʡåʡʝʝÏʧæʧáìãçåʢé ʧáʢçîãçåʢé ʧÞʢåãìãÞʡʢéʥãʦäÞ ʥʡâʡʧáʢçîãçãÞʥʡâʡʧæʧáìãç ʛʥãòéʤæʥãʦäʝʝÏæʤáʢéÝðéñçãáʢʧʦéʡçʤÞåʢççʤßʤèʤíäʡåʢ3#/2%ÞʦåʧìʡʢʤìʢçñÞðʦʤäʤßʤʧʥʤÞçôʠʝÑʔʛåãÝʤèʥãçʡåãìããàʤåßʤáãéʢåʢʣÞʦʢæñʢʒçʢàʤʦéʡéäʡæ íäʡåð 3#/2% æʤáçʤ ʤéçʢʦéã Þʤâʥʡʦéçðʢ ʤßʥʡçãìʢçãô ʤéʦʧéʦéÞãʢ Þäåóìʢçãô ʦʧÝäåãçãìʢʦäʤßʤ ʡéʢʥʤʦäåʢʥʤâʡ èʢʥãêʢʥãìʢʦäãʨ ʡʥéʢʥãʣ Þ ʦéʥʡéãêãäʡëãóʥãʦäʡ çʢʧìʢéàʥʧßãʨêʡäéʤʥʤÞʥãʦäʡçʡʦåʢàʦéÞʢççʤʦéñ ʝʕʠʝ Ñèʡ ;=ʔíäʡåʢ3#/2%ãæʢʢéʦôàʢåʢçãʢèʡëãʢçéʤÞéʤåñäʤçʡäʧʥôîãʨãçʢäʧʥôîãʨ èʤòéʤæʧçʢàʤäʤçëʡôʦçʤ äʡäʤëʢçãÞʡéñʥãʦäèʥãèʥʢäʥʡîʢçããèʡëãʢçéʤæäʧʥʢçãô äʡäãæʤÝʥʡâʤæʧìãéðÞʡéñàåãéʢåñçʤʦéñããçéʢçʦãÞçʤʦéñäʧʥʢçãô ʒʓʞʖʕʚʜÐÐʜÐʝʒʓʝʖʜÍʖÔʙʚ ʝʚʝÒÍÐʝʞØʠʚʝÑʚÎʙʖʙÐʗ ʚëʢçäʡäʡéʢßʤʥããʥãʦäʡÞʡáçʡàåôÞðʥʡÝʤéäãʤèéãæʡåñçʤʣéʡäéãäãÞʢàʢçãô ãçʡÝåóàʢçãôèʡëãʢçéʡ àåôãʦèʤåñâʤÞʡçãôòêêʢäéãÞçðʨçʢæʢàãäʡæʢçéʤâçðʨ ãæʢàãäʡæʢçéʤâçðʨæʢéʤàʤÞÞèʥʤêãåʡäéãäʢãåʢìʢçããʔʦʤʤéÞʢéʦéÞããʦʖÞʥʤèʢʣʦäãæã%3#%!3 ãʜʤʦʦãʣʦäãæã ʥʢäʤæʢçàʡëãôæãèʤäʤʥʥʢäëããàãʦåãèãàʢæããÞðàʢåôóéäʡéʢßʤʥããʥãʦäʡʤìʢçñÞðʦʤäãʣ Þðʦʤäãʣ ʧæʢʥʢççðʣãçãâäãʣ; = ʒʡéʢßʤʥãôʤìʢçñÞðʦʤäʤßʤʥãʦäʡ ą èʡëãʢçéð ʦ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðæ âʡÝʤåʢÞʡçãʢæ àʤäʧæʢçéãʥʤÞʡççðæ ãåã ÞðôÞåʢççðæ èʤ àʡççðæ àãʡßçʤʦéãìʢʦäãʨ Þãâʧʡåãâãʥʧóîãʨ ãʦʦåʢàʤÞʡçãʣ ÍʤäʧæʢçéãʥʤÞʡççðʢʝʝÏÞäåóìʡóéèʢʥʢçʢʦʢççðʣÐʘ ʚʒʝ ʦʤʦéʤôçãʢèʤʦåʢ ʥʢÞʡʦäʧåôʥãâʡëãã æãʤäʡʥàʡ ãåã èʢʥãêʢʥãìʢʦäãʨ ʡʥéʢʥãʣ ãçʦʧåñé ã ʞÐʓ ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʢ èʤʥʡáʢçãʢ èʢʥãêʢʥãìʢʦäãʨ ʡʥéʢʥãʣ Íʡççðʢ àãʡßçʤʦéãìʢʦäãʨ Þãâʧʡåãâãʥʧóîãʨ ãʦʦåʢàʤÞʡçãʣ Þäåóìʡóé ãâæʢçʢçãô éʢʦçʤ 45 ʟʡäéʤʥðʥãʦäʡʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʦÞôâʡççðʢʦʥãʦäʤæʝʝʚ éʡäãʢäʡäçʡåãìãʢâçʡìãæʤʣʓʝÌèʤàʡççðæʒʓʕãåã àʧèåʢäʦçʤßʤʦäʡçãʥʤÞʡçãôʦʤççðʨʡʥéʢʥãʣ ą èʡëãʢçéð ʦ ʝÍ ʦ èʤÞʥʢáàʢçãʢæ ʤʥßʡçʤÞ æãíʢçʢʣ Þ ìʡʦéçʤʦéã ʦ èʥʤéʢãçʧʥãʢʣ ãåãʦçʡåãìãʢæʨʤéôÝðʤàçʤßʤãâʤʦçʤÞçðʨêʡäéʤʥʤÞʥãʦäʡäʧʥʢçãʢ ßãèʢʥéʤçãôãåãàãʦåãèãàʢæãô ą èʡëãʢçéðʦéôáʢåðæéʢìʢçãʢæʨʥʤçãìʢʦäãʨâʡÝʤåʢÞʡçãʣèʤìʢä ʝʒʟæåæãç æ2 ą èʡëãʢçéð ʦ ʥʡʦʦìãéʡççðæ åʢéçãæ ʥãʦäʤæ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦæʢʥéã èʤíäʡåʢ3#/2%ħ ʒʡéʢßʤʥãôÞðʦʤäʤßʤʥãʦäʡ ą èʡëãʢçéðʦʤàçãæÞðʥʡáʢççðæêʡäéʤʥʤæʥãʦäʡ ÞìʡʦéçʤʦéãʦʧʥʤÞçʢæʚʠʝ ææʤåñåçʡèʥãæʢʥ èʡëãʢçéðʦʝʕʠʝ ãåãʦʧʥʤÞçʢæʓÍħææʥéʦé ą èʡëãʢçéðʦʝÍ çʢʤéçʤʦôîãʢʦôääʡéʢßʤʥããʤìʢçñÞðʦʤäʤßʤʥãʦäʡʙʢäʤéʤʥðʢ æʤåʤàðʢèʡëãʢçéðʦʝÍ)éãèʡæʤßʧéÝðéñʤéçʢʦʢçðääʡéʢßʤʥããçãâäʤßʤãåã ʧæʢʥʢççʤßʤʥãʦäʡ ą èʡëãʢçéðʦʧæʢʥʢççðæéʢìʢçãʢæʨʥʤçãìʢʦäãʨâʡÝʤåʢÞʡçãʣèʤìʢäʝʒʟą ąæåæãç æ2 ą èʡëãʢçéð ʦ ʥʡʦʦìãéʡççðæ åʢéçãæ ʥãʦäʤæ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦæʢʥéã èʤíäʡåʢ3#/2%ą ʒʡéʢßʤʥãôʧæʢʥʢççʤßʤʥãʦäʡ ą èʡëãʢçéð ʦ ʥʡʦʦìãéʡççðæ åʢéçãæ ʥãʦäʤæ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦæʢʥéã èʤíäʡåʢ3#/2%ą ÌʤåñíãçʦéÞʤåóàʢʣʦʥʢàçʢßʤÞʤâʥʡʦéʡÞèʤèʧåôëããʤéçʤʦãéʦôãæʢççʤäòéʤʣ ßʥʧèèʢÒçãʨìʡîʢÞʦʢßʤèʥʤãʦʨʤàãéåãÝʤçʢàʤʤëʢçäʡ åãÝʤèʢʥʢʤëʢçäʡäʡéʢßʤʥãã ʥãʦäʡ ãíäʡåʡ3#/2%àʡåʢäʤçʢÞʦʢßàʡèʤæʤßʡʢéèʥʡÞãåñçʤʤèʥʢàʢåãéñʧʥʤÞʢçñ ʥãʦäʡʛʥãʤëʢçäʢʥãʦäʡÞòéʤʣßʥʧèèʢëʢåʢʦʤʤÝʥʡâçʤʧìãéðÞʡéñàʤèʤåçãéʢåñçðʢ êʡäéʤʥð éʡäãʢäʡäʤéôßʤîʢççʡôçʡʦåʢàʦéÞʢççʤʦéñèʤʝʝÏ ʡÝàʤæãçʡåñçðʣéãè ʤáãʥʢçãô çãâäãʣ ʧʥʤÞʢçñ ʠʝ Ñʔʛ èʤÞðíʢççðʢ ʧʥʤÞçã ʞʕ ÞìʝʜÌ Ñèʡ ʡèʤʔ ʔʦʤæçãéʢåñçðʨʦåʧìʡôʨàåôÞðôÞåʢçãôʡéʢʥʤʦäåʢʥʤâʡ èʥʤéʢäʡóîʢßʤÝʢâäåãçãìʢʦäãʨ èʥʤôÞåʢçãʣ èʤäʡâʡçʤ èʥʤÞʢàʢçãʢ éʡäãʨ ãçʦéʥʧæʢçéʡåñçðʨ æʢéʤàʤÞ ʤÝʦåʢàʤÞʡçãô äʡäàʧèåʢäʦçʤʢʦäʡçãʥʤÞʡçãʢʦʤççðʨʡʥéʢʥãʣ òʨʤʒʕ ʒʡéʢßʤʥãôçãâäʤßʤʥãʦäʡ ą èʡëãʢçéð ʦ ʥʡʦʦìãéʡççðæ åʢéçãæ ʥãʦäʤæ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦæʢʥéã èʤíäʡåʢ3#/2% Úéʤ äʡäèʥʡÞãåʤ åãëʡæʤåʤàʤßʤÞʤâʥʡʦéʡÝʢâʤéôßʤîʢççʤʣçʡʦåʢàʦéÞʢççʤʦéã ʔ ÝʤåñíãçʦéÞʢ ʦåʧìʡʢÞ ʤçã çʢ çʧáàʡóéʦô Þ èʥʤÞʢàʢçãã ʦèʢëãʡåñçðʨ æʢéʤàʤÞ ʤÝʦåʢàʤÞʡçãô 46 ʒåãçãìʢʦäʡôʤëʢçäʡʦʤʦéʤôçãôèʥãʡéʢʥʤʦäåʢʥʤâʢ ʒÑÐʙÐÔʖʝʒʓÜʚÓʖʙʒʓʝʚʝʞʚÜʙÐÜʛʜÐ ʓʞʖʜʚʝʒÑʖʜʚÏʖ ʛʥã ʤÝʦåʢàʤÞʡçãã èʡëãʢçéʡ ʦåʢàʧʢé èʥãàʢʥáãÞʡéñʦô ʤʦçʤÞçðʨ èʥãçëãèʤÞ èʥʤèʢàʢÞéãäãʔʤÞʥʢæôʦÝʤʥʡʡçʡæçʢâʡÞðôʦçôóéçʡåãìãʢèʥãâçʡäʤÞÐÌʝ ʝÍ ʡéʢʥʤʦäåʢʥʤâʡèʢʥãêʢʥãìʢʦäãʨʡʥéʢʥãʣ ʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæããʝʕʠʝ ʘʝ ʤáãʥʢçãô ʨʥʤçãìʢʦäãʨ âʡÝʤåʢÞʡçãʣ èʤìʢä ʛʥã ʦÝʤʥʢ ʦʢæʢʣçʤßʤ ʡçʡæçʢâʡ ʤʦʤÝʤʢÞçãæʡçãʢʧàʢåôóéʥʡççʢæʧèʥʤôÞåʢçãóʝʝÏʧʥʤàʦéÞʢççãäʤÞ;= ʛʥã ʤʦæʤéʥʢ Ýʤåñçʤßʤ çʢʤÝʨʤàãæʤ ʤÝʥʡéãéñ Þçãæʡçãʢ çʡ Þʢäã çʡ äʤéʤʥðʨ ʧåãëʦàãʦåãèãàʢæãʢʣæʤáçʤʧÞãàʢéñäʦʡçéʢåʡâæðąèåʤʦäãʢãåãʦåʢßäʡÞʤâÞðíʡóîãʢʦôçʡàäʤáʢʣʤÝʥʡâʤÞʡçãôáʢåéʤßʤãåãʤʥʡçáʢÞʤßʤëÞʢéʡʛʥãʤʦæʤéʥʢßåʡâÞʤäʥʧßʥʡàʧáçʤʣʤÝʤåʤìäãæʤáçʤçʡÝåóàʡéñåãèãàçʧóàʧßʧÝʢåʤÞʡéʤ ʦʢʥʤÞʡéʤßʤëÞʢéʡòéʤʨʡʥʡäéʢʥçðʣèʥãâçʡäßãèʢʥåãèãàʢæãã ÞʤʦʤÝʢççʤʦéãʢʦåã ʤçÞʦéʥʢìʡʢéʦôʧåãëæʤåʤáʢåʢéʥãʦ ʚìʢçñÞʡáçʤʤÝʥʡéãéñÞçãæʡçãʢçʡʥʡâßãÝʡéʢåñçðʢèʤÞʢʥʨçʤʦéãäãʦéʢʣ åʤäéʢʣ äʤåʢçʢʣ ʡéʡäáʢçʡʡʨãååʤÞðʦʧʨʤáãåãôÒÝʤåñçðʨʦçʡʦåʢàʦéÞʢççðæãçʡʥʧíʢçãôæãåãèãàçʤßʤʤÝæʢçʡçʡòéãʨʧìʡʦéäʡʨéʢåʡæʤáçʤʤÝçʡʥʧáãéñäʦʡçéʤæð ʥãʦ ʔðàʢåôóéäʤáçðʢéʧÝʢʥʤâçðʢ ʦʧʨʤáãåñçðʢãòʥʧèéãÞçðʢäʦʡçéʤæð ʙʡåãìãʢ äʦʡçéʤæ ʡʨãååʤÞðʨ ʦʧʨʤáãåãʣ ôÞåôʢéʦô èʡéʤßçʤæʤçãìçðæ èʥãâçʡäʤæ ʝʕʠʝ ʡòʥʧèéãÞçðʢäʦʡçéʤæðÞʦéʥʢìʡóéʦôʧÝʤåñçðʨʦÞðʥʡáʢççʤʣßãèʢʥéʥãßåãëʢʥãàʢæãʢʣʔëʢåʤæçʡåãìãʢäʦʡçéʤæʦÞãàʢéʢåñʦéÞʧʢéÞèʤåñâʧçʡʦåʢàʦéÞʢççðʨçʡʥʧíʢçãʣåãèãàçʤßʤʤÝæʢçʡÒéʡäãʨÝʤåñçðʨÐÌʝæʤáʢéʥʡâÞãéñʦôÞÞʤâʥʡʦéʢąåʢé ʡãçʤßàʡãÞÝʤåʢʢæʤåʤàʤæÞʤâʥʡʦéʢ ʛʥãʡʧʦäʧåñéʡëããʤÝåʡʦéãʦʢʥàëʡçʢʥʢàäʤÞðʦåʧíãÞʡʢéʦôßʥʧÝðʣʦãʦéʤåãìʢʦäãʣíʧæʦçʡãÝʤåñíʢʣãçéʢçʦãÞçʤʦéñóÞʤÝåʡʦéãèʥʤʢäëããʡʤʥéʡåñçʤßʤäåʡèʡçʡÚéʤéíʧæʤÝʧʦåʤÞåʢçêʤʥæãʥʧóîãæʦôʦéʢçʤâʤæʧʦéñôʡʤʥéðãʧèåʤéçʢçãʢæ ʦéʢçʤäʡʤʥéðʛʥãÞðʦåʧíãÞʡçããàʥʧßãʨʦʤʦʧàãʦéðʨʤÝåʡʦéʢʣãçʤßàʡæʤáçʤʧʦåðíʡéñíʧæðÞʤÝåʡʦéãíʢãʡéʢʥʤʦäåʢʥʤâʦʤççðʨʡʥéʢʥãʣ ÞèʥʤʢäëããÝʥóíçʤʣʡʤʥéð Íãʦåãèãàʢæãô ʨʡʥʡäéʢʥãâʧʢéʦô æçʤßʤʤÝʥʡâãʢæ äåãçãìʢʦäãʨ èʥʤôÞåʢçãʣ ʤéãʨèʤåçʤßʤʤéʦʧéʦéÞãôàʤäåʡʦʦãìʢʦäãʨèʥãâçʡäʤÞʦçʡåãìãʢæäʦʡçéʤæãʦʤʦʧàãʦéðʨíʧæʤÞʔʥʡìʧçʢʤÝʨʤàãæʤèʥãʦÝʤʥʢʡçʡæçʢâʡʧéʤìçãéñ çʢÝðåʤåã ʦåʧìʡʢÞʥʡççʢßʤʥʡâÞãéãôÐÌʝʥʡÞçʤäʡäãåóÝðʨʢʢèʥʤôÞåʢçãʣ ʧÝåãáʡʣíãʨ ʥʤàʦéÞʢççãäʤÞ èʡëãʢçéʡ ą ʤéëʡ æʡéʢʥã ÝʥʡéñʢÞ ʦʢʦéʢʥ ʥʡʦʦèʥʤʦãéñ ʤ çʡãÝʤåʢʢâçʡìãæðʨêʡäéʤʥʡʨʥãʦäʡÐÌʝąʡʥéʢʥãʡåñçʤʣßãèʢʥéʤçãã äʧʥʢçãã ʦʡʨʡʥçʤæàãʡÝʢéʢ ʤáãʥʢçãã æʡåʤèʤàÞãáçʤæʤÝʥʡâʢáãâçãʒʥʤæʢéʤßʤ çʢʤÝʨʤàãæʤèʤæçãéñ ìéʤʡéʢʥʤʦäåʢʥʤâãʢßʤʤʦåʤáçʢçãôʥʡâÞãÞʡóéʦôìʡîʢãʥʡçñíʢ ʧåãëæʧáʦäʤßʤèʤåʡ 47 ʒåãçãìʢʦäʡôʤëʢçäʡʦʤʦéʤôçãôèʥãʡéʢʥʤʦäåʢʥʤâʢ ʜãʦʔçʢíçãʣʤʦæʤéʥèʡëãʢçéʡʦʝʕʠʝʓʒʦʡçéʢåʡâæðÞʢäÌÒéʤåîʢçãʢʡʨãååʤÞðʨ ʦʧʨʤáãåãʣʔʒʦʡçéʤæðʕÑãèʤãàçʡôàʧßʡʥʤßʤÞãëð 48 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ ÑʓÌʚʜʓʞʚʜʙʓÜÍÐʓʕʙʚʝʞÐʒʓ ÑÐʛÐÍʙØʗʛʜʚʟÐÑÙ ʚëʢçäʡ åãèãàçʤßʤ èʥʤêãåô çʡãÝʤåʢʢ Þʡáçʡ èʥã ʤÝʦåʢàʤÞʡçãã èʡëãʢçéʤÞ ʦʡéʢʥʤʦäåʢʥʤâʤæãåãèʤàʤâʥʢçãʢæçʡʢßʤçʡåãìãʢʝåʢàʧʢéʤÝʥʡéãéñÞçãæʡçãʢ çʡ éʤ ìéʤ àãʦåãèãàʢæãô ʤéʥʡáʡʢé åãíñ Þʢʥʤôéçʤʦéñ ʥʡâÞãéãô ãåã èʥʤßʥʢʦʦãʥʤÞʡçãô ʡéʢʥʤʦäåʢʥʤâʡ ôÞåôôʦñ ʤàçãæ ãâ êʡäéʤʥʤÞ ʥãʦäʡ ʢßʤ ʥʡâÞãéãô ;= ʒʥʤæʢ éʤßʤ èʡéʤåʤßãìʢʦäãʢ ãâæʢçʢçãô åãèãàçʤßʤ ʦèʢäéʥʡ ôÞåôóéʦô ʤʦçʤÞʡçãʢæ àåô çʡâçʡìʢçãô ʦʤʤéÞʢéʦéÞʧóîʢʣ àãʢéð ã éʢʥʡèãã Íåô äʡáàʤʣ äʡéʢßʤʥãã ʥãʦäʡ ʦʧîʢʦéÞʧóé ëʢåʢÞðʢ ʧʥʤÞçã ʨʤåʢʦéʢʥãçʡ Ñʙʛ äʡä ßåʡÞçʤßʤ ʡéʢʥʤßʢççʤßʤ êʡäéʤʥʡʘʤçãéʤʥãʥʤÞʡçãʢèʤäʡâʡéʢåʢʣåãèãàçʤßʤèʥʤêãåôãàʤʦéãáʢçãʢëʢåʢÞðʨʧʥʤÞçʢʣåãèãàʤÞèʤâÞʤåôʢéÞʤæçʤßãʨʦåʧìʡôʨʤʦéʡçʤÞãéñèʥʤßʥʢʦʦãʥʤÞʡçãʢ ʡéʢʥʤʦäåʢʥʤâʡ ã ʦéʡÝãåãâãʥʤÞʡéñ ʦʤʦéʤôçãʢ èʡëãʢçéʡ ʔ éʡÝå èʥʢàʦéʡÞåʢçð ʥʢäʤæʢçàʧʢæðʢëʢåʢÞðʢʧʥʤÞçãʠʝÑʙʛÞâʡÞãʦãæʤʦéãʤéäʡéʢßʤʥããʥãʦäʡéʤßʤ ãåããçʤßʤèʡëãʢçéʡ ʞʡÝåãëʡÓʢåʢÞʤʣʧʥʤÞʢçñʠʝÑʙʛ ÞâʡÞãʦãæʤʦéãʤéäʡéʢßʤʥããʥãʦäʡ ʒʡéʢßʤʥãôʥãʦäʡ ÓʢåʢÞʤʣʧʥʤÞʢçñʠʝÑʙʛ ææʤåñå ÒʥʤÞʢçñʠʝÑʙʛ ææʤåñå àåôçʡìʡåʡ æʢàãäʡæʢçéʤâçʤʣéʢʥʡèãã ʚìʢçñÞðʦʤäãʣ ʔðʦʤäãʣ Òæʢʥʢççðʣ ʙãâäãʣ ʔåʡÝʤʥʡéʤʥçʤʣèʥʡäéãäʢʠʝÑʙʛʤÝðìçʤʥʡʦʦìãéðÞʡʢéʦôèʤêʤʥæʧåʢʟʥãàÞʡåñàʡ ʠʝÑʙʛʚʠʝąʠʝÑʔʛ ʞʕ èʥãʤèʥʢàʢåʢçããèʤäʡâʡéʢåʢʣÞææʤåñå ʠʝÑʙʛʚʠʝąʠʝÑʔʛ ʞʕ èʥãʤèʥʢàʢåʢçããèʤäʡâʡéʢåʢʣÞæßàå ÒÝʤåñçðʨ ʤéçʤʦôîãʨʦôääʡéʢßʤʥããʤìʢçñÞðʦʤäʤßʤʥãʦäʡ ʧʥʤÞʢçñʠʝÑʙʛ çʢ àʤåáʢç èʥʢÞðíʡéñ ææʤåñå Ðæʢççʤ èʥã éʡäʤæ âçʡìʢçãã ʧʥʤÞçô ʠʝÑʙʛ ʧòéʤʣäʡéʢßʤʥããÝʤåñçðʨʥãʦäʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʦÞʤàãéʦôäæãçãæʧæʧÒèʡëãʢçéʤÞÞðʦʤäʤßʤʥãʦäʡëʢåʢÞʤʣʧʥʤÞʢçñʠʝÑʙʛʦʤʦéʡÞåôʢé ææʤåñå ʖʦåã áʢ ëʢåʢÞʤʣ ʧʥʤÞʢçñ èʥʢÞðíʡʢé òéʤ âçʡìʢçãʢ çʢʦæʤéʥô çʡÞðèʤåçʢçãʢʥʢäʤæʢçàʡëãʣèʤʦʤÝåóàʢçãóàãʢéð èʥʢäʥʡîʢçãóäʧʥʢçãô äʤʥʥʢäëããÞʢʦʡãàʥʧßãʨêʡäéʤʥʤÞʥãʦäʡ éʤÞòéãʨʦåʧìʡôʨéʢʥʡèãôßãèʤåãèãàʢæãìʢʦäãæãèʥʢèʡʥʡéʡæãÞèʢʥÞʧóʤìʢʥʢàñʦéʡéãçʡæã ôÞåôʢéʦôçʢʤÝʨʤàãæʤʣ;= 49 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ Ò åãë ʤéçʤʦôîãʨʦô ä äʡéʢßʤʥãã ʧæʢʥʢççʤßʤ ʥãʦäʡ ʤèéãæʡåñçðæ ëʢåʢÞðæ ʧʥʤÞçʢæʦìãéʡʢéʦôâçʡìʢçãʢʠʝÑʙʛ ʥʡÞçʤʢææʤåñåʔòéʤʣßʥʧèèʢàåôäʤʥʥʢäëãã àãʦåãèãàʢæãã Þ ʤʦçʤÞçʤæ ʤßʥʡçãìãÞʡóéʦô àãʢéãìʢʦäãæã æʢʥʤèʥãôéãôæã ãàʥʧßãæãæʢéʤàʡæãçʢæʢàãäʡæʢçéʤâçʤßʤåʢìʢçãôèʥʢäʥʡîʢçãʢäʧʥʢçãô èʤÞðíʢçãʢʧʥʤÞçôêãâãìʢʦäʤʣʡäéãÞçʤʦéã ʚÝðìçʤåʢìʡîãʣÞʥʡìèʥãçãæʡʢéʥʢíʢçãʢ ʤ çʡâçʡìʢçãã åʢäʡʥʦéÞʢççʤßʤ ʦʥʢàʦéÞʡ ʦ ʧìʢéʤæ ʨʡʥʡäéʢʥʡ àãʦåãèãàʢæãã ʢʦåãʤçʦìãéʡʢé ìéʤçʢæʢàãäʡæʢçéʤâçʡôéʢʥʡèãôçʢèʤâÞʤåôʢéàʤʦéãìñçʡæʢìʢççʤßʤëʢåʢÞʤßʤʧʥʤÞçô Ò åãë çãâäʤßʤ ʥãʦäʡ ʤèéãæʡåñçðʣ ëʢåʢÞʤʣ ʧʥʤÞʢçñ ʠʝÑʙʛ ʦʤʦéʡÞåôʢé ææʤåñå ìéʤÞèʤàʡÞåôóîʢæÝʤåñíãçʦéÞʢʦåʧìʡʢÞçʢéʥʢÝʧʢéçʡâçʡìʢçãôåʢäʡʥʦéÞʢççðʨʦʥʢàʦéÞ ʡäëʢçéàʢåʡʢéʦôÞèʢʥÞʧóʤìʢʥʢàñçʡʦʤÝåóàʢçããâàʤʥʤÞʤßʤʤÝʥʡâʡáãâçãʙʢʥʢàäʤèʥãʤëʢçäʢäʡéʢßʤʥããʥãʦäʡÞʤâçãäʡóéâʡéʥʧàçʢçãô ÞéʡäãʨʦåʧìʡôʨæʤáçʤèʥãÝʢßçʧéñäʤèʥʢàʢåʢçãóàʤèʤåçãéʢåñçðʨÝãʤʨãæãìʢʦäãʨæʡʥäʢʥʤÞéʡÝå ʞʡÝåãëʡ Ìãʤʨãæãìʢʦäãʢæʡʥäʢʥð ʥʢäʤæʢçàʧʢæðʢàåôʧéʤìçʢçãôäʡéʢßʤʥãã ʥãʦäʡ ʜʢêʢʥʢçʦçðʢëʢåʢÞðʢ âçʡìʢçãô ÞâʡÞãʦãæʤʦéãʤéäʡéʢßʤʥããʥãʦäʡ ʛʤäʡâʡéʢåñ ʠʝçʢ Ñʔʛ ææʤåñå ʡèʤ" æßàå Ñèʡ æßàå ÞìʝʜÌ æßå ʚìʢçñÞðʦʤäãʣ ʔðʦʤäãʣ Òæʢʥʢççðʣ ʙãâäãʣ Ħ Ħ Ħ Ħ Ħ ą ą ÒʥʤÞʢçñʠʝ çʢʦÞôâʡççʤßʤʦÑʔʛʠʝąʠʝÑʔʛ ʥʢäʤæʢçàʧʢéʦôʤèʥʢàʢåôéñ ʧåãëʦʧʥʤÞçʢæʞʕħ ææʤåñåÍʢåʤÞéʤæ ìéʤèʥãßãèʢʥéʥãßåãëʢʥãàʢæããäʤåãìʢʦéÞʤìʡʦéãë Ýʤßʡéðʨéʥãßåãëʢʥãàʡæãʠʘ ÑʚʙʛãÑʛʛ ʦʧîʢʦéÞʢççʤÞʤâʥʡʦéʡʢé ʦåʢàʤÞʡéʢåñçʤ ʧÞʢåãìãÞʡʢéʦôäʤåãìʢʦéÞʤʠʝ ʦʤàʢʥáʡîʢßʤʦôÞòéãʨìʡʦéãëʡʨʟʤʥæʧåʡʟʥãàÞʡåñàʡÞéʡäãʨʦåʧìʡôʨʧáʢçʢʤéʥʡáʡʢéʥʢʡåñçʤʢäʤåãìʢʦéÞʤ ʡéʢʥʤßʢççʤßʤʠʝʔçʡʦéʤôîʢʢÞʥʢæôèʤäʡâʡéʢåñʠʝçʢ ÑʔʛNON($, # ʥʢäʤæʢçàʧʢéʦôãʦèʤåñâʤÞʡéñÞäʡìʢʦéÞʢëʢåʢÞʤßʤʧʥʤÞçôʧÝʤåñçðʨʦʡʨʡʥçðæàãʡÝʢéʤæ ã æʢéʡÝʤåãìʢʦäãæ ʦãçàʥʤæʤæ èʤʦäʤåñäʧ ãæʢççʤ ʧ çãʨ ìʡîʢ Þʦéʥʢìʡóéʦô ßãèʢʥéʥãßåãëʢʥãàʢæãôãçãâäãʣʧʥʤÞʢçñʠʝÑʔʛÓʢåʢÞʤʢâçʡìʢçãʢèʤäʡâʡéʢåôʠʝ çʢ ÑʔʛàåôʦʤʤéÞʢéʦéÞʧóîãʨäʡéʢßʤʥãʣʥãʦäʡÞðìãʦåôʢéʦôèʧéʢæèʥãÝʡÞåʢçãô äëʢåʢÞʤæʧʧʥʤÞçóʠʝÑʙʛ ææʤåñå;= ʒʤçëʢçéʥʡëãô ʡèʤèʥʤéʢãàʡ ʡèʤʔ Ýʤåʢʢ éʤìçʤ çʢáʢåã ʧʥʤÞʢçñ ʠʝÑʙʛ ʤéʥʡáʡʢé ʦʤàʢʥáʡçãʢ ʡéʢʥʤßʢççðʨ ìʡʦéãë Þ èåʡâæʢ äʥʤÞã ã ʦåʢàʤÞʡéʢåñçʤ æʤáʢé Ýðéñ Ýʤåʢʢ àʤʦéʤÞʢʥçðæ èʤäʡâʡéʢåʢæ àãʦåãèãàʢæãã èʥã ʤëʢçäʢ 50 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤßʤʥãʦäʡʒʥʤæʢéʤßʤ òéʤéèʤäʡâʡéʢåñæʢçʢʢèʤàÞʢʥáʢçèʤßʥʢíçʤʦéôæåʡÝʤʥʡéʤʥçʤßʤãâæʢʥʢçãôÒÝʤåñçðʨʤìʢçñÞðʦʤäʤßʤʥãʦäʡʧʥʤÞʢçñ ʡèʤʔ Þðíʢ æßàå ßʤÞʤʥãé ʤ çʢàʤʦéʡéʤìçʤʣ òêêʢäéãÞçʤʦéã èʥʤÞʤàãæʤʣ åãèãàʦçãáʡóîʢʣéʢʥʡèããÍåôÞʦʢʨʤʦéʡåñçðʨäʡéʢßʤʥãʣʥãʦäʡʧʥʤÞʢçñʡèʤʔÞðíʢ æßàåéʡäáʢʦÞãàʢéʢåñʦéÞʧʢéÞèʤåñâʧÝʤåʢʢÞðʦʤäʤʣÞʢʥʤôéçʤʦéãʥʡâÞãéãô ʤʦåʤáçʢçãʣ ʚàçʡäʤ ʦåʤáçʡô ã âʡéʥʡéçʡô æʢéʤàãäʡ ʤèʥʢàʢåʢçãô òéʤßʤ èʡʥʡæʢéʥʡ ʦʧîʢʦéÞʢççʤ ʤßʥʡçãìãÞʡʢé ʢßʤ èʥãæʢçʢçãʢ Þ èʤÞʦʢàçʢÞçʤʣ äåãçãìʢʦäʤʣ èʥʡäéãäʢ ÒʥʤÞʢçñåãèʤèʥʤéʢãàʡʡ ʦÞðíʢæßàåʦÞãàʢéʢåñʦéÞʧʢéÞèʤåñâʧÞðʦʤäʤßʤ ʥãʦäʡʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣãéʥʢÝʧʢéÝʤåʢʢãçéʢçʦãÞçʤʣ åãèãàʦçãáʡóîʢʣ éʢʥʡèãã àʡáʢ èʥã çʤʥæʡåñçðʨ âçʡìʢçãôʨ ʠʝÑʙʛ ãåã ʠʝ çʢ ÑʔʛʖʦåãáʢʧʥʤÞʢçñÑèʡ èʥʢÞðíʡʢéæßàåãʧèʡëãʢçéʤÞãæʢóéʦôäåãçãìʢʦäãʢ èʥʤôÞåʢçãô ʡéʢʥʤʦäåʢʥʤâʡ éʤ ëʢåʢʦʤʤÝʥʡâçʤ àʤèʤåçãéʢåñçʤ ä ÝʡâʤÞʤʣ éʢʥʡèãã çʡâçʡìãéñ ʦèʢëãêãìʢʦäʧó éʢʥʡèãó çãäʤéãçʤÞʤʣ äãʦåʤéʤʣ ą ßʦʧé ʡÞʦåʧìʡôʨʤìʢçñÞðʦʤäʤʣäʤçëʢçéʥʡëããÑèʡ æßàå ąçʡìʡéñèʥʤÞʢàʢçãʢ ʦèʢëãêãìʢʦäʤʣãææʧçʤʦʤʥÝëãã ʔʚʝʛʓÑÐʞʖÑÙʙØʖÌÐʚʘʓʜʒʖʜØ ʛʥãåʢìʢçããÝʤåñçðʨʦʡéʢʥʤʦäåʢʥʤâʤæ Þʢʥʤôéçʤ ÞʡáçʢʢʧìãéðÞʡéñʦʤʦéʤôçãʢʓʝÌ ʢʢʦéʥʧäéʧʥʧ ʦéʡÝãåñçʤʦéñ ʡçʢʦéʢèʢçñʦʧáʢçãôʡʥéʢʥããʛʥãçʡåãìãã ʦéʡÝãåñçðʨʓʝÌʦèʤʦéʢèʢççðæʥʤʦéʤæÞäåóìʡóéʦôʡàʡèéãÞçðʢâʡîãéçðʢæʢʨʡçãâæð ÞìʡʦéçʤʦéãʥʢæʤàʢåãʥʤÞʡçãʢʦʤʦʧàʡ ʥʤʦéäʤååʡéʢʥʡåʢʣʔéʤáʢÞʥʢæô ʥʡâʥðÞèʤäʥðíäãçʢʦéʡÝãåñçʤʣʓʝÌæʤáʢéèʥãÞʢʦéãäʦʢʥñʢâçðæʤʦåʤáçʢçãôæ ãàʡáʢʦæʢʥéãÝʤåñçʤßʤÐâÞʢʦéçʤ ìéʤÞàʢʦéʡÝãåãâʡëããʓʝÌÞʡáçʧóʥʤåñãßʥʡóé êʡäéʤʥð èʥʤÞʤëãʥʧóîãʢ Þʤʦèʡåʢçãʢ Þ ʦʤʦʧàãʦéʤʣ ʦéʢçäʢ ; = ʒ éʡäãæêʡäéʤʥʡæÞèʢʥÞʧóʤìʢʥʢàñʤéçʤʦôéʦôʝ ʥʢʡäéãÞçðʣÝʢåʤä åãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʡô êʤʦêʤåãèʡâʡ ʓ ãçéʢʥåʢʣäãçð ã ʥôà àʥʧßãʨ Ýãʤåʤßãìʢʦäã ʡäéãÞçðʨÞʢîʢʦéÞ ʝ ʜʖʓʒʞÐʔʙØʗÌʖÑʚʒ ʛʡéʤßʢçʢéãìʢʦäʡô ʥʤåñ ʝ ʥʢʡäéãÞçʤßʤ Ýʢåäʡ ʝʜÌ Þ çʢʦéʡÝãåñçʤʦéã ʓʝÌ ʨʤʥʤíʤ ãâÞʢʦéçʡ ;= ʛʤäʡâʡçʤ ìéʤ Ýʤåʢʢ Þðʦʤäʡô äʤçëʢçéʥʡëãô ʝʜÌ ãæʢʢé éʢʦçʧó äʤʥʥʢåôëãó ʦ çʡåãìãʢæ êãÝʥʤʡéʢʥʤæ ʦ éʤçäʤʣ äʡèʦʧåʤʣ Ðâçʡìʡåñçʤ ʝʜÌʥʡʦʦæʡéʥãÞʡåʦôäʡäæʡʥäʢʥʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʥʤëʢʦʦʡ ʤàçʡäʤèʤâàçʢʢÝðåãèʤåʧìʢçðàʡççðʢ èʤâÞʤåôóîãʢèʥʢàèʤåʤáãéñ ìéʤʝʜÌæʤáʢéãæʢéñ èʥôæʤʢ èʥʤÞʤʦèʡåãéʢåñçʤʢ àʢʣʦéÞãʢ ã ʦèʤʦʤÝʦéÞʤÞʡéñ äʡä àʢʦéʡÝãåãâʡëãã ʓʝÌ éʡäãʢʢʥʤʦéʧʝʥʢàãÞʤâæʤáçðʨòêêʢäéʤÞʝʜÌʡäéãÞʡëãôãèʥãÞåʢìʢçãʢ ëãʥäʧåãʥʧóîãʨ æʤçʤëãéʤÞ èʤàʡÞåʢçãʢ ʡäéãÞçʤʦéã ./ ʦãçéʡâð èʤéʢçëãʥʤÞʡçãʢ òçàʤéʢåãʡåñçʤʣ àãʦêʧçäëãã ãçàʧäëãô èʥʤéʥʤæÝʤéãìʢʦäʤßʤ ʦʤʦéʤôçãô 51 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ èʤÞðíʢçãʢÞðÝʥʤʦʡëãéʤäãçʤÞ ʡäéãÞʡëãôʦãʦéʢæðäʤæèåʢæʢçéʡ ʧìʡʦéãʢÞʥʢæʤàʢåãʥʤÞʡçãã Þçʢäåʢéʤìçʤßʤ æʡéʥãäʦʡ ;= ʔæʢʦéʢ ʦ éʢæ ʥʢâʧåñéʡéð èʤåʧìʢççðʢ Þ òäʦèʢʥãæʢçéʡåñçðʨ ãʦʦåʢàʤÞʡçãôʨ èʥʤʡéʢʥʤßʢççʤßʤ àʢʣʦéÞãô ʝʜÌ èʥʤéãÞʤʥʢìãÞðʚàçʡäʤÞäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãôʨÝðåʤʧÝʢàãéʢåñçʤèʤäʡâʡçʤ ìéʤʝʜÌôÞåôʢéʦôèʥʢàãäéʤʥʤæʥãʦäʡʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣäʡäʧèʥʡäéãìʢʦäãâàʤʥʤÞðʨåãë éʡäãʧèʡëãʢçéʤÞʦʤʦéʢçʤäʡʥàãʢʣ ʚʒʝ èʢʥʢçʢʦʢççðæÐʘ æʢéʡÝʤåãìʢʦäãæʦãçàʥʤæʤæ;=ÒʥʤÞʢçñÞðʦʤäʤìʧÞʦéÞãéʢåñçʤßʤ ʝʜÌ æßå ʦìãéʡʢéʦô çʢâʡÞãʦãæðæ èʥʢàãäéʤʥʤæ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣ ʤÝʧʦåʤÞåʢççðʨ ʡéʢʥʤʦäåʢʥʤâʤæ ã àãäéʧʢé çʡâçʡìʢçãʢ åãèãàäʤʥʥãßãʥʧóîʢʣ éʢʥʡèãã ʦéʡéãçʡæã äʤéʤʥðʢ ʤÝåʡàʡóé èʥʤéãÞʤÞʤʦèʡåãéʢåñçðæàʢʣʦéÞãʢæ ʦçãáʡôäʤçëʢçéʥʡëãóʝʜÌʔæʢʦéʢʦéʢæʢîʢçʢéàʤʦéʡéʤìçʤʡʥßʧæʢçéãʥʤÞʡççðʨàʡççðʨ ìéʤÝðʦìãéʡéñʝʜÌéʢʥʡèʢÞéãìʢʦäʤʣæãíʢçñó ãÞèʤʦåʢàçãʨʜʤʦʦãʣʦäãʨʥʢäʤæʢçàʡëãôʨèʤäʤʥʥʢäëããàãʦåãèãàʢæããʤÝʤâçʡìʡʢéʦôʢßʤáʢåʡʢæðʣʧʥʤÞʢçñæßàå èʥãäʤéʤʥʤæÞʤʦèʡåʢçãʢÞʦʤʦʧàãʦéʤʣ ʦéʢçäʢ ʦäʤʥʢʢÞʦʢßʤ ʤéʦʧéʦéÞʧʢé ÑÐʛʚʛʜʚʞʖÐÍ ʓʝʝʚÓÐÐʜʚʔʓʙʙʓÜʟʚʝʟʚÑÐʛʓÏʓʓ Ñãèʤèʥʤéʢãà ʡʦʦʤëããʥʤÞʡççʡô êʤʦêʤåãèʡâʡ ʓ Ñè ʟÑʓ ãçéʢçʦãÞçʤ ãâʧìʡʢéʦôÞèʤʦåʢàçãʢßʤàðÞäʡìʢʦéÞʢæʡʥäʢʥʡçʢʦéʡÝãåñçʤʦéãʓʝÌ;=ÚéʤéòçâãæʤéçʤʦãéʦôäʦʢæʢʣʦéÞʧêʤʦêʤåãèʡâʓãèʥʤàʧëãʥʧʢéʦôæʤçʤëãéʡæã éʧìçðæã äåʢéäʡæã äåʢéäʡæã ʒʧèêʢʥʡ ã ʞ åãæêʤëãéʡæã ʔ èåʡâæʢ Ñè ʟÑʓ ʦÞôâʡçʤ ʦ Ñʙʛ ʤʦéʡåñçðʢ ą ʦ åãèʤèʥʤéʢãàʡæã Þðʦʤäʤʣ èåʤéçʤʦéã Ñʔʛ ã åãèʤèʥʤéʢãàʡæã ʤìʢçñ çãâäʤʣ èåʤéçʤʦéã Ñʚʙʛ ;= Ñè ʟÑʓ ßãàʥʤåãâʧʢé êʤʦêʤåãèãàðÞʤäÑʙʛ ʥʢʡäëãôʦʤèʥʤÞʤáàʡʢéʦôʤÝʥʡâʤÞʡçãʢæåãâʤêʤʦêʡéãàãåʨʤåãçʡ äʤéʤʥðʣ ôÞåôʢéʦô æʢàãʡéʤʥʤæ Þʤʦèʡåʢçãô ã èʥʤʡéʢʥʤßʢççðæ êʡäéʤʥʤæ;=ÑãâʤêʤʦêʡéãàãåʨʤåãçąʦãåñçðʣʨʢæʤʡééʥʡäéʡçéàåôæʡäʥʤêʡßʤÞ ã ʞ åãæêʤëãéʤÞ ʤç ãçàʧëãʥʧʢé æãßʥʡëãó ʕʘʒ çʡʥʧíʡʢé êʧçäëãó òçàʤéʢåãô ãʦéãæʧåãʥʧʢéòäʦèʥʢʦʦãóæʤåʢäʧåʡàßʢâãããëãéʤäãçʤÞ;= ʔãʦʦåʢàʤÞʡçãôʨçʡäʥʤåãäʡʨãæðíʡʨʦòäʦèʢʥãæʢçéʡåñçðæʡéʢʥʤʦäåʢʥʤâʤæ çʡÝåóàʡåãèʤÞðíʢçãʢäʤçëʢçéʥʡëããÑè ʟÑʓÞèåʡâæʢäʥʤÞããʡäéãÞʡëãóÞʤʦèʡåãéʢåñçʤßʤèʥʤëʢʦʦʡ;ą=ʚèʧÝåãäʤÞʡçʤæçʤáʢʦéÞʤʥʡÝʤé ÞäʤéʤʥðʨʤëʢçãÞʡåʡʦñäʤçëʢçéʥʡëãôÑè ʟÑʓʧÝʤåñçðʨʦʥʡâåãìçðæãʝʝÏʛʥʡäéãìʢʦäãÞʤ Þʦʢʨ ãʦʦåʢàʤÞʡçãôʨ èʤÞðíʢççðʣ ʧʥʤÞʢçñ Ñè ʟÑʓ ʡʦʦʤëããʥʤÞʡåʦô ʦ Þðʦʤäãæ ʥãʦäʤæʦæʢʥéãʤéʝʝÏÚéʡʦÞôâñæʢçôåʡʦñÞâʡÞãʦãæʤʦéãʤéÞʤâʥʡʦéʡãʤʦʤÝʢççʤìʢéäʤèʥʤʦåʢáãÞʡåʡʦñʧèʡëãʢçéʤÞæʤåʤáʢåʢé; =ʓçʡåãâÞâʡãæʤ ʦÞôâãʦʤàʢʥáʡçãôÞäʥʤÞãÑè ʟÑʓʦäʤʥʤçʡʥçðæãʡʤʥéʡåñçðæʡéʢʥʤʦäåʢʥʤâʤæ ʧèʡëãʢçéʡÞãʦʦåʢàʤÞʡçãã$ALLAS(EART3TUDYèʤäʡâʡå ìéʤʧʥʤÞʢçñÑè ʟÑʓ çʤçʢʢʢʡäéãÞçʤʦéñ ÝðåÞðíʢÞçʢâʡÞãʦãæʤʦéãʤéèʤåʡʧèʡëãʢçéʤÞʦäʡåñëãçʤâʤæäʤʥʤçʡʥçðʨʡʥéʢʥãʣÒʥʤÞʢçñãʡäéãÞçʤʦéñÑè ʟÑʓÝðåãÞðíʢʧáʢçîãç ʦʡéʢʥʤʦäåʢʥʤâʤæʡʤʥéð ʧæʧáìãçʧʥʤÞʢçñÑè ʟÑʓʧæʢʥʢççʤʡʦʦʤëããʥʤÞʡåʦô 52 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ ʦäʡåñëãçʤâʤæäʤʥʤçʡʥçðʨʡʥéʢʥãʣʜʢâʧåñéʡéðãʦʦåʢàʤÞʡçãôèʤâÞʤåãåãèʥʢàèʤåʤáãéñ ìéʤÑè ʟÑʓçʢʦéʤåñäʤʦéãæʧåãʥʤÞʡåʡèʥʤëʢʦʦʡéʢʥʤßʢçʢâʡ ʦäʤåñäʤ ʦèʤʦʤÝʦéÞʤÞʡåʡàʢʦéʡÝãåãâʡëããʓʝÌ;= ʛʥʤÞʢàʢçʤ ãʦʦåʢàʤÞʡçãʢ ʦÞôâã äʤçëʢçéʥʡëãã Ñè ʟÑʓ ã ãíʢæãìʢʦäʤßʤ ãçʦʧåñéʡʧèʤáãåðʨáʢçîãçʛʤÞðíʢççʤʢʦʤàʢʥáʡçãʢÑè ʟÑʓʡʦʦʤëããʥʤÞʡåʤʦñ ʦʥãʦäʤæʥʡâÞãéãô ãíʢæãìʢʦäʤßʤ ãçʦʧåñéʡ çʢâʡÞãʦãæʤ ʤé ʧʥʤÞçô ʝʜÌã éʥʡàãëãʤççðʨʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨêʡäéʤʥʤÞʥãʦäʡʛʥãòéʤæÞʢʥʤôéçʤʦéñʥʡâÞãéãô ãíʢæãìʢʦäʤßʤãçʦʧåñéʡÝðåʡæʡäʦãæʡåñçʤʣʧáʢçîãç ãæʢÞíãʨäʡäèʤÞðíʢççðʣ ʧʥʤÞʢçñÑè ʟÑʓ éʡäãèʤÞðíʢççðʣʧʥʤÞʢçñʝʜÌ;= ʔãʦʦåʢàʤÞʡçãã./")3 ))çʡÝåóàʡåãèʡëãʢçéʤÞʦʚʒ#ʔéʢìʢçãʢìʡʦʤÞ ʤé èʤôÞåʢçãô ʦãæèéʤæʤÞ ʧ çãʨ ʤèʥʢàʢåôåã Þ äʥʤÞã ʧʥʤÞʢçñ ÝãʤæʡʥäʢʥʤÞ éʥʤèʤçãçʡ) .4 PRO".0ãÑè ʟÑʓÏʡéʢæÞéʢìʢçãʢèʤʦåʢàʧóîãʨàçʢʣãâʧìʡåã ʦÞôâñʧʥʤÞçʢʣòéãʨÝãʤæʡʥäʢʥʤÞʦʥʡâÞãéãʢæʤʦåʤáçʢçãʣʔʦʢéʥãÝãʤæʡʥäʢʥʡ ʥʡʦʦæʡéʥãÞʡåãʦñ äʡä èʤéʢçëãʡåñçðʢ èʥʢàãäéʤʥð ʥʡâÞãéãô ʝʝʚ ʛʤÞðíʢççʡô äʤçëʢçéʥʡëãô ÞìʝʜÌ çʢ ãæʢåʡ èʥʤßçʤʦéãìʢʦäʤʣ âçʡìãæʤʦéã Ò èʡëãʢçéʤÞ ʦ ʤéʥãëʡéʢåñçðæ éʢʦéʤæ çʡ éʥʤèʤçãç çʤ ʦ èʤÞðíʢççðæã ʧʥʤÞçôæã .4 PRO".0 ãÑè ʟÑʓìʡʦéʤéʡʝʝʚÝðåʡàʤʦéʤÞʢʥçʤÞðíʢ ìʢæʧèʡëãʢçéʤÞʦçʤʥæʡåñçðæã âçʡìʢçãôæãòéãʨèʤäʡâʡéʢåʢʣ;= ʔßʤèʧÝåãäʤÞʡçæʢéʡʡçʡåãâãʦʦåʢàʤÞʡçãʣʦÑè ʟÑʓ;=ʘçʤßʤêʡäéʤʥçðʣʡçʡåãâéʥʡàãëãʤççðʨêʡäéʤʥʤÞʥãʦäʡèʤå Þʤâʥʡʦé äʧʥʢçãʢ ʦãʦéʤåãìʢʦäʤʢ ʓÍ àãʡÝʢé Ðʘʞ ʧʥʤÞçã ʠʝÑʙʛ ʠʝ Ñʔʛ ʝʜÌ èʤäʡâʡå àʤʦéʤÞʢʥçʧó ʦÞôâñæʢáàʧʧʥʤÞçʢæÑè ʟÑʓãʥãʦäʤæʥʡâÞãéãôÐÌʝʚàçʡäʤʥʢâʧåñéʡéðàʥʧßʤßʤäʥʧèçʤßʤãʦʦåʢàʤÞʡçãô"ALLANTYNEETAL çʢÞðôÞãåãäʤʥʥʢåôëããʧʥʤÞçô Ñè ʟÑʓʦʥãʦäʤæʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ âʡãʦäåóìʢçãʢæ åãëʦçãâäãæʧʥʤÞçʢæʠʝÑʙʛ ææʤåñå ʧäʤéʤʥðʨéʡäʡôäʤʥʥʢåôëãôãæʢåʡ æʢʦéʤ;= ʞʡäãæ ʤÝʥʡâʤæ ʧʥʤÞʢçñ Ñè ʟÑʓ èʤâÞʤåôʢé èʤåʧìãéñ àʤèʤåçãéʢåñçʧó ãçêʤʥæʡëãóèʥãʤëʢçäʢʥãʦäʡʝʝʚʚàçʡäʤÞʥʡâåãìçðʨʥʢäʤæʢçàʡëãôʨèʤèʥʤêãåʡäéãäʢʝʝÏçʢʧäʡâðÞʡʢéʦôʤçʢʤÝʨʤàãæʤʦéãʤèʥʢàʢåʢçãôÑè ʟÑʓÞíãʥʤäʤʣ äåãçãìʢʦäʤʣèʥʡäéãäʢãâ âʡæʢéʤàãìʢʦäʤʣʦåʤáçʤʦéãéʢʦéʡãʢßʤÞðʦʤäʤʣʦéʤãæʤʦéãʜʡâʤìʡʥʤÞðÞʡóîãæãʤäʡâʡåãʦñãʥʢâʧåñéʡéðäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãʣ èʤæʢàãäʡæʢçéʤâçʤæʧèʤàʡÞåʢçãóʡäéãÞçʤʦéãÑè ʟÑʓèʥʢèʡʥʡéàʡʥʡèåʡàãÝ ʤáãàʡʢæʤßʤʦçãáʢçãôʝʝʚãʦʦåʢàʤÞʡéʢåãçʢèʤåʧìãåã;= ÐʙʞʖʜÑʖʗʒÐʙØ ÐÑ ą Þʤʦèʡåãéʢåñçðʣ ëãéʤäãç ʦéãæʧåãʥʧóîãʣ ʦʢäʥʢëãó æʡäʥʤêʡßʡæã æʤçʤëãéʡʥçʤßʤ ʨʢæʤʡééʥʡäéʡçéçʤßʤ Ýʢåäʡ -#0 èʥʤåãêʢʥʡëãó ʕʘʒ ã ʡäéãÞçʤʦéñòçàʤéʢåãʡåñçðʨäåʢéʤä ìéʤʦʤèʥʤÞʤáàʡʢéʦôèʤÞðíʢççʤʣòäʦèʥʢʦʦãʢʣ )#!- ;= ʒʥʤæʢ éʤßʤ ÐÑ ʦéãæʧåãʥʧʢé òçàʤéʢåãʡåñçðʢ äåʢéäã ìéʤ èʥãÞʤàãéäèʤÞðíʢççʤʣòäʦèʥʢʦʦãã)#!- çʡãʨèʤÞʢʥʨçʤʦéã;=ʔʓʝÌʤÝçʡʥʧáʢçʤ 53 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ ÞðʦʤäʤʢʦʤàʢʥáʡçãʢÐÑ èʥãòéʤæÞçʢʦéʡÝãåñçðʨʓʝÌʦʤàʢʥáʡçãʢÐÑ Ýðåʤ Þðíʢ ìʢæÞʦéʡÝãåñçðʨ;=ʛʥʤßçʤʦéãìʢʦäʤʢâçʡìʢçãʢèʤÞðíʢççʤʣäʤçëʢçéʥʡëããÐÑ ÝðåʤãâʧìʢçʤÞʥʡâåãìçðʨäåãçãìʢʦäãʨãòèãàʢæãʤåʤßãìʢʦäãʨãʦʦåʢàʤÞʡçãôʨÒèʡëãʢçéʤÞʦçʢʦéʡÝãåñçʤʣʦéʢçʤäʡʥàãʢʣèʤÞðíʢççðʣʧʥʤÞʢçñÐÑ ìʢʥʢâìʡʦʤÞèʤʦåʢèʤʦéʧèåʢçãôʡʦʦʤëããʥʤÞʡåʦôʦèʤÞðíʢççʤʣßʤʦèãéʡåñçʤʣ âʡÝʤåʢÞʡʢæʤʦéñóãʦæʢʥéçʤʦéñó;=ʔãʦʦåʢàʤÞʡçãã&2)3# ))Ýðåʤèʤäʡâʡçʤ ìéʤʧèʡëãʢçéʤÞʦʚʒʝÝʢâèʤàïʢæʡʦʢßæʢçéʡ34ãÞðʦʤäãæʧʥʤÞçʢæÐÑ çʡãåʧìíãʣʥʢâʧåñéʡéàʤʦéãßʡʢéʦôèʥãèʥʤÞʢàʢçããʥʡççʢßʤãçÞʡâãÞçʤßʤÞæʢíʡéʢåñʦéÞʡ çʡäʤʥʤçʡʥçðʨʡʥéʢʥãôʨ;=ʔʥôàʢèʥʤʦèʢäéãÞçðʨãʦʦåʢàʤÞʡçãʣÝðåʤèʤäʡâʡçʤ ìéʤ ãʦʨʤàçðʢ ʧʥʤÞçã ÐÑ ôÞåôóéʦô ʦãåñçðæ èʥʢàãäéʤʥʤæ èʤéʢçëãʡåñçðʨ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʧèʥʡäéãìʢʦäãâàʤʥʤÞðʨåãë; =ʙʢʦæʤéʥô çʡ òéã ʥʢâʧåñéʡéð ʧ ãʦʦåʢàʤÞʡéʢåʢʣ çʢ ʦåʤáãåʤʦñ ʤèʥʢàʢåʢççʤßʤ æçʢçãô ÞʤéçʤíʢçããÞäåóìʢçãôèʤäʡâʡéʢåôÐÑ Þʦãʦéʢæʧʦéʥʡéãêãäʡëããʥãʦäʡ Íʡççðʢ ʤ Þʤâæʤáçʤʦéã ãʦèʤåñâʤÞʡçãô ãçéʢʥåʢʣäãçʡ ÐÑ Þ äʡìʢʦéÞʢ ÝãʤæʡʥäʢʥʡʧèʡëãʢçéʤÞʦÐÌʝéʡäáʢèʥʤéãÞʤʥʢìãÞðʜʢâʧåñéʡéðèʥʤʦèʢäéãÞçʤßʤäåãçãìʢʦäʤßʤãʦʦåʢàʤÞʡçãô èʥʤÞʢàʢççʤßʤʦʧìʡʦéãʢæèʡëãʢçéʤÞʦÐÌʝ èʤäʡâʡåã ìéʤãʦʨʤàçʤèʤÞðíʢççðʣʧʥʤÞʢçñÐÑ ôÞãåʦôçʢâʡÞãʦãæðæèʥʢàãäéʤʥʤæʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣʦæʢʥéãâʡ ßʤàʡçʡÝåóàʢçãôʚàçʡäʤèʥãʤëʢçäʢ ìʢʥʢâ ßʤàʡäʤçëʢçéʥʡëãôÐÑ çʢãæʢåʡèʥʤßçʤʦéãìʢʦäʤßʤâçʡìʢçãô;=ʛʤÞðíʢççðʣʧʥʤÞʢçñÐÑ çʢèʤäʡâʡåʧÝʢàãéʢåñçʤʣèʥʤßçʤʦéãìʢʦäʤʣâçʡìãæʤʦéã Þ ÞʤâçãäçʤÞʢçãã ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʦʤÝðéãʣ ʧ èʥʡäéãìʢʦäã âàʤʥʤÞðʨ åãë èʤàʡççðæàÞʧʨäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãʣ02)-%ã-/.)#!+/2!!UGSBURG; =ʔçʡʦéʤôîʢʢÞʥʢæôÐÑ æʤáçʤʥʡʦʦæʡéʥãÞʡéñÞäʡìʢʦéÞʢàʤèʤåçãéʢåñçʤßʤèʥʢàãäéʤʥʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʧèʡëãʢçéʤÞäʡéʢßʤʥããʧæʢʥʢççʤßʤʥãʦäʡèʤíäʡåʢ3#/2% ÍʜÒʕÐʖÌÐʚʘʓʜʒʖʜØ ÐʦèʤåñâʤÞʡçãʢʧʥʤÞçôæãʢåʤèʢʥʤäʦãàʡâðʘʛʚ äʡäèʥʤßçʤʦéãìʢʦäʤßʤæʡʥäʢʥʡ##ʚÝðåʤèʤäʡâʡçʤʧÝʤåñçðʨʦʚʒʝʔãʦʦåʢàʤÞʡçãã#!0452%C%&AB!NTI 0LATELET4HERAPYIN5NSTABLE2EFRACTORY!NGINA ÞäʤéʤʥʤæʧìʡʦéÞʤÞʡåʤÝʤåñçðʨʦʚʒʝ ÞðʦʤäãʣʧʥʤÞʢçñʘʛʚʦÞãàʢéʢåñʦéÞʤÞʡåʤʥʡâÞãéããʝʝʚ;=ʝʥʢàã èʡëãʢçéʤÞʦÝʤåñóÞßʥʧàçʤʣäåʢéäʢèʤÞðíʢççðʣʧʥʤÞʢçñʘʛʚèʥãèʤʦéʧèåʢçãã ßʤÞʤʥãåÞèʤåñâʧʤʦéʥʤßʤÐʘ;=ʞʢæçʢæʢçʢʢòéãʨàʡççðʨçʢàʤʦéʡéʤìçʤ ìéʤÝð ʤéçʤʦãéñʘʛʚäæʡʥäʢʥʡæâçʡìãæʤßʤʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤßʤʥãʦäʡ ʘʡéʥãäʦçðʢæʢéʡååʤèʥʤéʢãçʡâðÞÞðʦʤäʤʣʦéʢèʢçãòäʦèʥʢʦʦãʥʧóéʦôÞâʤçʡʨʓʝÌ Ýʤßʡéðʨæʡäʥʤêʡßʡæã ʤʦʤÝʢççʤÞèåʢìʢÞʤʣâʤçʢäʡèʦʧåð;= ìéʤæʤáʢéʦèʤʦʤÝʦéÞʤÞʡéñʤʦåʡÝåʢçãóêãÝʥʤâçʤʣäʡèʦʧåðãèʤʦåʢàʧóîʢʣàʢʦéʡÝãåãâʡëãã ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤ àʢêʢäéʡ ʙʢʦäʤåñäʤ èʢʥʢäʥʢʦéçðʨ ãʦʦåʢàʤÞʡçãʣ èʥʤàʢæʤçʦéʥãʥʤÞʡåãâçʡìãéʢåñçʤèʤÞðíʢççðʢäʤçëʢçéʥʡëããʘʘʛʧèʡëãʢçéʤÞ ʦʚʒʝèʤʦʥʡÞçʢçãóʦʤâàʤʥʤÞðæãàʤÝʥʤÞʤåñëʡæã;=ʞʢæçʢæʢçʢʢçʡàʡççðʣ 54 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ æʤæʢçé éʤåñäʤ ʤàçʤ èʥʤʦèʢäéãÞçʤʢ ãʦʦåʢàʤÞʡçãʢ èʥʤÞʢàʢççʤʢ ʦ ʧìʡʦéãʢæ èʡëãʢçéʤÞʦÐÌʝ èʤäʡâʡåʤ ìéʤãʦʨʤàçʤèʤÞðíʢççðʢäʤçëʢçéʥʡëããʘʘʛ ʡʦʦʤëããʥʧóéʦô ʦ ʥãʦäʤæ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦæʢʥéã ;= ʞʡäãæ ʤÝʥʡâʤæ ʘʘʛ çʢʦʤæçʢççʤ ãßʥʡóéÞʡáçʧóʥʤåñÞàʢʦéʡÝãåãâʡëããʓʝÌ ʤàçʡäʤéʥʢÝʧóéʦôàʡåñçʢʣíãʢãʦʦåʢàʤÞʡçãô ìéʤÝðàʤäʡâʡéñãåãʤèʥʤÞʢʥßçʧéñãʨäåãçãìʢʦäʧó èʥãßʤàçʤʦéñÞäʡìʢʦéÞʢʤàçʤßʤãâæʡʥäʢʥʤÞʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤßʤʥãʦäʡ ʞʡÝåãëʡ ÒʥʤÞçãàʤäʡâʡççʤʦéãʤèʥʢàʢåʢçãôèʤäʡâʡéʢåʢʣåãèãàçʤßʤ èʥʤêãåôʧÝʤåñçðʨʦʡéʢʥʤʦäåʢʥʤâʤæ;= ʜʢäʤæʢçàʡëãã ʚʠʝʥʢäʤæʢçàʧʢéʦôàåôʤëʢçäãʤÝîʢßʤʝʝʜèʤíäʡåʢ 3#/2% ʠʝÑʙʛʥʢäʤæʢçàʧʢéʦôÞäʡìʢʦéÞʢʤʦçʤÞçʤßʤ èʤäʡâʡéʢåôåãèãàçʤßʤʤÝæʢçʡèʥãèʥʤÞʢàʢçãã ʦäʥãçãçßʡãèʥãʤëʢçäʢʝʝʜ ʞʕàʡóéàʤèʤåçãéʢåñçʧóãçêʤʥæʡëãóèʥãʤëʢçäʢ ʥãʦäʡʝʝÏ ʠʝÑʔʛôÞåôʢéʦôâçʡìãæðæêʡäéʤʥʤæʥãʦäʡ ãéʥʢÝʧʢéʦôàåôʤëʢçäãʝʝʜ ʠʝçʢ ÑʔʛäʡäʡåñéʢʥçʡéãÞçðʣæʡʥäʢʥʥãʦäʡ ʧèʡëãʢçéʤÞʦʤʦæʢíʡççʤʣßãèʢʥåãèãàʢæãʢʣ ʝÍ ʘʝ ãåãʠÌʛ Ñèʡ ʦåʢàʧʢéʤèʥʢàʢåôéñʧÝʤåñçðʨÞðʦʤäʤßʤʥãʦäʡ ãèʥãçʡåãìããʦʢæʢʣçʤßʤʡçʡæçʢâʡʥʡççʢßʤʥʡâÞãéãô ʝʝÏ ʓèʤʔäʡäʡåñéʢʥçʡéãÞçðʣæʡʥäʢʥʥãʦäʡèʥã ʦæʢíʡççʤʣßãèʢʥåãèãàʢæãã ʝÍ ʘʝãåãʨʥʤçãìʢʦäʤæ âʡÝʤåʢÞʡçããèʤìʢä ʝʤʤéçʤíʢçãʢʡèʤʔʡèʤ!)äʡäʡåñéʢʥçʡéãÞçðʣæʢéʤà ʤëʢçäãʝʝʜèʥãʦäʥãçãçßʢ ʝʤʤéçʤíʢçãʢʠʝçʢ ÑʔʛʠʝÑʔʛæʤáʢéÝðéñ ʥʢäʤæʢçàʤÞʡçʤäʡäʡåñéʢʥçʡéãÞçðʣæʢéʤàʤëʢçäã ʝʝʜèʥãʦäʥãçãçßʢ ʒåʡʦʦ ÒʥʤÞʢçñ àʤäʡâʡççʤʦéã I # I # I # I # ))A # ))A # ))A # ))B # ))B # ʚʠʝąʤÝîãʣʨʤåʢʦéʢʥãç ʝʝʜąʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʣʥãʦä Ñʙʛąåãèʤèʥʤéʢãàðçãâäʤʣèåʤéçʤʦéã ÑʔʛąåãèʤèʥʤéʢãàðÞðʦʤäʤʣèåʤéçʤʦéã ʞʕąéʥãßåãëʢʥãàð ʝʝÏąʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʢâʡÝʤåʢÞʡ çãô ʝÍąʦʡʨʡʥçðʣàãʡÝʢé ʘʝąæʢéʡÝʤåãìʢʦäãʣʦãçàʥʤæ ʠÌʛąʨʥʤçãìʢʦäʡôÝʤåʢâçñèʤìʢä ʔʤâæʤáçʤʦéñãʦèʤåñâʤÞʡçãôèåʡëʢçéʡʥçʤßʤêʡäéʤʥʡʥʤʦéʡ0L'& ÞäʡìʢʦéÞʢ æʡʥäʢʥʡçʢʦéʡÝãåñçʤʣʓʝÌãâʧìʡåʡʦñÞãʦʦåʢàʤÞʡçãã#!0452%;=ÒÝʤåñçðʨ àʤʦéʡÞåʢççðʨ Þ ʤéàʢåʢçãʢ çʢʤéåʤáçʤʣ éʢʥʡèãã ʦ Ýʤåñó Þ ßʥʧàçʤʣ äåʢéäʢ èʤÞðíʢççðʣ ʧʥʤÞʢçñ 0L'& éʡäáʢ ßʤÞʤʥãå ʤ ʥãʦäʢ ʥʡâÞãéãô ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ 55 ÑʡÝʤʥʡéʤʥçʡôàãʡßçʤʦéãäʡ ʦʤÝðéãʣʛʥãʤéʦʧéʦéÞããèʤÞðíʢçãôʧʥʤÞçʢʣéʥʢʨæʡʥäʢʥʤÞéʥʤèʤçãç4 S#$, ã0L'& ʥãʦäÝðåçãâäãʣʒʥʤæʢéʤßʤ èʥãʥʡʦíãʥʢçããèʢʥãʤàʡèʤʦåʢàʧóîʢßʤçʡÝåóàʢçãô Þ ãʦʦåʢàʤÞʡçãã #!0452% ʦ àʤ æʢʦôëʢÞ èʤÞðíʢççʡô äʤçëʢçéʥʡëãô0L'&ʤʦéʡåʡʦñçʢâʡÞãʦãæðæèʥʢàãäéʤʥʤæʦæʢʥéʢåñçʤßʤãʦʨʤàʡâʡÝʤåʢÞʡçãô ;=ʚàçʡäʤ äʡäãÞʤéçʤíʢçããÞðíʢèʢʥʢìãʦåʢççðʨæʡʥäʢʥʤÞÞʤʦèʡåʢçãô ʥʤåñ 0L'&ÞʥʡâÞãéããʡéʢʥʤʦäåʢʥʤâʡéʥʢÝʧʢéàʡåñçʢʣíʢßʤãâʧìʢçãô ʒʤçëʢçéʥʡëãôʥʡʦéÞʤʥãæʤßʤåãßʡçàʡ#$S#$, äʤʥʥʢåãʥʧʢéʦʥʡâæʢʥʡæã åãèãàçʤßʤôàʥʡʓʝÌÚéʤÝðåʤèʥʤàʢæʤçʦéʥãʥʤÞʡçʤÞʥʡÝʤéʢʦãʦèʤåñâʤÞʡçãʢæ ʘʜʞÞðʦʤäʤßʤʥʡâʥʢíʢçãôʧèʡëãʢçéʤÞʦäʡʥʤéãàçʤʣʡéʢʥʤæʤʣ;=ʔãʦʦåʢàʤÞʡçãã#!0452%Ýðåʤèʤäʡâʡçʤ ìéʤèʤÞðíʢçãʢäʤçëʢçéʥʡëããS#$,ʤéæʢìʡʢéʦôʧèʡëãʢçéʤÞʦʚʒʝèʤʦʥʡÞçʢçãóʦÝʤåñçðæãʦʤʦéʡÝãåñçʤʣÐÌʝʛʤÞðíʢçãʢ äʤçëʢçéʥʡëããS#$,ʡʦʦʤëããʥʤÞʡåʤʦñʦèʤÞðíʢççðæʥãʦäʤæêʡéʡåñçðʨãçʢêʡéʡåñçðʨʤʦåʤáçʢçãʣÐÌʝ;=ÓʢåʢʦʤʤÝʥʡâçʤʦéñãʦèʤåñâʤÞʡçãôàʡççʤßʤåãßʡçàʡÞäʡìʢʦéÞʢèʥʢàãäéʤʥʡʝʝʚéʡäáʢéʥʢÝʧʢéàʤèʤåçãéʢåñçðʨãʦʦåʢàʤÞʡçãʣ 56 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ÐʙʝʞʜÒʘʖʙʞʓÑÙʙʓÜÍÐʓʕʙʚʝʞÐʒʓ ʔçʡʦéʤôîʢʢÞʥʢæôãâÞʢʦéçʤ ìéʤÞʢʥʤôéçʤʦéñÞʤâçãäçʤÞʢçãôçʢÝåʡßʤèʥãôéçðʨʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʦʤÝðéãʣßåʡÞçðæʤÝʥʡâʤæʤÝʧʦåʤÞåʢçʡçʡåãìãʢæ çʢʦéʡÝãåñçðʨ ʡéʢʥʤʦäåʢʥʤéãìʢʦäãʨ Ýåôíʢä ʓʝÌ ʚìʢçñ ìʡʦéʤ éʡäãʢ ʓʝÌ ôÞåôóéʦôÝʢʦʦãæèéʤæçðæãàʤéʤßʤæʤæʢçéʡ äʤßàʡʤçãʦéʡçʤÞôéʦôèʥãìãçʤʣãçêʡʥäéʡ æãʤäʡʥàʡ Ðʘ ãåã ãçʦʧåñéʡ éʡä äʡä çʢ ÞðâðÞʡóé ßʢæʤàãçʡæãìʢʦäã âçʡìãæʤßʤ ʦʧáʢçãô èʥʤʦÞʢéʡ ʦʤʦʧàʡ ;= ÒʦéʡçʤÞåʢçʤ ìéʤ çʡãÝʤåʢʢ ʥʡʦèʥʤʦéʥʡçʢççðæʦʧÝʦéʥʡéʤæäʤʥʤçʡʥçʤßʤéʥʤæÝʤâʡôÞåôʢéʦôêãÝʥʤʡéʢʥʤæʡʦéʤçäʤʣ äʡèʦʧåʤʣ ʔ ʤʦçʤÞʢ àãʡßçʤʦéãäã çʢʦéʡÝãåñçʤʣ ʓʝÌ èʥã èʤæʤîã ãçʦéʥʧæʢçéʡåñçðʨæʢéʤàʤÞãʦʦåʢàʤÞʡçãôåʢáʡéèʤèðéäãÞãâʧʡåãâʡëããʨʡʥʡäéʢʥçðʨ ʤʦʤÝʢççʤʦéʢʣéʡäãʨʓʝÌ ʙʢ æʢçʢʢ Þʡáçðæã âʡàʡìʡæã ôÞåôʢéʦô ʤëʢçäʡ ʤÝîʢßʤ ʤÝïʢæʡ ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤ èʤʥʡáʢçãô ʦʤʦʧàʤÞ ʡçßå PLAQUE BURDEN ʡ éʡäáʢ ʤëʢçäʡ ʦéʥʧäéʧʥçʤ êʧçäëãʤçʡåñçʤßʤ ʦʤʦéʤôçãô ʤʥßʡçʤÞ äʥʤÞʤʦçʡÝáʡʢæðʨ ãâæʢçʢççðæã ʡʥéʢʥãôæãʙãáʢèʥãÞʤàôéʦôʤÝîãʢʦÞʢàʢçãôʤÝʤʦçʤÞçðʨãçÞʡâãÞçðʨãçʢãçÞʡâãÞçðʨæʢéʤàʡʨÞãâʧʡåãâʡëããʓʝÌ ʙʖÐʙʔʓÏÐʔʙØʖʘʖʞʚÍØ ÒÑÙʞʜʓÏʔÒʒʚʔØʖʘʖʞʚÍØ ÒåñéʥʡâÞʧäʤÞʤʢ àʧèåʢäʦçʤʢ ʦäʡçãʥʤÞʡçãʢ Ýʥʡʨãʤëʢêʡåñçðʨ ʡʥéʢʥãʣ Íʝ ÌÓʓ èʥãæʢçôóé àåô ÞðôÞåʢçãô ʦʧÝäåãçãìʢʦäʤßʤ ʡéʢʥʤʦäåʢʥʤâʡ ʤëʢçäã ʦéʢèʢçãʦéʢçʤâʡ ʧéʤìçʢçãôʨʡʥʡäéʢʥʡʓʝÌ ʤèʥʢàʢåʢçãôèʤäʡâʡçãʣäéʢʥʡèʢÞéãìʢʦäãæãʨãʥʧʥßãìʢʦäãæÞæʢíʡéʢåñʦéÞʡæ æʤçãéʤʥãʥʤÞʡçãôéʢìʢçãôâʡÝʤåʢÞʡçãô ʒ èʥʢãæʧîʢʦéÞʡæ ʧåñéʥʡâÞʧäʤÞʤßʤ ãʦʦåʢàʤÞʡçãô ʤéçʤʦôéʦô ʤéʦʧéʦéÞãʢ åʧìʢÞʤʣ çʡßʥʧâäã Þʤâæʤáçʤʦéñ ʤʦæʤéʥʡ Þ àãçʡæãäʢ ã Þðʦʤäʡô ãçêʤʥæʡéãÞçʤʦéñ ÐʦèʤåñâʤÞʡçãʢ èʤʥéʡéãÞçðʨ èʥãÝʤʥʤÞ ʦ çʡåãìãʢæ àʤèèåʢʥʤÞʦäʤßʤ ʥʢáãæʡ èʤâÞʤåôʢéèʥʤÞʤàãéñãʦʦåʢàʤÞʡçãʢçʢèʤʦʥʢàʦéÞʢççʤʧèʤʦéʢåãÝʤåñçʤßʤÍʝÌÓʓ ãʦèʤåñâʧʢéʦôäʡäÞèåʡçʤÞʤæèʤʥôàäʢ éʡäãÞòäʦéʥʢççðʨʦåʧìʡôʨʧèʡëãʢçéʤÞ ʦ çʡʥʧíʢçãʢæ æʤâßʤÞʤßʤ äʥʤÞʤʤÝʥʡîʢçãô ;= ʒʤåãìʢʦéÞʢççðʣ ʡçʡåãâ ʓʝÌ Þäåóìʡʢé ʢʢ èʥʤéôáʢççʤʦéñ ã ʦéʢèʢçñ ʦʧáʢçãô èʥʤʦÞʢéʡ ʦʤʦʧàʡ èʥʤëʢçé ʦéʢçʤâʡ ʚèãʦʡçãʢäʡìʢʦéÞʢççðʨʨʡʥʡäéʢʥãʦéãäʓʝÌʤéʥʡáʡʢéʢʢʦéʥʧäéʧʥʧßʤæʤßʢççʡô ßʢéʢʥʤßʢççʡô ʧåñéʥʡâÞʧäʤÞʧó èåʤéçʤʦéñ æôßäʡô ʦʥʢàçʢʣ èåʤéçʤʦéã èåʤéçʡô äʡåñëãçãʥʤÞʡççʡô ʦʤʦéʤôçãʢ èʤÞʢʥʨçʤʦéã ßåʡàäʡô íʢʥʤʨʤÞʡéʡô ãâïôâÞåʢççʡô çʡåãìãʢ ʤʦåʤáçʢçãʣ äʥʤÞʤãâåãôçãʢ çʡåãìãʢ èʥãʦéʢçʤìçʤßʤ éʥʤæÝʡ ʜʡâʥʡÝʤéʡçð ʦãʦéʢæð ʤëʢçäã èʤâÞʤåôóîãʢ ÞðôÞåôéñ çʢʦéʡÝãåñçðʢ 57 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʓʝÌ ʤʥãʢçéãʥʧôʦñçʡòʨʤßʢççʤʦéñãʨʡʥʡäéʢʥäʤçéʧʥʤÞʡéʢʥʤæðʙʡãÝʤåʢʢʤèʡʦçðæãèʥʢàʦéʡÞåôóéʦôßʢéʢʥʤßʢççðʢÝåôíäãʦéʤçäʤʣèʤäʥðíäʤʣ çãâäʤʣòʨʤßʢççʤʦéñóãçʢʥʤÞçðæãäʤçéʧʥʡæã ìéʤæʤáʢéʧäʡâðÞʡéñçʡãâïôâÞåʢçãʢʓʝÌ;= ʝÞʤʢÞʥʢæʢççʡô àãʡßçʤʦéãäʡ èʥã èʤæʤîã àʧèåʢäʦçʤßʤ ʦäʡçãʥʤÞʡçãô èʤâÞʤåôʢé ÞʤÞʥʢæôçʡâçʡìãéñåʢìʢçãʢãʦʧîʢʦéÞʢççʤʦçãâãéñʥãʦäʥʡâÞãéãôãíʢæãìʢʦäʤßʤ ãçʦʧåñéʡ;= ÒåñéʥʡâÞʧäʤÞðʢ ãʦʦåʢàʤÞʡçãô ʦ äʤçéʥʡʦéçðæ ʧʦãåʢçãʢæ ʡçßå #ONTRAST %NHANCED 5LTRA3OUND #%53 ôÞåôóéʦô ʦåʢàʧóîʢʣ ʦéʧèʢçñó Þ ʥʡâÞãéãã æʢéʤàʡ èʥã òéʤæ ãʦʦåʢàʤÞʡçãã èʡëãʢçéʧ ÞÞʤàôé äʤçéʥʡʦéçʤʢ ÞʢîʢʦéÞʤ çʡ ʤʦçʤÞʢ æãäʥʤÞʢâãäʧåãâãçʢʥéçʤßʤßʡâʡÞåãèãàçʤʣãåãʡåñÝʧæãçʤÞʤʣʤÝʤåʤìäʢ æʢçôóîʢʢ ʡäʧʦéãìʢʦäãʢʨʡʥʡäéʢʥãʦéãäãäʥʤÞãʔçʡʦéʤôîʢʢÞʥʢæô#%53ãʦèʤåñâʧʢéʦôÞʤʦçʤÞçʤæàåôÞãâʧʡåãâʡëããæãäʥʤÞʡʦäʧåôʥãâʡëããʓʝÌÞʦʤççðʨʡʥéʢʥãôʨąʤàçʤßʤ ãâèʥãâçʡäʤÞ ʦÞôâʡççʤßʤʦʢʢÞʤâæʤáçðæʥʡâʥðÞʤæ;=ÐæʢóéʦôʤèʥʢàʢåʢççðʢçʡàʢáàðçʡèʤéʢçëãʡåñçðʢÞʤâæʤáçʤʦéãæʢéʤàʡàåôʤëʢçäãʦéʡÝãåñçʤʦéã ãçʢʦéʡÝãåñçʤʦéãʓʝÌ;=Ýåʡßʤàʡʥôéʤæʧ ìéʤæãäʥʤÞʢâãäʧåðâʡàʢʥáãÞʡóéʦô çʡèʤÞʢʥʨçʤʦéãèʤÞʥʢáàʢççʤßʤòçàʤéʢåãôãçʡæʤçʤëãéʡʨ; =ʘãäʥʤÞʢâãäʧåðéʡäáʢæʤßʧéÝðéñʨãæãìʢʦäãʦʤʢàãçʢçðʦåãßʡçàʡæã éʥʤèçðæãä6#!- ãåã ãçéʢßʥãçʡæ ²6³ ã ²³1 ʛʤʦéʢèʢççʤʢ Þçʢàʥʢçãʢ çʤÞðʨ Þʤâæʤáçʤʦéʢʣ #%53 ÞèʥʡäéãäʧèʥãÞʤàãéäèʤÞðíʢçãóʥʤåãʧåñéʥʡâÞʧäʤÞðʨæʢéʤàʤÞÞèʥʤßçʤâʢʝʝʚ ÞðâÞʡççðʨʡéʢʥʤʦäåʢʥʤâʤæ;=ʙʢʦæʤéʥôçʡéʤìéʤæʢéʤàãäʡÞëʢåʤæʤʦéʡʢéʦô ʦʧÝïʢäéãÞçʤʣ èʤôÞåôóéʦô çʤÞðʢ èʥʤßʥʡææçðʢ Þʤâæʤáçʤʦéã àåô ʡÞéʤæʡéãâãʥʤÞʡççʤßʤʥʡʦìʢéʡʧʥʤÞçôãçéʢçʦãÞçʤʦéãʦãßçʡåʡʤéÝåôíäããʢßʤãâæʢçʢçãʣÞʤ Þʥʢæʢçã;= ʘÒÑÙʞÐʝʛÐʜʓÑÙʙʓÜʒʚʘʛÙÛʞʖʜʙʓÜʞʚʘʚʕʜʓʟÐÜ ʒʤæèñóéʢʥçʡô éʤæʤßʥʡêãô ą èʤʦéʤôççʤ ʥʡâÞãÞʡóîãʣʦô æʢéʤà ʥʢçéßʢçʤÞʦäʤʣ àãʡßçʤʦéãäã ʞʤæʤßʥʡêãìʢʦäʤʢ ãâʤÝʥʡáʢçãʢ èʥã ʒʞ ôÞåôʢéʦô äʡʥéʤʣ ʥʡʦèʥʢàʢåʢçãô ʥʢçéßʢçʤÞʦäʤʣ èåʤéçʤʦéã Þ ʥʡæäʡʨ ʤÝïʢäéʡ Þðʥʡáʢççʤßʤ Þ ʦéʡçàʡʥéãâʤÞʡççʤʣ íäʡåʢ ʠʡʧçʦêãåàʡ (5 ʛʤôÞåʢçãʢ æʧåñéãʦèãʥʡåñçʤʣ ʥôàʡ àʢéʢäéʤʥʤÞãÝʤåʢʢ äʤæèñóéʢʥçʤʣéʤæʤßʥʡêããʘʝʒʞ àʡåʤçʤÞðʢÞʤâæʤáçʤʦéã ÞçʢãçÞʡâãÞçʤʣàãʡßçʤʦéãäʢèʤʥʡáʢçãôäʤʥʤçʡʥçʤßʤʥʧʦåʡʝèʤæʤîñóòéʤßʤæʢéʤàʡ æʤáçʤ ÞðôÞåôéñ çʢäʤéʤʥðʢ æʤʥêʤåʤßãìʢʦäãʢ èʥãâçʡäã àʢʦéʡÝãåãâʡëãã ʓʝÌ Þ ìʡʦéçʤʦéã Ýʤåñíʤʣ ʥʡâæʢʥ ʤÝïʢæ ʓʝÌ äʤʥʤçʡʥçðʣ éʥʤæÝʤâ ;= èʥãâçʡäããâïôâÞåʢçãô àãʦʦʢäëããʡʥéʢʥãã çʡàʥðÞʡãçéãæðçʡʧʥʤÞçʢʓʝÌ ÞäåóìʢçãôæãäʥʤäʡåñëãçʡéʤÞÞʦéʥʧäéʧʥʧʓʝÌ;=ãåãáʢ çʡʤÝʤʥʤé Þãâʧʡåãâʡëãó ʓʝÌʦçãâäʤʣèåʤéçʤʦéñó(5 äʤʦÞʢççʤʧäʡâðÞʡóîʧóçʡçʡåãìãʢåãèãàçʤßʤ ôàʥʡ; = ʘʝʒʞ ʡçßãʤßʥʡêãôʦÞÞʢàʢçãʢæäʤçéʥʡʦéçʤßʤèʥʢèʡʥʡéʡèʤâÞʤåôʢéʥʡâåãìʡéñ ʤʦçʤÞçðʢéãèðʓʝÌÞäʤʥʤçʡʥçðʨʡʥéʢʥãôʨʙʢäʡåñëãçãʥʤÞʡççðʢʓʝÌʦʤàʢʥáʡé òåʢæʢçéð Ýʤåʢʢ çãâäʤʣ èåʤéçʤʦéã ã çʢ ʦʤàʢʥáʡé Þãàãæðʨ ʤéåʤáʢçãʣ äʡåñëãô 58 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʝæʢíʡççðʢʓʝÌʦʤàʢʥáʡééʤìʢìçðʢÞäåóìʢçãôäʡåñëãçʡéʤÞʒʡåñëãçãʥʤÞʡççðʢ ʓʝÌ ʨʡʥʡäéʢʥãâʧóéʦô æʡʦʦãÞçðæã Þäåóìʢçãôæã äʡåñëãçʡéʤÞ ã ʤèʥʢàʢåôóéʦô äʡäʦéʥʧäéʧʥðʦÝʤåʢʢÞðʦʤäʤʣèåʤéçʤʦéñóèʤʦʥʡÞçʢçãóʦäʤçéʥʡʦéãʥʤÞʡççðæ èʥʤʦÞʢéʤæ äʤʥʤçʡʥçʤʣ ʡʥéʢʥãã ;= ʘʝʒʞ èʤâÞʤåôʢé ʤÝçʡʥʧáãÞʡéñ çʢäʡåñëãçãʥʤÞʡççðʢʓʝÌÞʦåʧìʡʢÞãâÞʦʢʨ äʤéʤʥðʢÝðåãʤÝçʡʥʧáʢçðèʥãèʤæʤîã ÞçʧéʥãʦʤʦʧàãʦéʤßʤʧåñéʥʡâÞʧäʤÞʤßʤãʦʦåʢàʤÞʡçãôʔʝÒÏÐ ʦæʢíʡççðʢąÞ äʡåñëãçãʥʤÞʡççðʢąÞ;= ʔçʡʦéʤôîʢʢÞʥʢæôèʥãʘʝʒʞçʢʧàʡʢéʦôàʤʦéʤÞʢʥçʤÞðôÞãéñêãÝʥʤʡéʢʥʤæð ʦéʤçäʤʣäʡèʦʧåʤʣʟʓʞʒ éʡääʡäʧæʢéʤàãäãçʢàʤʦéʡéʤìçʤʢèʥʤʦéʥʡçʦéÞʢççʤʢ ʥʡâʥʢíʢçãʢèʤʥôàäʡ ą ææ àåôʤèʥʢàʢåʢçãôéʤåîãçðêãÝʥʤâçʤʣèʤäʥðíäãʛʤòéʤʣáʢèʥãìãçʢçãʤàãçãâèʤäʡâʡéʢåʢʣʘʝʒʞçʢèʤâÞʤåôʢéìʢéäʤʤéåãìãéñ èʤʥʡáʢçãôʦçʢèʤÞʥʢáàʢççʤʣèʤäʥðíäʤʣʧÝʤåñçðʨʚʒʝʤéèʤʥʡáʢçãʣʧÝʤåñçðʨ ʦéʡÝãåñçʤʣʦéʢçʤäʡʥàãʢʣʚàçʡäʤʤçʡåãìããʟʓʞʒæʤáçʤäʤʦÞʢççʤʦʧàãéñèʤçʡåãìãó iʦÞʢéôîʢßʤʦô äʤåñëʡx Þ èʤèʢʥʢìçʤæ ʦʢìʢçãã äʤéʤʥʤʢ Þãâʧʡåãâãʥʧʢéʦô èʥã èʥʢʤÝåʡàʡçãã åãèãàçʤßʤ äʤæèʤçʢçéʡ Þ ʦéʥʧäéʧʥʢ ʓʝÌ èʥʤôÞåʢçãôʨ ʡçßãʤßʢçʢâʡãçʡåãìããæãäʥʤäʡåñëãçʡéʤÞ;=ÍʡåñçʢʣíʢʢʧåʧìíʢçãʢÞãâʧʡåãâʡëãã äʤæèʤçʢçéʤÞʓʝÌʦÞôâʡçʤʦʥʡâʥʡÝʤéäʤʣäʤçéʥʡʦéçðʨÞʢîʢʦéÞʦãʦèʤåñâʤÞʡçãʢæ çʡçʤìʡʦéãë;= ÍʡççðʢʘʝʒʞãʔʝÒÏÐäʡʦʡéʢåñçʤʤèʥʢàʢåʢçãôʤÝïʢæʡʓʝÌãæʢóéÞðʦʤäʧó ʦéʢèʢçñ äʤʥʥʢåôëãã ʚàçʡäʤ èʤ çʢäʤéʤʥðæ àʡççðæ èʥã ãʦèʤåñâʤÞʡçãã ʘʝʒʞ ʤÝîãʣʤÝïʢæʓʝÌèʢʥʢʤëʢçãÞʡʢéʦôÞʦʥʢàçʢæçʡææ èʥãòéʤæʤÝïʢæçʢäʡåñëãçãʥʤÞʡççðʨʓʝÌʤÝðìçʤçʢàʤʤëʢçãÞʡʢéʦô ʡäʡåñëãçãʥʤÞʡççðʨąèʢʥʢʤëʢçãÞʡʢéʦô;= ʒåãçãìʢʦäãʢ ãʦʦåʢàʤÞʡçãô èʤ Þãâʧʡåãâʡëãã ʓʝÌ ʦ èʤæʤîñó ʘʝʒʞ èʤäʡâʡåãʥʢâʧåñéʡéð ʡçʡåʤßãìçðʢʔʝÒÏÐʞʡä ʓʝÌʦèʥãâçʡäʡæãèʤåʤáãéʢåñçʤßʤʥʢæʤàʢåãʥʤÞʡçãôèʥʢÞðíʢçãʢàãʡæʢéʥʡʦʤʦʧàʡÞʤÝåʡʦéãʓʝÌÝʤåʢʢìʢæçʡ èʤʦʥʡÞçʢçãóʦàãʡæʢéʥʤæãçéʡäéçʤßʤʦʤʦʧàʡ ʦçãâäʤʣèåʤéçʤʦéñó çʡåãìãʢæ éʤìʢìçðʨ ææ äʡåñëãçʡéʤÞ àʤʦéʤÞʢʥçʤ ìʡîʢ ʤèʥʢàʢåôåãʦñ ʧ Ýʤåñçðʨ ʚʒʝ ÞéʤÞʥʢæôäʡäʧèʡëãʢçéʤÞʦʤʦéʡÝãåñçʤʣÐÌʝìʡîʢʤèʥʢàʢåôåãʦñʓʝÌʦäʡåñëãçʡéʡæãÝʤåʢʢäʥʧèçʤßʤʥʡâæʢʥʡ; = ʙʢʦæʤéʥô çʡ ʤßʥʡçãìʢçãô æʢéʤàʡ ʘʝʒʞ ʦÞôâʡççðʢ Þ éʤæ ìãʦåʢ ʦ çʢàʤʦéʡéʤìçʤ Þðʦʤäʤʣ ʥʡâʥʢíʡóîʢʣ ʦèʤʦʤÝçʤʦéñó ʢßʤ ëʢççʤʦéñ âʡäåóìʡʢéʦô Þ èʥʢàʤʦéʡÞåʢçããàʤʦéʡéʤìçʤʣãçêʤʥæʡëããàåôʦéʥʡéãêãäʡëããʥãʦäʡçʡʤʦçʤÞʡçãã ÞðôÞåʢççðʨãâæʢçʢçãʣʜôààʤʦéʡéʤìçʤäʥʧèçðʨèʥʤʦèʢäéãÞçðʨãʦʦåʢàʤÞʡçãʣ ʧäʡâðÞʡʢé çʡ éʤ ìéʤ Þðíʢʧäʡâʡççðʢ ʒʞ èʥãâçʡäã çʢʦéʡÝãåñçʤʣ ʓʝÌ Þ ʥʡâåãìçðʨ äʤæÝãçʡëãôʨ ôÞåôóéʦô àʤʦéʤÞʢʥçðæ èʥʢàãäéʤʥʤæ äʡʥàãʡåñçðʨ ʤʦåʤáçʢçãʣäʡäʧèʡëãʢçéʤÞʦʤʦéʡÝãåñçʤʣÐÌʝ éʡäãʧèʡëãʢçéʤÞʦÝʢʦʦãæèéʤæçðæ ʡéʢʥʤʦäåʢʥʤâʤæʒʓ; =ʒʥʤæʢéʤßʤ ʘʝʒʞæʤáʢéʤäʡâʡéñʦôèʤåʢâçʤʣ èʥã ÞðôÞåʢçãã Ýʤåñçðʨ ʦ Þðʦʤäãæ ʥãʦäʤæ èʤÞéʤʥçðʨ ãíʢæãìʢʦäãʨ ʤʦåʤáçʢçãʣ èʤʦåʢ èʢʥʢçʢʦʢççʤßʤ ʚʒʝ Ýʢâ èʤàïʢæʡ 3ʞ âʡ ʦìʢé ãâæʢʥʢçãô ʤÝîʢßʤ ìãʦåʡ 59 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ çʢäʡåñëãçãʥʤÞʡççðʨʓʝÌ äʤéʤʥðʢ ÞʤéåãìãʢʤéäʡåñëãçãʥʤÞʡççðʨ ʡʦʦʤëããʥʧóéʦôʦçʢÝåʡßʤèʥãôéçðæèʥʤßçʤâʤæÍʥʧßãæãʘʝʒʞ èʥʢàãäéʤʥʡæãäʡʥàãʡåñçðʨ ʤʦåʤáçʢçãʣ ôÞåôóéʦô ʤÝîãʣ ʤÝïʢæ çʢʤÝʦéʥʧäéãÞçðʨ ʓʝÌ ã ìãʦåʤ ʦʢßæʢçéʤÞ ʦçʢʤÝʦéʥʧäéãÞçðæãèʤʥʡáʢçãôæã;= ʘʓʕʙÐʞʙʚ ʜʖÏʚʙʓʙʝʙʓÜʞʚʘʚʕʜʓʟÐÜ ʘʡßçãéçʤ ʥʢâʤçʡçʦçʡôéʤæʤßʥʡêãôʘʜʞ ôÞåôʢéʦôÝʢâʤèʡʦçʤʣçʢãçÞʡâãÞçʤʣ æʢéʤàãäʤʣ çʢ àʡóîʢʣ åʧìʢÞʤʣ çʡßʥʧâäã çʡ èʡëãʢçéʡ çʢ éʥʢÝʧóîʢʣ ÞÞʢàʢçãô çʢêʥʤéʤäʦãìçðʨ äʤçéʥʡʦéçðʨ èʥʢèʡʥʡéʤÞ ʘʢéʤàãäʡ ʤÝåʡàʡʢé Þðʦʤäãæ èʥʤʦéʥʡçʦéÞʢççðæ ʥʡâʥʢíʢçãʢæ ã èʤâÞʤåôʢé àʢéʡåñçʤ ÞãâʧʡåãâãʥʤÞʡéñ æôßäãʢ éäʡçãʛʤéʢçëãʡåñçðʢÞʤâæʤáçʤʦéãʘʜʞÞÞãâʧʡåãâʡëããʓʝÌÞäʤʥʤçʡʥçðʨʡʥéʢʥãôʨÝðåãèʤäʡâʡçðʢîʢÞçʡìʡåʢ ʨßß;=ʘʜʞèʤâÞʤåãåʡÞãâʧʡåãâãʥʤÞʡéñʦéʢçäãʒʓãʧʦéʡçʤÞãéñ ìéʤʧÝʤåñçðʨÐÌʝãʨéʤåîãçʡÞðíʢèʥãʦʤʨʥʡçʢçãã ʤÝðìçʤßʤèʥʤʦÞʢéʡ;ą=ʚàçʡäʤʦéʢʨèʤʥãàʤçʡʦéʤôîʢßʤÞʥʢæʢçãÞãâʧʡåãâʡëãôãâæʢçʢçãʣÞʒʓèʥãʘʜʞʤʦéʡʢéʦôéʥʧàçʤʣâʡàʡìʢʣÞʦÞôâãʦãʨæʡåðæ àãʡæʢéʥʤæ ãâÞãåãʦéðæ ʨʤàʤæ éʢʦçʤʣ ʡçʡéʤæãìʢʦäʤʣ ʦÞôâñó ʦ äʤʥʤçʡʥçðæã Þʢçʡæããʦʢʥàëʢæ ʡʥéʢêʡäéʡæã ʦÞôâʡççðæãʦʦʤäʥʡîʢçãôæãʦʢʥàëʡãàðʨʡçãʢæʔéʤáʢÞʥʢæôèʥãʘʜʞʧàʡʢéʦôÞðôÞåôéñçʢʦéʡÝãåñçðʢʓʝÌÞÝʤåʢʢäʥʧèçðʨ ãæʢçʢʢèʤàÞãáçðʨʡʥéʢʥãôʨ ÞìʡʦéçʤʦéãÞʦʤççðʨ;= ÍãêêʢʥʢçëãʥʤÞäʡ äʤæèʤçʢçéʤÞ ʓʝÌ çʢäʥʤéãìʢʦäʤßʤ ôàʥʡ êãÝʥʤâçʤʣ èʤäʥðíäã Þʤʦèʡåãéʢåñçʤßʤãçêãåñéʥʡéʡ äʥʤÞʤãâåãôçãʣ ʤʦʧîʢʦéÞåôʢéʦôâʡʦìʢé ãʨʥʡâåãìçʤßʤʨãæãìʢʦäʤßʤʦʤʦéʡÞʡ ʦʤàʢʥáʡçãôÞʤàð æʤåʢäʧåôʥçʤßʤàÞãáʢçãô àãêêʧâãã;ą=ʘʜʞéʡäáʢèʤâÞʤåôʢéÞãâʧʡåãâãʥʤÞʡéñéʥʤæÝ ʤëʢçãéñʢßʤ ʥʡâæʢʥðãʥʡʦèʤåʤáʢçãʢ; =ʙʢʦæʤéʥôçʡʤßʥʡçãìʢççðʢÞʤâæʤáçʤʦéãʘʜʞ ÞʤëʢçäʢʦéʥʧäéʧʥðʓʝÌÞʒʓ æʢéʤàãäʡèʤʦéʤôççʤʥʡâÞãÞʡʢéʦôÐæʢóéʦôʦʥʡÞçãéʢåñçðʢàʡççðʢʔʝÒÏÐãʘʜʞ ʧäʡâðÞʡóîãʢçʡéʤ ìéʤèʥãʘʜʞʢʦéñÞʤâæʤáçʤʦéñàʤʦéʤÞʢʥçʤʤëʢçãéñèåʤîʡàãèʤèʢʥʢìçʤßʤʦʢìʢçãôʒʓãʢʢèʥʤʦÞʢéʡ ʤàçʡäʤèʥãʦʧéʦéÞʧóéʥʡʦʨʤáàʢçãôÞãâæʢʥʢçãôʨéʤåîãçðʦéʢçäãʡʥéʢʥãã; = ʙʢÝåʡßʤèʥãôéçðæʘʜ èʥãâçʡäʤæèʤéʢçëãʡåñçðʨʤʦåʤáçʢçãʣôÞåôʢéʦôÞðʦʤäʤʢ ʤéçʤíʢçãʢãçéʢçʦãÞçʤʦéãʓʝÌæãʤäʡʥàçʡ4 ÞâÞʢíʢççðʨãâʤÝʥʡáʢçãôʨ;= ʙʡãÝʤåʢʢèʢʥʦèʢäéãÞçðæÞʡʥãʡçéʤæʘʜʞÞʤëʢçäʢʦéʥʧäéʧʥäʤʥʤçʡʥçðʨʡʥéʢʥãʣôÞåôʢéʦôæʡßçãéçʤ ʥʢâʤçʡçʦçʡôʡçßãʤßʥʡêãôʘʜʓ ʘʢéʤàʤʦçʤÞʡççʡʤéåãìãã ʦãßçʡåʡ èʤàÞãáçʤʣ éäʡçã äʥʤÞã ʤé ʤäʥʧáʡóîãʨ çʢèʤàÞãáçðʨ éäʡçʢʣ ʔ òéʤæ ʥʢáãæʢ äʥʤÞñ ôÞåôʢéʦô ʢʦéʢʦéÞʢççðæ äʤçéʥʡʦéãʥʧóîãæ ÞʢîʢʦéÞʤæ ìéʤ èʤâÞʤåôʢé èʤåʧìʡéñ ãâʤÝʥʡáʢçãô ʦʤʦʧàʤÞ Ýʢâ äʡäãʨ åãÝʤ àʤèʤåçãéʢåñçðʨ ãçïʢäëãʣ ʛʥãæʢçʢçãʢ èʡʥʡæʡßçãéçðʨ äʤçéʥʡʦéãʥʧóîãʨ ÞʢîʢʦéÞ ÞðÞʤàãé òéʧ æʢéʤàãäʧ çʡ çʤÞðʣ ʧʥʤÞʢçñ ʙʡãÝʤåʢʢ ìʡʦéʤ ÞÞʤàôéʦô ʦʤʢàãçʢçãô ßʡàʤåãçãô ìéʤ èʤÞðíʡʢé àãʡßçʤʦéãìʢʦäʧó éʤìçʤʦéñ ʤëʢçäã ʦéʢçʤâãʥʧóîʢßʤ èʤʥʡáʢçãô äʤʥʤçʡʥçʤßʤ ʥʧʦåʡ ʡ éʡäáʢ àʡʢé Þʤâæʤáçʤʦéñ Þãâʧʡåãâʡëãã ʥʢæʤàʢåãʥʤÞʡçãô ʦʤʦʧàãʦéʤʣ ʦéʢçäã ; = ʛʥã ʤéʦʥʤìʢççʤæ ãʦʦåʢàʤÞʡçãã ʧ èʡëãʢçéʤÞ 60 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʦʧʦéʡçʤÞåʢççʤʣÐÌʝßʡàʤåãçãʣæʤáʢéâʡàʢʥáãÞʡéñʦôÞʤÝåʡʦéãâçʡìãæʤßʤʦéʢçʤâʡʒʓ; = ÍʥʧßʤʣäåʡʦʦäʤçéʥʡʦéãʥʧóîãʨÞʢîʢʦéÞàåôʘʜʞʦʤàʢʥáãéʦʧèʢʥèʡʥʡæʡßçãéçðʢçʡçʤìʡʦéãëðçʡʤʦçʤÞʢʤäãʦãáʢåʢâʡ30)/ ʚçãèʤßåʤîʡóéʦôæʡäʥʤêʡßʡæã ìéʤ èʤâÞʤåôʢé ÞãâʧʡåãâãʥʤÞʡéñ âʤçð Þʤʦèʡåʢçãô Þ çʢʦéʡÝãåñçðʨ ʓʝÌ ʔ òäʦèʢʥãæʢçéʡåñçðʨ ʥʡÝʤéʡʨ èʤäʡâʡçð Þʤâæʤáçʤʦéã æʢéäã ʦʧèʢʥèʡʥʡæʡßçãéçðæã çʡçʤìʡʦéãëʡæãʥʡâåãìçðʨʨãæãìʢʦäãʨÞʢîʢʦéÞ ʧìʡʦéÞʧóîãʨÞÝãʤʨãæãìʢʦäãʨ èʥʤëʢʦʦʡʨʓʝÌ Þìʡʦéçʤʦéã²6³ ãçéʢßʥãçʡ )#!- 6#!- ;ą= ʜʓÍÐʚʙÒʒÑÐÍʙʓÜÍÐʓʕʙʚʝʞÐʒʓ ʘʢéʤàðʥʡàãʤçʧäåãàçʤʣàãʡßçʤʦéãäãąʤàçʤêʤéʤççʡôʚÚʒʞ ãèʤâãéʥʤççʡô ʛÚʞ òæãʦʦãʤççʡô éʤæʤßʥʡêãô ą ʥʡʦèʤåʡßʡóé èʥãçëãèãʡåñçʤ ãçðæ èʤàʨʤàʤæ äÞãâʧʡåãâʡëããʚçâʡäåóìʡʢéʦôÞæʢéäʢʥʡâåãìçðʨÝãʤåʤßãìʢʦäãʡäéãÞçðʨÞʢîʢʦéÞ ʥʡàãʤçʧäåãàʤæ ʦ èʤʦåʢàʧóîʢʣ Þãâʧʡåãâʡëãʢʣ ʥʡʦèʥʢàʢåʢçãô àʡççʤßʤ ÞʢîʢʦéÞʡʥʡàãʤêʡʥæèʥʢèʡʥʡéʡ ʜʟʛ ÞʤʥßʡçãâæʢÌåʡßʤàʡʥôʧçãÞʢʥʦʡåñçʤʦéã éʡäʤßʤèʤàʨʤàʡãèʤʦéʤôççʤʥʡʦéʧîãæÞʤâæʤáçʤʦéôæʥʡàãʤʨãæãìʢʦäʤßʤʦãçéʢâʡãʤÝʢʦèʢìãÞʡʢéʦôÞðʦʤäãʣèʤéʢçëãʡåæʢéʤàʤÞʥʡàãʤçʧäåãàçʤʣàãʡßçʤʦéãäã ʕåʡÞçðæèʥʢãæʧîʢʦéÞʤæʥʡàãʤçʧäåãàçʤʣÞãâʧʡåãâʡëããôÞåôʢéʦôÞʤâæʤáçʤʦéñ ʤëʢçãéñ èʢʥêʧâãó êʧçäëãó æʢéʡÝʤåãâæ ʤʥßʡçʤÞ ãåã éäʡçʢʣ çʡ äåʢéʤìçʤæ ãæʤåʢäʧåôʥçʤæʧʥʤÞçʢ ʛʥʢáàʢ Þʦʢßʤ çʢʤÝʨʤàãæʤ ʤéæʢéãéñ ʥʤåñ ʚÚʒʞ ã ʛÚʞ Þ Þãâʧʡåãâʡëãã äåʢéʤìçʤʣ èʢʥêʧâãã ʤʥßʡçʤÞ æãíʢçʢʣ äʥʤÞʤʦçʡÝáʡʢæðʨ ʡéʢʥʤʦäåʢʥʤéãìʢʦäã èʤʥʡáʢççðæã ʡʥéʢʥãôæã Þ ìʡʦéçʤʦéã æãʤäʡʥàʡ ; = ʜʡàãʤçʧäåãàçðʢ èʢʥêʧâãʤççðʢãʦʦåʢàʤÞʡçãôæãʤäʡʥàʡèʤâÞʤåôóéÞðôÞãéñèʤÞʥʢáàʢçãôäʡʥàãʤæãʤëãéʤÞ ÞðâÞʡççðʢçʢéʤåñäʤʦçãáʢçãʢæäʥʤÞʤéʤäʡÞʦéʢçʤâãʥʤÞʡççʤʣäʤʥʤçʡʥçʤʣʡʥéʢʥããʒʓ çʤã ìéʤçʢæʢçʢʢÞʡáçʤ èʥãòçàʤéʢåãʡåñçʤʣàãʦêʧçäëãã æãäʥʤëãʥäʧåôéʤʥçðʨçʡʥʧíʢçãôʨäʤʥʤçʡʥçʤßʤʥʧʦåʡèʥããçéʡäéçðʨʒʓ èʤàʡççðæʒʓʕ ʡéʡäáʢèʥãàãêêʧâçʤæʡéʢʥʤʦäåʢʥʤâʢ ʡʥéʢʥãʡåñçʤʣßãèʢʥéʢçâãã çʢäʤʥʤçʡʥʤßʢççʤʣèʡéʤåʤßãã; =ʛʥãòéʤæÞʤâæʤáçʤʦéãʚÚʒʞãʛÚʞÞäåóìʡóéÞãâʧʡåãâʡëãóÞʦʢßʤʦèʢäéʥʡáãâçʢʦèʤʦʤÝçʤʦéãæãʤäʡʥàʡ éʤʢʦéñçʢéʤåñäʤ çʢʤÝʥʡéãæðʨ ãâæʢçʢçãʣ ʛÐʒʝ êãÝʥʤâ çʤ ã èʥʢʨʤàôîʢʣ ãíʢæãã èʥʤëʢʦʦʤÞ ßãÝʢʥçʡëãã ã ʤßåʧíʢçãô æãʤäʡʥàʡ ìéʤ äʥʡʣçʢ Þʡáçʤ àåô èʥʢàʦäʡâʡçãô èʤéʢçëãʡåñçʤßʤòêêʢäéʡʤéʥʢÞʡʦäʧåôʥãâʡëããʦéʢçʤâãʥʤÞʡççʤßʤãåãʤääåóâãʥʤÞʡççʤßʤʦʤʦʧàʡ; =ʛʥãèʢʥêʧâãʤççʤʣʚÚʒʞãʦèʤåñâʧóéʦôåãßʡçàð æʢìʢççðʢ éʢʨçʢëãʢæ MʘÐÌÐ éʢéʥʤêʤʦæãç ãàåôʤëʢçäãáãâçʢʦèʤʦʤÝçʤʦéãæãʤäʡʥàʡ èʥʤÞʤàãéʦôʦʤèʤʦéʡÞåʢçãʢæʢáàʧçʡʥʧíʢçãôæãèʢʥêʧâãããåʤäʡåñçʤʣʦʤäʥʡéãæʤʦéã æãʤäʡʥàʡ åʢÞʤßʤ áʢåʧàʤìäʡ ÑÎ ;= ʔʤâæʤáçʤʦéã çʤÞðʨ éʤæʤßʥʡêʤÞ ʦ ʒʞ äʤʥʥʢäëãʢʣ èʤßåʤîʢçãô ã ʦʤÞʥʢæʢççðæ èʥʤßʥʡææçðæ ʤÝʢʦèʢìʢçãʢæ èʥãÞʢåã ä âçʡìãéʢåñçʤæʧ ʧÞʢåãìʢçãó äʡìʢʦéÞʡ ãâʤÝʥʡáʢçãʣ ʦ Þãâʧʡåãâʡëãʢʣ Þʦʢ Ýʤåʢʢéʤçäãʨçʡʥʧíʢçãʣèʢʥêʧâãã;ą= 61 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ Ïʤåʤéðæ ʦéʡçàʡʥéʤæ Þ àãʡßçʤʦéãäʢ áãâçʢʦèʤʦʤÝçʤßʤ æãʤäʡʥàʡ ʦìãéʡʢéʦô èʥʤÞʢàʢçãʢʛÚʞʦàÞʧæôʥʡâåãìçðæãʜʟʛ ʤàãçãâäʤéʤʥðʨʤéʥʡáʡʢéäåʢéʤìçʧó èʢʥêʧâãó.( 2B ʨåʤʥãà (2ʚ ʡàʥʧßʤʣąèʤéʥʢÝåʢçãʢæãʤäʡʥàʤæßåóäʤâð& ʟÍʕ äʤéʤʥʤʢÞʧʦåʤÞãôʨʤÝʥʡéãæʤʣãíʢæããæʤáʢéÝðéñʦʤʨʥʡççðæãåã àʡáʢèʤÞðíʢççðæ ʙʢʦæʤéʥôçʡéʤìéʤʚÚʒʞôÞåôʢéʦôÝʤåʢʢàʤʦéʧèçðææʢéʤàʤæàåôʥʧéãççʤʣ äåãçãìʢʦäʤʣèʥʡäéãäã ÞʤâæʤáçʤʦéãʛÚʞÞëʢåʤæÞðíʢ ìʢæʚÚʒʞÚéʤʦÞôâʡçʤ ʦéʢæ ìéʤàåôʛÚʞãʦèʤåñâʧóéʦôèʤâãéʥʤç ãâåʧìʡóîãʢãâʤéʤèðêéʤʥʡ ʧßåʢʥʤàʡ ʡâʤéʡãäãʦåʤʥʤàʡ éʤʢʦéñòåʢæʢçéʤÞ äʤéʤʥðʢʢʦéʢʦéÞʢççðæʤÝʥʡâʤæÞʦéʧèʡóéÞʨãæãìʢʦäãʢʥʢʡäëããʦʤæçʤßãæãåãßʡçàʡæãʦʤÝʥʡâʤÞʡçãʢæäʤÞʡåʢçéçðʨ ʦÞôâʢʣʔéʤáʢÞʥʢæôòåʢæʢçéð ãâʤéʤèðäʤéʤʥðʨçʢèʤʦʥʢàʦéÞʢççʤãʦèʧʦäʡóé ßʡææʡ ãâåʧìʢçãʢããʦèʤåñâʧóéʦôàåôʚÚʒʞ èʥʢàʦéʡÞåôóéʦʤÝʤʣæʢéʡååðãßʡåʤßʢçð éʢʨçʢëãʣ ʣʤà ãçàãʣ éʡååãʣ ã æʢéäʡ ʨãæãìʢʦäãʨ ʦʤʢàãçʢçãʣ éʡäãæã òåʢæʢçéʡæãÝʤåʢʢʦåʤáçʡʔʥʢâʧåñéʡéʢçʡÝʤʥʜʟʛ èʥãæʢçôʢæðʨàåôʚÚʒʞ Þçʡʦéʤôîʢʢ Þʥʢæô ʤéçʤʦãéʢåñçʤ ʦäʥʤæʢç ʔ ìʡʦéçʤʦéã èʤæãæʤ ʤëʢçäã èʢʥêʧâãã æãʤäʡʥàʡ ÞʡáçʡÞãâʧʡåãâʡëãôãäʤåãìʢʦéÞʢççʡôʤëʢçäʡʤÝæʢçʡáãʥçðʨäãʦåʤé èʤʦäʤåñäʧ èʥã ãíʢæãã ʤç âʡæʢàåôʢéʦô ã âʡæʢîʡʢéʦô ʡçʡòʥʤÝçðæ ßåãäʤåãâʤæ ʛʥãʚÚʒʞʤëʢçäʡʤÝæʢçʡáãʥçðʨäãʦåʤéÞæãʤäʡʥàʢèʥʤÞʤàãéʦôåãíñʦãʦèʤåñâʤÞʡçãʢæ ʜʟʛ çʡ ʤʦçʤÞʢ æʢìʢçʤʣ áãʥçʤʣ äãʦåʤéð ) "-)00 Þ éʤ Þʥʢæô äʡä ʛÚʞʥʡʦèʤåʡßʡʢéëʢåðæʥôàʤææʢéʡÝʤåãìʢʦäãʨʜʟʛąäʡäàåôʤëʢçäãʤäãʦåʢçãô áãʥçðʨäãʦåʤé11ʝ èʡåñæãéʡé 11ʝ Ýʧéãʥʡé éʡäãàåôʤëʢçäãêʧçäëãʤçãʥʤÞʡçãô ëãäåʡʒʥʢÝʦʡ11ʝ ʡëʢéʡé ßåãäʤåãâʡ11ʝ åʡäéʡé ʛÚʞ ôÞåôʢéʦô éʡäáʢ ã ʤʦçʤÞçðæ æʢéʤàʤæ æʤåʢäʧåôʥçʤʣ Þãâʧʡåãâʡëãã ʡéʢʥʤʦäåʢʥʤâʡʔçʡʦéʤôîʢʢÞʥʢæôôàʢʥçʡôäʡʥàãʤåʤßãôʥʡʦèʤåʡßʡʢéçʢʦäʤåñäãæã àʢʦôéäʡæãʜʟʛàåôÞðʦʤäʤìʧÞʦéÞãéʢåñçʤʣÞãâʧʡåãâʡëããèʥʡäéãìʢʦäãäʡáàʤßʤ ãâòéʡèʤÞʡéʢʥʤßʢçʢâʡ Þäåóìʡôʨʢæʤéʡäʦãʦ;= ʡçßãʤßʢçʢâ;= ʡääʧæʧåôëãó åãèʤèʥʤéʢãàʤÞ;= èʥʤéʢʤåãâ;= éʥʤæÝʤßʢçʢâ;=ʛʥãòéʤæäʡäæãçãæʧæ éʥã ʜʟʛ ʧáʢ ʧʦèʢíçʤ èʥãæʢçôóéʦô Þ äåãçãìʢʦäʤʣ èʥʡäéãäʢ & ʟÍʕ & ʨʤåãç ã11# 0+ ʟéʤʥàʢâʤäʦãßåóäʤâʡʟÍʕ ôÞåôʢéʦôàʤʦéʡéʤìçʤéʤìçðæʡçʡåʤßʤæßåóäʤâð èʤʦäʤåñäʧ âʡʨÞʡé ʟÍʕ äåʢéäʡæã Þ éʤæ ìãʦåʢ äʡʥàãʤæãʤëãéʡæã ʦʤèʤʦéʡÞãæ ʦ âʡʨÞʡéʤæ ßåóäʤâð èʥã òéʤæ êʤʦêʤʥãåãʥʤÞʡçãʢ ʟÍʕ éʡäáʢ ʤʦʧîʢʦéÞåôʢéʦô ßʢäʦʤäãçʡâʤʣ Þ ʥʢâʧåñéʡéʢ ìʢßʤ ʟÍʕ êãäʦãʥʧʢéʦô Þ äåʢéäʢ ʟÍʕ ôÞåôʢéʦô ʧçãÞʢʥʦʡåñçðææʡʥäʢʥʤææʢéʡÝʤåãìʢʦäʤʣʡäéãÞçʤʦéãäåʢéäãʔãâʧʡåãâʡëãôçʢʦéʡÝãåñçðʨʓʝÌʦèʤæʤîñóʟÍʕʤʦçʤÞʡçʡçʡéʤæ ìéʤèʤÞðíʢççʡôæʢéʡÝʤåãìʢʦäʡô ʡäéãÞçʤʦéñÞéʡäʤʣÝåôíäʢʤÝʢʦèʢìãÞʡʢéʦôʡäéãÞçðææʡäʥʤêʡßʡåñçðæʤéÞʢéʤæ ÒáʢʦʦʡæðʨʥʡççãʨãʦʦåʢàʤÞʡçãʣèʤãâʧìʢçãóçʡäʤèåʢçãôʟÍʕÞʦéʢçäʢʦʤççðʨ ʡʥéʢʥãʣÝðåʤÞðôÞåʢçʤ ìéʤÞðʥʡáʢççʤʦéñòéʤßʤçʡäʤèåʢçãôèʥʤèʤʥëãʤçʡåñçʡ äʤåãìʢʦéÞʧ æʡäʥʤêʡßʤÞ Þ âʤçʢ ʓʝÌ èʤ àʡççðæ ßãʦéʤèʡéʤåʤßãìʢʦäʤßʤ ʡçʡåãâʡ çʤ èʥã òéʤæ çʢ ãæʢʢé ʦÞôâã ʦ èåʤîʡàñó ã ʤÝïʢæʤæ ʓʝÌ ;= ʘʢéʤà ôÞåôʢéʦô 62 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ äʤåãìʢʦéÞʢççðæ ʢßʤʤʦçʤÞçʤʣèʤäʡâʡéʢåñ3563TANDARDIZED5PTAKE6ALUE ʦéʡçàʡʥéãâʤÞʡççðʣ ʧʥʤÞʢçñ âʡʨÞʡéʡ ʜʟʛ ʤäʡâʡåʦô ÞðʦʤäʤÞʤʦèʥʤãâÞʤàãæðæ ìéʤ èʤâÞʤåãåʤèʥʤÞʤàãéñʤÝïʢäéãÞçðʢʦʤèʤʦéʡÞåʢçãôÞàãçʡæãäʢ;=ʞʡä çʡêʤçʢ éʢʥʡèãã ʦéʡéãçʡæã ʡ éʡäáʢ èʥã ãâæʢçʢçãã ʤÝʥʡâʡ áãâçã ʦçãáʢçãʢ çʡäʤèåʢçãôʟÍʕÞʦéʢçäʢʦʤʦʧàʤÞèʥʤãʦʨʤàãéèʡʥʡååʢåñçʤʦçʤʥæʡåãâʡëãʢʣåãèãàçʤßʤ èʥʤêãåô;=ÚéãʥʡÝʤéðäʡʦʡóéʦôÞãâʧʡåãâʡëããʦʤççðʨʡʥéʢʥãʣãʡʤʥéð Þéʤ ÞʥʢæôäʡäãʦʦåʢàʤÞʡçãôçʡäʤèåʢçãôʟÍʕÞäʤʥʤçʡʥçðʨʡʥéʢʥãôʨèʥʢàʦéʡÞåôóé ʦʤÝʤʣʤèʥʢàʢåʢççʧóéʢʨçãìʢʦäʧóèʥʤÝåʢæʧÚéʤʦÞôâʡçʤäʡäʦʤéçʤʦãéʢåñçʤçʢÞðʦʤäʤʣʥʡâʥʢíʡóîʢʣʦèʤʦʤÝçʤʦéñóʛÚʞąææ éʡäãʦéʢæ ìéʤÞçʤʥæʢʟÍʕ çʡäʡèåãÞʡʢéʦô Þ æãʤäʡʥàʢ ʦ ãçéʢçʦãÞçʤʦéñó çʡæçʤßʤ èʥʢÞðíʡóîʢʣ çʡäʤèåʢçãʢÞʒʓʔçʡʦéʤôîʢʢÞʥʢæôèʥʢàåʡßʡʢéʦôçʤÞðʣèʥʤéʤäʤåèʤàßʤéʤÞäãèʡëãʢçéʡ ä ãʦʦåʢàʤÞʡçãó Þäåóìʡóîãʣ èʥʢàÞʡʥãéʢåñçʧó çãâäʤʧßåʢÞʤàçʧó Þðʦʤäʤáãʥçʧóàãʢéʧ äʤéʤʥʡôèʤâÞʤåôʢéʦçãâãéñçʡäʤèåʢçãʢʟÍʕÞæãʤäʡʥàʢãâçʡìãéʢåñçʤ ʧåʧìíãéñÞãâʧʡåãâʡëãóʦéʢçʤäʒʓ;= ʘçʤßʤìãʦåʢççðʢäåãçãìʢʦäãʢãʦʦåʢàʤÞʡçãôʧäʡâðÞʡóéçʡéʤ ìéʤèʤÞðíʢççʤʢ çʡäʤèåʢçãʢ ʟÍʕ Þ ʦéʢçäʡʨ äʥʧèçðʨ ʡʥéʢʥãʣ ôÞåôʢéʦô àʤʦéʡéʤìçʤ æʤîçðæ èʥʢàãäéʤʥʤæʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ; =ʒʡäèʥʡÞãåʤ éʡäãʢãʦʦåʢàʤÞʡçãôèʥʤÞʤàôéʦôʧʤçäʤåʤßãìʢʦäãʨÝʤåñçðʨʦÝʢʦʦãæèéʤæçðæʡéʢʥʤʦäåʢʥʤâʤæ èʤʦäʤåñäʧʛÚʞʧòéãʨèʡëãʢçéʤÞèʥʤÞʤàãéʦôèʤèʤäʡâʡçãôæ ʦÞôâʡççðæ ʦ ʤʦçʤÞçðæ âʡÝʤåʢÞʡçãʢæ ìéʤ èʤâÞʤåôʢé èʥʤÞʤàãéñ ʥʢéʥʤʦèʢäéãÞçðʣ ʡçʡåãâ ʦʤʦéʤôçãô ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦãʦéʢæð çʡ Ýʤåñíãʨ ßʥʧèèʡʨ ;= ʙʡãÝʤåʢʢ èʢʥʦèʢäéãÞçðæã èʥʢàʦéʡÞåôóéʦô ãʦʦåʢàʤÞʡçãô çʡ ßãÝʥãàçðʨ ʛÚʞʒʞ éʤæʤßʥʡêʡʨ ßàʢÞʥʡæäʡʨʤàçʤßʤãʦʦåʢàʤÞʡçãôʧàʡʢéʦôʦʥʡÞçãéñÞʤâæʤáçʤʦéãʤÝʤãʨæʢéʤàʤÞ Þãâʧʡåãâãʥʧóîãʨ ʥʡâåãìçðʢ èʥʤëʢʦʦð ʡéʢʥʤßʢçʢâʡ ʖîʢ Þ ʨ ßß Ýðåʤ èʤäʡâʡçʤ ìéʤçʡåãìãʢäʡåñëãçʡéʤÞÞʒʓèʤàʡççðæʒʞàʡåʢäʤçʢÞʦʢßàʡʦʤÞèʡàʡʢé ʦ âʤçʡæã èʤÞðíʢççʤßʤ çʡäʤèåʢçãô ʟÍʕ èʤ àʡççðæ ʛÚʞ ;= Úéã àʡççðʢ âʡʦéʡÞãåãÝʤåʢʢàʢéʡåñçʤãʦʦåʢàʤÞʡéñèʡéʤêãâãʤåʤßãìʢʦäãʢèʥʤëʢʦʦð èʥʤéʢäʡóîãʢÞʥʡæäʡʨÝåôíäã ÞìʡʦéçʤʦéãÞâʡãæʤʤéçʤíʢçãʢèʥʤëʢʦʦʤÞäʡåñëãêãäʡëãã ã Þʤʦèʡåãéʢåñçʤßʤ ʤéÞʢéʡ ʔ ʤéåãìãʢ ʤé ʒʞ èʥã ʛÚʞ ʦ ʟÍʕ Þãâʧʡåãâãʥʧʢéʦô Þʤʦèʡåãéʢåñçðʣ äʤæèʤçʢçé Ýåôíäã èʥãìʢæ çʡãÝʤåʢʢ Þðʦʤäʤʢ Þäåóìʢçãʢ ʟÍʕ ôÞåôʢéʦô Þʥʢæʢççðæ ʤéʥʡáʡóîãæ éʢäʧîãʣ Þðʦʤäãʣ ʧʥʤÞʢçñ Þʤʦèʡåʢçãô ÞÝåôíäʢ ãæʢóîʢʣÞðʦʤäʧóÞʢʥʤôéçʤʦéñʥʡâʥðÞʡ;=ÐæʢʢéʦôʥôàãʦʦåʢàʤÞʡçãʣ ʧäʡâðÞʡóîãʨçʡéʤ ìéʤéʡäʤʢèʤÞðíʢçãʢÞäåóìʢçãôʟÍʕèʥʤãʦʨʤàãéÞéʢʨ Ýåôíäʡʨʒʓ äʤéʤʥðʢÞèʤʦåʢàʦéÞããèʥãÞʤàãåãäÐʘ;=ʖîʢʤàçʡéʤìäʡèʥãåʤáʢçãôÞãâʧʡåãâʡëããʦʟÍʕąòéʤʤèʥʢàʢåʢçãʢçʡåãìãôÞʤʦèʡåãéʢåñçðʨèʥʤëʢʦʦʤÞÞâʤçʢʦéʢçéãʥʤÞʡçãôʒʓʥãʦ ;= & ʨʤåãçãʦèʤåñâʧʢéʦôÞäåãçãìʢʦäʤʣèʥʡäéãäʢÞʤʦçʤÞçʤæäʡäʜʟʛàåôÞãâʧʡåãâʡëããʥʡäʡèʥʤʦéʡéð èʤʦäʤåñäʧÞèʥʤåãêʢʥãʥʧóîãʨäåʢéäʡʨÞʤâʥʡʦéʡʢé ʡäéãÞçʤʦéñ ʨʤåãç ʦèʢëãêãìçʤßʤ éʥʡçʦèʤʥéʢʥʡ #H4 Þ ʥʢâʧåñéʡéʢ ìʢßʤ & ʨʤåãç êʤʦêʤʥãåãʥʧʢéʦô ã âʡäʥʢèåôʢéʦô Þ æʢæÝʥʡçʢ äåʢéʤä ÒʦéʡçʤÞåʢç êʡäé 63 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ èʤÞðíʢççʤßʤâʡʨÞʡéʡ & ʨʤåãçʡçʢéʤåñäʤʤèʧʨʤåʢÞðæãäåʢéäʡæã çʤãʡäéãÞãʥʤÞʡççðæã æʡäʥʤêʡßʡæã èʥãìʢæ ʨʤåãç ʤäʡâʡåʦô Ýʤåʢʢ ìʧÞʦéÞãéʢåñçðæ æʡʥäʢʥʤæ Þʤʦèʡåʢçãô Þ äʤʥʤçʡʥçðʨ ʡʥéʢʥãôʨ ìʢæ ʟÍʕ çʢ Þ èʤʦåʢàçóó ʤìʢʥʢàñ Ýåʡßʤàʡʥôéʤæʧ ìéʤʨʤåãçèʥʡäéãìʢʦäãçʢçʡäʡèåãÞʡʢéʦôÞæãʤäʡʥàʢ;=ʒʡä ã Þ ʦåʧìʡʢ ʦ ʟÍʕ çʡäʤèåʢçãʢ ʨʤåãçʡ éʡäáʢ çʢ Þʦʢßàʡ ʦʤʤéÞʢéʦéÞʤÞʡåʤ âʤçʡæ äʡåñëãçʤâʡÞʡʥéʢʥãôʨ;= ʜãʦʛÚʞʒʞʦ& ʟÍʕʛʥãʒʞÞãâʧʡåãâãʥʧʢéʦôæôßäʡôÝåôíäʡʦèåʤíçʡôʦéʥʢåäʡ âʡèʥʢàʢåʡæãâʤçðʦéʢçéʡèʧçäéãʥçʡôʦéʥʢåäʡ ʛʥãʛÚʞàʡççðʣʧìʡʦéʤäÝåôíäãʡäéãÞçʤ çʡäʡèåãÞʡʢéʟÍʕ ìéʤʧäʡâðÞʡʢéçʡÞʤʦèʡåãéʢåñçðʣèʥʤëʢʦʦ ʛʢʥʦèʢäéãÞçʤʣ æãíʢçñó àåô ʛÚʞ Þãâʧʡåãâʡëãã ôÞåôʢéʦô æãéʤʨʤçàʥãʡåñçðʣÝʢåʤäąèʢʥʢçʤʦìãä430/4RANSLOCATOR0ROTEINäÍʡ äʤéʤʥðʣÞÝʤåñíãʨäʤåãìʢʦéÞʡʨ òäʦèʥʢʦʦãʥʧʢéʦô çʡ æʡäʥʤêʡßʡʨ ;= ʝʢåʢäéãÞçðʣ ʡßʤçãʦé àʡççʤßʤ ʥʢëʢèéʤʥʡ 0+ æʢìʢççðʣ ʧßåʢʥʤàʤæ ʤäʡâʡåʦô ÞðʦʤäʤìʧÞʦéÞãéʢåñçðæ æʡʥäʢʥʤææʡäʥʤêʡßʡåñçʤʣʡäéãÞçʤʦéã ãæʢóîʢʣæʢʦéʤèʥãʥʡʦʦʢôççʤæʦäåʢʥʤâʢ Ýʤåʢâçãʛʡʥäãçʦʤçʡ ʦãʦéʢæçðʨÞʤʦèʡåãéʢåñçðʨâʡÝʤåʢÞʡçãôʨʦʤʦʧàʤÞ;= ʒçʡʦéʤôîʢæʧÞʥʢæʢçãèʥʤÞʢàʢçðèʢʥÞðʢãʦʦåʢàʤÞʡçãôÞʤâæʤáçʤʦéʢʣàʡççʤßʤ ʜʟʛèʥãʡéʢʥʤʦäåʢʥʤâʢ èʤäʡâʡÞíãʢʤÝçʡàʢáãÞʡóîãʢʥʢâʧåñéʡéð;= ʙʡʥôàʧʦéʥʢæôÞðíʢʧäʡâʡççðæãʜʟʛÞæãʥʤÞʤʣåãéʢʥʡéʧʥʢèʤʦéʤôççʤèʤôÞåôóéʦô àʡççðʢ ʤ çʤÞðʨ òäʦèʢʥãæʢçéʡåñçðʨ åãßʡçàʡʨ ʒ çʡʦéʤôîʢæʧ Þʥʢæʢçã ãâÞʢʦéçʤ Ýʤåʢʢ ìʢæ ʦʤʢàãçʢçãʣ äʤéʤʥðʢ èʤâÞʤåôóé ÞãâʧʡåãâãʥʤÞʡéñ 64 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʥʡâåãìçðʢòéʡèðʡéʢʥʤßʢçʢâʡçʡæʤàʢåôʨáãÞʤéçðʨãåãINVITROʦʡäëʢçéʤæçʡÞãâʧʡåãâʡëãóçʢʦéʡÝãåñçðʨʓʝÌÚéãàʡççðʢ ʡéʡäáʢèʢʥʢìʢçñäʤçéʥʡʦéçðʨèʥʢèʡʥʡéʤÞàåôʒʞ ʘʜ ãÒÏ àãʡßçʤʦéãäãʡéʢʥʤʦäåʢʥʤâʡʦʧææãʥʤÞʡçðÞéʡÝå ʞʡÝåãëʡ ʜʡàãʤêʡʥæèʥʢèʡʥʡéðãäʤçéʥʡʦéçðʢèʥʢèʡʥʡéðàåô æʤåʢäʧåôʥçʤʣÞãâʧʡåãâʡëããèʥʤëʢʦʦʤÞÞçʢʦéʡÝãåñçðʨÝåôíäʡʨ ; = ʛʥʤëʢʦʦʤÝïʢäé Úçàʤéʢåãʡåñçʡô àãʦêʧçäëãô ʘãíʢçñ 0 ʦʢåʢäéãç Ñãèʤèʥʤéʢãàð ʔʤʦèʡåãéʢåñçðʣ ʤéÞʢé ʛÚʞ ÒÏÐ 6#!- ʔçʢäåʢéʤìçðʣ æʡéʥãäʦ ʘʢéʤà ʚÚʒʞ ʛʥʢèʡʥʡé #U ʡçéã 0 ʦʢåʢäéãç ʡçéãéʢåʡ 'A êʧäʤãàʡç ʘãäʥʤÞʢâãäʧåðʦʦãʡåãå Ññóãʦ8 4C 6#!- ʡçéãéʢåʡ M ʘʜʞ 6).0 ʞʢçʡʦëãç èʥʤéʢʤßåãäʡçð äʤååʡßʢç ʘʜʞ ʕʡàʤêåʧʤʥãç ʚäãʦåʢççðʢÑʙʛ ʚÚʒʞ ʜʢëʢèéʤʥðÑʙʛ ʛÚʞ Ñʔʛ ʘʜʞ ʘʢéʡÝʤåãâæ ßåóäʤâð ʛÚʞ ʜʢëʢèéʤʥÐÑ ʚÚʒʞ ʜʢëʢèéʤʥð ʨʢæʤäãçʤÞ ʛÚʞ ʛÚʞ 4C -$! M ) #$ &C ʤäÑʙʛ Ñʔʛ çʡçʤìʡʦéãëð 4C (9.)# ÐÑ M #U $/4! V-)0 )) #U $/4! $!04! )N %# ʚÚʒʞ 111 ʚÚʒʞ M ʛÚʞ ʚÚʒʞ ʘʜʞ 4C êʤåʡé & êéʤʥ $ æʡççʤâʡ )N ,/8 ʡçéãéʢåʡ 111 'D æãëʢååðąçʤʦãéʢåã ʦèʢëãêãìʢʦäʤßʤʡçéãéʢåʡ#$ ʛÚʞ 'A $/4!4!4% # 0+ ʛÚʞ 11 ʛÚʞ ʛÚʞ & ʟÍʕ &11# CHOLINE #U çʡçʤìʡʦéãëð ʘʜʞ 530)/ ìʡʦéãëð ʒʞ .ʣʤàãʦéðʢçʡçʤìʡʦéãëð 65 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʛʥʤéʢʤåãâ ʘʡéʥãäʦçðʢæʢéʡååʤèʥʤéʢãçʡâð ʚÚʒʞ ʓèʤèéʤâ ʟʤʦêʡéãàãåʦʢʥãç ʚÚʒʞ 4C 20 M ʘʜʞ 0 4C ʡççʢäʦãç 6 M ʘʜʞ ʓßʥʢßʡëãô éʥʤæÝʤëãéʤÞ ʙʢʤʡçßãʤßʢçʢâ ÐçßãÝãéʤʥʓÍʟ ʚÚʒʞ ²))B³ ãçéʢßʥãç ʚÚʒʞ ʟãÝʥãç ʘʜʞ Ðçéʢßʥãçð ʚÚʒʞ 30)/ ʡççʢäʦãç 6 4C !PP#(#LPP! M 4C ʡèëãéãà M %0 2 M4C .# ʛÚʞ ʛÚʞ ʛÚʞ ʘʜʞ ʜʢëʢèéʤʥ6%'& ʛÚʞ ʕãèʤäʦãô ʚäãʦåãéʢåñçʤ ÞʤʦʦéʡçʤÞãéʢåñçðʢ ʥʢʡäëãã ʛÚʞ ʒʡåñëãêãäʡëãô ʠʢæʤʦʤʥÝëãô ʛÚʞ 'A ./4! 2'$ & êåʤéʢßʡéãà & ßʡåʡäéʤ ʡʥßãçãå ßåãëãå ʡʦèʡʥʡßãçʤÞʡôäãʦåʤéʡ ʛʡʥʡæʡßçãéçðʢçʡçʤìʡʦéãëð :R ÝʢÞʡëãâʧæʡÝ & &-)3/ & êéʤʥãà ÐʙʔʓÏÐʔʙØʖʘʖʞʚÍØ ʚʦçʤÞçðʢ èʥʢãæʧîʢʦéÞʡ ãçÞʡâãÞçðʨ æʢéʤàãä ą Ýʤåñíʡô ʥʡâʥʢíʡóîʡô ʦèʤʦʤÝçʤʦéñ Þʤâæʤáçʤʦéñ ìʢéäʤʣ Þãâʧʡåãâʡëãã ã ʤèʥʢàʢåʢçãô ʥʡâæʢʥʤÞ Þʦʢʨ äʤæèʤçʢçéʤÞ ʓʝÌ ʝ èʤæʤîñó ãçÞʡâãÞçðʨ æʢéʤàʤÞ æʤáçʤ ÞðôÞãéñ Ýʤåñíʧó ìʡʦéñ ʨʡʥʡäéʢʥçðʨ àåô çʢʦéʡÝãåñçðʨ ʓʝÌ æʤʥêʤåʤßãìʢʦäãʨ èʥãâçʡäʤÞ ʚßʥʡçãìʢçãôãçÞʡâãÞçðʨæʢéʤàʤÞąʦåʤáçʤʦéñʤÝʦåʢàʤÞʡçãô çʢʤÝʨʤàãæʤʦéñßʤʦèãéʡåãâʡëãã Þʢʥʤôéçʤʦéñʤʦåʤáçʢçãʣ ʤéçʤʦãéʢåñçʤÞðʦʤäʡôʦéʤãæʤʦéñʔʦÞôâã ʦòéãæʤʦéʡʢéʦôʡäéʧʡåñçðæÞʤèʥʤʦʤÝʤèʥʢàʢåʢçããäʤçäʥʢéçðʨßʥʧèèèʡëãʢçéʤÞ äʤéʤʥðʢæʤßʧéãâÞåʢìñèʤåñâʧʤéãçÞʡâãÞçʤʣÞãâʧʡåãâʡëããÝåôíʢäʝåʢàʧʢéâʡæʢéãéñ ìéʤàʤçʡʦéʤôîʢßʤÞʥʢæʢçãʤéʦʧéʦéÞʧóéìʢéäãʢʡçßãʤßʥʡêãìʢʦäãʢ äʥãéʢʥããçʢʦéʡÝãåñçʤʦéãʓʝÌ ʤÝåʡàʡóîãʢçʡãÝʤåñíʢʣèʥʤßçʤʦéãìʢʦäʤʣâçʡìãæʤʦéñóʛʥãòéʤæàʡççðʢãʦʦåʢàʤÞʡçãô3%#2)44 èʤʦÞôîʢççʤßʤÞʤâæʤáçʤʦéôæ ʦéʢçéãʥʤÞʡçãôèʥãçʡåãìããêãÝʥʤʡéʢʥʤæʦéʤçäʤʣäʡèʦʧåʤʣʟʓʞʒ ʦʡæʤʥʡʦäʥðÞʡóîãæãʦôʦéʢçéʡæãʦʧåñéʥʡéʤçäãæäʡʥäʡʦʤæ èʤäʡâʡåã ìéʤòçàʤÞʡʦäʧåôʥçʤʢ åʢìʢçãʢèʡëãʢçéʤÞʦéʡäãæãçʢʦéʡÝãåñçðæãʓʝÌÞèʤåçʢÝʢâʤèʡʦçʤãæʤáʢéÝðéñ íãʥʤäʤãʦèʤåñâʤÞʡçʤÞäʡʥàãʤåʤßãìʢʦäʤʣèʥʡäéãäʢ; = 66 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʒʚʜʚʙʓʜʚʓʙʕÐʚʕʜʓʟÐÜ ʒʤʥʤçʡʥʤʡçßãʤßʥʡêãôʒʓʕ ąçʡãÝʤåʢʢʥʡʦèʥʤʦéʥʡçʢççðʣæʢéʤàãçÞʡâãÞçʤʣ àãʡßçʤʦéãäããíʢæãìʢʦäʤʣÝʤåʢâçãʦʢʥàëʡãʤëʢçäãʦʤʦéʤôçãôäʤʥʤçʡʥçʤßʤʥʧʦåʡ èʥãäʤéʤʥʤʣʡéʢʥʤʦäåʢʥʤéãìʢʦäãʢÝåôíäãÞãâʧʡåãâãʥʧóéʦôʥʢçéßʢçʤåʤßãìʢʦäãʚʦçʤÞçðæãèʤäʡâʡçãôæãäèʥʤÞʢàʢçãóäʤʥʤçʡʥʤßʥʡêããôÞåôóéʦô ʥʢíʢçãʢÞʤèʥʤʦʡʤÝãçÞʡâãÞçʤæÞæʢíʡéʢåñʦéÞʢʦéʢçéãʥʤÞʡçãʢʡʥéʢʥãʣãåã ʓʒÕÞåʢìʢçããÝʤåñçðʨÐÌʝ ʧéʤìçʢçãʢàãʡßçʤâʡʧèʡëãʢçéʤÞʦçʢéãèãìçʤʣäåãçãäʤʣʦéʢçʤäʡʥàãã ʤÝʦåʢàʤÞʡçãʢåãë èʥʤêʢʦʦãôäʤéʤʥðʨʦÞôâʡçʡʦʤéÞʢéʦéÞʢççʤʦéñóâʡÝʢâʤèʡʦçʤʦéñàʥʧßãʨåóàʢʣåʢéìãäã äʤʦæʤçʡÞéð Þʤàãéʢåãéʥʡçʦèʤʥéʡãàʥ ʤʦéʥðʣãçêʡʥäéæãʤäʡʥàʡÞèʢʥÞðʢìʡʦðâʡÝʤåʢÞʡçãôàåôèʥʤÞʢàʢçãôʦʥʤìçʤʣʥʢÞʡʦäʧåôʥãâʡëããæãʤäʡʥàʡ ʤëʢçäʡʦʤʦéʤôçãôíʧçéʤÞãʡʥéʢʥãʣèʤʦåʢʤèʢʥʡëããʡʤʥéʤäʤʥʤçʡʥçʤßʤíʧçéãʥʤÞʡçãô ʚʦçʤÞçʤʢʤßʥʡçãìʢçãʢʒʓʕâʡäåóìʡʢéʦôÞéʤæ ìéʤæʢéʤàãäʡèʥʢàʤʦéʡÞåôʢé éʤåñäʤ æʡäʥʤʡçʡéʤæãìʢʦäãʢ àʡççðʢ Þãâʧʡåãâãʥʧô èʥʤʦÞʢé ʡʥéʢʥãã iåóæãçʤßʥʡêãôx ʒʓʕçʢèʤâÞʤåôʢéʤʨʡʥʡäéʢʥãâʤÞʡéñäʤçʦãʦéʢçëãóʓʝÌ ìéʤʦʧîʢʦéÞʢççʤ ʦçãáʡʢé èʥʤßçʤʦéãìʢʦäʧó ëʢççʤʦéñ ãʦʦåʢàʤÞʡçãô ʒʥʤæʢ éʤßʤ äåãçãìʢʦäʡô âçʡìãæʤʦéñ ÞðôÞåôʢæðʨ èʥã äʤʥʤçʡʥʤßʥʡêãã èʤʥʡáʢçãʣ âʡÞãʦãé çʢ éʤåñäʤ ʤé ʦéʢèʢçã ʦʧáʢçãô ʡʥéʢʥãʣ çʤ éʡäáʢ ʤé êãâãʤåʤßãìʢʦäãʨ èʢʥêʧâãʤççðʨ çʡʥʧíʢçãʣ Þ ʧìʡʦéäʡʨ áãâçʢʦèʤʦʤÝçʤßʤ æãʤäʡʥàʡ äʥʤÞʤʦçʡÝáʡʢæðʨ ʦéʢçʤâãʥʤÞʡççðæãʦʤʦʧàʡæãʚàçʡäʤ çʢʦæʤéʥôçʡçʢàʤʦéʡéäãæʢéʤàʡ ʒʓʕʤʦéʡʢéʦôâʤåʤéðæʦéʡçàʡʥéʤæÞʤëʢçäʢʦʤʦéʤôçãôäʤʥʤçʡʥçʤßʤʥʧʦåʡ ãÞʦʢàʥʧßãʢãçÞʡâãÞçðʢ æʢéʤàãäãʤëʢçäãʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʤʥʡáʢçãôʡʥéʢʥãʣÞçʡʦéʤôîʢʢÞʥʢæô ôÞåôóéʦô åãíñ àʤèʤåçãéʢåñçðæã ʦʥʢàʦéÞʡæã àåô ʧéʤìçʢçãô ãçêʤʥæʡëãã èʤåʧìʢççʤʣèʥãèʥʤÞʢàʢçããʒʓʕ ʔʙÒʞʜÐʝʚʝÒÍÐʝʞʚʖÒÑÙʞʜʓÏʔÒʒʚʔʚʖÐʝʝÑʖÍʚʔʓʙÐʖ ʔçʧéʥãʦʤʦʧàãʦéʤʢʧåñéʥʡâÞʧäʤÞʤʢãʦʦåʢàʤÞʡçãʢʔʝÒÏÐ èʤâÞʤåôʢéèʤåʧìãéñ àÞʧʨæʢʥçʤʢèʤèʢʥʢìçʤʢãâʤÝʥʡáʢçãʢʡʥéʢʥãʡåñçʤʣʦéʢçäãʓçʡåãâòʨʤßʢççʤʦéã äʤæèʤçʢçéʤÞ ʦéʢçäã ʡʥéʢʥãã èʤâÞʤåôʢé ʤëʢçãéñ ʢʢ ʦéʥʧäéʧʥʧ çʡåãìãʢ èʥãʦéʢçʤìçðʨ éʥʤæÝʤéãìʢʦäãʨ æʡʦʦ àãʦʦʢäëãó ʛʥã äʤåãìʢʦéÞʢççʤʣ ʤëʢçäʢ ãâʤÝʥʡáʢçãʣÞʦʢʥʤʣíäʡåʢʤèʥʢàʢåôóéʦôʦåʢàʧóîãʢèʡʥʡæʢéʥðèåʤîʡàñèʥʤʦÞʢéʡ èʥʤëʢçé ʦéʢçʤâʡ æʡäʦãæʡåñçðʣ ã æãçãæʡåñçðʣ àãʡæʢéʥð èʥʤʦÞʢéʡ ãçàʢäʦ ʦãææʢéʥãìçʤʦéã èʥʤʦÞʢéʡ æʡäʦãæʡåñçʡô ã æãçãæʡåñçʡô éʤåîãçʡ ʓʝÌ ãçàʢäʦ òäʦëʢçéʥãìçʤʦéãʓʝÌ æʡäʦãæʡåñçðʣãæãçãæʡåñçðʣàãʡæʢéʥðʦʤʦʧàʡ èʥʤëʢçé ʦéʢçʤâʡʤéàãʡæʢéʥʡ; =ʛʥãèʤæʤîãÞãàʢʤàʢçʦãéʤæʢéʥãìʢʦäʤßʤʡçʡåãâʡ ÞʦʢʥʤʣíäʡåʢæʤáçʤʤëʢçãéñʦéʥʧäéʧʥʧçʢäʤéʤʥðʨäʤæèʤçʢçéʤÞʓʝÌ; = ʘʢéʤàʤÝåʡàʡʢéÞðʦʤäʤʣʥʡâʥʢíʡóîʢʣʦèʤʦʤÝçʤʦéñóèʤʥôàäʡæäæ ìéʤèʤâÞʤåôʢéãâʧìʡéñèʥʤʦÞʢéʦʤʦʧàʤÞàãʡæʢéʥʤæÞèåʤéñàʤ ææʥãʦ 67 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ÍåôʧéʤìçʢçãôʦéʥʧäéʧʥðʓʝÌÞäʡìʢʦéÞʢʧåñéʥʡâÞʧäʤÞʤßʤʦéʡçàʡʥéʡèʥãçãæʡʢéʦôòʨʤèåʤéçʤʦéñʡàÞʢçéãëããʝʧîʢʦéÞʧʢéʦåʢàʧóîʡôäʡìʢʦéÞʢççʡôòʨʤßʥʡêãìʢʦäʡôäåʡʦʦãêãäʡëãôʓʝÌ ą ßʤæʤßʢççðʢ ʓʝÌ äʤéʤʥðʢ ʥʡâàʢåôóé çʡ æôßäãʢ éÞʢʥàðʢ äʡåñëãçãʥʤÞʡççðʢ èåʤîʡàãéʡäʤʣʓʝÌʦʤʦéʡÞåôóéäʤæèʤçʢçéðʤàãçʡäʤÞʤʣòʨʤèåʤéçʤʦéã ą ßʢéʢʥʤßʢççðʢʓʝÌ äʤéʤʥðʢʦʤʦéʤôéãâʥʡâåãìçðʨäʤæèʤçʢçéʤÞéʤʢʦéñäʤæèʤçʢçéðʤàãçʡäʤÞʤʣòʨʤèåʤéçʤʦéãâʡçãæʡóéæʢçʢʢèåʤîʡàãʓʝÌ ʜãʦʔʝÒÏÐʓʙʤʥæʡÌʞʥʤæÝÞèʥʤʦÞʢéʢʒʓʔʛʤßʥʡçãìçðʣʦéʢçʤâʦéÞʤåʡÑʒʓ ʒʡä èʥʡÞãåʤ çʢʦéʡÝãåñçðʢ ʓʝÌ ãæʢóé èʤ àʡççðæ ʔʝÒÏÐ çʢäʤéʤʥðʢ ʤéåãìãéʢåñçðʢ ʤʦʤÝʢççʤʦéã èʥãâçʡäã èʤåʤáãéʢåñçʤßʤ ʥʢæʤàʢåãʥʤÞʡçãô èʥãʦéʢçʤìçðʣéʥʤæÝʤâãÝʤåñíʤʣʤÝïʢæʓʝÌ;=ÐæʢʢéʦôʦÞôâñæʢáàʧʥʡâæʢʥʤæåãèãàçʤßʤôàʥʡÝåôíäã ʥʡʦʦìãéʡççðæèʤàʡççðæʔʝÒÏÐ ãʥãʦäʤæèʤʦåʢàʧóîãʨ äʤʥʤçʡʥçðʨʦʤÝðéãʣ;=ʔʤâæʤáçʤʦéãʔʝÒÏÐʦʧîʢʦéÞʢççʤʥʡʦíãʥôóéʦôʦèʤæʤîñóëÞʢéʤÞʤßʤäʡʥéãʥʤÞʡçãôëãêʥʤÞðʨãâʤÝʥʡáʢçãʣÞãʥéʧʡåñçʡôßãʦéʤåʤßãô ʔʕ ÚéʤéèʤàʨʤàʤÝåʢßìʡʢéÞãâʧʡåñçʤʢʥʡâßʥʡçãìʢçãʢʥʡâåãìçðʨßãʦéʤåʤßãìʢʦäãʨʦéʥʧäéʧʥʓʝÌåãèãàçʧó êãÝʥʤâçʧóãäʡåñëãçãʥʤÞʡççʧóʜʡâʥʢíʡóîʡô ʦèʤʦʤÝçʤʦéñæʢéʤàʡąąæäæ; =ʛʥãʦʥʡÞçʢçããâçʡìʢçãʣʔʝÒÏÐ ʔʕ ʦßãʦéʤåʤßãìʢʦäãæãàʡççðæãʒʓʧʦéʡçʤÞåʢçʤ ìéʤìʧÞʦéÞãéʢåñçʤʦéñæʢéʤàʡàåô ʤèʥʢàʢåʢçãôäʡåñëãêãäʡëããʦʤʦéʡÞåôʢé êãÝʥʤâʡą åãèãàçʤßʤèʧåʡą ;= ʚàçʤʣãâÞʡáçʢʣíãʨʤʦʤÝʢççʤʦéʢʣʔʝÒÏÐôÞåôʢéʦôÞʤâæʤáçʤʦéñÞãâʧʡåãâʡëããçʡãÝʤåʢʢʤèʡʦçʤßʤéãèʡʓʝÌąêãÝʥʤʡéʢʥʤæʦéʤçäʤʣäʡèʦʧåʤʣʟʓʞʒ Ìðåʤ èʤäʡâʡçʤ ìéʤʟʓʞʒàʤʦéʤÞʢʥçʤìʡîʢÞãâʧʡåãâãʥʧʢéʦôʧèʡëãʢçéʤÞʦʚʒʝ çʢáʢåã ʧ èʡëãʢçéʤÞ ʦʤ ʦéʡÝãåñçʤʣ ÐÌʝ ʟʓʞʒ ʥʡʦèʤåʡßʡóéʦô Þ èʥʢàʢåʡʨ ææ ʤéʦéÞʤåʡÑʒʓ;=ʜʢâʧåñéʡéðãʦʦåʢàʤÞʡçãô#5,0,!#èʤäʡâʡåã ìéʤʧÝʤåñçðʨ ʚʒʝçʡãÝʤåʢʢìʡʦéðæêʢçʤéãèʤæʓʝÌôÞåôʢéʦôʟʓʞʒʦäʥʧèçðæçʢäʥʤéãìʢʦäãæ ôàʥʤæããçàʢäʦʤæʥʢæʤàʢåãʥʤÞʡçãô ;=ʝʧîʢʦéÞʧʢéäåʡʦʦãêãäʡëãôʡéʢʥʤʦäåʢʥʤéãìʢʦäãʨÝåôíʢäèʤàʡççðæʔʝÒÏÐ 68 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʛʡéʤåʤßãìʢʦäʤʢʧéʤåîʢçãʢãçéãæðʓʝÌâʡçãæʡʢéèåʤîʡàãèʤèʢʥʢìçʤßʤ ʦʢìʢçãôʡʥéʢʥãããæʤáʢéʦʤàʢʥáʡéñÞʦʢäʤæèʤçʢçéð çʤÞʤʦçʤÞçʤæêãÝʥʤâçʤ åãèãàçðʣʙʢäʥʤéãìʢʦäʤʢôàʥʤãäʡåñëãçʤâʦʤʦéʡÞåôóéʤéʤÝîʢßʤʤÝïʢæʡʓʝÌ ʟãÝʥʤâçʡôʓʝÌʓʝÌâʡçãæʡʢéèåʤîʡàãèʤèʢʥʢìçʤßʤʦʢìʢçãôʡʥéʢʥãã çʢäʥʤéãìʢʦäʤʢôàʥʤãäʡåñëãʣʦʤʦéʡÞåôóéʤéʤÝîʢßʤʤÝïʢæʡ êãÝʥʤâçʤ åãèãàçðʣäʤæèʤçʢçéą ʟãÝʥʤâçʤ äʡåñëãçãʥʤÞʡççʡô ʓʝÌ âʡçãæʡʢé èåʤîʡàã èʤèʢʥʢìçʤßʤ ʦʢìʢçãôʡʥéʢʥãã ÞʤʦçʤÞçʤæʦʤʦéʤãéãâêãÝʥʤâçʤʣéäʡçãʦʦʤàʢʥáʡçãʢæäʡåñëãôãʤÝïʢæʤæçʢäʥʤéãìʢʦäʤßʤôàʥʡʤéʤÝîʢßʤʤÝïʢæʡʓʝÌ ʟãÝʥʤʡéʢʥʤæʡʓʝÌʦʦʤàʢʥáʡçãʢæçʢäʥʤéãìʢʦäʤßʤôàʥʡʤéʤÝîʢßʤʤÝïʢæʡʓʝÌ ʦéʤåʦéʤʣ ʨʤʥʤíʤÞãâʧʡåãâãʥʧʢæʤʣêãÝʥʤâçʤʣäʡèʦʧåʤʣ ʟãÝʥʤʡéʢʥʤæʡʦéʤçäʤʣäʡèʦʧåʤʣʓʝÌâʡçãæʡʢéèåʤîʡàãèʤèʢʥʢìçʤßʤ ʦʢìʢçãôʡʥéʢʥããʔʝÒÏÐèʤâÞʤåôʢéäʤʦÞʢççʤʦʧàãéñʤçʡåãìããéʤçäʤʣäʡèʦʧåð èʤʤéʦʧéʦéÞãóêãÝʥʤâçʤʣéäʡçã ʤéàʢåôóîʢʣèʥʤʦÞʢéʦʤʦʧàʡʤéçʢäʥʤéãìʢʦäʤʣìʡʦéã èʤÝʤåñíʤæʧçʢäʥʤéãìʢʦäʤæʧôàʥʧ ãʦʤàʢʥáʡçãóäʡåñëãô âʡçãæʡóîʢæʧʤéʤÝîʢßʤʤÝïʢæʡʓʝÌ ʒʡåñëãçãʥʤÞʡççʡôêãÝʥʤʡéʢʥʤæʡʦéʤçäʤʣäʡèʦʧåʤʣʦʦʤàʢʥáʡçãʢæäʡåñëãô ʤéʤÝîʢßʤʤÝïʢæʡʓʝÌ ʔ ʥʡæäʡʨ æçʤßʤëʢçéʥʤÞʤßʤ ãʦʦåʢàʤÞʡçãô 02/30%#4 ÞäåóìãÞíʢßʤ ʤäʤåʤ Ýʤåñçðʨʦʚʒʝ äʤéʤʥðæèʥʤÞʢåãʦéʢçéãʥʤÞʡçãʢʒʓ Ýðåʤèʤäʡâʡçʤ ìéʤÝʤåʢʢ èʤʦåʢàʧóîãʨäʤʥʤçʡʥçðʨʤʦåʤáçʢçãʣçʢÝðåãʦÞôâʡçðʦʤʦéʢçéãʥʤÞʡççʤʣ ʡʥéʢʥãʢʣʔʦåʧìʡʢÞðôÞåʢçãôʓʝÌʦéʤçäʤʣêãÝʥʤâçʤʣèʤäʥðíäʤʣʤéçʤʦãéʢåñçðʣʥãʦäʤʦåʤáçʢçãʣʧÞʢåãìãÞʡåʦôÞ ʥʡâʡʖʦåãʓʝÌʦéʤçäʤʣêãÝʥʤâçʤʣèʤäʥðíäʤʣʦʤìʢéʡåʡʦñʦʤÝïʢæʤæʓʝÌèåʤîʡàãèʤèʢʥʢìçʤßʤʦʢìʢçãôʡʥéʢʥãã ʥãʦäʧÞʢåãìãÞʡåʦôèʤìéãÞʥʡâʔæʢʦéʢʦéʢæÞðʥʡáʢççʤʢʦʧáʢçãʢèʥʤʦÞʢéʡ ʡʥéʢʥãã Þãâʧʡåãâãʥʧʢæʤʢäʡäèʥãʒʓʕ éʡäãʦèʤæʤîñóʔʝÒÏÐ èʥʡäéãìʢʦäãçʢ Þåãôåʤçʡèʥʤßçʤâ;=ʞʡäãæʤÝʥʡâʤæ ÝʤåñíãçʦéÞʤÝåôíʢä äʤéʤʥðʢÞèʤʦåʢàʦéÞããèʥãÞʢåãääʤʥʤçʡʥçðæʤʦåʤáçʢçãôæ çʢÞðâðÞʡåãʦʧîʢʦéÞʢççʤßʤʦʧáʢçãô èʥʤʦÞʢéʡäʤʥʤçʡʥçʤʣʡʥéʢʥããèʤàʡççðæʒʓʕ çʤãæʢåãèʥãâçʡäãçʢʦéʡÝãåñçʤʦéã èʤàʡççðæʔʝÒÏÐ ʔʕ;=ÚéãʥʢâʧåñéʡéðÝðåãèʤàéÞʢʥáàʢçðÞãʦʦåʢàʤÞʡçãôʨ 6)6!;=ã!4%2/-!;= ʔʝÒÏÐ èʤâÞʤåôʢé ÞðôÞãéñ ʥʡâʥðÞ ʓʝÌ èʥã òéʤæ ʥʢâʧåñéʡéð ʦʤÞèʡàʡóé ʦ àʡççðæã ʡʧéʤèʦãã ʛʤ àʡççðæ ' 2ODRIGUEZ 'RANILLO ET AL ʧ Ýʤåñçðʨ ʚʒʝ ÞðôÞåôåãʦñ ʥʡâʥðÞð ʓʝÌ äʤéʤʥðʢ ʤéåãìʡåãʦñ Ýʤåñíʤʣ èåʤîʡàñó èʤèʢʥʢìçʤßʤ ʦʢìʢçãô ã Þðʥʡáʢççðæ èʤåʤáãéʢåñçðæ ʥʢæʤàʢåãʥʤÞʡçãʢæ ;= ʛʥã òéʤæ ʓʝÌ ʦäåʤççðʢ ä ʥʡâʥðÞʧ ãæʢóé Ýʤåñíãʣ ʤÝïʢæ èʤ ʦʥʡÞçʢçãó ʦʤ ʦéʡÝãåñçðæã ʓʝÌ ;= ʛʤ àʡççðæ (ONG ET AL ʥʡâʥðÞ ʓʝÌ Þ ãçêʡʥäé ʦÞôâʡççʤʣ ʡʥéʢʥãã èʤàʡççðæʔʝÒÏÐÞðôÞåôʢéʦôʧÝʤåñçðʨʦÐʘãʧèʡëãʢçéʤÞʦʤʦéʡÝãåñçʤʣ ÐÌʝ Þ ʦãæèéʤæ çʢʦÞôâʡççðʨ ʡʥéʢʥãôʨ ą ʧ ã ʦʤʤéÞʢéʦéÞʢççʤ ;= 69 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʛʤʨʤáãʢàʡççðʢ ʧäʡâðÞʡóîãʢçʡéʤ ìéʤçʢʦéʡÝãåñçðʢʓʝÌʤèʥʢàʢåôóéʦôäʡä Þ ʦãæèéʤæ ʦÞôâʡççðʨ éʡä ã Þ ʦãæèéʤæ çʢʦÞôâʡççðʨ ʡʥéʢʥãôʨ Ýðåã èʤåʧìʢçð ãÞàʥʧßãʨãʦʦåʢàʤÞʡçãôʨ;ą= ʛʥʢãæʧîʢʦéÞʢççʡô åʤäʡåãâʡëãô ʓʝÌ Þ éʤæ ìãʦåʢ ʟʓʞʒ ʤÝʧʦåʤÞåʢçʡ æʢʦéçðæçʡèʥôáʢçãʢæʦàÞãßʡ éʤʢʦéñʦʤèʥʤéãÞåʢçãʢæ Þʤâçãäʡóîãææʢáàʧéʤäʤæ äʥʤÞããòçàʤéʢåãʢæʦʤʦʧàãʦéʤʣʦéʢçäã;=ʔʝÒÏÐæʤáʢéʤëʢçãéñæʢʦéçʤʢçʡèʥôáʢçãʢʦàÞãßʡ ʦʤâàʡÞʡʢæʤßʤäʥʤÞʤéʤäʤæ àåôìʢßʤãʦèʤåñâʧóéʦôéʥʢʨæʢʥçðʢ ʥʢäʤçʦéʥʧäëããʦʤʦʧàʤÞãʥʡʦʦìãéðÞʡóéʦôèʤäʡâʡéʢåãßãàʥʤàãçʡæãäãʓʝÌêʤʥæãʥʧóéʦôìʡîʢÞʧìʡʦéäʡʨʦçãâäãæʦʤèʥʤéãÞåʢçãʢæʦàÞãßʡ çʤÞâʤçʡʨʦÞðʦʤäãæʦʤèʥʤéãÞåʢçãʢæʦàÞãßʡʧÞʢåãìãÞʡʢéʦôʥãʦäʥʡâʥðÞʡʓʝÌ;=ʜʢâʧåñéʡéð èʥʤʦèʢäéãÞçʤßʤãʦʦåʢàʤÞʡçãô02%$)#4)/.ʧäʡâðÞʡóéçʡéʤ ìéʤÝʤåñíʤʣʤÝïʢæ ʓʝÌãçãâäʤʢæʢʦéçʤʢçʡèʥôáʢçãʢʦàÞãßʡôÞåôóéʦôçʢÝåʡßʤèʥãôéçðæãèʥʤßçʤʦéãìʢʦäãæãêʡäéʤʥʡæã;= ʛʢʥʦèʢäéãÞçʤʣ æʢéʤàãäʤʣ ʔʝÒÏÐ ôÞåôʢéʦô òåʡʦéʤßʥʡêãô ʘʢéʤà èʤâÞʤåôʢé ʤëʢçãÞʡéñæʢʨʡçãìʢʦäãʢʦÞʤʣʦéÞʡʦʤʦʧàʡ ʤçʤʦçʤÞʡççʡʥʡâåãìçʤʣòåʡʦéãìçʤʦéãéäʡçʢʣʥʡâçʤʣèåʤéçʤʦéã Þʥʢâʧåñéʡéʢìʢßʤʤçããæʢóéʥʡâåãìçðʢʦäʤʥʤʦéã àʢêʤʥæʡëããʝÍ ÞʤéÞʢéçʡæʢʨʡçãìʢʦäʤʢʥʡâàʥʡáʢçãʢèʧåñʦʤÞʧóÞʤåçʧ ; =ʙʢʦéʡÝãåñçðʢʓʝÌʤéåãìʡóéʦôÞðʦʤäʤʣʦäʤʥʤʦéñóàʢêʤʥæʡëããÞʤÝåʡʦéã êãÝʥʤâçʤʣèʤäʥðíäãèʤʦʥʡÞçʢçãóʦʤÝåʡʦéôæãʦçãâäʤʣʦäʤʥʤʦéñóàʢêʤʥæʡëããÞʦʤʦʢàçãʨʤÝåʡʦéôʨ;=ʔéʤáʢÞʥʢæô ʦʤßåʡʦçʤàʡççðæ02/30%#4 òåʡʦéʤßʥʡêãôçʢèʥʢàʤʦéʡÞåôʢéàʤèʤåçãéʢåñçʤʣàãʡßçʤʦéãìʢʦäʤʣëʢççʤʦéãàåôãàʢçéãêãäʡëããêãÝʥʤʡéʢʥʤæʦÞðʦʤäãæʥãʦäʤæʥʡâʥðÞʡãàåôèʥʤßçʤâãʥʤÞʡçãôʝʝʚ èʥãàåãéʢåñçʤæçʡÝåóàʢçãã;= ʘʢéʤàãäã ʔʝÒÏÐ èʥʢéʢʥèʢÞʡóé èʤʦéʤôççʤʢ ʥʡâÞãéãʢ ʝʤÞʥʢæʢççʤʢ ʔʝÒÏÐ Þðʦʤäʤßʤ ʥʡâʥʢíʢçãô ã ãʦèʤåñâʤÞʡçãʢ àʡéìãäʤÞ ʦ ìʡʦéʤéʤʣ ʘʕë ã Ýʤåñíʤʣ ʦäʤʥʤʦéñóèʥʤéôáäãàʡéìãäʡèʤâÞʤåôóéèʥãÝåãâãéñʦôäʥʡâʥʢíʡóîʢʣʦèʤʦʤÝçʤʦéãʤèéãìʢʦäʤʣäʤßʢʥʢçéçʤʣéʤæʤßʥʡêãã ʦʤʨʥʡçôôèʥʢãæʧîʢʦéÞʡʧåñéʥʡâÞʧäʡ ÞʤéçʤíʢçããÞãâʧʡåãâʡëããʦʤʦʧàãʦéʤʣʦéʢçäãʔʝÒÏÐéʡäʤßʤäʡìʢʦéÞʡèʤâÞʤåôʢé ÞãâʧʡåãâãʥʤÞʡéñèʥʤëʢʦʦðʦéʡÝãåãâʡëããʓʝÌÞìʡʦéçʤʦéã ʧæʢçñíʢçãʢʤÝïʢæʡ åãèãàçʤßʤôàʥʡ çʡèʥãæʢʥçʡêʤçʢéʢʥʡèããʦéʡéãçʡæã;= ʚʛʞÐÔʖʝʒʓÜʒʚʕʖʜʖʙʞʙʓÜʞʚʘʚʕʜʓʟÐÜ ʔçʧéʥãʦʤʦʧàãʦéʡôʤèéãìʢʦäʡôäʤßʢʥʢçéçʡôéʤæʤßʥʡêãôʚʒʞ èʤʦèʤʦʤÝʧèʤåʧìʢçãô ãâʤÝʥʡáʢçãô Ýåãâäʡ ä ÒÏÐ çʤ ʦ ãʦèʤåñâʤÞʡçãʢæ ãçêʥʡäʥʡʦçðʨ Þʤåç ;=ʚʒʞèʤâÞʤåôʢéÞãâʧʡåãâãʥʤÞʡéñʦÞðʦʤäʤʣéʤìçʤʦéñóʦéʢçäʧʒʓãäʤæèʤçʢçéðʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣʓʝÌêãÝʥʤâçʧóäʡèʦʧåʧ åãèãàçʧóìʡʦéñ èʥãåʢßʡóîʧóäêãÝʥʤâçʤʣèʤäʥðíäʢ äʡåñëãçʤâʛʥãèʤæʤîãʚʒʞæʤáçʤʤèʥʢàʢåãéñ ʦéʢèʢçñãçêãåñéʥʡëããêãÝʥʤâçʤʣèʤäʥðíäãäåʢéäʡæãÞʤʦèʡåʢçãô èʥãʦéʢçʤìçðʣéʥʤæÝʤâ çʢʤãçéãæʧ çʢʤÞʡʦäʧåôʥãâʡëãóʓʝÌ;=ʛʥʤʦéʥʡçʦéÞʢççʡôʥʡâʥʢíʡóîʡô ʦèʤʦʤÝçʤʦéñ ʦÞʢéʤÞʤßʤ àʡéìãäʡ ãçéʢʥêʢʥʤæʢéʥʡ ãʦèʤåñâʧʢæʤßʤ 70 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ èʥã ʚʒʞ ʦʤʦéʡÞåôʢé ą æäæ ʧ ʔʝÒÏÐ ą èʤʥôàäʡ ą æäæ èʤòéʤæʧ ʚʒʞ èʤâÞʤåôʢé éʤìçʤ ʤèʥʢàʢåôéñ éʤåîãçʧ êãÝʥʤâçʤʣ äʡèʦʧåð ;= ʛʤ ʦʥʡÞçʢçãó ʦʔʝÒÏÐʚʒʞʤÝåʢßìʡʢéãàʢçéãêãäʡëãóßãèʢʥèåʡâãããçéãæð Þçʧéʥʢççʢʣãçʡʥʧáçʤʣ òåʡʦéãìʢʦäãʨ æʢæÝʥʡç ʡ éʡäáʢ òʨʤèʤâãéãÞçðʨ âʤç ʚʒʞ èʤâÞʤåôʢé ÞãâʧʡåãâãʥʤÞʡéñ ã ãâæʢʥôéñ äʤæèʤçʢçéð çʢʦéʡÝãåñçðʨ ʓʝÌ éʤçäʧó êãÝʥʤâçʧó äʡèʦʧåʧéʤåîãçʤʣ ææ ãåãèãàçʤʢôàʥʤ; =ÐçéãæʡʤÝðìçʤéʤåîãçʤʣąæäæ ÞãâʧʡåãâãʥʧʢéʦôèʥãʚʒʞôʥäãæʦãßçʡåʤæÞçʧéʥʢççʢʣòåʡʦéãìʢʦäʤʣ æʢæÝʥʡçð æʢàãʡèʥʢàʦéʡÞåʢçʡéʢæçðæãßʤæʤßʢççðæʦãßçʡåʤæ ʡàÞʢçéãëãôą ʦãßçʡåʤæÞðʦʤäʤʣãçéʢçʦãÞçʤʦéãʟãÝʥʤâçðʢʓʝÌÞãâʧʡåãâãʥʧóéʦôôʥäãæããßʤæʤßʢççðæã ÝʤßʡéðʢåãèãàçðæäʤæèʤçʢçéʤæąʦãßçʡåʤæçãâäʤʣãçéʢçʦãÞçʤʦéã ʦçʢìʢéäãæãßʥʡçãëʡæãʒʡåñëãçãʥʤÞʡççðʢʓʝÌÞðßåôàôéäʡäʦãßçʡåçãâäʤʣãçéʢçʦãÞçʤʦéãʦʥʢâäʤʤìʢʥìʢççðæãßʥʡçãëʡæãʥãʦ ʜãʦʚʒʞäʤʥʤçʡʥçðʨʡʥéʢʥãʣʓʟãÝʥʤâçʡôʓʝÌÌʒʡåñëãçãʥʤÞʡççʡôʓʝÌʔʓʝÌ çʡʦðîʢççʡôåãèãàʡæã ʚßʥʡçãìʢçãʢæ ʚʒʞ ôÞåôʢéʦô çʢʤÝʨʤàãæʤʦéñ âʡæʢîʢçãô äʥʤÞã Þʤ Þʥʢæô ãʦʦåʢàʤÞʡçãô äʤçéʥʡʦéçðæ èʥʢèʡʥʡéʤæ ìéʤ èʥãÞʤàãé ä çʢäʤéʤʥʤæʧ ʧÞʢåãìʢçãó èʥʤàʤåáãéʢåñçʤʦéã èʥʤëʢàʧʥð ã ʥãʦäʧ ʤʦåʤáçʢçãʣ Íʥʧßʤʢ ʤßʥʡçãìʢçãʢ æʢéʤàʡ ʤÝʧʦåʤÞåʢçʤ çãâäʤʣ èʥʤçãäʡóîʢʣ ʦèʤʦʤÝçʤʦéñó çʡ ą ææ ʡʥéʢʥãʡåñçʤʣ ʦéʢçäã èʤòéʤæʧʤÝïʢæʓʝÌçʢÞʦʢßàʡæʤáʢéÝðéñʤèʥʢàʢåʢçʔéʤÞʥʢæôäʡäʚʒʞ ôÞåôʢéʦô Þðʦʤäʤéʤìçðæ æʢéʤàʤæ Þãâʧʡåãâʡëãã èʤÞʢʥʨçʤʦéçðʨ ʦéʥʧäéʧʥ ʓʝÌ ßåʧÝãççðʢʦéʥʧäéʧʥðʓʝÌãʤʦʤÝʢççʤʦéãʥʢæʤàʢåãʥʤÞʡçãôʦʤʦʧàʡåʧìíʢʤèʥʢàʢåôóéʦôʦèʤæʤîñóʔʝÒÏÐʦʔʕ;= ʚàçãæ ãâ Þʡáçðʨ èʥʢãæʧîʢʦéÞ ʚʒʞ ôÞåôʢéʦô Þʤâæʤáçʤʦéñ ìʢéäʤʣ Þãâʧʡåãâʡëãã èʤÞʥʢáàʢçãʣ ãçéãæð ã èʤäʥðíäã ʓʝÌ àãʦʦʢäëãã ʥʡâʥðÞʡ òʥʤâãã èʤäʥðíäã;ą=ʝèʤæʤîñóʚʒʞʧàʡåʤʦñʧʦéʡçʤÞãéñ ìéʤàãʦʦʢäëãôìʡîʢ Þʤâçãäʡʢé çʡ ßʥʡçãëʢ ʓʝÌ ã çʢãâæʢçʢççʤʣ ʡʥéʢʥãã Íãʡßçʤʦéãäʡ àãʦʦʢäëãã Ýåôíäã ʤʦçʤÞʡçʡ çʡ Þãâʧʡåãâʡëãã éʤçäãʨ èʤàÞãáçðʨ äʥʡʢÞ çʡàʤʥÞʡççʤʣ ãçéãæðæʢàãã ÞèʥʤʦÞʢéʢʡʥéʢʥããʜʡâʥðÞʤèʥʢàʢåôʢéʦôäʡäàʢêʢäéèʤäʥðíäã 71 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʓʝÌ ʦ ʤÝʥʡâʤÞʡçãʢæ èʤåʤʦéã Þ ʓʝÌ Þ òéʤʣ âʤçʢ åãèãàçðʣ èʧå äʤçéʡäéãʥʧʢé ʦ èʥʤʦÞʢéʤæ ʦʤʦʧàʡ Úʥʤâãô Þðßåôàãé äʡä èʤéʢʥô çʢèʥʢʥðÞçʤʦéã èʤäʥðíäã ÝʢâʤÝʥʡâʤÞʡçãôèʤåʤʦéãʛʤçʢäʤéʤʥðæàʡççðæ ʥʡâʥðÞðãòʥʤâããèʤäʥðíäã ʓʝÌèʥãʚÐʘçʡÝåóàʡóéʦôʦèʤæʤîñóʚʒʞçʡæçʤßʤìʡîʢ ìʢæèʥãʡçßãʤʦäʤèãã ãʔʝÒÏÐ;=ʛʥãʦéʢçʤìçðʢéʥʤæÝðÞãâʧʡåãâãʥʧóéʦôäʡäæʡʦʦð ÞðʦéʧèʡóîãʢÞèʥʤʦÞʢéʦʤʦʧàʡʛʥãòéʤæäʥʡʦçðʢòʥãéʥʤëãéʡʥçðʢ éʥʤæÝðãàʢçéãêãëãʥʧóéʦôäʡäʦéʥʧäéʧʥʡÞèʥʤʦÞʢéʢʡʥéʢʥããʦʦãßçʡåʤæÞðʦʤäʤʣãçéʢçʦãÞçʤʦéã àʡóîʡôéʢçñ âʡäʤéʤʥʤʣʦãßçʡåèʤåçʤʦéñóòäʥʡçãʥʤÞʡç ʡÝʢåðʢåʢʣäʤëãéʡʥçðʢ ã éʥʤæÝʤëãéʡʥçðʢ Ýʤåʢʢ ʨʡʥʡäéʢʥçðʢ àåô ʒʓ Þãâʧʡåãâãʥʧóéʦô äʡä ʤÝʥʡâʤÞʡçãô ʦ ãçéʢçʦãÞçðæ ʦãßçʡåʤæ äʤéʤʥðʢ èʥʤʢëãʥʧóéʦô çʡ ʦéʢçäʧ ʦʤʦʧàʡ ã èʤßåʤîʡóé ʦãßçʡå çʤ Þ æʢçñíʢʣ æʢʥʢ ìʢæ äʥʡʦçðʢ ;= Ôʡʦéʤéʡ ʤÝçʡʥʧáʢçãô éʥʤæÝʤéãìʢʦäãʨ æʡʦʦ ʧ èʡëãʢçéʤÞ ʦ ʚÐʘ ʦ ãʦèʤåñâʤÞʡçãʢæ ʚʒʞ éʡäáʢ âçʡìãéʢåñçʤÞðíʢ ìʢæʦèʤæʤîñóʔʝÒÏÐ ʔðʦʤäʡô èåʤéçʤʦéñ æʡäʥʤêʡßʤÞ çʡ êãÝʥʤâçʤʣ èʤäʥðíäʢ æʤáʢé ʤäʡâʡéñʦô ʤìʢçñÞʡáçðæêʡäéʤʥʤæàåôʤèʥʢàʢåʢçãôʥãʦäʡʥʡâʥðÞʡʟʓʞʒʛʥãèʤæʤîãʚʒʞ ÞʤèʥʢàʢåʢççʤʣʦéʢèʢçãÞʤâæʤáçʤãàʢçéãêãëãʥʤÞʡéñʧìʡʦéäãʦÞðʦʤäʤʣãçéʢçʦãÞçʤʦéñóʦãßçʡåʡäʡäãçêãåñéʥʡëãóêãÝʥʤâçʤʣèʤäʥðíäãäåʢéäʡæãÞʤʦèʡåʢçãô; =ʙʢʦæʤéʥôçʡéʤìéʤæʢéʤàèʤâÞʤåôʢéÞãâʧʡåãâãʥʤÞʡéñʦäʤèåʢçãô Þʤʦèʡåãéʢåñçðʨ äåʢéʤä åãíñ ʥʡâæʢʥʤæ æäæ òéã àʡççðʢ ãæʢóé Þðʦʤäʧó äʤʥʥʢåôëãó ʦ ãææʧçʤßãʦéʤʨãæãìʢʦäãæ ʡçʡåãâʤæ ;= ʛʥã òéʤæ ãçêãåñéʥʡëãô ʓʝÌ æʡäʥʤêʡßʡæã ʧ Ýʤåñçðʨ ʚʒʝ èʥãʦʧîʡ çʢ éʤåñäʤ ʦãæèéʤæ ʦÞôâʡççðæ çʤ ã ʦãæèéʤæ çʢʦÞôâʡççðæ ʡʥéʢʥãôæ ʤàçʡäʤ Þ ʟʓʞʒ ã Þ ʤÝåʡʦéã ʥʡâʥðÞʡ ʓʝÌ èåʤéçʤʦéñ æʡäʥʤêʡßʤÞ Þðíʢ ìʢæ Þ ʧìʡʦéäʡʨ Ýʢâ ʥʡâʥðÞʡ ; = Ìʤåñíʡô èåʤéçʤʦéñ æʡäʥʤêʡßʤÞ ʤÝçʡʥʧáʢçʡ ʧ èʡëãʢçéʤÞ ʦ çʢʦéʡÝãåñçʤʣ ʦéʢçʤäʡʥàãʢʣ Þʥʡâåãìçðʨʧìʡʦéäʡʨʡʥéʢʥãʣ äʡäÞêãÝʥʤâçðʨ éʡäãÞÝʤßʡéðʨåãèãàʡæãʓʝÌ ; = ʘʢéʤàʚʒʞéʡäáʢàʡʢéÞʤâæʤáçʤʦéñãàʢçéãêãëãʥʤÞʡéñçʢʤÞʡʦäʧåôʥãâʡëãó VASAVASORUM ÞʓʝÌ äʤéʤʥʡôôÞåôʢéʦôʤàçãæãâèʥãâçʡäʤÞçʢʦéʡÝãåñçʤʦéããÞðßåôàãé äʡä æãäʥʤʦäʤèãìʢʦäãʢ äʡçʡåð ;= Ðæʢóéʦô àʡççðʢ ʤ Ýʤåʢʢ Þðʦʤäʤʣ èåʤéçʤʦéãVASAVASORUMʧèʡëãʢçéʤÞʚʒʝʦçʢʦéʡÝãåñçðæãʓʝÌ;= ʔçʡʦéʤôîʢʢÞʥʢæôʚʒʞãʦèʤåñâʧʢéʦôèʥãèʥʤÞʢàʢçããäʤʥʤçʡʥçʤßʤʦéʢçéãʥʤÞʡçãôʝéʥʡéðôìʢʣäã ʦéʢçéʡÞãâʧʡåãâãʥʧóéʦôäʡäʦèåʤíçðʢèʤåʤʦð èʤʦäʤåñäʧ æʢéʡåå çʢ èʥʤèʧʦäʡʢé ʦÞʢé Úéʤ àʡʢé Þʤâæʤáçʤʦéñ ʤëʢçãéñ ʦ èʤæʤîñó ʚʒʞ ʥʡʦèʥʤʦéʥʡçʢçãʢçʢʤãçéãæðçʡʦéʥʡéʡʨʦéʢçéʤÞãèʤâÞʤåôʢéʤèʥʢàʢåãéñéʤåîãçʧʦåʤôʢʢßãèʢʥèåʡâãã;ą=ʛʤäʡâʡçʤ ìéʤʚʒʞôÞåôʢéʦôëʢççðææʢéʤàʤæ àåôÞðÝʤʥʡʤèéãæʡåñçʤßʤæʢʦéʡʧʦéʡçʤÞäãʦéʢçéʡ àåôÞãâʧʡåãâʡëããʤʦåʤáçʢçãʣèʥããæèåʡçéʡëããʦéʢçéʤÞąæʡåñèʤâãëããʦéʢçéʡ àãʦʦʢäëããʦéʢçäãʦʤʦʧàʡ èʥʤéʥʧâããéäʡçãæʢáàʧʦéʥʡéʡæãʦéʢçéʡ; = ʜʡâÞãéãʢ éʢʨçʤåʤßãã ʚʒʞ èʥãÞʢåʤ ä èʤôÞåʢçãó æʢéʤàãäã ʚʒʞ Þ ìʡʦéʤéçʤʣ ʤÝåʡʦéã äʤéʤʥʡô ʨʡʥʡäéʢʥãâʧʢéʦô Ýðʦéʥʤʣ èʥʤéôáäʤʣ ææʦ Þðʦʤäãæ 72 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ äʡìʢʦéÞʤæãâʤÝʥʡáʢçãô ʤéʦʧéʦéÞãʢæçʢʤÝʨʤàãæʤʦéãÞʤääåóâãʥʧóîʢæÝʡååʤçʢãèʤåʧìʢçãʢæãâʤÝʥʡáʢçãôèʤèʢʥʢìçʤßʤʦʥʢâʡÞʥʢʡåñçʤæÞʥʢæʢçã;= ÍʜÒʕÐʖÐʙʔʓÏÐʔʙØʖʘʖʞʚÍØ ʒʤʥʤçʡʥçʡô ʡçßãʤʦäʤèãô ôÞåôʢéʦô æʢéʤàʤæ èʥôæʤʣ Þãâʧʡåãâʡëãã èʥʤʦÞʢéʡʡʥéʢʥããʚçʡèʤâÞʤåôʢéãâʧìʡéñæʤʥêʤåʤßãóʓʝÌãÞðôÞåôéñèʥãʦéʢçʤìçðʢ éʥʤæÝðãèʤÞʥʢáàʢçãôʦéʢçäãʛʤàʡççðæʡçßãʤʦäʤèããèʥãçôéʤʥʡâàʢåôéñʓʝÌ çʡ áʢåéðʢ ʦ éʤçäʤʣ äʡèʦʧåʤʣ Ýʤßʡéðʢ åãèãàʡæã ã Ýʢåðʢ ʦ éʤåʦéʤʣ äʡèʦʧåʤʣ ã Ýʤåñíãæ äʤåãìʢʦéÞʤæ êãÝʥʤâçʤʣ éäʡçã ;= ʛʥã ʦʤèʤʦéʡÞåʢçãã àʡççðʨ ʔʝÒÏÐ ã ʡçßãʤʦäʤèãã Ýðåʤ èʤäʡâʡçʤ ìéʤ áʢåéðʢ ʓʝÌ ʤÝåʡàʡóé èʤÞðíʢççʤʣ ʥʡʦéôáãæʤʦéñó ʦçãáʢççʤʣ áʢʦéäʤʦéñó ã èʤåʤáãéʢåñçðæ ʥʢæʤàʢåãʥʤÞʡçãʢæ Ìʢåðʢ ãåã ʦéʡÝãåñçðʢ ʓʝÌ ʤÝåʡàʡóé ʤÝʥʡéçðæã ʨʡʥʡäéʢʥãʦéãäʡæã ;= ʛʤäʡâʡçʡäʤʥʥʢåôëãôéʤåîãçð êãÝʥʤâçʤʣèʤäʥðíäãÝåôíäãʦ ʢʢëÞʢéʤæãçéʢçʦãÞçʤ áʢåéðʢʓʝÌãæʢóéçʡãæʢçñíʧóéʤåîãçʧèʤäʥðíäã ãâçãʨʦʤʦéʡÞåôóéʟʓʞʒ;=ʔãʦʦåʢàʤÞʡçãôʨÝðåʤèʤäʡâʡçʤ ìéʤʚʒʝʥʡâÞãÞʡʢéʦôàʤʦéʤÞʢʥçʤ ìʡîʢʧèʡëãʢçéʤÞʦʡçßãʤʦäʤèãìʢʦäãáʢåéðæãʓʝÌ; =ʝʧîʢʦéÞʢççðæèʥʢãæʧîʢʦéÞʤæʡçßãʤʦäʤèããôÞåôʢéʦôÞãâʧʡåãâʡëãôèʥãʦéʢçʤìçʤßʤéʥʤæÝʤâʡÒèʡëãʢçéʤÞ èʢʥʢçʢʦíãʨʚʒʝ ʓʝÌʦèʥãʦéʢçʤìçðæéʥʤæÝʤâʤæʤèʥʢàʢåôåãʦñèʥãʒʓʕ åãíñÞąʦåʧìʡʢÞ éʤßàʡäʡäèʥãʡçßãʤʦäʤèããąʧąÝʤåñçðʨ; = ʛʥãòéʤæìʡʦéʤéʡÞðôÞåʢçãôéʥʤæÝʤâʡãæʢåʡèʥôæʧóäʤʥʥʢåôëãóʦãçéʢçʦãÞçʤʦéñóáʢåéʤßʤëÞʢéʡ;= ʚʦçʤÞçðæçʢʧàʤÝʦéÞʤææʢéʤàʡôÞåôóéʦôçʢʤÝʨʤàãæʤʦéñâʡæʢîʢçãôäʥʤÞã ãâʤéʤçãìʢʦäãæʥʡʦéÞʤʥʤæçʡéʥãôʨåʤʥãàʡ ʡéʡäáʢʦʧÝïʢäéãÞçʤʦéñʤëʢçäã çʢÞʤâæʤáçʤʦéñãâʧìʢçãôæʢåäãʨʦʤʦʧàʤÞʔëʢåʤæ çʢʦæʤéʥôçʡéʤìéʤæʢéʤàãäʡ ʡçßãʤʦäʤèãã ãæʢʢé àʡÞçóó ãʦéʤʥãó ʢʢ èʥãæʢçʢçãʢ Þ äåãçãìʢʦäʤʣ èʥʡäéãäʢ ʤßʥʡçãìʢççʤ Þ ʦÞôâã ʦʤ ʦåʤáçʤʦéñó èʥʤÞʢàʢçãô éʥʧàçʤʦéñó ãçéʢʥèʥʢéʡëãã ʥʢâʧåñéʡéʤÞãçʢÝʤåñíʤʣãçêʤʥæʡëãʢʣʤÞçʧéʥʢççʢʣʦéʥʧäéʧʥʢʓʝÌ ʘʢéʤàCèʢäéʥʤʦäʤèããÞÝåãáçʢʣãçêʥʡäʥʡʦçʤʣʤÝåʡʦéãÌÐʒ ʦèʢäéʥʤʦäʤèãã ʤʦçʤÞʡççʡéʤæ ìéʤʥʡâçðʢéäʡçãèʤßåʤîʡóéʦÞʢéʦʥʡâåãìçðæãàåãçʡæã ÞʤåçʛʥãòéʤæʤÝʥʡâʧʢéʦôʦèʢäéʥʤßʥʡææʡèʤßåʤîʢçãô èʤâÞʤåôóîʡôʤèʥʢàʢåãéñʨãæãìʢʦäãʣʦʤʦéʡÞéäʡçãʜʡâʥʡÝʤéʡçʦèʤʦʤÝʡçʡåãâʡåãèãàçʤßʤʦʤʦéʡÞʡ ÝåôíʢäçʢèʤʦʥʢàʦéÞʢççʤÞäʤʥʤçʡʥçðʨʦʤʦʧàʡʨʦèʤæʤîñóʦèʢëãʡåñçʤßʤäʡéʢéʢʥʡ ʚäʡâʡåʤʦñ ìéʤ ãæʢççʤ Þ àãʡèʡâʤçʢ Ýåãâäʤæ ä ãçêʥʡäʥʡʦçʤæʧ ʨʤʥʤíʤ ʥʡâåãìãæ åãèãàçðʣ äʤæèʤçʢçé ʓʝÌ ÐʦʦåʢàʤÞʡçãʢ 30%#4!#, Þ äʤéʤʥʤæ èʥʤÞʤàãåʤʦñʦʤèʤʦéʡÞåʢçãʢàʡççðʨʦèʢäéʥʤʦäʤèããʒʓãʡʧéʤèʦããʧÝʤåñçðʨÐÌʝ èʤäʡâʡåʤ ìéʤ ÌÐʒ ʦèʢäéʥʤʦäʤèãô èʤâÞʤåôʢé ʦ Ýʤåñíʢʣ éʤìçʤʦéñó ÞðôÞåôéñ ʓʝÌʦåãèãàçðæôàʥʤæ;=ÚéʤèʤâÞʤåôʢéãʦèʤåñâʤÞʡéñàʡççʧóæʢéʤàãäʧàåô ãʦʦåʢàʤÞʡçãôàãçʡæãäãʦʤàʢʥáʡçãôåãèãàʤÞÞʓʝÌçʡêʤçʢéʢʥʡèããʦéʡéãçʡæã ãʦʦåʢàʤÞʡçãʢ9%,,/7 ;=ÌÐʒ ʦèʢäéʥʤʦäʤèãôèʤâÞʤåãåʡʤëʢçãéñʥʡʦèʥʢàʢåʢçãʢ ʥʡâåãìçðʨ éãèʤÞ ʓʝÌ Þ ʒʓ ʔ ʦãæèéʤæ çʢʦÞôâʡççðʨ ʦʤʦʧàʡʨ ʧ Ýʤåñçðʨ 73 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʦʤʦéʡÝãåñçʤʣÐÌʝãʚʒʝʓʝÌʦäʥʧèçðæåãèãàçðæôàʥʤæÞʤʦçʤÞçʤæʥʡʦèʤåʡßʡóéʦôÞèʥʤäʦãæʡåñçðʨʧìʡʦéäʡʨèʢʥʢàçʢʣçãʦʨʤàôîʢʣãʤßãÝʡóîʢʣʡʥéʢʥãã ;=ÌÐʒ ʦèʢäéʥʤʦäʤèãôéʡäáʢèʤæʤßʡʢéʤèʥʢàʢåãéñèʤÞʢʥʨçʤʦéçðʢåãèãàçðʢ Þäåóìʢçãô ìʥʢÞʡéðʢÞðʦʤäãæʥãʦäʤæòæÝʤåããèʤÞʥʢæôʦéʢçéãʥʤÞʡçãôʔçʡʦéʤôîʢʢ Þʥʢæô èʥã Ôʒʔ ìʡîʢ ãʦèʤåñâʧʢéʦô äʤæÝãçʡëãô ÌÐʒ ʦèʢäéʥʤʦäʤèãã ã ʔʝÒÏÐ Þ ʢàãçʤæ ʧʦéʥʤʣʦéÞʢ Úéʤ èʤâÞʤåôʢé èʤåʧìʡéñ ʧåñéʥʡâÞʧäʤÞʤʢ ã ãçêʥʡäʥʡʦçʤʢãâʤÝʥʡáʢçãʢʦèʤæʤîñóʤàçʤßʤäʡéʢéʢʥʡàåôʦʤèʤʦéʡÞåʢçãôʡçʡéʤæãã ã ʨãæãìʢʦäʤßʤ ʦʤʦéʡÞʡ ʦéʢçäã ʡʥéʢʥãã ʜʢâʧåñéʡéð ÌÐʒ ʦèʢäéʥʤʦäʤèãã ʤéʥʡáʡóéʦôÞÞãàʢʨʢæʤßʥʡææðʦʤʦʧàãʦéʤʣʦéʢçäãʦëÞʢéʤÞðæäʡʥéãʥʤÞʡçãʢæ âʤçʦÞðʦʤäʤʣÞʢʥʤôéçʤʦéñóÞðôÞåʢçãôåãèãàçʤßʤôàʥʡ;=Ðæʢóéʦôàʡççðʢ ʧäʡâðÞʡóîãʢçʡéʤ ìéʤʦèʤæʤîñóéʡäʤʣàãʡßçʤʦéãäã âʡʦìʢéÝʤåʢʢéʤìçʤßʤ ʤèʥʢàʢåʢçãôàåãçðʓʝÌãʤÝîʢʣéôáʢʦéãèʤʥʡáʢçãô ʧàʡʢéʦôʦçãâãéñìʡʦéʤéʧ ʥʡâÞãéãôèʢʥãʤèʢʥʡëãʤççðʨʤʦåʤáçʢçãʣèʥãʦéʢçéãʥʤÞʡçãã;= ʘʢéʤà éʢʥæʤßʥʡêãã èʤâÞʤåôʢé ÞðôÞãéñ ʧìʡʦéäã èʤÞðíʢççʤʣ éʢæèʢʥʡéʧʥðÞéäʡçãʖßʤèʥãæʢçʢçãʢÞäʡʥàãʤåʤßãìʢʦäʤʣèʥʡäéãäʢʤʦçʤÞʡçʤçʡéʤæ ìéʤ çʢʦéʡÝãåñçðʢʓʝÌãçêãåñéʥãʥʤÞʡçðÞʤʦèʡåãéʢåñçðæãäåʢéäʡæã ãçéʢçʦãÞçʤ èʤéʥʢÝåôóîãæãßåóäʤâʧãäãʦåʤʥʤàʦÞðàʢåʢçãʢæéʢèåʡʞʢæèʢʥʡéʧʥçʤʢʥʡâʥʢíʢçãʢʦʤÞʥʢæʢççðʨäʡéʢéʢʥʤÞàåôéʢʥæʤßʥʡêããʦʤʦéʡÞåôʢéèʤʥôàäʡ mʝ èʥʤʦéʥʡçʦéÞʢççʤʢą ææʛʤäʡâʡçʤ ìéʤʧèʡëãʢçéʤÞʦçʢʦéʡÝãåñçʤʣʦéʢçʤäʡʥàãʢʣãÐʘéʢæèʢʥʡéʧʥʡÝåôíʢäÞðíʢ ìʢæʧèʡëãʢçéʤÞʦʤʦéʡÝãåñçʤʣʦéʢçʤäʡʥàãʢʣ; =ʔéʤáʢÞʥʢæôʥʢâʧåñéʡéðʥôàʡãʦʦåʢàʤÞʡçãʣèʤäʡâʡåã ìéʤ ãâæʢçʢçãôàʡÞåʢçãôÞäʤʥʤçʡʥçðʨʦʤʦʧàʡʨãʦʡæäʥʤÞʤéʤäæʢçôóééʢæèʢʥʡéʧʥʧ çʡèʤÞʢʥʨçʤʦéãʡʥéʢʥããʒʥʤæʢéʤßʤ éʢæèʢʥʡéʧʥçʡôçʢʤàçʤʥʤàçʤʦéñèʤÞʢʥʨçʤʦéãʧìʡʦéäʤÞʦéʢçäãʦʓʝÌæʤáʢéÝðéñʤÝʧʦåʤÞåʢçʡʡʥéʢêʡäéʡæã;=ʘʢéʤà ʤÝåʡàʡʢéãàʥʧßãæãʤßʥʡçãìʢçãôæãàåôéʤìçʤßʤãâæʢʥʢçãôéʢæèʢʥʡéʧʥçʤʣçʢʤàçʤʥʤàçʤʦéãçʢʤÝʨʤàãæʡÞʥʢæʢççʡôʤääåóâãôʦʤʦʧàʡ ʥʡʦʦéʤôçãʢʤéàʡéìãäʡ àʤʦéʢçäãʦʤʦʧàʡàʤåáçʤÝðéñ ææ ìéʤæʤáʢééʥʡÞæãʥʤÞʡéñʦéʢçäʧʦʤʦʧàʡ ʝʧìʢéʤæòéʤßʤ ʡéʡäáʢÞʦÞôâãʦéʢʨçãìʢʦäʤʣʦåʤáçʤʦéñóæʢéʤàéʢʥæʤßʥʡêãã Þ çʡʦéʤôîʢʢ Þʥʢæô ãʦèʤåñâʧʢéʦô ßåʡÞçðæ ʤÝʥʡâʤæ Þ òäʦèʢʥãæʢçéʡåñçðʨ ãʦʦåʢàʤÞʡçãôʨ ʘʢéʤà Þçʧéʥãʦʤʦʧàãʦéʤʣ æʡßçãéçʤ ʥʢâʤçʡçʦçʤʣ éʤæʤßʥʡêãã ʔʝ ʘʜʞ èʥʢàʧʦæʡéʥãÞʡʢé ÞÞʢàʢçãʢ Þçʧéʥãʦʤʦʧàãʦéʤʣ ʥʡàãʤìʡʦéʤéçʤʣ äʡéʧíäã Þ ʒʓ ʜʡâåãìçðʢ äʤæèʤçʢçéð ʓʝÌ ãæʢóé ʥʡâçðʣ ʨãæãìʢʦäãʣ ʦʤʦéʡÞ ʦʤàʢʥáʡçãʢ Þʤàð ã ÝʢåäʤÞðʨ æʤåʢäʧå ã Ýåʡßʤàʡʥô òéʤæʧ ʔʝ ʘʜʞ èʤâÞʤåôʢé ÞãâʧʡåãâãʥʤÞʡéñ äʤæèʤçʢçéð ʓʝÌ ą çʢäʥʤéãìʢʦäʤʢ ôàʥʤ êãÝʥʤâçʧó èʤäʥðíäʧ ã Þʤʦèʡåãéʢåñçðʣ ãçêãåñéʥʡé ; = ʛʥã ʔʝ ʘʜʞ Þʤâæʤáçʡ Þãâʧʡåãâʡëãô èʥãʦéʢçʤìçʤßʤ éʥʤæÝʡ ã ʤëʢçäʡ ʢßʤ ʥʡâæʢʥʡ ã ʥʡʦèʤåʤáʢçãô ;= Ðæʢóéʦô èʥʢàÞʡʥãéʢåñçðʢ àʡççðʢ ʤ èʥʢãæʧîʢʦéÞʢ ʔʝ ʘʜʞ Þ ʤèʥʢàʢåʢçãã åãèãàçðʨ ãäʡåñëãçãʥʤÞʡççðʨäʤæèʤçʢçéʤÞʓʝÌèʤʦʥʡÞçʢçãóʦʔʝÒÏÐ; = 74 Ðçʦéʥʧæʢçéʡåñçʡôàãʡßçʤʦéãäʡ ʝéʢçäʡʦʤʦʧàʡ Ñãèãàçðʣäʤæèʤçʢçé ʟãÝʥʤâ ʒʡåñëãʣ ʞʥʤæÝʤâ ʔʤʦèʡåʢçãʢ ʛʥʤßçʤâãʥʤÞʡçãʢ ʦʤÝðéãʣ ʝéʢèʢçñʦéʢçʤâʡ + ġ ġ ġ ġ ġ ġ ġ ʔʝÒÏÐ òåʡʦéʤßʥʡêãô èʡåñèʤßʥʡêãô ʔʕ ʚÝïʢæʓʝÌ èʥʤʦÞʢé ʦʤʦʧàʡ òʨʤßʢççʤʦéñ ʦéʥʧäéʧʥçʡô ßʢéʢʥʤßʢççʤʦéñ ʦʤʦéʡÞʓʝÌ ÞðôÞåʢçãʢʟʓʞʒ + + ġ + + ġ ġ ġ ʓçßãʤʦäʤèãô Ñãèãàçʤʢôàʥʤ èʤäʥðíäʡëÞʢé ʓʝÌ éʥʤæÝʤâ òʥʤâãã ġ ġ + + ġ + ġ ġ ʚʒʞ ʞʤåîãçʡèʤäʥðíäã ʤÝçʡʥʧáʢçãʢ ʥʡâʥðÞʡ éʥʤæÝʤâʡʓʝÌ æʡäʥʤêʡßʡåñçʡô ãçêãåñéʥʡëãô + + + + + + ġ ? ʞʢʥæʤßʥʡêãô ʞʢæèʢʥʡéʧʥʡʓʝÌ æʡäʥʤêʡßʡåñçʡô ãçêãåñéʥʡëãô ġ ġ ? ? ? ? + ġ ÌÐʒ ʦèʢäéʥʤʦäʤèãô Ñãèãàçʤʢôàʥʤ æʡäʥʤêʡßʡåñçʡô ãçêãåñéʥʡëãô ġ ġ + + + ġ ġ ? ʔçʧéʥãʦʤʦʧàãʦéʡô ʘʜʞ ġ ġ + + + ġ ġ ? ʔʤâæʤáçʤʦéã ʓçßãʤßʥʡêãô ʘʢéʤàãäʡ ʝéʢçʤâèʥʤʦÞʢéʡ ʞʡÝåãëʡ ʝʥʡÞçãéʢåñçðʢÞʤâæʤáçʤʦéããçÞʡâãÞçðʨæʢéʤàʤÞãʦʦåʢàʤÞʡçãô ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʤʥʡáʢçãô;= ʝʤʦéʡÞʓʝÌåãèãàð êãÝʥʤâçʡôéäʡçñ äʡåñëãʣ 75 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʛʜʚʟÐÑʓʒʞÐʒʓÐÑʖÔʖʙÐʖʓʞʖʜʚʝʒÑʖʜʚÏʓ ÐÍÐʝÑÐʛÐÍʖʘÐʗ ʛʥãæʢçãéʢåñçʤäʡéʢʥʤʦäåʢʥʤâʧãàãʦåãèãàʢæãôæèʤçôéãôièʥʤêãåʡäéãäʡx ãiåʢìʢçãʢxÞÝʤåñíʤʣʦéʢèʢçãèʢʥʢʦʢäʡóéʦôãæʢáàʧçãæãçʢéìʢéäʤʣßʥʡçãÚéʤ ʦÞôâʡçʤʦéʢæ ìéʤÞåʢìʢçããÝʤåñçðʨÞʦʢʨäʡéʢßʤʥãʣʥãʦäʡ Þéʤæìãʦåʢʧæʢʥʢççʤßʤãçãâäʤßʤ ÝʤåñíʡôʥʤåñʧàʢåôʢéʦôäʤʥʥʢäëããêʡäéʤʥʤÞʥãʦäʡ éʤʢʦéñʦʤÝʦéÞʢççʤ èʥʤêãåʡäéãäʢ ʞʢʥʡèãô àãʦåãèãàʢæãʣ Þäåóìʡʢé Þ ʦʢÝô àÞʡ ʤʦçʤÞçðʨ äʤæèʤçʢçéʡ çʢæʢàãäʡæʢçéʤâçʡôéʢʥʡèãô çʡèʥʡÞåʢççʡôçʡãâæʢçʢçãʢʤÝʥʡâʡáãâçããçʡäʤʥʥʢäëãóʤʦçʤÞçðʨêʡäéʤʥʤÞʥãʦäʡ æʢàãäʡæʢçéʤâçʡôéʢʥʡèãô ääʤéʤʥʤʣèʥãÝʢßʡóéʧÝʤåñçðʨʤìʢçñÞðʦʤäʤßʤãÞðʦʤäʤßʤʥãʦäʡ ʡéʡäáʢʧåãëÝʢâäåãçãìʢʦäãʨèʥʤôÞåʢçãʣʡéʢʥʤʦäåʢʥʤâʡ çʤʦÞðʥʡáʢççʤʣàãʦåãèãàʢæãʢʣ;= ʙʖʘʖÍÐʒʓʘʖʙʞʚÏʙʓÜʞʖʜʓʛÐÜ ʙʢæʢàãäʡæʢçéʤâçʡôèʥʤêãåʡäéãäʡôÞåôʢéʦôäʥʡʣçʢÞʡáçʤʣʦʤʦéʡÞåôóîʢʣåʢìʢçãôʖʢÞäåʡàÞèʥʢàʤéÞʥʡîʢçãʢʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʦʤÝðéãʣʦéʤåñáʢÞðʦʤä äʡäãÞäåʡàæʢàãäʡæʢçéʤâçʤʣéʢʥʡèããÍʤäʡâʡéʢåñʦéÞʤæòéʤæʧʦåʧáʡéʥʢâʧåñéʡéðêãçʦäʤßʤãʦʦåʢàʤÞʡçãôiʝʢÞʢʥʤäʡʥʢåñʦäãʣèʥʤʢäéxą ÞäʤéʤʥʤæÝðå ʦàʢåʡçʡäëʢçéçʡèʥʤèʡßʡçàʧÞʥʢàʡäʧʥʢçãôãçʡãâæʢçʢçãʢʨʡʥʡäéʢʥʡèãéʡçãôą ʤéäʡâʤéêʡʦé êʧàʡãÞäåóìʢçãʢÞʥʡëãʤçʤÞʤîʢʣãêʥʧäéʤÞÚéʤèʥãÞʢåʤäʦçãáʢçãóäʤåãìʢʦéÞʡäʧʥôîãʨʦàʤ äʦçãáʢçãóʦãʦéʤåãìʢʦäʤßʤʓÍʦʤ àʤææʥéʦé ʦçãáʢçãóʧʥʤÞçôʠʝʦ àʤ ææʤåñåʔʥʢâʧåñéʡéʢʦæʢʥéçʤʦéñʤéÐÌʝʦçãâãåʡʦñçʡÞʝʢÞʢʥçʤʣʒʡʥʢåãããçʡÞʟãçåôçàãã;= ʙʢæʢàãäʡæʢçéʤâçʡôéʢʥʡèãôÞäåóìʡʢéÞʦʢÝô ʦʤÝåóàʢçãʢàãʢéð äʤçéʥʤåñʡʥéʢʥãʡåñçʤʣßãèʢʥéʤçãã èʥʢäʥʡîʢçãʢäʧʥʢçãô èʤÞðíʢçãʢʧʥʤÞçôêãâãìʢʦäʤʣʡäéãÞçʤʦéã ʡàʢäÞʡéçʧóéʢʥʡèãóâʡÝʤåʢÞʡçãʣ ÞðâðÞʡóîãʨÞéʤʥãìçʧóàãʦåãèãàʢæãóàãʡÝʢé ßãèʤéãʥʢʤâ çʢêʥãé ʨʥʤçãìʢʦäãʣʡåäʤßʤåãâæ ʤáãʥʢçãʢãàʥ ÍãʢéʡôÞåôʢéʦôÞʡáçðæêʡäéʤʥʤæäʤʥʥʢäëããàãʦåãèãàʢæãʣʔʦåʧìʡôʨÞðʥʡáʢççʤʣàãʦåãèãàʢæããàãʢéʡçʡâçʡìʡʢéʦôʦʤÞæʢʦéçʤʦÞʥʡìʤæ àãʢéʤåʤßʤæ ʚʦçʤÞçðʢèʥãçëãèðàãʢéʤéʢʥʡèãã ʚßʥʡçãìʢçãʢçʡʦðîʢççðʨáãʥʤÞãâʡæʢçʡãʨçʢçʡʦðîʢççðæãáãʥʡæãæʡʦåʡæã äʤéʤʥðʢèʥãòéʤæàʤåáçðʦʤʦéʡÞåôéñçʢÝʤåʢʢʤéʤÝîʢßʤìãʦåʡäʡåʤʥãʣ 76 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʛʥʢʤÝåʡàʡçãʢÞàãʢéʢʦåʤáçðʨʧßåʢÞʤàʤÞãßʥʧÝʤʣäåʢéìʡéäãçʢæʢçʢʢʤéʤÝîʢßʤìãʦåʡäʡåʤʥãʣ ʚßʥʡçãìʢçãʢèʤʦéʧèʡóîʢßʤʦèãîʢʣʨʤåʢʦéʢʥãçʡæßʦʧé àåôÝʤåñçðʨÞðʦʤäʤßʤʥãʦäʡąæßʦʧé ʛʡëãʢçéʡæʥʢäʤæʢçàʧʢéʦôãâÝʢßʡéñèʥʤàʧäéʤÞʦÞðʦʤäãæʦʤàʢʥáʡçãʢæáãʥʤÞ áãÞʤéçʤßʤ èʥʤãʦʨʤáàʢçãô æʤåʤäʤ ʦåãÞäã ʦæʢéʡçʡ áãʥçðʢ ʦʤʥéʡ æôʦʡ ʜʢäʤæʢçàʧʢéʦôìʡîʢãʦèʤåñâʤÞʡéñÞʥʡëãʤçʢʤÞʤîããêʥʧäéð ʥðÝʧ çʢáãʥçðʢ ʦʤʥéʡæôʦʡãæʤåʤìçðʨèʥʤàʧäéʤÞ ʥʡʦéãéʢåñçʤʢæʡʦåʤ ʔèʤʦåʢàçʢʢÞʥʢæôÞʥʢäʤæʢçàʡëãôʨèʤäʤʥʥʢäëããàãʦåãèãàʢæããʤÝʥʡîʡóé Þçãæʡçãʢ çʡ Þʤâæʤáçʤʦéñ Ýʤåʢʢ íãʥʤäʤßʤ èʥãæʢçʢçãô ʥʡʦéãéʢåñçðʨ ʦéʢʥʤåʤÞ ãʦéʡçʤåʤÞʡçʡåʤßʤÞʨʤåʢʦéʢʥãçʡ ʦʤàʢʥáʡîãʨʦôÞʥʡʦéʢçãôʨ ÚéãʦéʢʥʤåðÝåʤäãʥʧóéâʡæʢàåôóé ÞʦʡʦðÞʡçãʢʨʤåʢʦéʢʥãçʡÞäãíʢìçãäʢãâèʥʤàʧäéʤÞáãÞʤéçʤßʤ èʥʤãʦʨʤáàʢçãô ʜʢäʤæʢçàʧʢæʡô àʤâʡ ʥʡʦéãéʢåñçðʨ ʦéʢʥʤåʤÞʦéʡçʤåʤÞ ą ąßʦʧéʒçʡãÝʤåʢʢãâÞʢʦéçðæèʥʤàʧäéʡæ ʦʤàʢʥáʡîãæʥʡʦéãéʢåñçðʢʦéʢʥʤåð ʦéʡçʤåð ʤéçʤʦôéʦôæʡʥßʡʥãçãçʢäʤéʤʥðʢʣʤßʧʥéðÍʥʧßʤʣÞʡáçʤʣèãîʢÞʤʣàʤÝʡÞäʤʣôÞåôʢéʦôäʥʡʦçðʣàʥʤááʢÞʤʣʥãʦ äʤéʤʥðʣèʤʦÞʤʢʣßãèʤåãèãàʢæãìʢʦäʤʣ ʡäéãÞçʤʦéã ʦʤèʤʦéʡÞãæ ʦ èʥãʢæʤæ ą æß åʤÞʡʦéʡéãçʡ ʚàçʡäʤ Þ ʜʤʦʦãã òéã èãîʢÞðʢàʤÝʡÞäã éʡäáʢäʡäãʥʡʦéãéʢåñçðʢʦéʢʥʤåðãʦéʡçʤåð èʤäʡçʢèʤåʧìãåãʥʡʦèʥʤʦéʥʡçʢçãô ʔʢʦñæʡèʤèʧåôʥçðæãôÞåôóéʦôʦʥʢàãâʢæçʤæʤʥʦäʡôãʦäʡçàãçʡÞʦäʡôàãʢéð ʝʥʢàãâʢæçʤæʤʥʦäʡôàãʢéʡèʤåʧìãåʡãâÞʢʦéçʤʦéñÞäʤçëʢ ʨßß äʤßàʡʦéʡåããâÞʢʦéçðʥʢâʧåñéʡéðãʦʦåʢàʤÞʡçãôiʦéʥʡçx!+EYS -+EYS ʚʦçʤÞʧʦʥʢàãâʢæçʤæʤʥʦäʤʣàãʢéðʦʤʦéʡÞåôʢéèãéʡçãʢʦèʥʢãæʧîʢʦéÞʢççðæèʤéʥʢÝåʢçãʢæèʥʤàʧäéʤÞæʤʥôʥðÝʡ ʤÞʤîʢʣ êʥʧäéʤÞ ʤʥʢʨʤÞ ʤåãÞäʤÞʤßʤæʡʦåʡ äʥʡʦçʤßʤÞãçʡ ãçãâäãæʦʤàʢʥáʡçãʢæÞàãʢéʢæôʦçðʨèʥʤàʧäéʤÞ áãʥʤÞáãÞʤéçʤßʤèʥʤãʦʨʤáàʢçãô æʤåʤìçðʨèʥʤàʧäéʤÞʦÞðʦʤäãæʦʤàʢʥáʡçãʢæáãʥʡÍãʢéʡʦéʡåʡèʤèʧåôʥçʤʣ èʤʦåʢéʤßʤ äʡäÞðôʦçãåʤʦñ ìéʤʧáãéʢåʢʣʦéʥʡçʝʥʢàãâʢæçʤæʤʥñôçʡÝåóàʡåʡʦñ çʡãÝʤåʢʢçãâäʡôìʡʦéʤéʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣ ʤÝʧʦåʤÞåʢççðʨʡéʢʥʤʦäåʢʥʤâʤæ èʤʦʥʡÞçʢçãóʦàʥʧßãæãʦéʥʡçʡæãʖÞʥʤèð;= ʝäʡçàãçʡÞʦäʡôàãʢéʡéʡäáʢôÞåôʢéʦôʦãʦéʢæʤʣèãéʡçãôãʤÝʥʡâʡáãâçã ʤçʡ ÝʤåñíʢèʤàʨʤàãéàåôáãéʢåʢʣʦʢÞʢʥçðʨʦéʥʡç èʤʦäʤåñäʧçʡãÝʤåʢʢèʥãÝåãáʢçʡ äèʥãÞðìçʤæʧàåôçãʨäåãæʡéʧãʤÝʥʡâʧáãâçãÍãʢéʡãʦäåóìʡʢéèʤåʧêʡÝʥãäʡéð ʦåʡàäʤʢ ʡåäʤßʤåñ ʤßʥʡçãìãÞʡʢé ãʦèʤåñâʤÞʡçãʢ äʤçʦʢʥÞãʥʤÞʡççðʨ èʥʤàʧäéʤÞ ʛʥã èʥãßʤéʤÞåʢçãã èãîã ãʦäåóìʡóé áʡʥʢçãʢ ʤéàʡÞʡô èʥʢàèʤìéʢçãʢ Ýåóàʡæ Þéʧíʢçʤæ ÞʡʥʢçʤæãèʢìʢçʤæÞãàʢ âʡèʥʡÞåʢççðæʥʡèʦʤÞðææʡʦåʤæ ʤßʥʡçãìãÞʡóéèʤéʥʢÝåʢçãʢʦʤåãʔʡáçʧóʥʤåñãßʥʡʢéʧèʤéʥʢÝåʢçãʢʥðÝðåʤʦʤʦñ éʧçʢë ʦʢåñàñ ʦʤàʢʥáʡîʢʣæçʤßʤʤæʢßʡ èʤåãçʢçʡʦðîʢççðʨáãʥçðʨäãʦåʤéąÞʡáçʤßʤêʡäéʤʥʡÞèʥʢàʧèʥʢáàʢçããʡéʢʥʤʦäåʢʥʤâʡ;= 77 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʔ ʜʤʦʦãʣʦäãʨ ʥʢäʤæʢçàʡëãôʨ èʤ äʤʥʥʢäëãã àãʦåãèãàʢæãã 6 èʢʥʢʦæʤéʥ èʥãÞʢàʢçð ʦåʢàʧóîãʢ àãʢéãìʢʦäãʢ ʥʢäʤæʢçàʡëãã ʧìãéðÞʡóîãʢ Þʦʢ ʥʡëãʤçʡåñçðʢèʤåʤáʢçãôʦʧîʢʦéÞʧóîãʨàãʢé ʝåʢàʧʢé ʧèʤéʥʢÝåôéñ ʥʡâçʤʤÝʥʡâçʧó èãîʧ ʒʡåʤʥãʣçʤʦéñ ʥʡëãʤçʡ àʤåáçʡ Ýðéñ àʤʦéʡéʤìçʤʣàåôèʤààʢʥáʡçãôçʤʥæʡåñçʤßʤÞʢʦʡ èʥʢàʧèʥʢáàʡéñʥʡâÞãéãʢʤáãʥʢçãôãåããâÝðéʤìçʤʣæʡʦʦðéʢåʡ ʛʥʢàèʤìéʢçãʢ Þ àãʢéʢ àʤåáçʤ ʤéàʡÞʡéñʦô êʥʧäéʡæ ʤÞʤîʡæ ÝʤÝʤÞðæ ʤʥʢʨʡæ ëʢåñçʤâʢʥçʤÞðæäʥʧèʡæãʨåʢÝʧ ʥðÝʢʦÞðʦʤäãæʦʤàʢʥáʡçãʢæʤæʢßʡ èʤåãçʢçʡʦðîʢççðʨáãʥçðʨäãʦåʤéʛʙÎʒ ʛʥʤàʧäéð ʦʤàʢʥáʡîãʢçʡʦðîʢççðʢáãʥçðʢäãʦåʤéðʙÎʒ ʦåʢàʧʢéìʡîʢâʡæʢçôéñèʥʤàʧäéʡæã ʦʤàʢʥáʡîãæãæʤçʤ ãèʤåãçʢçʡʦðîʢççðʢáãʥçðʢäãʦåʤéð ìéʤ ʤÝʢʦèʢìãÞʡʢéʦʤàʢʥáʡçãʢÞʥʡëãʤçʢçʢÝʤåʢʢʤÝîʢßʤáãʥʡ çʢÝʤåʢʢéʥʡçʦáãʥʤÞãçʢÝʤåʢʢæßʨʤåʢʦéʢʥãçʡÞʦʧéäã ʛʤéʥʢÝåʢçãʢʦʤåãʦçãâãéñàʤßÞʦʧéäã ʔʤâæʤáçʤʧæʢʥʢççʤʢèʤéʥʢÝåʢçãʢʡåäʤßʤåôàʤąßÞàʢçñàåôæʧáìãçãąß Þàʢçñàåôáʢçîãç ʦʤÝôâʡéʢåñçðæʦʤÝåóàʢçãʢæÝʢâʡåäʤßʤåñçðʨàçʢʣÒÝʤåñçðʨ ʦßãèʢʥéʥãßåãëʢʥãàʢæãʢʣʧèʤéʥʢÝåʢçãʢʡåäʤßʤåôçʢʥʢäʤæʢçàʧʢéʦô ʚßʥʡçãìãéñʧèʤéʥʢÝåʢçãʢʦåʡàʤʦéʢʣãèʥʤàʧäéʤÞ ʦʤàʢʥáʡîãʨʦʡʨʡʥ ʤʦʤÝʢççʤåãëʡæʦßãèʢʥéʥãßåãëʢʥãàʢæãʢʣãæʢéʡÝʤåãìʢʦäãæʦãçàʥʤæʤæ;= ʚéäʡâ ʤé äʧʥʢçãô ìʡʦéʤ ʤäʡâðÞʡʢéʦô çʢèʥʤʦéʤʣ âʡàʡìʢʣ àåô èʡëãʢçéʡ ʚàçʡäʤ Þʥʡì àʤåáʢç ʡäéãÞçʤ ʧÝʢáàʡéñ èʡëãʢçéʡ Þ çʢʤÝʨʤàãæʤʦéã èʥʢäʥʡîʢçãô äʧʥʢçãô èʤʦäʤåñäʧ ʤéäʡâ ʤé òéʤʣ Þʥʢàçʤʣ èʥãÞðìäã âʡìʡʦéʧó ãßʥʡʢé çʢ æʢçʢʢ ÞʡáçʧóʥʤåñÞèʥʤêãåʡäéãäʢʡéʢʥʤʦäåʢʥʤâʡ ìʢæèʥãʢææʢàãäʡæʢçéʤÞ ʔʢʦéʢåʡãêãâãìʢʦäʡôʡäéãÞçʤʦéñÐâÝðéʤìçðʣÞʢʦâʡʦìʢéʤáãʥʢçãôʦèʤʦʤÝʦéÞʧʢéʥʡâÞãéãóàãʦåãèãàʢæããÐâÝðéʤìçðʣÞʢʦʤèʥʢàʢåôʢéʦôèʥããçàʢäʦʢ æʡʦʦð éʢåʡ Ðʘʞ ʤé àʤ äßæ2 ʤáãʥʢçãʢ ą èʥã Ðʘʞ äßæ2 ʒʥãéʢʥãʢæ ʡÝàʤæãçʡåñçʤßʤʤáãʥʢçãôôÞåôʢéʦôéʡäáʢʤäʥʧáçʤʦéñéʡåããʧæʧáìãçąħʦæ ʧáʢçîãçąħʦæ Íåô èʤààʢʥáʡçãô çʤʥæʡåñçʤʣ æʡʦʦð éʢåʡ èʡëãʢçéʡæ ʦ àãʦåãèãàʢæãʢʣ ʥʢäʤæʢçàʧʢéʦô Þðèʤåçôéñ ʥʢßʧåôʥçðʢ êãâãìʢʦäãʢ ʧèʥʡáçʢçãô ʧæʢʥʢççʤʣ ãçéʢçʦãÞçʤʦéã ã ʡòʥʤÝçʤʣ çʡèʥʡÞåʢççʤʦéã ʛʤʦéʤôççʡô éʥʢçãʥʤÞäʡ Þʢàʢé ä ʦçãáʢçãóʧʥʤÞçôʞʕãèʤÞðíʢçãóʧʥʤÞçôâʡîãéçʤßʤʠʝÑʔʛ ìéʤ ÞʦÞʤóʤìʢʥʢàñ ʦʤèʥʤÞʤáàʡʢéʦô ʦçãáʢçãʢæ ʓÍ ʧæʢçñíʢçãʢæ ãçʦʧåãçʤʥʢâãʦéʢçéçʤʦéã ʧåʧìíʢçãʢæêʧçäëããòçàʤéʢåãôʜʢäʤæʢçàʧʢæðʣʧʥʤÞʢçñêãâãìʢʦäʤʣʡäéãÞçʤʦéãą ąæãçʧéąʥʡâʡÞçʢàʢåóçʡêʤçʢÔʝʝąʤéæʡäʦãæʡåñçʤʣàåôàʡççʤßʤ Þʤâʥʡʦéʡ ʘʡäʦãæʡåñçʡô Ôʝʝ ʥʡʦʦìãéðÞʡʢéʦô èʤ êʤʥæʧåʢ ą Þʤâʥʡʦé åʢé Ìʤåñçðæ ʦ ÐÌʝ ã àʥʧßãæã âʡÝʤåʢÞʡçãôæã ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦãʦéʢæð ʥʢáãæ éʥʢçãʥʤÞʤìçðʨ çʡßʥʧâʤä èʤàÝãʥʡʢéʦô ãçàãÞãàʧʡåñçʤ ʦ ʧìʢéʤæ ʥʢâʧåñéʡéʤÞçʡßʥʧâʤìçʤßʤéʢʦéʡʟãâãìʢʦäʡôçʡßʥʧâäʡéʡäáʢòêêʢäéãÞçʡàåôäʤʥʥʢäëããæʢéʡÝʤåãìʢʦäãʨçʡʥʧíʢçãʣãèʥʢàʤéÞʥʡîʢçãôʝÍ))éãèʡÌʤåñçðæʦÐÌʝ ʓʕ 78 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ã àʥʧßãæã âʡÝʤåʢÞʡçãôæã ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣ ʦãʦéʢæð ʦåʢàʧʢé ãâÝʢßʡéñ ãçéʢçʦãÞçʤʣêãâãìʢʦäʤʣçʡßʥʧâäã ʧìʡʦéãôÞʦʤʥʢÞçʤÞʡçãôʨ éôáʢåʤʣêãâãìʢʦäʤʣ ʥʡÝʤéðãâ âʡʤèʡʦçʤʦéãʤÝʤʦéʥʢçãôʤʦçʤÞçʤßʤâʡÝʤåʢÞʡçãôãåãʥʡâÞãéãôéôáʢåðʨ ʤʦåʤáçʢçãʣ áʢåʧàʤìäʤÞʡô éʡʨãäʡʥàãô êãÝʥãååôëãô áʢåʧàʤìäʤÞ ʦʢʥàëʡ ßãèʢʥéʤçãìʢʦäãʣäʥãâ ãçʦʧåñéãéè ʘʖÍÐʒʓʘʖʙʞʚÏʙʓÜʕÐʛʚÑÐʛÐÍʖʘÐÔʖʝʒʓÜʞʖʜʓʛÐÜ ʕãèʤåãèãàʢæãìʢʦäʡôéʢʥʡèãôçʢʤÝʨʤàãæʡàåôàʤʦéãáʢçãôëʢåʢÞðʨʧʥʤÞçʢʣ ÓÒ åãèãàʤÞʚÝðìçʤÞäʡìʢʦéÞʢæãíʢçããʦèʤåñâʧóéʧʥʤÞʢçñʠʝÑʙʛÓʢåʢÞʤʣ ʧʥʤÞʢçñʠʝÑʙʛâʡÞãʦãéʤéäʡéʢßʤʥããʥãʦäʡèʡëãʢçéʡʔʡáçʤçʢèʥʤʦéʤçʡâçʡìãéñ ßãèʤåãèãàʢæãìʢʦäãʣ èʥʢèʡʥʡé çʡèʥãæʢʥ ʦéʡéãç ʡ ʦçãâãéñ ʠʝÑʙʛ àʤ ʤèʥʢàʢåʢççʤßʤʧʥʤÞçôʔʦʤʤéÞʢéʦéÞããʦʖÞʥʤèʢʣʦäãæãʥʢäʤæʢçàʡëãôæã ëʢåʢÞðʢ ʧʥʤÞçãʠʝÑʙʛʦʤʦéʡÞåôóé ą ææʤåñå ʧ èʡëãʢçéʤÞ ʤìʢçñ Þðʦʤäʤßʤ ʥãʦäʡ ʛʥã òéʤæ ʢʦåã ãʦʨʤàçʤ ʠʝÑʙʛçʡʨʤàãåʦôÞèʥʢàʢåʡʨ ą ææʤåñå éʤçʢʤÝʨʤàãæʤàʤʦéãßʡéñʢßʤ ʦçãáʢçãôäʡäæãçãæʧæçʡ ą ææʤåñåʧèʡëãʢçéʤÞÞðʦʤäʤßʤʥãʦäʡʖʦåããʦʨʤàçʤʧʥʤÞʢçñʠʝÑʙʛçʡʨʤàãåʦôÞèʥʢàʢåʡʨ ą ææʤåñå éʤçʢʤÝʨʤàãæʤàʤʦéãßʡéñʢßʤʦçãáʢçãôäʡä æãçãæʧæçʡ ą ææʤåñåʧèʡëãʢçéʤÞçãâäʤßʤãʧæʢʥʢççʤßʤʥãʦäʡ;= ʝʧîʢʦéÞʧʢéÓÒãàåôʠʝçʢ Ñʔʛ ã ææʤåñåàåôÝʤåñçðʨʤìʢçñ Þðʦʤäʤßʤ Þðʦʤäʤßʤ ã ʧæʢʥʢççʤßʤ ʥãʦäʡ ʦʤʤéÞʢéʦéÞʢççʤ ʤàçʡäʤ òéʡ ëʢåñ ÞéʤʥãìçʡÍåôʧʥʤÞçôʠʝÑʔʛãʞʕçʢéëʢåʢÞðʨâçʡìʢçãʣ ʤàçʡäʤáʢåʡéʢåʢçʧʥʤÞʢçñ ʠʝÑʔʛ ææʤåñåʧæʧáìãç ææʤåñåʧáʢçîãçãʧʥʤÞʢçñʞʕ ææʤåñå èʤʦäʤåñäʧéʡäãʢʧʥʤÞçãʦÞôâʡçðʦæʢçñíãæʥãʦäʤæʥʡâÞãéãôʝʝʚ;= ʒßãèʤåãèãàʢæãìʢʦäãæèʥʢèʡʥʡéʡæ òêêʢäéãÞçʤʦéñãÝʢâʤèʡʦçʤʦéñäʤéʤʥðʨ àʤäʡâʡçʡÞäʥʧèçðʨʥʡçàʤæãâãʥʤÞʡççðʨäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãôʨ ʤéçʤʦôéʦô ãçßãÝãéʤʥðʦãçéʢâʡʨʤåʢʦéʢʥãçʡąʦéʡéãçð ãçßãÝãéʤʥðÞʦʡʦðÞʡçãôʠʝÞäãíʢìçãäʢąòâʢéãæãÝ ʡçéãéʢåʡä0#3+ èʥʤãâÞʤàçðʢêãÝʥʤʢÞʤʣäãʦåʤéðąêãÝʥʡéð ʤæʢßʡ èʤåãçʢçʡʦðîʢççðʢáãʥçðʢäãʦåʤéð ʦʢäÞʢʦéʥʡçéðáʢåìçðʨäãʦåʤé;= ʝʞʓʞÐʙØ ʝéʡéãçð äʤçäʧʥʢçéçʤ ãçßãÝãʥʧóé ʕʘʕ ʒʤʓ ʥʢàʧäéʡâʧ äåóìʢÞʤʣ êʢʥæʢçé ʦãçéʢâʡ ʨʤåʢʦéʢʥãçʡ çʡ òéʡèʢ èʥʢÞʥʡîʢçãô ʡëʢéãå ʒʤʓ Þ æʢÞʡåʤçʤÞʧó äãʦåʤéʧ ;= ÌåʤäãʥʤÞʡçãʢ ʦãçéʢâʡ ʠʝ çʡ ʥʡççʢæ òéʡèʢ çʢ ÞðâðÞʡʢé çʡäʤèåʢçãô èʥʤæʢáʧéʤìçðʨ æʢéʡÝʤåãéʤÞ Þ òéʤʣ æçʤßʤʦéʧèʢçìʡéʤʣ ʥʢʡäëãã ìéʤ Þʤ æçʤßʤæ 79 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʤÝïôʦçôʢé ʤéʦʧéʦéÞãʢ éʤäʦãìʢʦäãʨ èʥʤôÞåʢçãʣ èʥã éʢʥʡèãã ʦéʡéãçʡæã ;= ʔʜʤʦʦããâʡʥʢßãʦéʥãʥʤÞʡçðʦåʢàʧóîãʢʦéʡéãçðåʤÞʡʦéʡéãç ʦãæÞʡʦéʡéãç èʥʡÞʡʦéʡéãç êåʧÞʡʦéʡéãç ʡéʤʥÞʡʦéʡéãç ʥʤâʧÞʡʦéʡéãç;= ÑʤÞʡʦéʡéãç ôÞåôʢéʦô èʥʤàʧäéʤæ êʢʥæʢçéʡëãã ßʥãÝäʤÞ !SPERGILLUS TERREUS ãèʢʥÞðæãâʦéʡéãçʤÞ ʤàʤÝʥʢççðæʡæʢʥãäʡçʦäãæʥʡâʥʢíãéʢåñçðæäʤæãéʢéʤæ èʤ èãîʢÞðæã åʢäʡʥʦéÞʢççðæ èʥʤàʧäéʡæ&$! Þ ß ʔ ʥʡçàʤæãâãʥʤÞʡççʤæ äåãçãìʢʦäʤæ ãʦʦåʢàʤÞʡçãã !&4EX #!03 èʤ èʢʥÞãìçʤʣ èʥʤêãåʡäéãäʢ äʤéʤʥʤʢ âʡÞʢʥíãåʤʦñÞß åʤÞʡʦéʡéãçʦçãáʡåʧʥʤÞçãʚʠʝãʠʝÑʙʛçʡãʦʤʤéÞʢéʦéÞʢççʤʔʥʢâʧåñéʡéʢåʢìʢçãôÞʤʦçʤÞçʤʣßʥʧèèʢìʡʦéʤéʡÞçʢâʡèçʤʣʦæʢʥéã Ðʘ çʤÞðʨ ʦåʧìʡʢÞ ʦéʢçʤäʡʥàãã ʦçãâãåʡʦñ çʡ èʤ ʦʥʡÞçʢçãó ʦ ßʥʧèèʤʣ èåʡëʢÝʤʞʡäãæʤÝʥʡâʤæ ãʦʦåʢàʤÞʡçãʢèʤʦåʧáãåʤʤʦçʤÞʡçãʢæàåôçʡâçʡìʢçãô ʦéʡéãçʤÞ ʦ ëʢåñó èʢʥÞãìçʤʣ èʥʤêãåʡäéãäã ÐÌʝ ʛʥʢèʡʥʡé çʡâçʡìʡóé Þ àʤâʢ ą æßʦʧé èʥãæʢçôóé èʤʦåʢ ʧáãçʡ èʤʦäʤåñäʧ ʦãçéʢâ ʠʝ Ýʤåʢʢ ãçéʢçʦãÞçʤ èʥʤéʢäʡʢéÞçʤìçʤʢÞʥʢæôʘʡäʦãæʡåñçðʣòêêʢäéèʥʤôÞåôʢéʦôìʢʥʢâąàçʢʣ ʤéçʡìʡåʡéʢʥʡèããʔçʡʦéʤôîʢʢÞʥʢæôÞʦÞôâãʦèʤôÞåʢçãʢæàʥʧßãʨ ÝʤåʢʢòêêʢäéãÞçðʨʦéʡéãçʤÞåʤÞʡʦéʡéãçÞäåãçãìʢʦäʤʣèʥʡäéãäʢçʡâçʡìʡʢéʦôÞʦʢʥʢáʢ ʝãæÞʡʦéʡéãçèʤʦÞʤʢʣʦéʥʧäéʧʥʢÝåãâʤääåʤÞʡʦéʡéãçʧãʤéåãìʡʢéʦôʤéçʢßʤ çʡåãìãʢæÞæʤåʢäʧåʢÞʦʢßʤåãíñʤàçʤʣæʢéãåñçʤʣßʥʧèèðʚàçʡäʤèʤʦÞʤʢʣßãèʤåãèãàʢæãìʢʦäʤʣ ʡäéãÞçʤʦéã ʦãæÞʡʦéʡéãç èʥʡäéãìʢʦäã ÞàÞʤʢ èʥʢÞʤʦʨʤàãé åʤÞʡʦéʡéãç ÚêêʢäéãÞçʤʦéñ ʦãæÞʡʦéʡéãçʡ èʤ èʥʢàʧèʥʢáàʢçãó äʤʥʤçʡʥçðʨ ʤʦåʤáçʢçãʣ ʧ Ýʤåñçðʨ Þðʦʤäʤßʤ ʥãʦäʡ Ýðåʡ èʥʤàʢæʤçʦéʥãʥʤÞʡçʡ Þ æçʤßʤìãʦåʢççðʨ ʥʡçàʤæãâãʥʤÞʡççðʨ äåãçãìʢʦäãʨ ãʦʦåʢàʤÞʡçãôʨ ãâ äʤéʤʥðʨ çʡãÝʤåʢʢ ãâÞʢʦéçðæããëãéãʥʧʢæðæãôÞåôóéʦôãʦʦåʢàʤÞʡçãô3ãʙʜ3ÔʡʦéʤéʡʝʝʚÞãʦʦåʢàʤÞʡçãã3ʦçãáʡåʡʦñçʡ ÞãʦʦåʢàʤÞʡçãã(03ąçʡ èʥãìʢæÞçʢâʡÞãʦãæʤʦéãʤéãʦʨʤàçʤßʤʧʥʤÞçôʠʝʝãæÞʡʦéʡéãçíãʥʤäʤèʥãæʢçôʢéʦôÞʦʤÞʥʢæʢççʤʣäåãçãìʢʦäʤʣèʥʡäéãäʢãçʡâçʡìʡʢéʦôÞàʤâʢąæßʦʧé èʥãçãæʡʢéʦô èʤʦåʢʧáãçʡʙʡâçʡìʢçãʢʦãæÞʡʦéʡéãçʡÞàʤâʢæßʦʧéçʢʥʢäʤæʢçàʧʢéʦôãâ âʡ ÞðʦʤäʤʣÞʢʥʤôéçʤʦéãʥʡâÞãéãôèʤÝʤìçðʨôÞåʢçãʣèʤÞðíʢçãʢèʢìʢçʤìçðʨêʢʥæʢçéʤÞ æãʤèʡéãô ʛʥʡÞʡʦéʡéãç Þ ʤéåãìãʢ ʤé åʤÞʡʦéʡéãçʡ ã ʦãæÞʡʦéʡéãçʡ ôÞåôʢéʦô ʡäéãÞçʤʣ åʢäʡʥʦéÞʢççʤʣ êʤʥæʤʣ éʤ ʢʦéñ çʡìãçʡʢé àʢʣʦéÞʤÞʡéñ äʡä ãçßãÝãéʤʥ ʦãçéʢâʡ ʨʤåʢʦéʢʥãçʡçʢèʤʦʥʢàʦéÞʢççʤèʥãÞʦʡʦðÞʡçããÞäʥʤÞñʔãʦʦåʢàʤÞʡçãôʨèʤèʢʥÞãìçʤʣ 7/3#/03 ã Þéʤʥãìçʤʣ ,)0)$ èʥʤêãåʡäéãäʢ éʢʥʡèãô èʥʡÞʡʦéʡéãçʤæ ʦʤèʥʤÞʤáàʡåʡʦñ ʦçãáʢçãʢæ ìãʦåʡ ʝʝʚ çʡ ą ʛʥʢèʡʥʡé çʡâçʡìʡóé Þ àʤâʢ ą æßʦʧé ʧʥʤÞʢçñ ʠʝÑʙʛ ʦçãáʡʢéʦô èʥã òéʤæ çʡ ą ʛʥʡÞʡʦéʡéãç ÞðßʤàçʤʤéåãìʡʢéʦôʤéàʥʧßãʨʦéʡéãçʤÞéʢæ ìéʤçʢæʢéʡÝʤåãâãʥʧʢéʦôìʢʥʢâʦãʦéʢæʧ ëãéʤʨʥʤæʡʜ èʤòéʤæʧʥãʦäʥʡâÞãéãôèʤÝʤìçðʨôÞåʢçãʣèʥãäʤæÝãçʡëããʢßʤ ʦàʥʧßãæãèʥʢèʡʥʡéʡæãæãçãæʡåʢç ʟåʧÞʡʦéʡéãçąèʢʥÞðʣʦãçéʢéãìʢʦäãʣʦéʡéãç ʢßʤèʥãæʢçôóéèʥã))Aã))Béãèʡʨ àãʦåãèãàʢæãã ʔ ʦãåʧ ʦÞʤʢßʤ ʤéçʤʦãéʢåñçʤ ʦåʡÝʤßʤ ßãèʤåãèãàʢæãìʢʦäʤßʤ 80 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ òêêʢäéʡèʥʢèʡʥʡéçʡâçʡìʡóéÞàʤâʢąæßʦʧéʔàʤâʢæßʦʧéêåʧÞʡʦéʡéãç ʦçãáʡʢéʧʥʤÞʢçñʨʤåʢʦéʢʥãçʡçʡą ʧæʢʥʢççʤʦçãáʡʢéʧʥʤÞʢçñʞʕãçʢâçʡìãéʢåñçʤèʤÞðíʡʢéäʤçëʢçéʥʡëãóʠʝÑʔʛʔʦãåʧéʤßʤ ìéʤêåʧÞʡʦéʡéãçæʢéʡÝʤåãâãʥʧʢéʦôìʢʥʢâãâʤêʤʥæʧëãéʤʨʥʤæʡʜʝ ʤççʢÞʦéʧèʡʢéÞäʤçäʧʥʢçéçðʣ æʢéʡÝʤåãâæ ʦ ëãéʤʦéʡéãäʡæã ã çʢ ÞðâðÞʡʢé èʤÝʤìçðʨ ôÞåʢçãʣ çʡÝåóàʡʢæðʨ èʥãçʡâçʡìʢçããʦéʡéãçʤÞ äʤéʤʥðʢæʢéʡÝʤåãâãʥʧóéʦôìʢʥʢâãâʤêʤʥæʧʜʓ åʤÞʡʦéʡéãç ʦãæÞʡʦéʡéãç ʡéʤʥÞʡʦéʡéãç ʚàçʡäʤèʤʦåʢèʤôÞåʢçãôʥʤâʧÞʡʦéʡéãçʡ äʤéʤʥðʣ éʡäáʢ æʢéʡÝʤåãâãʥʧʢéʦô èʤʦʥʢàʦéÞʤæ ëãéʤʨʥʤæʡ ʜ ʝ ʦéʡåʤ ÞʤâæʤáçðæçʡâçʡìʢçãʢãʥʤâʧÞʡʦéʡéãçʡàåôåʢìʢçãôèʡëãʢçéʤÞ èʥãçãæʡóîãʨ ëãéʤʦéʡéãäãʔæʢʦéʢʦéʢæêåʧÞʡʦéʡéãçèʤ èʥʢáçʢæʧʤʦéʡʢéʦôʦéʡéãçʤæʦçʡãæʢçñíʢʣìʡʦéʤéʤʣʥʡâÞãéãôʤʦåʤáçʢçãʣèʥãʢßʤèʥãʢæʢÞʦʤìʢéʡçããʦàʥʧßãæã èʥʢèʡʥʡéʡæã ʓéʤʥÞʡʦéʡéãç ą ʦãçéʢéãìʢʦäãʣ ʦéʡéãç äʤéʤʥðʣ Þ àʤâʡʨ ą æßʦʧé ʦçãáʡʢé ʧʥʤÞʢçñ ʠʝÑʙʛ çʡ ą ʔ ʦʥʡÞçʢçãã ʦ àʥʧßãæã ʦéʡéãçʡæã òêêʢäéãÞçʢʢ ʦçãáʡʢé ʧʥʤÞʢçñ ʞʕ çʡ ą ʝ ʡéʤʥÞʡʦéʡéãçʤæ èʥʤÞʢàʢçʤ æçʤáʢʦéÞʤ ãʦʦåʢàʤÞʡçãʣ Þ éʤæ ìãʦåʢ èʤ éʡä çʡâðÞʡʢæʤʣ ʡßʥʢʦʦãÞçʤʣ åãèãàʦçãáʡóîʢʣ éʢʥʡèãã -)2!#, 02/6% )4 4)-) 4.4 )$%!, ʔ òéãʨ ãʦʦåʢàʤÞʡçãôʨ éʢʥʡèãô ʡéʤʥÞʡʦéʡéãçʤæÞàʤâʢæßʦʧéʦʤèʥʤÞʤáàʡåʡʦñÞðʥʡáʢççðæʦçãáʢçãʢæʧʥʤÞçô ʠʝÑʙʛ ìéʤ Þ äʤçʢìçʤæ ãéʤßʢ èʥãÞʢåʤ ä Þçʢàʥʢçãó Þ äåãçãìʢʦäʧó èʥʡäéãäʧ çʤÞʤßʤ ëʢåʢÞʤßʤ ʧʥʤÞçô ʠʝÑʙʛ àåô Ýʤåñçðʨ ʤìʢçñ Þðʦʤäʤßʤ ʥãʦäʡ ʥʡÞçʤßʤ ææʤåñåʔòéãʨãʦʦåʢàʤÞʡçãôʨçʡÝåóàʡåãâçʡìãéʢåñçʤʢèʤʦʥʡÞçʢçãóʦßʥʧèèʡæãʧæʢʥʢççʤʣʦéʡéãçʤéʢʥʡèããʦçãáʢçãʢìʡʦéʤéðʝʝʚ éʡäãʨäʡäãçêʡʥäéæãʤäʡʥàʡ ãíʢæãìʢʦäãʣ ãçʦʧåñé çʢʦéʡÝãåñçʡô ʦéʢçʤäʡʥàãô äʤʥʤçʡʥçʡô ʦæʢʥéñ ÐʦʦåʢàʤÞʡçãʢ2%6%23!,ÝðåʤèʢʥÞðæ ÞäʤéʤʥʤæʦèʤæʤîñóÞçʧéʥãʦʤʦʧàãʦéʤßʤ ʧåñéʥʡâÞʧäʤÞʤßʤ ãʦʦåʢàʤÞʡçãô Ýðåʡ èʤäʡâʡçʡ Þʤâæʤáçʤʦéñ ʦéʡÝãåãâʡëãã ʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäãÞäʤʥʤçʡʥçðʨʡʥéʢʥãôʨçʡêʤçʢʡßʥʢʦʦãÞçʤʣéʢʥʡèãã ʡéʤʥÞʡʦéʡéãçʤæ;=ʛʥʢèʡʥʡéçʡâçʡìʡóéÞàʤâʡʨʤéàʤæßʦʧéʔðʦʤäãʢ àʤâðèʥʢèʡʥʡéʡąæßʦʧé èʤäʡâʡçðßåʡÞçðæʤÝʥʡâʤæÞʦåʧìʡôʨÞðʥʡáʢççʤʣ ßãèʢʥåãèãàʢæãã))ʡã))BéãèʤÞ Þìʡʦéçʤʦéãèʥãʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãã ÌʤåñíãçʦéÞʤ ãʦʦåʢàʤÞʡçãʣ èʤ Þéʤʥãìçʤʣ èʥʤêãåʡäéãäʢ Þ ìʡʦéçʤʦéã èʤ åʢìʢçãó èʡëãʢçéʤÞ ʦ ÐÌʝ Ýðåʤ Þðèʤåçʢçʤ ʦ ʤʥãßãçʡåñçðæ ʡéʤʥÞʡʦéʡéãçʤæ Ñãèʥãæʡʥ Ìðåʡ àʤäʡâʡçʡ çʢʤÝʨʤàãæʤʦéñ ʢßʤ ãʦèʤåñâʤÞʡçãô ʧ Ýʤåñçðʨ ʦ ʝÍ ãíʢæãìʢʦäãæ ãçʦʧåñéʤæ èʥã ʕÌ ã èʢʥʢà èʥʤÞʢàʢçãʢæ Ôʒʔ ʞʡä Þ ãʦʦåʢàʤÞʡçãã !3#/4 èʥʤÞʤàãÞíʢæʦôÞéʢìʢçãʢåʢé ÝðåʤÞäåóìʢçʤÝʤåñçðʨʦʕÌ ʧʥʤÞçʢæ ʠʝ ææʤåñå ʠʝ Ñʙʛ ææʤåñå ʓéʤʥÞʡʦéʡéãç ʦçãáʡå ʥãʦä ʥʡâÞãéãô Ðʘçʢêʡéʡåñçðʨ Ýʢʦʦãæèéʤæçðʨãêʡéʡåñçðʨ çʡ ʡʥãʦäʥʡâÞãéãôÞʦʢʨʝʝʚ ã çʢʤÝʨʤàãæʤʦéñ èʥʤÞʢàʢçãô Ôʒʔ ą çʡ ;= ʔ ãʦʦåʢàʤÞʡçãã 30!2#, ãâʧìʡåʡʦñÞʤâæʤáçʤʦéñãʦèʤåñâʤÞʡçãôʦéʡéãçʤÞʧÝʤåñçðʨʦãçʦʧåñéʤæÌðåʤÞäåóìʢçʤ ÝʤåñçðʨãâëʢçéʥʤÞ ÝʢâÐÌʝ çʤʦãçʦʧåñéʤæãåãèʥʢʨʤàôîãæçʡʥʧíʢçãʢæ æʤâßʤÞʤßʤäʥʤÞʤʤÝʥʡîʢçãôÞʡçʡæçʢâʢ ãʧʥʤÞçʢæʠʝÑʙʛ ą ææʤåñåÌðåʤ 81 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ èʤäʡâʡçʤʦçãáʢçãʢʥãʦäʡèʤÞéʤʥçðʨãíʢæãìʢʦäãʨãçʦʧåñéʤÞçʡ äʤʥʤçʡʥçðʨ ʦʤÝðéãʣąçʡ èʤÞéʤʥçðʨêʡéʡåñçðʨãçʦʧåñéʤÞąçʡ;=ʔãʦʦåʢàʤÞʡçãã #!2$3ãâʧìʡåʤʦñÞåãôçãʢéʢʥʡèããʡéʤʥÞʡʦéʡéãçʤæçʡäʤçʢìçðʢéʤìäãʧÝʤåñçðʨʦʝÍ))éãèʡ ÝʢâÐÌʝ ʧʥʤÞçʢæʠʝÑʙʛ ææʤåñåãʞʕ ææʤåñåÒèʡëãʢçéʤÞ èʤåʧìʡÞíãʨʡéʤʥÞʡʦéʡéãç ʥãʦäʝʝʚʦçãâãåʦôçʡ;= ʔßʙʡëãʤçʡåñçðʣãçʦéãéʧéâàʤʥʤÞñôãäåãçãìʢʦäʤßʤʦʤÞʢʥíʢçʦéÞʤÞʡçãô ʔʢåãäʤÝʥãéʡçãã .)#% ʤèʧÝåãäʤÞʡå äåãçãìʢʦäãʢ ʥʢäʤæʢçàʡëãã èʤ ʤëʢçäʢ ʝʝʜãäʤʥʥʢäëããåãèãàçʤßʤèʥʤêãåôàåôèʢʥÞãìçʤʣãÞéʤʥãìçʤʣèʥʤêãåʡäéãäã ʝʝʝ ÞßàʡççðʢʥʢäʤæʢçàʡëããÝðåãʤÝçʤÞåʢçðʔòéʤæàʤäʧæʢçéʢʡéʤʥÞʡʦéʡéãçʤÝʤâçʡìʢçäʡäèʥʢèʡʥʡéèʢʥÞʤʣåãçããäʡäàåôèʢʥÞãìçʤʣ éʡäãÞéʤʥãìçʤʣ èʥʤêãåʡäéãäã ʝʝʝ ʔ ìʡʦéçʤʦéã ʡéʤʥÞʡʦéʡéãç Þ àʤâʢ æßʦʧé ʥʢäʤæʢçàʤÞʡç àåô èʢʥÞãìçʤʣ èʥʤêãåʡäéãäã ʝʝʝ ʧ èʡëãʢçéʤÞ ʦ åʢéçãæ ʥãʦäʤæ ʝʝʝ 12)3+ ħ ÞéʤæìãʦåʢàåôèʡëãʢçéʤÞʦʝÍ ʠÌʛ ʧèʤáãåðʨħåʢé ʡÞàʤâʢ æßʦʧéąàåôÞéʤʥãìçʤʣèʥʤêãåʡäéãäãʧèʡëãʢçéʤÞʦʝʝÏʔçãâäãʨàʤâʡʨʡéʤʥÞʡʦéʡéãçéʡäáʢæʤáʢéãʦèʤåñâʤÞʡéñʦôèʥãèʤàÝʤʥʢåʢäʡʥʦéÞʢççʤʣéʢʥʡèãã èʥã ÞðʦʤäʤæʥãʦäʢçʢáʢåʡéʢåñçðʨôÞåʢçãʣʔòéʤæáʢàʤäʧæʢçéʢèʥãÞʢàʢçʧʥʤÞʢçñ ʦçãáʢçãôʠʝÑʙʛÞâʡÞãʦãæʤʦéãʤéàʤâðʦéʡéãçʤÞʥãʦ ʜãʦʝçãáʢçãʢʧʥʤÞçôʠʝÑʙʛÞâʡÞãʦãæʤʦéãʤéàʤâðʥʡâåãìçðʨʦéʡéãçʤÞ ʜʤâʧÞʡʦéʡéãç äʡä ã ʡéʤʥÞʡʦéʡéãç ʤéçʤʦãéʦô ä ʦãçéʢéãìʢʦäãæ ʦéʡéãçʡæ èʤʦåʢàçʢßʤ èʤäʤåʢçãô ʙʡãÝʤåʢʢ Þʡáçðʢ ʥʢâʧåñéʡéð èʤ èʥʢàʤéÞʥʡîʢçãó ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣ ʦ èʤæʤîñó ʥʤâʧÞʡʦéʡéãçʡ Ýðåã èʤåʧìʢçð 82 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ Þ äåãçãìʢʦäãʨ ãʦʦåʢàʤÞʡçãôʨ !34%2/)$ *50)4%2 ã 3!452. ʔ ãʦʦåʢàʤÞʡçãã 3!452. Þìʡʦéçʤʦéã ÝðåʡÞèʢʥÞðʢèʥʤàʢæʤçʦéʥãʥʤÞʡçʡʥʢßʥʢʦʦãôʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäãÞäʤʥʤçʡʥçðʨʡʥéʢʥãôʨèʥãèʥʤàʤåáãéʢåñçʤʣéʢʥʡèããʥʤâʧÞʡʦéʡéãçʤæÞàʤâʢæßʦʧéʔãʦʦåʢàʤÞʡçããèʤèʢʥÞãìçʤʣèʥʤêãåʡäéãäʢ*50)4%2 çʡÝåóàʡåã ʦçãáʢçãʢ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣ çʡ ìʢʥʢâ ßʤàʡ éʢʥʡèããʥʤâʧÞʡʦéʡéãçʤæÞàʤâʢæßʦʧéʧåãëʦçʤʥæʡåñçðæʧʥʤÞçʢæʠʝÑʙʛ çʤʦèʤÞðíʢççðæʧʥʤÞçʢæʝ ʥʢʡäéãÞçʤßʤÝʢåäʡæßå ÚéãʥʢâʧåñéʡéðèʤʦåʧáãåãʤʦçʤÞʡçãʢæàåôèʥãæʢçʢçãôʥʤâʧÞʡʦéʡéãçʡÞʝÕʓãʥôàʢʦéʥʡçÏʡèʡàçʤʣ ʖÞʥʤèðʦëʢåñóèʢʥÞãìçʤʣèʥʤêãåʡäéãäãʧåãëʦèʤÞðíʢççðæʦʤàʢʥáʡçãʢæʝʜÌ ãçʡåãìãʢæʨʤéôÝðʤàçʤßʤàʤèʤåçãéʢåñçʤßʤêʡäéʤʥʡʥãʦäʡʝʝÏʘʡäʦãæʡåñçʡô àʤâʡʥʤâʧÞʡʦéʡéãçʡʦʤʦéʡÞåôʢéæßʦʧéʔàʤâʢæßʦʧéʥʤâʧÞʡʦéʡéãççʢçʡâçʡìʡʢéʦôãâ âʡÞðʦʤäʤʣÞʢʥʤôéçʤʦéãʤʦåʤáçʢçãʣÞÞãàʢæãʤèʡéãããèʤÞðíʢçãô èʢìʢçʤìçðʨêʢʥæʢçéʤÞʓʝʞ ʓÑʞ ʛãéʡÞʡʦéʡéãçÝðåʥʡâʥʡÝʤéʡçÞÜèʤçãããÞðÞʢàʢççʡêʡʥæʡëʢÞéãìʢʦäãʣʥðçʤäÞßʙʡʦʢßʤàçôíçãʣàʢçñèʥʢèʡʥʡéãʦèʤåñâʧʢéʦôÞʦéʥʡçʡʨʖÞʥʤèð ʓâãã ãʓæʢʥãäãʘʤåʢäʧåʡèãéʡÞʡʦéʡéãçʡãæʢʢéʥôàʤéåãìãéʢåñçðʨʤéàʥʧßãʨʦéʡéãçʤÞ ʤʦʤÝʢççʤʦéʢʣ ʖʢ ʦéʥʤʢçãʢ ʤʦçʤÞʡ ą ßʢèéʡçʤʡé ëʢçéʥʡåñçʤʢ ʨãçʤåãçʤÞʤʢ äʤåñëʤãÝʤäʤÞðʢëʢèããâìʡʦéʢʣêéʤʥêʢçãåʡãëãäåʤèʥʤèãåʡ ʤÝʢʦèʢìãÞʡʢéåʧìíʧó êʡʥæʡäʤäãçʢéãäʧ ã àʤʦéʤÞʢʥçʧó òêêʢäéãÞçʤʦéñ ʦçãáʢçãô ʠʝÑʙʛ èʥã æʡåðʨ àʤâʡʨʔʤéåãìãʢʤéàʥʧßãʨʦéʡéãçʤÞëãäåʤèʥʤèãåʤÞʡôßʥʧèèʡæʤåʢäʧåðèãéʡÞʡʦéʡéãçʡãʦäåóìʡʢéʢßʤæʢéʡÝʤåãâæìʢʥʢâʦãʦéʢæʧëãéʤʨʥʤæʡ0 ìéʤʤÝʢʦèʢìãÞʡʢé çãâäʧó ìʡʦéʤéʧ ÞâʡãæʤàʢʣʦéÞãʣ ʦ àʥʧßãæã êʡʥæʡäʤåʤßãìʢʦäãæã èʥʢèʡʥʡéʡæã ʛãéʡÞʡʦéʡéãç Þ çʢãâæʢççʤæ Þãàʢ Ýðʦéʥʤ ÞðÞʤàãéʦô ãâ èʢìʢçã Þ áʢåìñ çʤ èʤàÞʢʥßʡʢéʦôòçéʢʥʤßʢèʡéãìʢʦäʤʣʥʢëãʥäʧåôëãã ìéʤʤÝʧʦåʤÞåãÞʡʢéàåãéʢåñçʤʦéñʢßʤ àʢʣʦéÞãôʔæʢʦéʢʦéʢæèãéʡÞʡʦéʡéãçʤÝåʡàʡʢéʦãåñçðæòêêʢäéʤæʧÞʢåãìʢçãôʠʝ ÑʔʛʦæãçãæʡåñçðæÞåãôçãʢæçʡʤÝæʢçßåóäʤâðʚʦçʤÞçʤʣäåãçãìʢʦäãâçʡìãæʤʣ ʤʦʤÝʢççʤʦéñó òéʤßʤ çʤÞʤßʤ ãçßãÝãéʤʥʡ ʕʘʕ ʒʤʓ ʥʢàʧäéʡâð ôÞåôʢéʦô ʦʤìʢéʡçãʢ Þðʦʤäʤʣ åãèãàʥʢßʧåãʥʧóîʢʣ òêêʢäéãÞçʤʦéã ʦ çãâäãæ èʤéʢçëãʡåʤæ æʢáåʢäʡʥʦéÞʢççʤßʤ ÞâʡãæʤàʢʣʦéÞãô ìéʤ ʤÝʢʦèʢìãÞʡʢé ʤèéãæʡåñçʤʢ åʢìʢçãʢ èʡëãʢçéʤÞ Þðçʧáàʢççðʨ èʤʦéʤôççʤ èʥãçãæʡéñ çʢʦäʤåñäʤ æʢàãäʡæʢçéʤÞ ʘʢéʡÝʤåãìʢʦäãʣ èʥʤêãåñ ʤÝʧʦåʤÞåʢç éʢæ ìéʤ èãéʡÞʡʦéʡéãç æãçãæʡåñçʤ æʢéʡÝʤåãâãʥʧʢéʦô ëãéʤʨʥʤæʤæ0#ʝéʡçàʡʥéçʡôçʡìʡåñçʡôàʤâʡąæßʦʧé ʤàçʡäʤÝʤåñíãçʦéÞʧ èʡëãʢçéʤÞçʢʤÝʨʤàãæʡàʤâʡæßʦʧéʒʤʥʥʢäéãʥʤÞʡéñàʤâʧʥʢäʤæʢçàʧʢéʦôʦãçéʢʥÞʡåʤæçʢæʢçʢʢçʢàʢåñʛʥʢèʡʥʡéæʤáʢéÝðéñãʦèʤåñâʤÞʡçÞåóÝʤʢÞʥʢæôʦʧéʤä çʢâʡÞãʦãæʤʤéèʥãʢæʡèãîã;=ʔʜʤʦʦããèʥʢèʡʥʡéèʤäʡçʢâʡʥʢßãʦéʥãʥʤÞʡç ʔèʢìʡéåôóîãʢ ʥʢâʧåñéʡéð éʢʥʡèãã ʦéʡéãçʡæã çʢ æʤßåã Ýðéñ ʤÝïôʦçʢçð ʦ èʤâãëãã éʤåñäʤ ãʨ åãèãàʦçãáʡóîʢßʤ òêêʢäéʡ Íʡåñçʢʣíãʢ ãʦʦåʢàʤÞʡçãô ÞðôÞãåã çʡåãìãʢ ʧ ʦéʡéãçʤÞ èåʢʣʤéʥʤèçðʨ ʦÞʤʣʦéÞ äʤéʤʥðʢ ʥʢʡåãâʤÞðÞʡåãʦñ èʡʥʡååʢåñçʤ ʦ ʤʦçʤÞçðæ ßãèʤåãèãàʢæãìʢʦäãæ òêêʢäéʤæ ã èʥʤôÞåôåãʦñ ʧåʧìíʢçãʢæ êʧçäëãã òçàʤéʢåãô èʤÞðíʢçãʢæ ʡçéãʤäʦãàʡçéçʤʣ ʡäéãÞçʤʦéã 83 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʦçãáʢçãʢæʧʥʤÞçʢʣæʡʥäʢʥʤÞÞʤʦèʡåʢçãôʔʥôàʢãʦʦåʢàʤÞʡçãʣʦʡéʤʥÞʡʦéʡéãçʤæ ã ʥʤâʧÞʡʦéʡéãçʤæ Þ Þðʦʤäʤʣ àʤâʢ ą æßʦʧé çʡʥôàʧ ʦʤ âçʡìãéʢåñçðæ ʦçãáʢçãʢæ ʠʝÑʙʛ ææʤåñå çʡÝåóàʡåã ʦçãáʢçãʢ ʝʜÌ Ýʤåʢʢ ìʢæ çʡ èʤʦʥʡÞçʢçãóʦåãëʡæã èʥãçãæʡÞíãæãʦéʡéãçðÞʤÝðìçʤʣàʤâʢąæßʦʧé ìéʤʦʤèʥʤÞʤáàʡåʤʦñàʤèʤåçãéʢåñçðæʧæʢçñíʢçãʢæìãʦåʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣ Íʥʧßʤʣ èåʢʣʤéʥʤèçðʣ òêêʢäé ʦéʡéãçʤÞ èʥʤôÞãåʦô Þ èʤÞðíʢçãã ʧʥʤÞçôÞäʥʤÞãòçàʤéʢåãʡåñçðʨèʥʤßʢçãéʤʥçðʨäåʢéʤäêʢçʤéãèʡ#$ #$ #$ èʥãçãæʡóîãʨʧìʡʦéãʢÞÞʤʦʦéʡçʤÞåʢçããêʧçäëããòçàʤéʢåãô;ą= ʚʦåʤáçʢçãô èʥã éʢʥʡèãã ʦéʡéãçʡæã ʔʦʢ ʦéʡéãçð äʡä èʥʡÞãåʤ ʨʤʥʤíʤ èʢʥʢçʤʦôéʦô Ýʤåñçðæã ʚàçʡäʤ éʢʥʡèãô ʦéʡéãçʡæã èʥãæʢʥçʤ Þ ą ʦåʧìʡʢÞ æʤáʢéʤʦåʤáçãéñʦôèʤÞðíʢçãʢæʧʥʤÞçôêʢʥæʢçéʤÞʓʝʞãʓÑʞʘʢʨʡçãâæòéʤßʤ èʤÝʤìçʤßʤôÞåʢçãôàʤäʤçëʡçʢèʤçôéʢçʞʢæçʢæʢçʢʢʦéʡéãçðçʢʥʢäʤæʢçàʧʢéʦô çʡâçʡìʡéñÝʤåñçðæʦʤʦéʥðæãâʡÝʤåʢÞʡçãôæãèʢìʢçãßʢèʡéãé èʥãʢʢéʤäʦãìʢʦäʤæèʤʥʡáʢçãã ʦʤèʥʤÞʤáàʡóîʢæʦôèʤÞðíʢçãʢæêʢʥæʢçéʤÞʖʦåãçʡêʤçʢéʢʥʡèããʦéʡéãçʡæãÞʢʥʨçãʢèʥʢàʢåðçʤʥæʡåñçðʨâçʡìʢçãʣòéãʨêʢʥæʢçéʤÞèʥʢÞðíʡóéʦôÞʥʡâʡ èʥʢèʡʥʡéçʧáçʤʤéæʢçãéñãèʤàʤáàʡéñçʤʥæʡåãâʡëããʧʥʤÞçʢʣ êʢʥæʢçéʤÞ ʛʤʦåʢ òéʤßʤ æʤáçʤ ÞʤâʤÝçʤÞãéñ éʢʥʡèãó çʡâçʡìãÞ èʥʢèʡʥʡé åãÝʤ Þæʢçñíʢʣàʤâʢ åãÝʤâʡæʢçãÞʢßʤçʡàʥʧßʤʣʦéʡéãçæʢçʢʢʦãåñçʤßʤàʢʣʦéÞãô çʡèʥãæʢʥâʡæʢçãéñʡéʤʥÞʡʦéʡéãççʡêåʧÞʡʦéʡéãçãåãèʥʡÞʡʦéʡéãç Íʥʧßʤʢʤʦåʤáçʢçãʢ äʤéʤʥʤʢÞʦéʥʢìʡʢéʦôèʥãÝåãâãéʢåñçʤÞąʦåʧìʡʢÞ ą æãʤèʡéãô ÝʤåñãʦåʡÝʤʦéñÞʦäʢåʢéçðʨæðíëʡʨ ìéʤæʤáʢéʦʤèʥʤÞʤáàʡéñʦôèʤÞðíʢçãʢæ ʧʥʤÞçô äʥʢʡéãçêʤʦêʤäãçʡâð ʒʟʒ ą èʤäʡâʡéʢåô èʤÞʥʢáàʢçãô æðíʢìçʤʣ éäʡçã ʒåãçãìʢʦäã âçʡìãæðæ ʦìãéʡʢéʦô èʤÞðíʢçãʢ ʒʟʒ Þ ʥʡâ Þðíʢ Þʢʥʨçʢʣ ßʥʡçãëð çʤʥæð ʔʥʡì àʤåáʢç ãʦäåóìãéñ àʥʧßãʢ èʥãìãçð èʤÞðíʢçãô ʒʟʒ äʤéʤʥðʢ æʤßʧé Ýðéñ ʤÝʧʦåʤÞåʢçð ìʥʢâæʢʥçʤʣ êãâãìʢʦäʤʣ çʡßʥʧâäʤʣ ãåã èʤʥʡáʢçãʢææðíë çʢʦÞôâʡççðæʦèʥãʢæʤæʦéʡéãçʤÞʞʡäéãäʡÞàʡççʤʣʦãéʧʡëããéʡäʡôáʢ äʡäãèʥãèʤÞðíʢçããʧʥʤÞçôʓʝʞãʓÑʞ ʚìʢçñʥʢàäãæãçʡãÝʤåʢʢéôáʢåðæʤʦåʤáçʢçãʢæéʢʥʡèããʦéʡéãçʡæãôÞåôʢéʦô ʥʡÝàʤæãʤåãâ ʥʡʦèʡà æðíʢìçʤʣ éäʡçã äʤéʤʥðʣ æʤáʢé âʡäʤçìãéñʦô åʢéʡåñçðæ ãʦʨʤàʤæ ãâ âʡ ʥʡâÞãÞʡóîʢʣʦô èʤìʢìçʤʣ çʢàʤʦéʡéʤìçʤʦéã Ôʡîʢ Þʦʢßʤ ʥʡÝàʤæãʤåãâçʡÝåóàʡʢéʦôèʥãʦʤìʢéʡçããʦéʡéãçʤÞʦëãäåʤʦèʤʥãçʤæ êãÝʥʡéʡæãßʢæêãÝʥʤâãåʤæ çãäʤéãçʤÞʤʣäãʦåʤéʤʣ òʥãéʥʤæãëãçʤæ ʥôàʤæèʥʤéãÞʤßʥãÝäʤÞðʨèʥʢèʡʥʡéʤÞʛʤòéʤæʧÞʦåʧìʡôʨçʢʤÝʨʤàãæʤʦéãçʡâçʡìʢçãôäʤæÝãçãʥʤÞʡççʤʣéʢʥʡèãã äʤçéʥʤåñêʢʥæʢçéʤÞʒʟʒ ʓÑʞ ʓʝʞ àʤåáʢçèʥʤÞʤàãéñʦôìʡîʢ ʡÝʤåñçðʨʦåʢàʧʢé èʤàʥʤÝçʤãçʦéʥʧäéãʥʤÞʡéñʤÞʤâæʤáçʤʦéããʦãæèéʤæʡʨòéãʨʤʦåʤáçʢçãʣ ʔ èʤʦåʢàçʢʢ Þʥʢæô Þ åãéʢʥʡéʧʥʢ èʤôÞãåãʦñ ʦʤʤÝîʢçãô ʤ éʤæ ìéʤ àåãéʢåñçðʣèʥãʢæʦéʡéãçʤÞæʤáʢéʡʦʦʤëããʥʤÞʡéñʦôʦÝʤåʢʢÞðʦʤäãæʥãʦäʤæʥʡâÞãéãô ʦʡʨʡʥçʤßʤàãʡÝʢéʡʝÍ ÌðåʤèʥʤÞʢàʢçʤçʢʦäʤåñäʤæʢéʡʡçʡåãâʤÞ èʤäʡâʡÞíãʨ ìéʤ èʥãʢæ ʦéʡéãçʤÞ Þ Þðʦʤäãʨ àʤâʡʨ àʢʣʦéÞãéʢåñçʤ ʦʤèʥʤÞʤáàʡʢéʦô Ýʤåñíʢʣ ìʡʦéʤéʤʣʥʡâÞãéãôʝÍ çʢáʢåãʧåãë èʥãçãæʡÞíãʨʦéʡéãçðÞʧæʢʥʢççðʨàʤâʡʨ 84 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʔæʢʦéʢ ʦ éʢæ Ýðåʤ ʤéìʢéåãÞʤ èʤäʡâʡçʤ ìéʤ èʤåñâʡ ʤé ʦéʡéãçʤÞ ʦÞôâʡççʡô ʦʤ ʦçãáʢçãʢæìãʦåʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣãʦæʢʥéʢåñçðʨãʦʨʤàʤÞ ʦʧîʢʦéÞʢççʤèʥʢÞðíʡʢéʥãʦä ʦÞôâʡççðʣʦʥʡâÞãéãʢæʦʡʨʡʥçʤßʤàãʡÝʢéʡʞʢæçʢ æʢçʢʢòéãêʡäéð åãíçãʣʥʡâʦÞãàʢéʢåñʦéÞʧóéÞèʤåñâʧéʤßʤ ìéʤéʢʥʡèãôʦéʡéãçʡæã àʤåáçʡ èʥʤÞʤàãéñʦô ʦ ʧìʢéʤæ ãçàãÞãàʧʡåñçðʨ ʤʦʤÝʢççʤʦéʢʣ äʡáàʤßʤ èʡëãʢçéʡ ãéʡæ ßàʢÞòéʤæçʢéçʢʤÝʨʤàãæʤʦéã çʢʦåʢàʧʢéçʡâçʡìʡéñèʥʢèʡʥʡé ÞÞðʦʤäʤʣàʤâʢʔʤæçʤßãʨʦåʧìʡôʨëʢåʢÞʤʣʧʥʤÞʢçñʠʝÑʙʛàʤʦéãßʡʢéʦôèʥãçʡâçʡìʢçããʧæʢʥʢççðʨàʤâʦéʡéãçʤÞãåãèʥããʨäʤæÝãçʡëããʦòâʢéãæãÝʤæãåãàʥʧßãæãåãèãàʦçãáʡóîãæãèʥʢèʡʥʡéʡæã ʝéʡéãçð çʢåñâô çʡâçʡìʡéñ Ýʢʥʢæʢççðæ ã áʢçîãçʡæ àʢéʤʥʤàçʤßʤ Þʤâʥʡʦéʡ èåʡçãʥʧóîãææʡéʢʥãçʦéÞʤʛʥʢèʡʥʡééʡäáʢçʢåñâôèʥãæʢçôéñʧàʢéʢʣæʤåʤáʢ åʢé ʢʦåãéʤåñäʤʥʢìñçʢãàʢéʤßʤæʤâãßʤéçʤʣêʤʥæʢʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæããʛʥãʢæʦéʡéãçʤÞʦåʢàʧʢéèʥʢäʥʡéãéñèʥãèʤÞðíʢçããʧʥʤÞçôéʥʡçʦʡæãçʡâ ÞðíʢéʥʢʨÞʢʥʨçãʨßʥʡçãëçʤʥæðãåãʒʟʒÞðíʢèôéãÞʢʥʨçãʨèʥʢàʢåʤÞåʡÝʤʥʡéʤʥçʤʣçʤʥæð ʔäåãçãìʢʦäʤʣèʥʡäéãäʢÝʤåʢʢʤèéãæʡåñçðæôÞåôʢéʦôçʡâçʡìʢçãʢʤʥãßãçʡåñçðʨ ʦéʡéãçʤÞ ãʦèʤåñâʤÞʡçãʢ àáʢçʢʥãäʤÞ æʤáʢé Ýðéñ ʥʢäʤæʢçàʤÞʡçʤ Þ ʥôàʢ ʦåʧìʡʢÞ èʤ êãçʡçʦʤÞðæ ʦʤʤÝʥʡáʢçãôæ ;= ʝåʢàʧʢé ʤéæʢéãéñ ìéʤ ʥʡâçãëʡ ÞëʢçʢÝʥʢçàʤÞðʨèʥʢèʡʥʡéʤÞãàáʢçʢʥãìʢʦäãʨÞçʢäʤéʤʥðʨʦåʧìʡôʨæãçãæʡåñçʡ ÚÏʖʞÐʘÐÌ ÚâʢéãæãÝ ÞʤéåãìãʢʤéʦéʡéãçʤÞ ʦçãáʡʢéçʢʦãçéʢâʠʝ ʡʢßʤÞʦʡʦðÞʡçãʢÞáʢåʧàʤìçʤ äãíʢìçʤæ éʥʡäéʢ ʕãèʤʨʤåʢʦéʢʥãçʢæãìʢʦäãʣ òêêʢäé òâʢéãæãÝʡ àʤʦéãßʡʢéʦôâʡʦìʢéãçßãÝãʥʤÞʡçãôèʢʥʢçʤʦìãäʡòäâʤßʢççʤßʤʠʝ åʤäʡåãâʤÞʡççʤßʤ çʡîʢéʤìçʤʣäʡʢæäʢòèãéʢåãôéʤçäʤʣäãíäãʛʢʥʢçʤʦìãäʠʝèʥʢàʦéʡÞåôʢéʦʤÝʤʣ Ýʢåʤä éãèʡ ʙãæʡççʡąʛãäʡ .IEMANN 0ICK # LIKE ÐçßãÝãʥʤÞʡçãʢ éʥʡçʦèʤʥéʡ èãîʢÞʤßʤãÝãåãʡʥçʤßʤʠʝÞäãíʢìçãäʢÞʢàʢéäʧæʢçñíʢçãóäʤåãìʢʦéÞʡʠʝÞßʢèʡéʤëãéʡʨ äʤéʤʥðʢÞʤéÞʢéçʡʥʡâÞãÞʡóîãʣʦôÞäåʢéäʢàʢêãëãéʠʝʧÞʢåãìãÞʡóé ìãʦåʤʥʢëʢèéʤʥʤÞäÑʙʛçʡʦÞʤʢʣèʤÞʢʥʨçʤʦéã ìéʤãʦʤèʥʤÞʤáàʡʢéʦôʦçãáʢçãʢæ ʧʥʤÞçôʠʝÑʙʛÞäʥʤÞã;= ʔéʢʥʡèʢÞéãìʢʦäʤʣàʤâʢæßʦʧéòâʢéãæãÝʦçãáʡʢéʧʥʤÞʢçñʠʝÑʙʛçʡą ʧʥʤÞʢçñʞʕąçʡąãèʤÞðíʡʢéʧʥʤÞʢçñʠʝÑʔʛçʡąÚâʢéãæãÝçʡâçʡìʡóé ßåʡÞçðæ ʤÝʥʡâʤæ Þ äʤæÝãçʡëãã ʦʤ ʦéʡéãçʡæã ʧ Ýʤåñçðʨ ʦ ÐÌʝ ã ÍÑʛ ʡ éʡäáʢ ʧ åãë ʦ Þðʦʤäãæ ʥãʦäʤæ ʤʦåʤáçʢçãʣ ʡéʢʥʤʦäåʢʥʤâʡ ʔ äʡìʢʦéÞʢ æʤçʤéʢʥʡèãã òâʢéãæãÝæʤáçʤçʡâçʡìʡéñèʡëãʢçéʡæʦçʢèʢʥʢçʤʦãæʤʦéñóʦéʡéãçʤÞʛʥʢèʡʥʡé òêêʢäéãÞʢç ã ʧ ʦéʥʤßãʨ ÞʢßʢéʡʥãʡçëʢÞ âʡ ʦìʢé ÝåʤäãʥʤÞʡçãô ʥʢʡÝʦʤʥÝëãã òçàʤßʢççʤßʤ ʠʝ èʤʦéʧèʡóîʢßʤ Þ äãíʢìçãä Þ ʦʤʦéʡÞʢ áʢåìã ʔ ʜʤʦʦãã âʡʥʢßãʦéʥãʥʤÞʡçʡêãäʦãʥʤÞʡççʡôäʤæÝãçʡëãôòâʢéãæãÝʡæßʦʧé ʦʦãæÞʡʦéʡéãçʤæ æßʦʧé ʒʤæÝãçʡëãô òâʢéãæãÝ ʦãæÞʡʦéʡéãç æʤáʢé Ýðéñ ʡåñéʢʥçʡéãÞʤʣ ʦéʡéãçʡæÞÞðʦʤäãʨàʤâʡʨ 85 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ÒÝʤåñçðʨʦʨʥʤçãìʢʦäʤʣèʤìʢìçʤʣçʢàʤʦéʡéʤìçʤʦéñóâçʡìãéʢåñçʤʧÞʢåãìãÞʡʢéʦôʥãʦäʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʔʥʡçàʤæãâãʥʤÞʡççʤææçʤßʤëʢçéʥʤÞʤæãʦʦåʢàʤÞʡçãã3(!20Ýðåʤèʤäʡâʡçʤ ìéʤäʤæÝãçãʥʤÞʡççʡôéʢʥʡèãôʦéʡéãç òâʢéãæãÝÞʢàʢéäʦçãáʢçãóʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤßʤʥãʦäʡʧòéʤʣäʡéʢßʤʥãã Ýʤåñçðʨçʡ ÚâʢéãæãÝ çʢ ʥʢäʤæʢçàʧʢéʦô çʡâçʡìʡéñ åãëʡæ èʥãçãæʡóîãæ ëãäåʤʦèʤʥãç ʨʤåʢʦéãʥʡæãç ã ãæʢóîãæ èʤÞðíʢççðʢ ʧʥʤÞçã ʦðÞʤʥʤéʤìçðʨ êʢʥæʢçéʤÞ ʓʝʞ ʓÑʞãʒʟʒ;= ʓʙʞÐʞʖÑʓʒ0#3+ ÏʡèʤʦåʢàçãʢßʤàʡÞʥôàʧßãèʤåãèãàʢæãìʢʦäãʨèʥʢèʡʥʡéʤÞèʤôÞãåʦôèʥãçëãèãʡåñçʤçʤÞðʣäåʡʦʦÝãʤåʤßãìʢʦäãʨʦʤʢàãçʢçãʣąãçßãÝãéʤʥðèʥʤèʥʤéʢãçʤÞʤʣ äʤçÞʢʥéʡâð ʦʧÝéãåãâãç äʢäʦãç éãèʡ 0#3+ ʞʡäãʢ èʥʢèʡʥʡéð èʥʢàʦéʡÞåôóé ʦʤÝʤʣ æʤçʤäåʤçʡåñçðʢ ʡçéãéʢåʡ ìéʤ Þãàçʤ ãâ ãʨ æʢáàʧçʡʥʤàçʤßʤ çʢèʡéʢçéʤÞʡççʤßʤ çʡâÞʡçãô ʦ ʧçãÞʢʥʦʡåñçðæ ʤäʤçìʡçãʢæ i æʡÝx éʤ ʢʦéñ MONOCLONAL ANTIBODIES ÐçßãÝãéʤʥð0#3+ʦʧîʢʦéÞʢççʤʤéåãìʡóéʦôʤéʦéʡéãçʤÞãòâʢéãæãÝʡ äʡäèʤʦÞʤʢʣèʥãʥʤàʢ éʡäãèʤæʢʨʡçãâæʧàʢʣʦéÞãôʔçʡʦéʤôîʢʢÞʥʢæôèʥʤʨʤàôé Ýʤåñíãʢ äåãçãìʢʦäãʢ èʥʤßʥʡææð Þ äʤéʤʥðʨ ãâʧìʡóéʦô ʡçéãéʢåʡ òÞʤåʤäʧæʡÝ !-' ʡåãʥʤäʧæʡÝ 2%'.3!2 ã ÝʤäʤëãâʧæʡÝ 2. Ôʡʦéñ ãʦʦåʢàʤÞʡçãʣʧáʢâʡÞʢʥíʢçʡ ããʨʥʢâʧåñéʡéðʧäʡâðÞʡóéçʡÞðʥʡáʢççðʣòêêʢäé òéʤʣßʥʧèèðèʥʢèʡʥʡéʤÞÞèåʡçʢʦçãáʢçãôäʡäʧʥʤÞçôʠʝÑʙʛ éʡäãàʥʧßãʨʡéʢʥʤßʢççðʨåãèãàʤÞèåʡâæð ÞäåóìʡôÑèʡ ; = ʜʡâʥʡÝʤéäʡʡçéãéʢåąãçßãÝãéʤʥʤÞ0#3+éʢʦçʤʦÞôâʡçʡʦʤéäʥðéãʢæʥʤåãßʢçʡ ãÝʢåäʡ0#3+ÞßʤæʢʤʦéʡâʢãæʢéʡÝʤåãâæʢʨʤåʢʦéʢʥãçʡʔçʤʥæʢëãʥäʧåãʥʧóîãʣ ÞèåʡâæʢäʥʤÞãʠʝÑʙʛâʡʨÞʡéðÞʡʢéʦôßʢèʡéʤëãéʡæãèʤʦʥʢàʦéÞʤæʦÞôâðÞʡçãôʦʤ ʦèʢëãêãìʢʦäãæ ʥʢëʢèéʤʥʤæ ʜ Ñʙʛ ʚÝʥʡâʤÞʡÞíãʣʦô äʤæèåʢäʦ ʠʝÑʙʛʜ Ñʙʛ ãçéʢʥçʡåãâʧʢéʦô Þ ßʢèʡéʤëãé Þ ʦʤʦéʡÞʢ äåʡéʥãçʤÞðʨ èʧâðʥñäʤÞ äʤéʤʥðʢ âʡéʢæ ʦåãÞʡóéʦô ʦ òçàʤʦʤæʡæã ʒãʦåʡô ʦʥʢàʡ Þçʧéʥã òçàʤʦʤæ ʦèʤʦʤÝʦéÞʧʢé àãʦʦʤëãʡëãã äʤæèåʢäʦʡ ʠʝÑʙʛʜ Ñʙʛ ʛʤʦåʢ àãʦʦʤëãʡëãã ʦÞʤÝʤàçðʢ ʜ Ñʙʛ èʤÞéʤʥçʤ ÞʤâÞʥʡîʡóéʦôçʡèʤÞʢʥʨçʤʦéñßʢèʡéʤëãéʡ ßàʢʤçãʦÞôâðÞʡóéãÞðÞʤàôéãâäʥʤÞʤéʤäʡçʤÞðʢìʡʦéãëðʠʝÑʙʛ0#3+ʥʢßʧåãʥʧʢéòéʤéëãäåãìʢʦäãʣèʥʤëʢʦʦ ʦÞôâðÞʡôʦñʦʜ ÑʙʛçʡèʤÞʢʥʨçʤʦéãßʢèʡéʤëãéʡãæʡʥäãʥʧôàʡççðʣʥʢëʢèéʤʥàåôʢßʤ èʤʦåʢàʧóîʢßʤ ʥʡâʥʧíʢçãô Þ åãâʤʦʤæʡʨ äåʢéäã Ôãʦåʤ ʡäéãÞçðʨ ʜ Ñʙʛ ã èʤßåʤîʢçãʢʠʝÑʙʛãâäʥʤÞʤéʤäʡʧæʢçñíʡʢéʦô ìéʤÞʢàʢéäʥʤʦéʧäʤçëʢçéʥʡëããʠʝÑʙʛ ÞèåʡâæʢäʥʤÞãʙʡèʥʡÞåʢççʤʢãçßãÝãʥʤÞʡçãʢ0#3+ʦèʤæʤîñóæʤçʤäåʤçʡåñçʤßʤ ʡçéãéʢåʡʧÞʢåãìãÞʡʢéìãʦåʤʡäéãÞçðʨʜ Ñʙʛ ìéʤÞʢàʢéäʧʦãåʢçãóâʡʨÞʡéʡʠʝÑʙʛ ãâäʥʤÞʤéʤäʡãʦçãáʢçãóʢßʤʦʤàʢʥáʡçãôÞèåʡâæʢäʥʤÞãʥãʦ ;= ÚÞʤåʤäʧæʡÝãʡåãʥʤäʧæʡÝâʡʥʢßãʦéʥãʥʤÞʡçðÞʝÕʓãʦéʥʡçʡʨʖÞʥʤèʢʣʦäʤßʤ ʦʤóâʡ Þ ß ʔ çʡʦéʤôîãʣ æʤæʢçé Þ ʜʟ éʤåñäʤ òÞʤåʤäʧæʡÝ ʤàʤÝʥʢç ä äåãçãìʢʦäʤæʧ èʥãæʢçʢçãó Ðʦéʤʥãìʢʦäã òÞʤåʤäʧæʡÝ ôÞåôʢéʦô èʢʥÞðæ 86 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ èʤåçʤʦéñóìʢåʤÞʢìʢʦäãææʤçʤäåʤçʡåñçðæʡçéãéʢåʤæ èʥãæʢçôʢæðæÞäʡʥàãʤåʤßãã ʒ çʡʦéʤôîʢæʧ Þʥʢæʢçã èʥʢèʡʥʡé ʧʦèʢíçʤ âʡÞʢʥíãå äåãçãìʢʦäãʢ ãʦʦåʢàʤÞʡçãô êʡâð))) ã èʥʤàʢæʤçʦéʥãʥʤÞʡå çʢàʤʦéãáãæʤʢ ʦ èʤæʤîñó ʦéʡçàʡʥéçʤʣ éʢʥʡèããòêêʢäéãÞçʤʢãʦéʡÝãåñçʤʢʦçãáʢçãʢʧʥʤÞçʢʣʠʝÑʙʛʧʥʡâåãìçðʨßʥʧèè èʡëãʢçéʤÞʦÞðʦʤäãæʥãʦäʤæÞʤâçãäçʤÞʢçãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣ ÐʦʦåʢàʤÞʡçãʢ)))êʡâð,!0,!#% èʥʤÞʤàãåʤʦñʦʧìʡʦéãʢæèʡëãʢçéʤÞʦÞðʦʤäãæ ʧʥʤÞçʢæ ʠʝÑʙʛ Þ ʦʥʢàçʢæ ææʤåñå çʡÝåóàʡʢæðæ çʢʦæʤéʥô çʡ éʢʥʡèãó ʦéʡéãçʡæãÞæʡäʦãæʡåñçʤòêêʢäéãÞçʤʣàʤâʢʔäʤæÝãçʡëããʦʤʦéʡéãçʡæãòÞʤåʤäʧæʡÝ èʥʤàʢæʤçʦéʥãʥʤÞʡå òêêʢäéãÞçʤʢ ʦçãáʢçãʢ ʧʥʤÞçʢʣ ʠʝÑʙʛ àʤ àʤèʤåçãéʢåñçʤ èʤ ʦʥʡÞçʢçãó ʦ éʢʥʡèãʢʣ éʤåñäʤ ʦéʡéãçʡæã ʝéʤãé ʤéæʢéãéñ ìéʤ èʥã òéʤæ àʤ èʡëãʢçéʤÞ àʤʦéãßʡåʤ ʧʥʤÞçô ʠʝÑʙʛ ææʤåñå ʕãèʤåãèãàʢæãìʢʦäãʣòêêʢäéòÞʤåʤäʧæʡÝʡÝðåʦéʡÝãåñçðæãèʥʢàʦäʡâʧʢæðæãçʢ âʡÞãʦʢå ʤé èʤåʡ Þʤâʥʡʦéʡ çʡìʡåñçʤßʤ ʧʥʤÞçô ʠʝÑʙʛ ã éãèʡàʤâð ʦéʡéãçʡ Þʦéʡçàʡʥéçʤʣéʢʥʡèãã;=ʔàʥʧßʤæãʦʦåʢàʤÞʡçãã)))êʡâð'!533 òÞʤåʤäʧæʡÝ çʡâçʡìʡåʦô èʡëãʢçéʡæ ʦ çʢèʢʥʢçʤʦãæʤʦéñó òêêʢäéãÞçðʨ àʤâ ʦéʡéãçʤÞ ÚÞʤåʤäʧæʡÝʦèʤʦʤÝʦéÞʤÞʡåʦçãáʢçãóʧʥʤÞçʢʣʠʝÑʙʛàʤʧʥʤÞçô ææʤåñå ʧ èʡëãʢçéʤÞ ʦʤ ʦʥʢàçãæ ãʦʨʤàçðæ ʧʥʤÞçʢæ ʠʝÑʙʛ ææʤåñå ʦçãáʢçãʢÞʦʥʢàçʢæçʡ ;=ÚêêʢäéãÞçʤʦéñòÞʤåʤäʧæʡÝʡÞéʢʥʡèããèʡëãʢçéʤÞ ʦʦʢæʢʣçʤʣßʢéʢʥʤâãßʤéçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣßʢʝʕʠʝ ʦèʢëãʡåñçðæʤÝʥʡâʤæãâʧìʡåʡʦñÞäåãçãìʢʦäʤæãʦʦåʢàʤÞʡçãã)))êʡâð254(%2&/2$ Þäʤéʤʥʤæ èʡëãʢçéʡæʦèʤàʤÝʥʡççʤʣßãèʤåãèãàʢæãìʢʦäʤʣéʢʥʡèãʢʣàʤèʤåçãéʢåñçʤçʡâçʡìʡåʦôòÞʤåʤäʧæʡÝãåãèåʡëʢÝʤÌðåʤèʤäʡâʡçʤ ìéʤòÞʤåʤäʧæʡÝèʥãàʤÝʡÞåʢçãã ä èʥʤÞʤàãæʤʣ ßãèʤåãèãàʢæãìʢʦäʤʣ éʢʥʡèãã ʦçãáʡå ʧʥʤÞʢçñ ʠʝÑʙʛ àʤèʤåçãéʢåñçʤçʡèʤʦʥʡÞçʢçãóʦèåʡëʢÝʤ ìéʤèʤâÞʤåãåʤàʤʦéãìñëʢåʢÞʤßʤʧʥʤÞçô ʠʝÑʙʛ ææʤåñåʧãʦèðéʧʢæðʨçʡòÞʤåʤäʧæʡÝʢąèʤʦʥʡÞçʢçãóåãíñ ʦʧåãë èʤåʧìʡÞíãʨèåʡëʢÝʤ;= ʞʡäãæ ʤÝʥʡâʤæ òÞʤåʤäʧæʡÝ èʥʤàʢæʤçʦéʥãʥʤÞʡå òêêʢäéãÞçʤʢ ã ʦéʡÝãåñçʤʢʦçãáʢçãʢʧʥʤÞçʢʣʠʝÑʙʛÞʤÞʦʢʨʤèãʦʡççðʨßʥʧèèʡʨèʡëãʢçéʤÞʦÞðʦʤäãæ ãʤìʢçñÞðʦʤäãæʥãʦäʤæʝʝÏ èʥãìʢæçʢâʡÞãʦãæʤʤéãçàãÞãàʧʡåñçðʨʨʡʥʡäéʢʥãʦéãäéʡäãʨèʡëãʢçéʤÞ ãʦéʤʥããèʥʢàðàʧîʢʣéʢʥʡèãããçʡìʡåñçʤßʤʧʥʤÞçôʠʝÑʙʛ ʛʥãæʢçʢçãʢ èʥʢèʡʥʡéʡ ʦʧîʢʦéÞʢççʤ ʥʡʦíãʥôʢé Þʤâæʤáçʤʦéã Þʢàʢçãô èʡëãʢçéʤÞʦʥʢêʥʡäéʢʥçʤʣßãèʢʥåãèãàʢæãʢʣ ʧäʤéʤʥðʨòêêʢäéãÞçʤʢʦçãáʢçãʢʠʝÑʙʛ çʢÞʤâæʤáçʤʦèʤæʤîñóʦéʡçàʡʥéçʤʣéʢʥʡèãããʧäʤéʤʥðʨʦʤʨʥʡçôʢéʦôÞðʦʤäãʣ ʥãʦä ʝʝÏ ʔ ìʡʦéçʤʦéã èʥʢèʡʥʡé æʤáʢé ãʦèʤåñâʤÞʡéñʦô ʧ èʡëãʢçéʤÞ ʦ èʢʥÞãìçʤʣßãèʢʥåãèãàʢæãʢʣãʦæʢíʡççʤʣàãʦåãèãàʢæãʢʣʦʢæʢʣçʤʣãçʢʦʢæʢʣçʤʣ äʡä Þʦʤìʢéʡçããʦʤʦéʡéãçʡæã éʡäãÝʢâçãʨÞʦåʧìʡʢãʨçʢèʢʥʢçʤʦãæʤʦéã ÐʦʦåʢàʤÞʡçãʢ èʥʤêãåô Ýʢâʤèʡʦçʤʦéã òÞʤåʤäʧæʡÝʡ äʡä èʥʢèʡʥʡéʡ ʦ çʤÞðæ äʡìʢʦéÞʢççʤ ʤéåãìçðæ æʢʨʡçãâæʤæ àʢʣʦéÞãô èʥʢàʦéʡÞåôʢé Ýʤåñíʤʣ ãçéʢʥʢʦ ʔʤ Þʦʢʨ èʥãÞʢàʢççðʨ Þðíʢ äåãçãìʢʦäãʨ ãʦèðéʡçãôʨ òÞʤåʤäʧæʡÝ èʤäʡâʡå èʥʤêãåñ Ýʢâʤèʡʦçʤʦéã ʦʥʡÞçãæðʣ ʦ èåʡëʢÝʤ ʙãäʡäãʨ ʦéʡéãʦéãìʢʦäã àʤʦéʤÞʢʥ87 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ çðʨʦèʢëãêãìʢʦäãʨèʤÝʤìçðʨʥʢʡäëãʣ èʥãʦʧîãʨãʦäåóìãéʢåñçʤòÞʤåʤäʧæʡÝʧ çʢʤÝçʡʥʧáʢçʤʒʥʤæʢéʤßʤ äèʥʢèʡʥʡéʧçʢÞðôÞåʢçʤçʢʣéʥʡåãâʧóîãʨʡçéãéʢå ìéʤèʤàéÞʢʥáàʡʢéʢßʤÞðʦʤäãʣèʥʤêãåñÝʢâʤèʡʦçʤʦéã; = ʜãʦʘʢʨʡçãâæàʢʣʦéÞãôʡçéãéʢåä0#3+çʡèʥãæʢʥʢèʥʢèʡʥʡéʡòÞʤåʤäʧæʡÝ ÚÞʤåʤäʧæʡÝèʥãçãæʡʢéʦôÞàʤâãʥʤÞäʢæßʥʡâÞçʢàʢåãÞÞãàʢèʤàäʤáçðʨãçïʢäëãʣ ÞðèʤåçôʢæðʨʦʡæãæèʡëãʢçéʤæèʥãèʤæʤîãʦèʢëãʡåñçʤʥʡâʥʡÝʤéʡççðʨåʢßäãʨÞèʥãæʢçʢçããèʥʢàÞʡʥãéʢåñçʤâʡèʤåçʢççðʨíèʥãë ʥʧìʢäʛʥãʢæ òÞʤåʤäʧæʡÝʡʦçãáʡʢéʧʥʤÞʢçñʠʝÑʙʛçʡąʧáʢçʡèʢʥÞʤʣçʢàʢåʢéʢʥʡèãã ãàåãéʢåñçʤèʤààʢʥáãÞʡʢéʢßʤçʡàʤʦéãßçʧéʤæʧʥʤÞçʢ ʛʥôæʤʢ Þåãôçãʢ éʢʥʡèãã ãçßãÝãéʤʥʡæã 0#3+ çʡ ʥãʦä ʝʝÏ ôÞåôʢéʦô èʥʢàæʢéʤæ ãâʧìʢçãô ëʢåʤʣ ʦʢʥãã äåãçãìʢʦäãʨ ãʦʦåʢàʤÞʡçãʣ àåô äʡáàʤßʤ èʥʢèʡʥʡéʡ &/52)%2 àåô òÞʤåʤäʧæʡÝʡ éðʦ èʡëãʢçéʤÞ /$933%9 àåô ʡåãʥʤäʧæʡÝʡ éðʦ èʡëãʢçéʤÞ 30)2% àåô ÝʤäʤëãâʧæʡÝʡ éðʦ èʡëãʢçéʤÞ ʛʢʥÞðʢ ʥʢâʧåñéʡéðäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãʣèʤÞåãôçãóãçßãÝãéʤʥʤÞ0#3+çʡʥãʦäʝʝÏ ʦèʢʥãʤàʤæçʡÝåóàʢçãʣʤéàʤåʢé ÝʧàʧéàʤʦéʧèçðÞß ʙʡãÝʤåʢʢ èʤåçʤ ʤëʢçãéñ èʤéʢçëãʡå ã æʢʦéʤ ãçßãÝãéʤʥʤÞ 0#3+ çʡ ʤʦçʤÞʢ æʤçʤäåʤçʡåñçðʨʡçéãéʢåÞʦʤÞʥʢæʢççʤʣéʢʥʡèããßãèʢʥåãèãàʢæããæʤáçʤÝʧàʢé èʤʦåʢèʤåʧìʢçãôàʡççðʨäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãʣèʤÞåãôçãóéʢʥʡèããçʡʥãʦä ʝʝÏʚàçʡäʤʧáʢʦʢʣìʡʦ ʦʧìʢéʤæÞðʦʤäʤʣòêêʢäéãÞçʤʦéãàʡççðʨèʥʢèʡʥʡéʤÞ ʦéʡçʤÞôéʦô ôʦçð Þðʦʤäãʢ èʢʥʦèʢäéãÞð ãʨ èʥãæʢçʢçãô àåô éʢʥʡèãã éôáʢåðʨ èʡëãʢçéʤÞ çʢ àʤʦéãßʡóîãʨ ʥʢäʤæʢçàʤÞʡççʤßʤ ʦçãáʢçãô ʠʝÑʙʛ ʦ èʤæʤîñó 88 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʦéʡçàʡʥéçʤʣéʢʥʡèããããæʢóîãʨʤìʢçñÞðʦʤäãʣʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʣʥãʦäÍåô éʡäãʨ èʡëãʢçéʤÞ ãçßãÝãéʤʥð 0#3+ ôÞåôóéʦô òêêʢäéãÞçðæ éʢʥʡèʢÞéãìʢʦäãæ ʥʢíʢçãʢæ ʟÐÌʜʓʞØ ʟãÝʥʡéðʤéçʤʦôéʦôäèʥʤãâÞʤàçðæêãÝʥʤʢÞʤʣäãʦåʤéðʚʦçʤÞçðæãèʥʢàʦéʡÞãéʢåôæãäåʡʦʦʡêãÝʥʡéʤÞôÞåôóéʦôÝʢâʡêãÝʥʡé ßʢæêãÝʥʤâãå ëãèʥʤêãÝʥʡé ãêʢçʤêãÝʥʡé;=ʔçʡʦéʤôîʢʢÞʥʢæôÞʜʤʦʦããÞèʥʤàʡáʢãæʢʢéʦôéʤåñäʤêʢçʤêãÝʥʡé ʘʢʨʡçãâæ àʢʣʦéÞãô êãÝʥʡéʤÞ âʡäåóìʡʢéʦô Þ ʦéãæʧåôëãã Þçʧéʥãäåʢéʤìçðʨ ôàʢʥçðʨ ʥʢëʢèéʤʥʤÞʜʜʓ2 ² ʡäéãÞʡëãôäʤéʤʥðʨÞʢàʢéäèʥʤåãêʢʥʡëããèʢʥʤäʦãʦʤæ ą ʦèʢëãêãìʢʦäãʨ Þçʧéʥãäåʢéʤìçðʨ ʤʥßʡçʢåå ʥʢßʧåãʥʧóîãʨ äʡéʡÝʤåãâæ áãʥçðʨäãʦåʤé èʥʤàʧäëãóʡèʤʝ)))ãʡèʤʓ)!))ʒʤçʢìçðæʥʢâʧåñéʡéʤæéʡäʤßʤÞâʡãæʤàʢʣʦéÞãôôÞåôʢéʦôʧʦãåʢçãʢåãèʤåãâʡìʡʦéãë ÝʤßʡéðʨʞʕÑʚʙʛ ʠʘ ãèʤÞðíʢçãʢʦãçéʢâʡʡèʤʓ ʦʤàʢʥáʡîãʨåãèʤèʥʤéʢãàʤÞʛʤòéʤæʧêãÝʥʡéðòêêʢäéãÞçʤ ʦçãáʡóé ʧʥʤÞʢçñ ʞʕ ã èʤÞðíʡóé ʧʥʤÞʢçñ ʠʝ Ñʔʛ ʡ éʡäáʢ ʧæʢʥʢççʤ ʦçãáʡóé ʧʥʤÞʢçñʠʝÑʙʛ;= ʟʢçʤêãÝʥʡéÝðåãâʧìʢçÞàÞʧʨäʥʧèçðʨʥʡçàʤæãâãʥʤÞʡççðʨãʦʦåʢàʤÞʡçãôʨ ʔ ãʦʦåʢàʤÞʡçãã !##/2$ Þ äʤéʤʥʤʢ Ýðåã Þäåóìʢçð èʡëãʢçéʤÞ ʦ ʝÍ ʤàçʡ ßʥʧèèʡ èʤåʧìʡåʡ êʢçʤêãÝʥʡé Þ äʤæÝãçʡëãã ʦ ʦãæÞʡʦéʡéãçʤæ àʥʧßʡô ą ʦãæÞʡʦéʡéãçÞäʤæÝãçʡëããʦèåʡëʢÝʤÐʦʦåʢàʤÞʡçãʢàåãåʤʦñåʢéãèʥʢʦåʢàʤÞʡåʤëʢåñ àʤäʡâʡéñ ìéʤäʤæÝãçãʥʤÞʡççʡôéʢʥʡèãôʦçãáʡʢéìʡʦéʤéʧʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣʧÝʤåñçðʨʝÍÞÝʤåñíʢʣʦéʢèʢçã çʢáʢåãæʤçʤéʢʥʡèãôʦãæÞʡʦéʡéãçʤæ Ò Ýʤåñçðʨ ʦ ʧʥʤÞçʢæ ʞʕ æßàå ææʤåñå ã ʧʥʤÞçʢæ ʠʝ Ñʔʛ çãáʢ æßàå ææʤåñå ʥãʦäʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʦçãâãåʦôçʡ ;=ʜʢâʧåñéʡéðãʦʦåʢàʤÞʡçãô!##/2$èʤʦåʧáãåãʤʦçʤÞʡçãʢæʥʢäʤæʢçàʤÞʡéñ êʢçʤêãÝʥʡéÞʦʤìʢéʡçããʦʦãæÞʡʦéʡéãçʤæèʡëãʢçéʡæʦʦʡʨʡʥçðæàãʡÝʢéʤæãåã æʢéʡÝʤåãìʢʦäãæʦãçàʥʤæʤæèʥãʧʥʤÞçʢʞʕ ææʤåñåãʧʥʤÞçʢʠʝÑʔʛçãáʢ ææʤåñå ʓçʡåʤßãìçðʢ ʥʢâʧåñéʡéð Ýðåã èʤåʧìʢçð ã Þ ãʦʦåʢàʤÞʡçãã &)%,$ äʤéʤʥʤʢ èʥʢàíʢʦéÞʤÞʡåʤ ãʦʦåʢàʤÞʡçãó !##/2$ êʢçʤêãÝʥʡé çʡ ʦçãáʡå ìʡʦéʤéʧʥʡâÞãéãôçʢêʡéʡåñçʤßʤÐʘ çʡʦçãáʡåìʡʦéʤéʧÞʦʢʨʝʝʚÔʡʦéʤéʡçʢäʤʥʤçʡʥçʤʣãʤÝîʢʣʦæʢʥéçʤʦéãÞãʦʦåʢàʧʢæðʨßʥʧèèʡʨâçʡìãæʤçʢʤéåãìʡåʡʦñ ;=ʞʡäãæʤÝʥʡâʤæ ʤʦçʤÞçðæèʤäʡâʡçãʢæàåôàʤÝʡÞåʢçãôêʢçʤêãÝʥʡéʡäéʢʥʡèããʦéʡéãçʡæãʧÝʤåñçðʨʝÍôÞåôʢéʦôßãèʢʥéʥãßåãëʢʥãàʢæãô ÞʤʦʤÝʢççʤʦéã ÞʦʤìʢéʡçããʦçãâäãæʧʥʤÞçʢæʠʝÑʔʛʟãÝʥʡéðʤʦéʡóéʦôʦʥʢàʦéÞʤæèʢʥÞʤʣåãçããʧÝʤåñçðʨʦʧʥʤÞçʢæʞʕææʤåñå Þòéãʨʦåʧìʡôʨʤçãçʡâçʡìʡóéʦôʦëʢåñó èʥʢàʧèʥʢáàʢçãôʥʡâÞãéãôʤʦéʥʤßʤèʡçäʥʢʡéãéʡ ʛʤæãæʤ ʤʦçʤÞçʤßʤ ßãèʤåãèãàʢæãìʢʦäʤßʤ àʢʣʦéÞãô êʢçʤêãÝʥʡé ʞʥʡʣäʤʥ ʤÝåʡàʡʢé æçʤßãæã àʤèʤåçãéʢåñçðæã èåʢʣʤéʥʤèçðæã òêêʢäéʡæã äʤéʤʥðʢ 89 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʦʧîʢʦéÞʢççʤʥʡʦíãʥôóéʤÝåʡʦéãʢßʤèʥãæʢçʢçãôʞʡä çʡèʥãæʢʥ éʢʥʡèãôêʢçʤêãÝʥʡéʤæʦʤèʥʤÞʤáàʡʢéʦôʦçãáʢçãʢæʧʥʤÞçʢʣæʡʥäʢʥʤÞÞʤʦèʡåʢçãô Þäåóìʡô ʝ ʥʢʡäéãÞçðʣÝʢåʤä ʟʙʚ ² ÐÑ ³ ÐÑ ʡéʡäáʢʧåʧìíʢçãʢæèʤäʡâʡéʢåʢʣßʢæʤʦéʡâʡ Þäåóìʡô ʦçãáʢçãʢ ʧʥʤÞçʢʣ êãÝʥãçʤßʢçʡ ã ãçßãÝãéʤʥʡ ʡäéãÞʡéʤʥʡ èåʡâæãçʤßʢçʡ; =ʔʡáçðæʦÞʤʣʦéÞʤæêʢçʤêãÝʥʡéʡôÞåôʢéʦôʢßʤʦèʤʦʤÝçʤʦéñ ÝåʤäãʥʤÞʡéñʡäéãÞçʤʦéñ6%'& ÞʥʢâʧåñéʡéʢéʤʥæʤâãéʦôʡçßãʤßʢçʢâʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôíäã ʡéʡäáʢèʥʢàʤéÞʥʡîʡʢéʦôÞʡʦäʧåôʥãâʡëãôʦʢéìʡéäãʧèʡëãʢçéʤÞ ʦ àãʡÝʢéãìʢʦäʤʣ ʥʢéãçʤèʡéãʢʣ ;= ʔ ãʦʦåʢàʤÞʡçãã &)%,$ Ýðåã èʤåʧìʢçð ʧÝʢàãéʢåñçðʢàʤäʡâʡéʢåñʦéÞʡàʢʣʦéÞãôêʢçʤêãÝʥʡéʡçʡæãäʥʤʦʤʦʧàãʦéʤʢʥʧʦåʤʧÝʤåñçðʨʦʡʨʡʥçðæàãʡÝʢéʤæ))éãèʡ âʡäåóìʡóîʢʢʦôÞéʤʥæʤáʢçããèʥʤßʥʢʦʦãʥʤÞʡçãôæãäʥʤʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʦçãáʢçãʢèʥʤßʥʢʦʦãʥʤÞʡçãôàãʡÝʢéãìʢʦäʤʣʥʢéãçʤèʡéããçʡ ʦçãáʢçãʢìãʦåʡæʡåðʨçʢéʥʡÞæʡéãìʢʦäãʨʡæèʧéʡëãʣ èʤèʥãìãçʢàãʡÝʢéãìʢʦäʤʣèʤåãçʢʣʥʤèʡéããçʡãʦçãáʢçãʢæãäʥʤʡåñÝʧæãçʧʥããçʡ ʛʤÝʤìçðʢ ôÞåʢçãô éʢʥʡèãã êãÝʥʡéʡæã Þʦéʥʢìʡóéʦô ʧ ą èʡëãʢçéʤÞ ʦʤ ʦéʤʥʤçð Îʒʞ æʢéʢʤʥãâæ Ýʤåã âʡèʤʥð àãʡʥʢô èʤÞðíʢçãʢ èʢìʢçʤìçðʨ êʢʥæʢçéʤÞ æãʤèʡéãô ìʡîʢ èʥã ʦʤìʢéʡçãã êãÝʥʡéʤÞ ʦʤ ʦéʡéãçʡæã ʙʢʤÝʨʤàãæʤ ʦʤÝåóàʡéñʤʦéʤʥʤáçʤʦéñèʥãçʡâçʡìʢçããêãÝʥʡéʤÞʧåãëʦʦʤèʧéʦéÞʧóîãæʨʤåʢåãéãʡâʤæãʧÝʤåñçðʨ èʥãçãæʡóîãʨÞʡʥêʡʥãçÞèʤʦåʢàçʢæʦåʧìʡʢÞʤâʥʡʦéʡʢéʥãʦäßʢæʤʥʥʡßãìʢʦäãʨʤʦåʤáçʢçãʣ ;=ʔäʤæÝãçʡëããʦʤʦéʡéãçʡæãʥʢäʤæʢçàʧʢéʦôçʡâçʡìʡéñêʢçʤêãÝʥʡé èʤʦäʤåñäʧèʥãòéʤæʥãʦäʥʡâÞãéãôæãʤèʡéãã æãçãæʡåʢç ʚʘʖʕʓ ʛʚÑÐʙʖʙʓʝØÖʖʙʙØʖÎÐʜʙØʖʒÐʝÑʚʞØ ʚæʢßʡ èʤåãçʢçʡʦðîʢççðʢáãʥçðʢäãʦåʤéðòʣäʤâʡèʢçéʡʢçʤÞʡôãàʤäʤâʡßʢäʦʡʢçʤÞʡôáãʥçðʢäãʦåʤéð ʛʙÎʒ ÞðàʢåʢçðãâʥðÝñʢßʤáãʥʡʚæʢßʡ ʛʙÎʒ ʤÝåʡàʡóéÞðʥʡáʢççðæßãèʤéʥãßåãëʢʥãàʢæãìʢʦäãæàʢʣʦéÞãʢæèʥãʧʦåʤÞãã ìéʤ ãʨʤÝîʢʢʦʤàʢʥáʡçãʢÞèʥʢèʡʥʡéʢʦʤʦéʡÞåôʢéçʢæʢçʢʢʛãîʢÞðʢàʤÝʡÞäãçʢ ʦʤàʢʥáʡé éʡäʤßʤ äʤåãìʢʦéÞʡ ʛʙÎʒ ã ãʨ òêêʢäéãÞçʤʦéñ âçʡìãéʢåñçʤ ʧʦéʧèʡʢé òêêʢäéãÞçʤʦéãæʢàãëãçʦäãʨèʥʢèʡʥʡéʤÞ ʚæʢßʡ ʛʙÎʒʦçãáʡóéʧʥʤÞʢçñʞʕèʥãæʢʥçʤçʡ ʦʧîʢʦéÞʢççʤçʢÞåãôô çʡ ʧʥʤÞʢçñ ʚʠʝ ã ʠʝÑʙʛ ʔ ãʦʦåʢàʤÞʡçãã ')33) 0REVENZIONE èʥãʢæ ʤæʢßʡ ʛʙÎʒ Þ àʤâʢ ßʦʧé ʧ Ýʤåñçðʨ èʢʥʢçʢʦíãʨ Ðʘ èʥãÞʢå ä ʦçãáʢçãó ʦåʧìʡʢÞ ÞçʢâʡèçʤʣʦæʢʥéãçʡèʤʦʥʡÞçʢçãóʦäʤçéʥʤåñçʤʣßʥʧèèʤʣʙʡÝåóàʡʢæðʣòêêʢäéçʢÝðåʦÞôâʡçʦèʥôæðæÞʤâàʢʣʦéÞãʢæçʡʧʥʤÞçãåãèãàʤÞãÝðåʤÝïôʦçʢç Þʤâæʤáçðæ ʡçéãʡʥãéæãìʢʦäãæ àʢʣʦéÞãʢæ èʥʢèʡʥʡéʡ ʚàçʡäʤ Þ èʤʦåʢàʧóîãʨ ãʦʦåʢàʤÞʡçãôʨ ÞìʡʦéçʤʦéãÞãʦʦåʢàʤÞʡçãã/2)'). ʡçéãʡʥãéæãìʢʦäãʣòêêʢäé ʤæʢßʡ ʛʙÎʒçʢÝðåàʤäʡâʡçÌʤåʢʢéʤßʤ èʥãʢæèʥʢèʡʥʡéʡÞàʤâʢßʦʧéçʢàʡå çãäʡäãʨèʤåʤáãéʢåñçðʨʥʢâʧåñéʡéʤÞèʤʦʥʡÞçʢçãóʦßʥʧèèʤʣ èʥãçãæʡÞíʢʣèåʡëʢÝʤʞʡäãæʤÝʥʡâʤæ ʤæʢßʡ ʛʙÎʒÞʥʢäʤæʢçàʧʢæðʨàʤâʡʨąßʦʧé ʦåʢàʧʢé 90 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʥʡʦʦæʡéʥãÞʡéñäʡäʦʥʢàʦéÞʤ çʤʥæʡåãâʧóîʢʢʧʥʤÞʢçñʞʕÞäʥʤÞãÒÝʤåñçðʨʦßãèʢʥéʥãßåãëʢʥãàʢæãʢʣãçʢèʢʥʢçʤʦãæʤʦéñóêãÝʥʡéʤÞʤæʢßʡ ʛʙÎʒæʤßʧéÝðéñ èʥʢèʡʥʡéʤæ ÞðÝʤʥʡ ʔ ëʢåʤæ ʤæʢßʡ ʛʙÎʒ ôÞåôʢéʦô Ýʢâʤèʡʦçðæ èʥʢèʡʥʡéʤæ åãíʢççðæ äʡäʤßʤ åãÝʤ ÞâʡãæʤàʢʣʦéÞãô ʦ àʥʧßãæã åʢäʡʥʦéÞʢççðæã ʦʥʢàʦéÞʡæã çʢʧʨʧàíʡʢéʦʤʦéʤôçãôèʡëãʢçéʤÞʦçʡʥʧíʢçãôæãʥãéæʡʦʢʥàëʡʚàçʡäʤʢßʤ ʧæʢʥʢççðʣʡçéãʡßʥʢßʡëãʤççðʣòêêʢäéæʤáʢéʧÞʢåãìãÞʡéñʥãʦääʥʤÞʤéʢìʢçãʣ ʤʦʤÝʢççʤʧåãë èʥãçãæʡóîãʨʡʦèãʥãçãåãÞʡʥêʡʥãç;= ʝʖʒʔʖʝʞʜʓʙʞØÎʖÑÔʙØʠʒÐʝÑʚʞ ʝʢäÞʢʦéʥʡçéð áʢåìçðʨ äãʦåʤé ʝÎʒ èʥãæʢçôóé Þ äʡìʢʦéÞʢ ßãèʤåãèãàʢæãìʢʦäãʨ ʦʥʢàʦéÞ ʤäʤåʤ åʢé ʔ çʢäʤéʤʥðʨ äåãçãìʢʦäãʨ ãʦʦåʢàʤÞʡçãôʨ àʢæʤçʦéʥãʥʧʢéʦôãʨÞåãôçãʢçʡìʡʦéʤéʧʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʛʤôÞåʢçãʢ ʦéʡéãçʤÞ ʤÝåʡàʡóîãʨ Ýʤåʢʢ Þðʥʡáʢççðæ ßãèʤåãèãàʢæãìʢʦäãæ òêêʢäéʤæ èʥãÞʢåʤäéʤæʧ ìéʤʝÎʒÞʜʤʦʦããèʥʡäéãìʢʦäãçʢèʥãæʢçôóéʦôʔàʥʧßãʨʦéʥʡçʡʨ ʝÎʒ èʥãæʢçôóé Þ äʡìʢʦéÞʢ àʤèʤåçãéʢåñçʤßʤ ʦʥʢàʦéÞʡ ä éʢʥʡèãã ʦéʡéãçʡæã ʧ Ýʤåñçðʨ ʦ ʦʢæʢʣçʤʣ ßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣ ʝÎʒ çʢ ÞʦʡʦðÞʡóéʦô Þ äʥʤÞñ ã åãíʢçð ʦãʦéʢæçʤßʤ àʢʣʦéÞãô èʥãʦʧîʢßʤ àʥʧßãæ åʢäʡʥʦéÞʢççðæ ʦʥʢàʦéÞʡæ èʤòéʤæʧʤçãæʤßʧéÝðéñʦʥʢàʦéÞʤæÞðÝʤʥʡ çʡèʥãæʢʥ ʧÝʢʥʢæʢççðʨãåãʧàʢéʢʣ ʦʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣ ʝÎʒ ôÞåôôʦñ ʦåʤáçðæã èʤåãæʢʥçðæã ʦʤʢàãçʢçãôæã ʦÞôâðÞʡóé áʢåìçðʢ äãʦåʤéð ʦʤʦéʤôîãʢ Þ ʤʦçʤÞçʤæ ãâ ʠʝ Þ èʥʤʦÞʢéʢ éʤçäʤßʤ äãíʢìçãäʡ ã ʧʦãåãÞʡóéãʨòäʦäʥʢëãóʦäʡåʤÞðæãæʡʦʦʡæãʔʥʢâʧåñéʡéʢʥʡâÞãÞʡʢéʦôàʢêãëãéʠʝ Þßʢèʡéʤëãéʢ àåôäʤæèʢçʦʡëããäʤéʤʥʤßʤʧÞʢåãìãÞʡʢéʦôäʤåãìʢʦéÞʤʥʢëʢèéʤʥʤÞ äÑʙʛ ìéʤʤÝʢʦèʢìãÞʡʢéàʤèʤåçãéʢåñçðʣäåãʥʢçʦʠʝÑʙʛãâèåʡâæðʝÎʒçʡâçʡìʡóéÝʤåñçðæʦÍÑʛ))ʡéãèʡ ʛʥʢàʦéʡÞãéʢåôæã ʝÎʒ ôÞåôóéʦô ʨʤåʢʦéãʥʡæãç äʤåʢʦéãèʤå ã äʤåʢʦʢÞʢåʡæ ʒʤåʢʦʢÞʢåʡæ Þ èʤʦåʢàçãʢ ßʤàð èʤåʧìãå íãʥʤäʤʢ ʥʡʦèʥʤʦéʥʡçʢçãʢ éʡä äʡä ʤç åãíʢçʤéʥãëʡéʢåñçðʨʤʥßʡçʤåʢèéãìʢʦäãʨʦÞʤʣʦéÞ èʥãʦʧîãʨàʥʧßãæèʥʢèʡʥʡéʡæ òéʤʣßʥʧèèð ʒʤåʢʦʢÞʢåʡæçʡâçʡìʡóéÞàʤâʢ ßʦʧéÞÞãàʢéʡÝåʢéʤäÞʤàçʤʣéʡÝåʢéäʢ ʦʤàʢʥáãéʦôæß ʝÎʒʦçãáʡóéʧʥʤÞʢçñʤÝîʢßʤʠʝãʠʝÑʙʛçʡąãèʤÞðíʡóéʧʥʤÞʢçñʠʝÑʔʛçʡʚçãèʥʤéãÞʤèʤäʡâʡçðèʥã)))ã)6éãèʡʨÍÑʛ èʤʦäʤåñäʧèʤÞðíʡóéʧʥʤÞʢçñʞʕ ʞʢʥʡèãô ʝÎʒ Þ ʦåʧìʡʢÞ æʤáʢé ʦʤèʥʤÞʤáàʡéñʦô áʢåʧàʤìçʤ äãíʢìçðæã ʥʡʦʦéʥʤʣʦéÞʡæãâʡèʤʥð æʢéʢʤʥãâæ àãʦèʢèʦãô ʘçʤßãʢÝʤåñçðʢʤéäʡâðÞʡóéʦô ãʨ èʥãçãæʡéñ ãâ âʡ çʢèʥãôéçðʨ ÞäʧʦʤÞðʨ ʤîʧîʢçãʣ ʝÎʒ ʦçãáʡóé ÞʦʡʦðÞʡʢæʤʦéñàʥʧßãʨèʥʢèʡʥʡéʤÞèʥããʨʦʤÞæʢʦéçʤæèʥãæʢçʢçãã èʤòéʤæʧãʨçʡâçʡìʡóé âʡąìàʤãåãìèʤʦåʢèʥãʢæʡàʥʧßãʨåʢäʡʥʦéÞ;= ʕʤÞʤʥô ʤ ßãèʤåãèãàʢæãìʢʦäʤʣ éʢʥʡèãã çʢåñâô çʢ ʧèʤæôçʧéñ çãäʤéãçʤÞʧó äãʦåʤéʧ èʤʦäʤåñäʧ ʤçʡ èʥãæʢçôåʡʦñ Þ éʢìʢçãʢ æçʤßãʨ àʢʦôéãåʢéãʣ ʛʥʢèʡʥʡé 91 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ìʡʦéãìçʤÝåʤäãʥʧʢéʦãçéʢâÑʚʙʛÞèʢìʢçã èʤÞðíʡʢéãʨäåãʥʢçʦãâèåʡâæð âʡæʢàåôʢé ÞðʦÞʤÝʤáàʢçãʢ ʦÞʤÝʤàçðʨ Îʒ ãâ ʡàãèʤëãéʤÞ ʙãäʤéãçʤÞʡô äãʦåʤéʡ ÞʥʡÞçʤʣʦéʢèʢçãʦçãáʡʢéʧʥʤÞçãʠʝãʞʕ ʧæʢʥʢççʤèʤÞðíʡʢéʧʥʤÞʢçñʠʝÑʔʛ ʦçãáʡʢé ʧʥʤÞʢçñ Ñèʡ ʔ ãʦʦåʢàʤÞʡçãã #$0 #ORONARY $RUG 0ROJECT Ýðåʤ èʤäʡâʡçʤ ʦçãáʢçãʢ ʥãʦäʡ ʥʡâÞãéãô Ðʘ çʡ ã ʤÝîʢʣ ʦæʢʥéçʤʦéã çʡ Þ ßʥʧèèʢ Ýʤåñçðʨ èʤåʧìʡÞíãʨ çãäʤéãçʤÞʧó äãʦåʤéʧ ;= ʕãèʤåãèãàʢæãìʢʦäãʣ òêêʢäé çãäʤéãçʤÞʤʣäãʦåʤéðèʥʤôÞåôʢéʦôèʥãʢʢçʡâçʡìʢçããÞÞðʦʤäʤʣàʤâʢąąßʦʧé Íʤʦéãßʡéñòéʤʣàʤâðʥʢäʤæʢçàʧʢéʦôèʤʦéʢèʢççʤ çʡìãçʡôʦ ßʦʧé ÞèʥʤéãÞçʤæ ʦåʧìʡʢçʢʧàʡʢéʦôãâÝʢáʡéñèʤÝʤìçðʨʥʢʡäëãʣÞÞãàʢèʥãåãÞʤÞ áʡʥʡ èʤäʥʡʦçʢçãôäʤáçðʨèʤäʥʤÞʤÞ ʦðèã ʛʤʦéʢèʢççðʣʤéäʡâʤéãʦèʤåñâʤÞʡçãôçãäʤéãçʤÞʤʣäãʦåʤéðʦÞôâʡçʦʥʢâʧåñéʡéʡæãàÞʧʨäʥʧèçðʨäåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãʣèʤʤëʢçäʢòêêʢäéãÞçʤʦéãäʤæÝãçãʥʤÞʡççʤʣéʢʥʡèããʦéʡéãçʤÞʦçãäʤéãçʤÞʤʣäãʦåʤéʤʣ!)- ()'(ã(03 4(2)6% ʒʤçëʢèëãôòéãʨãʦʦåʢàʤÞʡçãʣʦéʥʤãåʡʦñçʡéʤæ ìéʤçãäʤéãçʤÞʡôäãʦåʤéʡàʤåáçʡ ʧåʧìíãéñʥʢâʧåñéʡéðéʢʥʡèããʦéʡéãçʡæãâʡʦìʢéÝʤåʢʢÞðʥʡáʢççʤßʤèʤÞðíʢçãô ʧʥʤÞçô ʠʝ Ñʔʛ ʒ ʦʤáʡåʢçãó ʤÝʡ ãʦʦåʢàʤÞʡçãô çʢ àʡåã ʤáãàʡʢæʤßʤ òêêʢäéʡ ʒʥʤæʢ éʤßʤ Þ çãʨ çʡÝåóàʡåã ʧÞʢåãìʢçãʢ ìãʦåʡ ʤʦåʤáçʢçãʣ Þ ʤʦçʤÞçʤʣ ßʥʧèèʢ ãíʢæãìʢʦäãʢ ãçʦʧåñéð æãʤèʡéãã ʔʤâæʤáçʤʣ èʥãìãçʤʣ òéʤʣ çʢʧàʡìã æʤßåʤ ÝðéñèʥãæʢçʢçãʢæʤàãêãëãʥʤÞʡççðʨêʤʥæçãäʤéãçʤÞʤʣäãʦåʤéð; = ʙʚʔØʖÑÐʛʚʞʜʚʛʙØʖʛʜʖʛʓʜʓʞØ ʙʢʦæʤéʥô çʡ àʤʦéãáʢçãô ʦʤÞʥʢæʢççʤʣ ßãèʤåãèãàʢæãìʢʦäʤʣ éʢʥʡèãã ʦʤʨʥʡçôʢéʦôâçʡìãéʢåñçʤʢìãʦåʤÝʤåñçðʨą ʧäʤéʤʥðʨ çʢʦæʤéʥôçʡèʥãʢæ ʦéʡéãçʤÞ ʥʡâÞãÞʡóéʦôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʢʤʦåʤáçʢçãôÚéʤéêʢçʤæʢçÞåãéʢʥʡéʧʥʢʤÝʤâçʡìʡʢéʦôäʡäʥʢâãàʧʡåñçðʣʥãʦäʔʦÞôâãʦòéãæÞʤâçãäʡʢéÞʤèʥʤʦ çʡ äʡäãʢ åãèãàçðʢ èʡʥʡæʢéʥð èʤæãæʤ ʠʝÑʙʛ æʤáçʤ ÞʤâàʢʣʦéÞʤÞʡéñ ìéʤÝð æʡäʦãæʡåñçʤ ʦçãâãéñ Þʢåãìãçʧ ʥʢâãàʧʡåñçʤßʤ ʥãʦäʡ ʔ çʡʦéʤôîʢʢ Þʥʢæô ʥʡâʥʡÝʤéʡç ʥôà èʥãçëãèãʡåñçʤ çʤÞðʨ åʢäʡʥʦéÞʢççðʨ ʦʥʢàʦéÞ àʢʣʦéÞãʢ äʤéʤʥðʨ çʡèʥʡÞåʢçʤçʡÝʤåʢʢéʤçäãʢæʢʨʡçãâæðçʡʥʧíʢçãʣåãèãàçʤßʤæʢéʡÝʤåãâæʡ;= ÑʤæãéʡèãàôÞåôʢéʦôèʥʢàʦéʡÞãéʢåʢæäåʡʦʦʡãçßãÝãéʤʥʤÞæãäʥʤʦʤæʡåñçʤßʤ Ýʢåäʡąèʢʥʢçʤʦìãäʡʞʕ-40 ÐçßãÝãʥʤÞʡçãʢʘʞʜʦʤèʥʤÞʤáàʡʢéʦôʧæʢçñíʢçãʢæʤÝʥʡâʤÞʡçãôãʦçãáʢçãʢæʦʢäʥʢëããÑʚʙʛÞèʢìʢçããʠʘÞéʤçäʤæäãíʢìçãäʢ ÑʤæãéʡèãàʦʧîʢʦéÞʢççʤʦçãáʡʢéʧʥʤÞçãʤÝîʢßʤʠʝ ʠʝÑʙʛ ʠʝÑʚʙʛãʞʕʔèʥʢàÞʡʥãéʢåñçðʨäåãçãìʢʦäãʨãʦèðéʡçãôʨèʥʢèʡʥʡéʤäʡâʡåʦôòêêʢäéãÞçðæʧÝʤåñçðʨʦßʤæʤâãßʤéçʤʣêʤʥæʤʣʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæããʤçʦçãáʡåʧʥʤÞçã ʠʝÑʙʛçʡ ʞʕąçʡ èʤÞðíʡåʧʥʤÞʢçñʠʝÑʔʛçʡʚàçʡäʤèʥãèʥãʢæʢ èʥʢèʡʥʡéʡ Þʤâçãäʡåã ʦʢʥñʢâçðʢ èʤÝʤìçðʢ ôÞåʢçãô ʤÝʧʦåʤÞåʢççðʢ çʡäʤèåʢçãʢæÑʚʙʛÞèʢìʢçãèʤÞðíʢçãʢèʢìʢçʤìçðʨêʢʥæʢçéʤÞ áãʥʤÞʡôãçêãåñéʥʡëãô èʢìʢçã ʦéʢʡéʤâ ßʢèʡéãé êãÝʥʤâèʢìʢçãʛʤòéʤæʧåʢìʢçãʢåʤæãéʡèãàʤæàʤåá- 92 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ çʤèʥʤÞʤàãéñʦôèʤʦéʥʤßãæèʤäʡâʡçãôæãèʤàéîʡéʢåñçðæäʤçéʥʤåʢæêʧçäëãã èʢìʢçãʛʥʢèʡʥʡéʤàʤÝʥʢç&$!àåôåʢìʢçãôéʤåñäʤÝʤåñçðʨʦʦʢæʢʣçʤʣßʤæʤâãßʤéçʤʣ ßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣ Þ ʝÕʓ ą éʡäáʢ èʥã ʦʢæʢʣçʤʣ äʤæÝãçãʥʤÞʡççʤʣ ßãèʢʥåãèãàʢæãã ÞðʥʡáʢççʤʣʨãåʤæãäʥʤçʢæããʔʜʤʦʦããåʤæãéʡèãàèʤäʡçʢâʡʥʢßãʦéʥãʥʤÞʡç ʘãèʤæʢʥʦʢç èʥʢàʦéʡÞåôʢé ʦʤÝʤʣ ʡçéãʦæðʦåʤÞðʢ ʤåãßʤçʧäåʢʤéãàð èʤàʡÞåôóîãʢçʡʧʥʤÞçʢæʜʙʒʦãçéʢâʡèʤèʥʤéʢãàʡʡèʤʔÌðåãèʥʤÞʢàʢçðäåãçãìʢʦäãʢãʦʦåʢàʤÞʡçãô)ã))êʡâðʧÝʤåñçðʨʦßʢéʢʥʤâãßʤéçʤʣêʤʥæʤʣʦʢæʢʣçʤʣ ßãèʢʥʨʤåʢʦéʢʥãçʢæãã äʤéʤʥðʢ èʤåʧìʡåã æʡäʦãæʡåñçʤ èʢʥʢçʤʦãæʧó àʤâʧ ʦéʡéãçʤÞ çʤèʥãòéʤæçʢàʤʦéãßʡåãëʢåʢÞʤßʤʧʥʤÞçôåãèʤèʥʤéʢãàʤÞʛʤʦʥʡÞçʢçãó ʦèåʡëʢÝʤæãèʤæʢʥʦʢçàʤèʤåçãéʢåñçʤʦçãáʡåʧʥʤÞʢçñʠʝÑʙʛçʡąʛʥʢèʡʥʡéÞÞʤàãåʦôèʤàäʤáçʤʥʡâÞçʢàʢåóʔçʡʦéʤôîʢʢÞʥʢæôèʥʤÞʤàôéʦôäåãçãìʢʦäãʢãʦèðéʡçãôæãèʤæʢʥʦʢçʡ)))êʡâðʛʥʢèʡʥʡéʤàʤÝʥʢç&$!éʤåñäʤàåôåʢìʢçãô èʡëãʢçéʤÞʦßʤæʤâãßʤéçʤʣʝʕʠʝ ʓçʡëʢéʥʡèãÝ ą ãçßãÝãéʤʥ Ýʢåäʡ ą èʢʥʢçʤʦìãäʡ òêãʥʤÞ ʨʤåʢʦéʢʥãçʡ #%4ʜ CHOLESTERYLESTERTRANSFERPROTEIN ʛʢʥÞðæèʥʢèʡʥʡéʤæ ʦèʤæʤîñóäʤéʤʥʤßʤÝðåã èʥʢàèʥãçôéð èʤèðéäã èʤÞðʦãéñ ʧʥʤÞʢçñ âʡîãéçʤßʤ ʠʝ Ñʔʛ Ýðå éʤʥëʢéʥʡèãÝ ʙʡ èʥʢàÞʡʥãéʢåñçðʨ òéʡèʡʨ ãʦʦåʢàʤÞʡçãô ʤç ʦʧîʢʦéÞʢççʤ èʤÞðíʡå ʧʥʤÞʢçñ ʠʝÑʔʛãʦçãáʡåʧʥʤÞʢçñʠʝÑʙʛãʞʕʙʢäʤéʤʥʧóʤâʡÝʤìʢççʤʦéñÞðâðÞʡåʤéʤ ìéʤʧåãë èʥãçãæʡÞíãʨéʤʥëʢéʥʡèãÝ ʧæʢʥʢççʤèʤÞðíʡåãʦñʓÍãʧʥʤÞʢçñäʤʥéãâʤåʡÞèåʡâæʢ ãÞèʤʦåʢàʧóîʢæãæʢççʤòéʤʤÝʦéʤôéʢåñʦéÞʤʦðßʥʡåʤçʢßʡéãÞçʧó ʥʤåñ ʛʥã èʥʤÞʢàʢçãã ))) êʡâð äåãçãìʢʦäʤßʤ ãʦʦåʢàʤÞʡçãô ʤäʡâʡåʤʦñ ìéʤ Þßʥʧèèʢ èʥãçãæʡÞíʢʣéʤʥëʢéʥʡèãÝ ìãʦåʤʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʦʤ ʦæʢʥéʢåñçðæãʦʨʤàʤæʤäʡâʡåʤʦñâçʡìãéʢåñçʤÝʤåñíʢ ìʢæÞßʥʧèèʢèåʡëʢÝʤ ìéʤ ã èʤʦéʡÞãåʤ éʤìäʧ Þ àʡåñçʢʣíʢʣ ʦʧàñÝʢ éʤʥëʢéʥʡèãÝʡ Ôʢʥʢâ çʢäʤéʤʥʤʢ Þʥʢæô éʡäʡôáʢʦʧàñÝʡèʤʦéãßåʡãèʥʢèʡʥʡéòÞʡëʢéʥʡèãÝʔçʡʦéʤôîʢʢÞʥʢæôèʥʤʨʤàãé ãʦèðéʡçãôçʤÞðʣèʥʢèʡʥʡéòéʤßʤäåʡʦʦʡąʡçʡëʢéʥʡèãÝ äʤéʤʥðʣåãíʢçèʤÝʤìçðʨ ʦÞʤʣʦéÞéʤʥëʢéʥʡèãÝʡ çʤéʡäáʢʦʧîʢʦéÞʢççʤèʤÞðíʡʢéʧʥʤÞʢçñʠʝÑʔʛʔʤèʥʤʦ ʤÞʤâæʤáçʤʦéãèʥãæʢçʢçãôʡçʡëʢéʥʡèãÝʡÝʧàʢéʥʢíʢçèʤʦåʢʤäʤçìʡçãôãʦʦåʢàʤÞʡçãô2%6%!, ʞʡäãæ ʤÝʥʡâʤæ çʤÞʢʣíãʢ åãèãàæʤàʧåãʥʧóîãʢ èʥʢèʡʥʡéð àʢʣʦéÞʧóîãʢ ÞʥôàʢʦåʧìʡʢÞçʡæʤåʢäʧåôʥçʤ ßʢçʢéãìʢʦäʤæʧʥʤÞçʢ ʤéäʥðÞʡóéèʥãçëãèãʡåñçʤçʤÞðʢÞʤâæʤáçʤʦéãÞäʤʥʥʢäëããçʡʥʧíʢçãʣåãèãàçʤßʤʤÝæʢçʡʔʢʥʤôéçʤ òéʤ èʤâÞʤåãéʥʢíãéñèʥʤÝåʢæðʥʢâãàʧʡåñçʤßʤʥãʦäʡãàʤÝãéñʦôàʡåñçʢʣíãʨʧʦèʢʨʤÞ Þ ʦçãáʢçãã ʦæʢʥéçʤʦéã ʤé ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ âʡÝʤåʢÞʡçãʣ ʤÝʧʦåʤÞåʢççðʨ ʡéʢʥʤʦäåʢʥʤâʤæ 93 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʔʚÏʘʚÎʙʚʝʞÐʒʚʘÌÐʙÐʜʚʔʓʙʙʚʗʕÐʛʚÑÐʛÐÍʖʘÐÔʖʝʒʚʗ ʞʖʜʓʛÐÐ ÐʦʦåʢàʤÞʡçãô$93)3)ã))èʤäʡâʡåã ìéʤéʤåñäʤ èʡëãʢçéʤÞʤìʢçñÞðʦʤäʤßʤ ʥãʦäʡ èʡëãʢçéʤÞ Þðʦʤäʤßʤ ʥãʦäʡ ã èʡëãʢçéʤÞ ʧæʢʥʢççʤßʤ ʥãʦäʡàʤʦéãßʡóéëʢåʢÞðʨâçʡìʢçãʣʠʝÑʙʛ;=ʔʢʥʤôéçðʢèʥãìãçðòéʤßʤôÞåʢçãôéʡäʤÞð ʔʥʡìã ʤèʡʦʡóéʦô çʡâçʡìʡéñ æʡäʦãæʡåñçðʢ àʤâð ʦéʡéãçʤÞ ãâ âʡ Þʤâæʤáçðʨ èʤÝʤìçðʨʥʢʡäëãʣ;= ʝʧîʢʦéÞʧʢéèʥʤÝåʢæʡéʤåʢʥʡçéçʤʦéãäʦéʡéãçʡæããʨçʢèʢʥʢçʤʦãæʤʦéãʔìʡʦéçʤʦéã ʥʢâʧåñéʡéðãʦʦåʢàʤÞʡçãô*50)4%2ʧäʡâðÞʡóéçʡÝʤåñíʧóÞʡʥãʡÝʢåñçʤʦéñʤéÞʢéʡçʡʦéʡéãçð ʥʢâãʦéʢçéçʤʦéñäçãæ;ą= ʘçʤßãʢèʡëãʢçéðãæʢóéçãâäʧóèʥãÞʢʥáʢççʤʦéñäéʢʥʡèãããçʢʦʤÝåóàʡóéçʡâçʡìʢçãʣÞʥʡìʡ ÞʤʦʤÝʢççʤʦéãÞéʢʨʦåʧìʡôʨ äʤßàʡʥʢìñãàʢéʤèʢʥÞãìçʤʣèʥʤêãåʡäéãäʢÐÌʝʝʥʢàãèʥãìãççãâäʤʣèʥãÞʢʥáʢççʤʦéãÞʦåʧìʡʢÞʧäʡâðÞʡóéæãʡåßãó ÞąÞðʦʤäʧóëʢçʧèʥʢèʡʥʡéʡ ÞąʤéʦʧéʦéÞãʢäåãçãìʢʦäʤßʤòêêʢäéʡ;= ʚàçãæ ãâ ʦèʤʦʤÝʤÞ èʥʢʤàʤåʢçãô çãâäʤʣ èʥãÞʢʥáʢççʤʦéã ä éʢʥʡèãã ôÞåôʢéʦôçʡâçʡìʢçãʢèʥʢèʡʥʡéʤÞ ʧʦãåãÞʡóîãʨòêêʢäéæʤçʤéʢʥʡèããʛʥãçʡâçʡìʢçãã äʤæÝãçãʥʤÞʡççʤʣ éʢʥʡèãã èʤ æçʢçãó ʥôàʡ ʡÞéʤʥʤÞ àʤʦéãßʡʢéʦô çʡãÝʤåñíãʣ èåʢʣʤéʥʤèçðʣòêêʢäéãçʡÝåóàʡʢéʦôæʢçñíʢʤʦåʤáçʢçãʣ; =ʔìʡʦéçʤʦéã èʥʢèʡʥʡéð äʤéʤʥðʢæʤßʧéÝðéñàʤÝʡÞåʢçðäʦéʡéãçʡæàåôʦçãáʢçãôʧʥʤÞçô ʠʝÑʙʛ ąòâʢéãæãÝãåãʡçéãéʢåʡä0#3+ ʚàçʡäʤ ʤʦéʡʢéʦô ʤéäʥðéðæ Þʤèʥʤʦ ʤ éʤæ äʡäʤʣ äʡéʢßʤʥãã èʡëãʢçéʤÞ ãâçʡìʡåñçʤ çʢʤÝʨʤàãæʤ çʡâçʡìãéñ äʤæÝãçãʥʤÞʡççʧó éʢʥʡèãó Ðʦʨʤàô ãâ ʡçʡåãâʡ ʥʡÝʤé èʤ èʥãæʢçʢçãó äʤæÝãçãʥʤÞʡççʤʣ ßãèʤåãèãàʢæãìʢʦäʤʣ éʢʥʡèãã æʤáçʤ Þðàʢåãéñʦåʢàʧóîãʢʦãéʧʡëãã äʤßàʡʧáʢãâçʡìʡåñçʤÞʤâæʤáçʤçʡâçʡìʡéñäʤæÝãçãʥʤÞʡççʧóéʢʥʡèãó ÐʦʨʤàçʤÞðʦʤäãʣʠʝ ææʤåñå ʠʝÑʙʛ ææʤåñå ʝʕʠʝ ʛʤáãåðʢèʡëãʢçéðåʢé ʝçãáʢççʡôæʡʦʦʡéʢåʡÐʘʞ ʠÌʛãʠʛʙçʡʤʦçʤÞʡçãããʦʦåʢàʤÞʡçãô3(!20 ;= ÐʦʨʤàçʤʢèʤÞðíʢçãʢéʥʡçʦʡæãçʡâÝʤåʢʢìʢæÞʥʡâʡʤéÞʢʥʨçʢʣßʥʡçãëðçʤʥæð ʙʢèʢʥʢçʤʦãæʤʦéñʦéʡéãçʤÞ ʞʤåʢʥʡçéçʤʦéñäʦéʡéãçʡæ ʔ ãʦʦåʢàʤÞʡçãã )-02/6% )4 Ýðåʤ èʤäʡâʡçʤ èʥʢãæʧîʢʦéÞʤ ʦʤìʢéʡççʤʣ ßãèʤåãèãàʢæãìʢʦäʤʣ éʢʥʡèãã ʦãæÞʡʦéʡéãçʡ ʦ òâʢéãæãÝʤæ èʤ Þåãôçãó çʡ äʤçʢìçðʢ éʤìäã;=ʔãʦʦåʢàʤÞʡçãʢÝðåʤÞäåóìʢçʤÝʤåñçðʨ èʢʥʢçʢʦíãʨʤʦéʥðʣ äʤʥʤçʡʥçðʣ ʦãçàʥʤæ Ìʤåñçðʢ Ýðåã ʥʡçàʤæãâãʥʤÞʡçð çʡ àÞʢ ßʥʧèèð ą ßʥʧèèʧ æʤçʤéʢʥʡèãã ʦãæÞʡʦéʡéãçʤæ Þ àʤâʢ æßʦʧé ã ßʥʧèèʧ äʤæÝãçãʥʤÞʡççʤʣ éʢʥʡèããąʦãæÞʡʦéʡéãçÞàʤâʢæßʦʧé òâʢéãæãÝÞàʤâʢæßʦʧéʛʢʥÞãìçʤʣäʤçʢìçʤʣéʤìäʤʣÝðåʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéʡôʦæʢʥéñ ãçêʡʥäéæãʤäʡʥàʡ çʢʦéʡÝãåñçʡô 94 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʦéʢçʤäʡʥàãô ʥʢÞʡʦäʧåôʥãâʡëãô Þ éʢìʢçãʢ àçʢʣ èʤʦåʢ ʥʡçàʤæãâʡëãã ʛʢʥÞãìçʤʣ äʤçʢìçʤʣ éʤìäã àʤʦéãßåã Ýʤåñçðʨ ãâ ßʥʧèèð äʤæÝãçãʥʤÞʡççʤʣ éʢʥʡèããã ãâßʥʧèèðæʤçʤéʢʥʡèããʦéʡéãçʡæã ʥʡâåãìãôÝðåãàʤʦéʤÞʢʥçð ʛʥãòéʤæʦʥʢàçãʣʧʥʤÞʢçñʠʝÑʙʛÞßʥʧèèʢäʤæÝãçãʥʤÞʡççʤʣéʢʥʡèããʦʤʦéʡÞãå ææʤåñå ìéʤèʤʦåʧáãåʤèʥʢàæʢéʤæàãʦäʧʦʦããʤèʢʥʢʦæʤéʥʢçãáçʢʣßʥʡçãëð ëʢåʢÞʤßʤ ʧʥʤÞçô ʠʝÑʙʛ ʧ Ýʤåñçðʨ ʤìʢçñ Þðʦʤäʤßʤ ʥãʦäʡ )-02/6% )4 ą èʢʥÞʤʢ äʥʧèçʤʢäåãçãìʢʦäʤʢãʦʦåʢàʤÞʡçãʢ èʤäʡâʡÞíʢʢëʢåʢʦʤʤÝʥʡâçʤʦéñäʤæÝãçãʥʤÞʡççʤʣ éʢʥʡèãã ʦãæÞʡʦéʡéãçʡ ʦ òâʢéãæãÝʤæ ʧ Ýʤåñçðʨ ʦ ÐÌʝ ʤʦåʤáçãÞíʢʣʦô ʤʦéʥðæ äʤʥʤçʡʥçðæ ʦãçàʥʤæʤæ Ðâ àʥʧßãʨ ÞʡʥãʡçéʤÞ äʤæÝãçãʥʤÞʡççʤʣ éʢʥʡèããʦåʢàʧʢéʦìãéʡéñʥʡëãʤçʡåñçʤʣäʤæÝãçʡëãóʦãæÞʡʦéʡéãçʡʦêʢçʤêãÝʥʡéʤæ ʧÝʤåñçðʨʦʝÍ ßãèʢʥéʥãßåãëʢʥãàʢæãʢʣãçãâäãæʧʥʤÞçʢæʠʝÑʔʛÍʥʧßãʢäʤæÝãçʡëããßãèʤåãèãàʢæãìʢʦäãʨʦʥʢàʦéÞ ÞéʤæìãʦåʢʦãçßãÝãéʤʥʡæã0#3+ ÞçʡʦéʤôîʢʢÞʥʢæôçʡʨʤàôéʦôÞʦéʡàãããâʧìʢçãô ʙʢʦæʤéʥô çʡ ʤéʦʧéʦéÞãʢ ãʦʦåʢàʤÞʡçãʣ ʤèãʦðÞʡóîãʨ éʥʤʣçʧó äʤæÝãçãʥʤÞʡççʧó éʢʥʡèãó ʦéʡéãç òâʢéãæãÝ ʡçéãéʢåʡ ä 0#3+ ą èʥʤéãÞʤèʤäʡâʡçãʣ äéʡäʤʣéʢʥʡèããéʡäáʢçʢéʔʢʥʤôéçʤ éʡäʡôäʤæÝãçʡëãôÝʧàʢéʤèʥʡÞàʡççʡʧèʡëãʢçéʤÞʦʝʕʠʝʛʥʢàèʤìéãéʢåñçʤʣäʤæÝãçʡëãʢʣʧèʡëãʢçéʤÞʦßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣãßãèʢʥéʥãßåãëʢʥãàʢæãʢʣôÞåôʢéʦôʦéʡéãç êʢçʤêãÝʥʡéʘʤáçʤèʤåʡßʡéñ ìéʤàʤÝʡÞåʢçãʢêʢçʤêãÝʥʡéʡäʦéʡéãçʡæʧòéʤʣàʤÞʤåñçʤʤÝíãʥçʤʣèʤèʧåôëãã èʡëãʢçéʤÞàʤèʤåçãéʢåñçʤʦçãâãéʧçãʨʥãʦäʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʚʝʚÌʖʙʙʚʝʞÐʞʖʜʓʛÐÐʔʚʞÍʖÑÙʙØʠʕʜÒʛʛʓʠʙʓʝʖÑʖʙÐÜ ÎʢçîãçðʔãʦʦåʢàʤÞʡçãã(03çʢÝðåʤçʡʣàʢçʤßʢçàʢʥçðʨʥʡâåãìãʣèʤäʤçʢìçðæʥʢâʧåñéʡéʡæéʢʥʡèããʦãæÞʡʦéʡéãçʤæÞéʢìʢçãʢåʢéçʡÝåóàʢçãôʔãʦʦåʢàʤÞʡçãã èʤ èʢʥÞãìçʤʣ èʥʤêãåʡäéãäʢ *50)4%2 ʥʤâʧÞʡʦéʡéãç ą æßʦʧé ʧìʡʦéÞʤÞʡåʤ áʢçîãç ʧ äʤéʤʥðʨ ʥʢâʧåñéʡéð éʢʥʡèãã çãìʢæ çʢ ʤéåãìʡåãʦñ ʤé éʡäʤÞðʨ ʧ æʧáìãç ʞʢʥʡèãô ʦéʡéãçʡæã ʧ áʢçîãç èʥʤéãÞʤèʤäʡâʡçʡ Þ èʢʥãʤà ÝʢʥʢæʢççʤʦéããäʤʥæåʢçãôßʥʧàñóʒʤʥʥʢäëãôàãʦåãèãàʢæããʦëʢåñóÞéʤʥãìçʤʣ èʥʤêãåʡäéãäãʧáʢçîãçèʥʤÞʤàãéʦôèʤéʢæáʢèʤäʡâʡçãôæ ìéʤãʧæʧáìãç ʛʤáãåðʢèʡëãʢçéðÒèʤáãåðʨêʡʥæʡäʤäãçʢéãäʡʦéʡéãçʤÞãàʥʧßãʨßãèʤåãèãàʢæãìʢʦäãʨ èʥʢèʡʥʡéʤÞ ãâæʢçʢçʡ èʤòéʤæʧ ʥãʦä ʥʡâÞãéãô ʤʦåʤáçʢçãʣ ʧ çãʨ Þðíʢ ʙʡàʤ éʡäáʢ ʧìãéðÞʡéñ ìéʤ èʤáãåðʢ äʡä èʥʡÞãåʤ Þðçʧáàʢçð èʥãçãæʡéñçʢʦäʤåñäʤèʥʢèʡʥʡéʤÞÞʦÞôâãʦʦʤèʧéʦéÞʧóîãæãâʡÝʤåʢÞʡçãôæã ìéʤèʤÞðíʡʢéʧçãʨʥãʦäʥʡâÞãéãôèʤÝʤìçðʨòêêʢäéʤÞʒʥʤæʢéʤßʤ àʥʧßãʢèʥʢèʡʥʡéð æʤßʧé Þåãôéñ çʡ êʡʥæʡäʤäãçʢéãäʧ ʦéʡéãçʤÞ èʤòéʤæʧ éʢʥʡèãó ʥʢäʤæʢçàʧʢéʦô çʡìãçʡéñʦçãâäãʨàʤâʦèʤʦéʢèʢççðæéãéʥʤÞʡçãʢæàʤàʤʦéãáʢçãôʤèéãæʡåñçʤʣ àʤâðʔãʦʦåʢàʤÞʡçãã02/30%2 ÞäåóìʡÞíʢæèʤáãåðʨåãëąßʤàʡ éʢʥʡèãô èʥʡÞʡʦéʡéãçʤæÞàʤâʢæßʦʧéÞéʢìʢçãʢåʢéʦʤèʥʤÞʤáàʡåʡʦñʦçãáʢçãʢæìãʦåʡ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣ çʡ èʤ ʦʥʡÞçʢçãó ʦ ßʥʧèèʤʣ äʤçéʥʤåô 95 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʔ ʥʢâʧåñéʡéʢ Þ ʦʤʤéÞʢéʦéÞãã ʦ ʖÞʥʤèʢʣʦäãæã ã ʜʤʦʦãʣʦäãæã ʥʢäʤæʢçàʡëãôæã èʤäʤʥʥʢäëããàãʦåãèãàʢæããʦéʡéãçðèʤäʡâʡçðåãëʡæèʤáãåʤßʤÞʤâʥʡʦéʡ ʦéʥʡàʡóîãæʦʢʥàʢìçʤ ʦʤʦʧàãʦéðæãâʡÝʤåʢÞʡçãôæã ʤÝʧʦåʤÞåʢççðæãʡéʢʥʤʦäåʢʥʤâʤæ ÌʤåñçðʢʦʦʡʨʡʥçðæàãʡÝʢéʤæãæʢéʡÝʤåãìʢʦäãæʦãçàʥʤæʤæʝÍãʘʝ äʡä èʥʡÞãåʤ ʦʤèʥʤÞʤáàʡóéʦô Þðʥʡáʢççðæã çʡʥʧíʢçãôæã åãèãàçʤßʤ ʤÝæʢçʡ Íåô ʝÍ))éãèʡãʘʝÝʤåʢʢʨʡʥʡäéʢʥçʡßãèʢʥéʥãßåãëʢʥãàʢæãô çãâäãʣʧʥʤÞʢçñʠʝÑʔʛ ãèʥʢʤÝåʡàʡçãʢæʢåäãʨèåʤéçðʨìʡʦéãëÑʙʛÚéãʤʦʤÝʢççʤʦéãÍÑʛʦèʤʦʤÝʦéÞʧóé ʧʦäʤʥʢççʤæʧ ʥʡâÞãéãó ʡéʢʥʤʦäåʢʥʤâʡ Ìʤåʢʢ éʤßʤ Þ ʦʤìʢéʡçãã ʦ àʥʧßãæã èʥãʦʧîãæã òéãæ ʦʤʦéʤôçãôæ êʡäéʤʥʡæã ʥãʦäʡ ʤçã ʦèʤʦʤÝʦéÞʧóé èʡéʤåʤßãìʢʦäãæãâæʢçʢçãôæÞæãäʥʤëãʥäʧåôéʤʥçʤæʥʧʦåʢ ÞðâðÞʡôéãèãìçðʢʤʦåʤáçʢçãô ʝÍąàãʡÝʢéãìʢʦäʧóʥʢéãçʤèʡéãó çʢʣʥʤèʡéãó ʡçßãʤèʡéãóʞʢʥʡèãôèʡëãʢçéʤÞ ʦʝÍãʘʝàʤåáçʡèʥʤÞʤàãéñʦôèʤàçʡÝåóàʢçãʢæäʡäòçàʤäʥãçʤåʤßʤÞ éʡäãäʡʥàãʤåʤßʤÞ ʔ ʥʡçàʤæãâãʥʤÞʡççðʨ äåãçãìʢʦäãʨ ãʦʦåʢàʤÞʡçãôʨ 3 ã #!2$3 Ýðåʡ èʤäʡâʡçʡòêêʢäéãÞçʤʦéñʦéʡéãçʤÞÞäʤʥʥʢäëããÍÑʛãʦçãáʢçããìãʦåʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʧÝʤåñçðʨʦʝÍ ÒÝʤåñçðʨʦʘʝãʝÍèʥãʧʥʤÞçʢéʥãßåãëʢʥãàʤÞ ææʤåñåëʢåʢʦʤʤÝʥʡâçʤʤʥãʢçéãʥʤÞʡéñʦôçʡàʤèʤåçãéʢåñçðʣëʢåʢÞʤʣèʤäʡâʡéʢåñąʠʝ çʢʦÞôâʡççðʣ ʦÑʔʛÒÝʤåñçðʨʦʝÍ)éãèʡãæãäʥʤʡåñÝʧæãçʧʥãʢʣéʢʥʡèãôʦéʡéãçʡæãèʥʤÞʤàãéʦôéʡäáʢ äʡäãʧÝʤåñçðʨʦʤìʢçñÞðʦʤäãæʥãʦäʤæʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ éʤʢʦéñàʤàʤʦéãáʢçãôëʢåʢÞʤßʤʧʥʤÞçôʠʝÑʙʛ ææʤåñå ÌʤåñçðʢʦʤʦéʥðæäʤʥʤçʡʥçðæʦãçàʥʤæʤæʜʢâʧåñéʡéðʥʡçàʤæãâãʥʤÞʡççðʨ äåãçãìʢʦäãʨãʦʦåʢàʤÞʡçãʣèʤàéÞʢʥáàʡóéëʢåʢʦʤʤÝʥʡâçʤʦéñçʡâçʡìʢçãôʦéʡéãçʤÞʧÝʤåñçðʨʦʤʦéʥðæäʤʥʤçʡʥçðæʦãçàʥʤæʤæʚʒʝ ʝéʡéãçðʥʢäʤæʢçàʧʢéʦô çʡâçʡìʡéñÞÞðʦʤäãʨàʤâʡʨʡéʤʥÞʡʦéʡéãçąæßʦʧé ÞéʢìʢçãʢèʢʥÞðʨàçʢʣ ßʤʦèãéʡåãâʡëãã èʥã ʚʒʝ ʖʦåã ãâÞʢʦéʢç ãʦʨʤàçðʣ ʧʥʤÞʢçñ ʠʝÑʙʛ àʤâʧ èʥʢèʡʥʡéʡʦåʢàʧʢéèʤàÝãʥʡéñàʤàʤʦéãáʢçãôʧʥʤÞçôʠʝÑʙʛ ææʤåñåæßàå ʛʡëãʢçéʡæ ʦ ʥãʦäʤæ ʥʡâÞãéãô èʤÝʤìçðʨ ôÞåʢçãʣ èʤáãåʤʣ Þʤâʥʡʦé çʡʥʧíʢçãʢ êʧçäëããèʢìʢçã èʤìʢä ʥãʦäçʢÝåʡßʤèʥãôéçʤßʤÞâʡãæʤàʢʣʦéÞãôʦéʡéãçʤÞʦàʥʧßãæãèʥʢèʡʥʡéʡæã èʤäʡâʡçʡæʢçʢʢãçéʢçʦãÞçʡôéʢʥʡèãôÒʥʤÞʢçñåãèãàʤÞÞäʥʤÞãʦåʢàʧʢéèʤÞéʤʥçʤèʥʤÞʢʥãéñìʢʥʢâąçʢàʢåñ ìéʤÝðʧÝʢàãéñʦôÞàʤʦéãáʢçãã ëʢåʢÞʤßʤ âçʡìʢçãô ʠʝÑʙʛ ã ʤéʦʧéʦéÞãã èʤÞðíʢçãô ʡäéãÞçʤʦéã ʦðÞʤʥʤéʤìçðʨ êʢʥæʢçéʤÞʜʢâʧåñéʡééʢʥʡèããʦéʡéãçʡæãÞÞðʦʤäãʨàʤâʡʨʧÝʤåñçðʨʦʚʒʝ Þʢʥʤôéçʤ ÞʤæçʤßʤæʦÞôâʡççʢʦéʤåñäʤʦãʨßãèʤåãèãàʢæãìʢʦäãæàʢʣʦéÞãʢæ ʦäʤåñäʤ ʦèʥʤéãÞʤÞʤʦèʡåãéʢåñçðæòêêʢäéʤæ ʖʦåãʦéʡéãçðçʢÝðåãçʡâçʡìʢçðÞʤʦéʥʧóʦéʡàãóʚʒʝ éʤãʨçʢʤÝʨʤàãæʤçʡâçʡìãéñ àʤ Þðèãʦäã èʡëãʢçéʡ ãâ ʦéʡëãʤçʡʥʡ ʛʥʡäéãäʡ èʤäʡâðÞʡʢé ìéʤ éʡäʤʣ èʤàʨʤàʦʧîʢʦéÞʢççʤèʤÞðíʡʢéèʥãÞʢʥáʢççʤʦéñèʡëãʢçéʤÞäèʤʦåʢàʧóîʢʣàåãéʢåñçʤʣéʢʥʡèããʦéʡéãçʡæã Ìʤåñçðʢ èʢʥʢà èʥʤÞʢàʢçãʢæ òçàʤÞʡʦäʧåôʥçʤßʤ åʢìʢçãô ʔ ãʦʦåʢàʤÞʡçãã !2-9$! Ýðåʤ èʤäʡâʡçʤ ìéʤ çʡâçʡìʢçãʢ ʡéʤʥÞʡʦéʡéãçʡ èʢʥʢà Þðèʤåçʢçãʢæ 96 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ìʥʢʦäʤáçʤʣ éʥʡçʦåóæãçʡåñçʤʣ ʡçßãʤèåʡʦéãäã äʤʥʤçʡʥçðʨ ʡʥéʢʥãʣ Ôʞʒʓ ÞàʤâʢąæßʦʧéʦçãáʡʢéʥãʦäʥʡâÞãéãôÐʘÞʤÞʥʢæôèʥʤëʢàʧʥðãÞÝåãáʡʣíʢʢÞʥʢæôèʤʦåʢçʢʢ ÌʤåñçðʢʦèʢʥãêʢʥãìʢʦäãæʡéʢʥʤʦäåʢʥʤâʤæÒèʡëãʢçéʤÞ ʦéʥʡàʡóîãʨâʡÝʤåʢÞʡçãôæã èʢʥãêʢʥãìʢʦäãʨ ʡʥéʢʥãʣ èʤÞðíʢç ʥãʦä ʥʡâÞãéãô ʡéʢʥʤʦäåʢʥʤâʡ äʤʥʤçʡʥçðʨʡʥéʢʥãʣʔéʤáʢÞʥʢæôèʡëãʢçéðʦâʡÝʤåʢÞʡçãôæãèʢʥãêʢʥãìʢʦäãʨ ʡʥéʢʥãʣàʡåʢäʤçʢÞʦʢßàʡèʤåʧìʡóéʡàʢäÞʡéçʤʢåʢìʢçãʢèʤäʤʥʥʢäëããÍÑʛʔʦʤʤéÞʢéʦéÞãã ʦ ʖÞʥʤèʢʣʦäãæã ã ʜʤʦʦãʣʦäãæã ʥʢäʤæʢçàʡëãôæã Ýʤåñçðæ ʦ èʥʤôÞåʢçãôæãèʢʥãêʢʥãìʢʦäʤßʤʡéʢʥʤʦäåʢʥʤâʡçʢʤÝʨʤàãæʡéʢʥʡèãôʦéʡéãçʡæãàʤàʤʦéãáʢçãôëʢåʢÞʤßʤʧʥʤÞçôʠʝÑʙʛĦ ææʤåñå Ìʤåñçðʢ ʦ ʠʛʙ èʤåʧìʡóîãʢ æʤçʤéʢʥʡèãó ʦéʡéãçʡæã ãæʢóé èʤÞðíʢççðʣ ʥãʦäæãʤèʡéãããʥʡÝàʤæãʤåãâʡʞʡä ÞãʦʦåʢàʤÞʡçãã2%'!2$3ʡçʡåãâèʤàßʥʧèèð åãë ʦéʥʡàʡóîãʨèʤìʢìçʤʣçʢàʤʦéʡéʤìçʤʦéñóʝʒʟæåæãç èʤäʡâʡåéʡäʧó áʢãåãÝʤåʢʢÞðʦʤäʧóìʡʦéʤéʧèʤÞéʤʥçðʨʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ äʡä ãʧèʡëãʢçéʤÞ ʤéçʤʦôîãʨʦôäßʥʧèèʢʤìʢçñÞðʦʤäʤßʤʥãʦäʡʝåʢàʤÞʡéʢåñçʤ ÝʤåñíãçʦéÞʤèʡëãʢçéʤÞʦèʤìʢìçʤʣçʢàʤʦéʡéʤìçʤʦéñóçʧáàʡʢéʦôÞéʢʥʡèããʦéʡéãçʡæãʛʥãʝʒʟæåæãçʥʢäʤæʢçàʧóéçʡâçʡìʡéñʡéʤʥÞʡʦéʡéãç éʡääʡäåãíñ èʥʢèʡʥʡéʡ ÞðÞʤàãéʦô èʤìäʡæã ʓåñéʢʥçʡéãÞçʡô éʢʥʡèãô ą êåʧÞʡʦéʡéãç Þ àʤâʢ æßʦʧé ʔ ʥʡçàʤæãâãʥʤÞʡççðʨ ãʦʦåʢàʤÞʡçãôʨ $ ʡéʤʥÞʡʦéʡéãç ą æßʦʧé !52/2!ʥʤâʧÞʡʦéʡéãçąæßʦʧé ʧÝʤåñçðʨʦéʢʥæãçʡåñçʤʣèʤìʢìçʤʣçʢàʤʦéʡéʤìçʤʦéñó çʡʨʤàôîãʨʦôçʡèʥʤßʥʡææçʤæßʢæʤàãʡåãâʢ çʢçʡÝåóàʡåãʦçãáʢçãô ìʡʦéʤéðʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʚàçʡäʤÞãʦʦåʢàʤÞʡçãã3(!20äʤæÝãçʡëãôʦãæÞʡʦéʡéãçʡʦòâʢéãæãÝʤæʧÝʤåñçðʨʦʥʡâåãìçʤʣʦéʢèʢçñóʠʛʙçʡ ʦçãáʡåʡ ìʡʦéʤéʧ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣ ã çʢ ÞðâðÞʡåʡ ʦʢʥñʢâçðʨ èʤÝʤìçðʨôÞåʢçãʣʜʢâʧåñéʡéðòéʤßʤãʦʦåʢàʤÞʡçãôèʤʦåʧáãåãʤʦçʤÞʡçãʢæʥʢäʤæʢçàʤÞʡéñäʤæÝãçãʥʤÞʡççʧóéʢʥʡèãóʦãæÞʡʦéʡéãçʤææßʦʧé ãòâʢéãæãÝʤæ æßʦʧé ʧÝʤåñçðʨʦÞðʥʡáʢççʤʣʠʛʙ;= ÌʤåñçðʢèʤʦåʢéʥʡçʦèåʡçéʡëããʤʥßʡçʤÞʝéʡéãçðèʤäʡâʡçðÞäʡìʢʦéÞʢèʥʢèʡʥʡéʤÞ èʢʥÞʤʣ åãçãã éʢʥʡèãã ʧ èʡëãʢçéʤÞ èʢʥʢçʢʦíãʨ ʤèʢʥʡëãó èʤ éʥʡçʦèåʡçéʡëããʤʥßʡçʤÞÑʢìʢçãʢçʧáçʤçʡìãçʡéñʦçãâäʤʣàʤâð èʤʦéʢèʢççʤèʤÞðíʡôʢʢàʤàʤʦéãáʢçãôëʢåʢÞʤßʤʧʥʤÞçôʠʝÑʙʛʒʤçéʥʤåñêʢʥæʢçéʤÞÞçʡìʡåʢ éʢʥʡèããàʤåáʢçèʥʤÞʤàãéñʦôçʢʥʢáʢʥʡâʡÞæʢʦôë ʤʦʤÝʢççʤèʥãʦʤèʧéʦéÞʧóîʢæèʥãʢæʢëãäåʤʦèʤʥãçʡʤèʡʦçʤʦéñæãʤèʡéãã ʛʥʢàèʤìéʢçãʢʦåʢàʧʢéʤéàʡéñ êåʧÞʡʦéʡéãçʧ ą æßʦʧé ãåã ʥʤâʧÞʡʦéʡéãçʧ ą æßʦʧé èʤʦäʤåñäʧ òéã èʥʢèʡʥʡéð æʢéʡÝʤåãâãʥʧóéʦô ãçʤʣ ãâʤêʤʥæʤʣ ëãéʤʨʥʤæʡ ʜ ʝ çʢáʢåã ëãéʤʦéʡéãäãʓ Ìʤåñçðʢ ʦ ãçʦʧåñéʤæ Íãʦåãèãàʢæãã æʤßʧé ãßʥʡéñ ʥʡâåãìçʧó ʥʤåñ Þ èʡéʤßʢçʢâʢãçʦʧåñéʡʘʢáàʧçʡåãìãʢæÍÑʛãʥʡâÞãéãʢæãíʢæãìʢʦäʤßʤãçʦʧåñéʡãåã éʥʡçâãéʤʥçʤʣãíʢæãìʢʦäʤʣʡéʡäãʦʧîʢʦéÞʧʢééʢʦçʡôÞâʡãæʤʦÞôâñʙʡâçʡìʢçãʢ ʦéʡéãçʤÞ ʡéʤʥÞʡʦéʡéãç ą æßʦʧé ʧ Ýʤåñçðʨ ʦ ʓʕ ã ʦ èʤÞðíʢççðæ ʧʥʤÞçʢæ 97 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʠʝÑʙʛʦçãáʡʢéʥãʦäʥʡâÞãéãôãíʢæãìʢʦäʤßʤãçʦʧåñéʡÚéʤÝðåʤèʥʤàʢæʤçʦéʥãʥʤÞʡçʤÞʡçßåʤ ʦäʡçàãçʡÞʦäʤæãʦʦåʢàʤÞʡçãã!3#/4 ,,!ʔãʦʦåʢàʤÞʡçãã30!2#, éʡäáʢ Ýðåʤ èʤäʡâʡçʤ àʤʦéʤÞʢʥçʤʢ ʦçãáʢçãʢ ìʡʦéʤéð ãíʢæãìʢʦäãʨ ãçʦʧåñéʤÞ çʡêʤçʢéʢʥʡèããʡéʤʥÞʡʦéʡéãçʤæÞàʤâʢæßʦʧéʞʡäãæʤÝʥʡâʤæ ʧèʡëãʢçéʤÞ ʦ ʥãʦäʤæ ʥʡâÞãéãô ãíʢæãìʢʦäʤßʤ ãçʦʧåñéʡ ʦéʡéãçð èʤäʡâʡçð àåô ʢßʤ èʥʢàʧèʥʢáàʢçãô ʔ éʤ áʢ Þʥʢæô çʡâçʡìʢçãʢ ʦéʡéãçʤÞ èʥã ßʢæʤʥʥʡßãìʢʦäʤæ ãçʦʧåñéʢ çʢʤäʡâðÞʡʢéʦäʤåñ çãÝʧàñâçʡìãæʤßʤòêêʢäéʡÚéʤʦÞôâʡçʤʦéʢæ ìéʤÞʤʦçʤÞʢʥʡâÞãéãôßʢæʤʥʥʡßãìʢʦäʤßʤãçʦʧåñéʡåʢáʡéàʥʧßãʢæʢʨʡçãâæð çʢʦÞôâʡççðʢ ʦàãʦåãèãàʢæãʢʣ ʔÐÔ ãçêãëãʥʤÞʡççðʢèʡëãʢçéðʤÝðìçʤãæʢóéçãâäãʢʧʥʤÞçãʚʠʝ ʠʝÑʙʛ ã ʠʝ Ñʔʛ ã èʤÞðíʢçãʢ ʧʥʤÞçô ʞʕ ʓçéãʥʢéʥʤÞãʥʧʦçʡô éʢʥʡèãô ʦ éʢìʢçãʢæ ÞʥʢæʢçãèʤÞðíʡʢéʧʥʤÞʢçñʠʝÑʙʛʦèʥʢÞʡåãʥʤÞʡçãʢæÞʦʤʦéʡÞʢÑʙʛæʢåäãʨèåʤéçðʨìʡʦéãë ìéʤʧàÞʡãÞʡʢéʥãʦäʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣʝʤÝåóàʢçãʢ àãʢéðʦçãâäãæʦʤàʢʥáʡçãʢæçʡʦðîʢççðʨáãʥʤÞãʥʢßʧåôʥçʡôêãâãìʢʦäʡôʡäéãÞçʤʦéñèʤåʤáãéʢåñçʤÞåãôóéçʡʦʤʦéʡÞåãèʤèʥʤéʢãàʤÞèåʡâæð ʤàçʡäʤæçʤßãʢ èʡëãʢçéðçʧáàʡóéʦôÞçʡâçʡìʢçããßãèʤåãèãàʢæãìʢʦäãʨèʥʢèʡʥʡéʤÞʝʧîʢʦéÞʧʢé ʤèʡʦçʤʦéñåʢäʡʥʦéÞʢççʤßʤÞâʡãæʤàʢʣʦéÞãôæʢáàʧåãèãàʦçãáʡóîãæããʡçéãʥʢéʥʤÞãʥʧʦçðæã ʦʥʢàʦéÞʡæã ʝéʡéãçð ôÞåôóéʦô èʥʢèʡʥʡéʡæã ÞðÝʤʥʡ Þ ʦåʧìʡôʨ ßãèʢʥʨʤåʢʦéʢʥãçʢæãã ʚçã æʤßʧé èʤ ʥʡâçʤæʧ ÞâʡãæʤàʢʣʦéÞʤÞʡéñ ʦ ʡçéãʥʢéʥʤÞãʥʧʦçðæã èʥʢèʡʥʡéʡæã ʞʡä ʦãæÞʡʦéʡéãç èʥʤéãÞʤèʤäʡâʡç èʡëãʢçéʡæ èʤåʧìʡóîãæʡçéãʥʢéʥʤÞãʥʧʦçʧóéʢʥʡèãóçʡʤʦçʤÞʢãçßãÝãéʤʥʤÞèʥʤéʢʡâðʝʤʦéʤʥʤáçʤʦéñó ʦåʢàʧʢé èʥãæʢçôéñ äʤæÝãçʡëãó ʥʤâʧÞʡʦéʡéãçʡ ʦ åʤèãçʡÞãʥʤæ ʥãéʤçʡÞãʥʤæ ÚâʢéãæãÝ æʤáʢé Ýðéñ çʡâçʡìʢç èʡëãʢçéʡæ ʦ çʢèʢʥʢçʤʦãæʤʦéñó äʦéʡéãçʡæ ʚʝʚÌʖʙʙʚʝʞÐʞʖÔʖʙÐÜÐʞʖʜʓʛÐÐʝʖʘʖʗʙʚʗ ʕÐʛʖʜʠʚÑʖʝʞʖʜÐʙʖʘÐÐ ÚʞÐʚÑʚʕÐÜÐʜʓʝʛʜʚʝʞʜʓʙʖʙʙʚʝʞÙʝʕʠʝ ʝʢæʢʣçʡô ßãèʢʥʨʤåʢʦéʢʥãçʢæãô ʝʕʠʝ ą òéʤ çʡʦåʢàʦéÞʢççʤʢ ʡʧéʤʦʤæçʤ àʤæãçʡçéçʤʢâʡÝʤåʢÞʡçãʢ äʤéʤʥʤʢÞʢàʢéäÞðʥʡáʢççʤæʧçʡʥʧíʢçãóæʢéʡÝʤåãâæʡåãèʤèʥʤéʢãàʤÞ ʤÝʧʦåʤÞåʢççʤʢæʧéʡëãôæãßʢçʤÞ ʥʢßʧåãʥʧóîãʨòäʦèʥʢʦʦãó ʥʢëʢèéʤʥʤÞÑʙʛ,$,2 ʡèʤåãèʤèʥʤéʢãàʡʔ èʥʤêʢʥæʢçéʡ0#3+ʝʕʠʝèʥʤôÞåôʢéʦôʦéʤʣäãæèʤÞðíʢçãʢæʧʥʤÞçôʠʝÑʙʛãʥʡççãæʥʡâÞãéãʢæʡéʢʥʤʦäåʢʥʤâʡ ʝʕʠʝ ÞèʢʥÞðʢ ʤèãʦʡçʡ Þ ß çʤʥÞʢáʦäãæ Þʥʡìʤæ # -ǩLLER äʡä iÞʥʤáàʢççʡô ʤíãÝäʡæʢéʡÝʤåãâæʡx ʦʤèʥʤÞʤáàʡóîʡôʦôÞðʦʤäãæʧʥʤÞçʢæʨʤåʢʦéʢʥãçʡÞʦðÞʤʥʤéäʢäʥʤÞããÞʤâæʤáçðæʥʡâÞãéãʢæãçêʡʥäéʡæãʤäʡʥàʡÞæʤåʤàʤæÞʤâʥʡʦéʢ ;=ʔßÝðåʤèʤäʡâʡçʤ ìéʤâʡÝʤåʢÞʡçãʢèʥʤôÞåôʢéʦôÞÞãàʢàÞʧʨäåãçãìʢʦäãʨêʤʥææʢçʢʢéôáʢåʤʣßʢéʢʥʤâãßʤéçʤʣßʢʝʕʠʝ ãÝʤåʢʢéôáʢåʤʣßʤæʤâãßʤéçʤʣ 98 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ßʤʝʕʠʝ ;=ʔßÝðåʤʧʦéʡçʤÞåʢçʤ ìéʤìʡîʢÞʦʢßʤèʥãìãçʤʣʥʡâÞãéãôʝʕʠʝ ôÞåôʢéʦôʦçãáʢçãʢèåʤéçʤʦéãʥʢëʢèéʤʥʤÞÑʙʛãåãçʡʥʧíʢçãʢãʨêʧçäëãã;= ʔèʤʦåʢàʦéÞããʡæʢʥãäʡçʦäãʢʧìʢçðʢʘ"ROWNã*'OLDSTEINèʥʤàʢæʤçʦéʥãʥʤÞʡåã ìéʤʝʕʠʝÞðâðÞʡʢéʦôæʧéʡëãʢʣßʢçʡÑʙʛ ʥʢëʢèéʤʥʡ;= ʕʢéʢʥʤâãßʤéçʡô êʤʥæʡ ʝʕʠʝ ʨʡʥʡäéʢʥãâʧʢéʦô àʤʦéʡéʤìçʤ Þðʦʤäʤʣ ʥʡʦèʥʤʦéʥʡçʢççʤʦéñóą ßʤæʤâãßʤéçʡôʝʕʠʝÞʦéʥʢìʡʢéʦôʥʢàäʤ ʜʡʦèʥʤʦéʥʡçʢççʤʦéñßʢéʢʥʤâãßʤéçʤʣʝʕʠʝÞʥʡâçðʨʦéʥʡçʡʨçʢʤàãçʡäʤÞʡ Ýʤåʢʢ ÞðʦʤäʡôÞʦéʥʢìʡʢæʤʦéñʝʕʠʝʤéæʢìʢçʡÞèʤèʧåôëããäʡçʡàëʢÞêʥʡçëʧâʦäʤßʤèʥʤãʦʨʤáàʢçãô ʢÞʥʢʢÞ ʡíäʢçʡâã êãççʤÞiòêêʢäéʤʦçʤÞʡéʢåôx ;ą=ʔçʢʦʢåʢäéãÞçʤæ ãʦʦåʢàʤÞʡçãã èʥʤÞʢàʢççʤæ Þ Íʡçãã ã Þäåóìʡóîʢæ éðʦ ʧìʡʦéçãäʤÞ èʤåʧìʢçðàʡççðʢʤʥʡʦèʥʤʦéʥʡçʢççʤʦéãßʢʝʕʠʝèʤäʥãéʢʥãôæ$UTCH ,IPID#LINIC.ETWORK ;= ʛʤèʧåôëãʤççðʢ ãʦʦåʢàʤÞʡçãô èʤäʡâʡåã ìéʤ ìãʦåʤ Ýʤåñçðʨ ʦ ʝʕʠʝ Þʤ Þʦʢæ æãʥʢæʤáʢéʦʤʦéʡÞåôéñèʥãæʢʥçʤąæåçìʢåʤÞʢä;ą=ÍʤåôÞðôÞåʢççðʨʦåʧìʡʢÞÞʥʡâåãìçðʨʦéʥʡçʡʨâçʡìãéʢåñçʤäʤåʢÝåʢéʦôçʡãÝʤåñíʢʢìãʦåʤèʡëãʢçéʤÞʦʝʕʠʝÞðôÞåʢçʤÞʙãàʢʥåʡçàʡʨʤéèʥʢàèʤåʡßʡʢæʤßʤʤÝîʢßʤìãʦåʡ Ýʤåñçðʨ ;ą= ʔ ʜʤʦʦãã äʤåãìʢʦéÞʤ àãʡßçʤʦéãʥʤÞʡççðʨ ʦåʧìʡʢÞ ʝʕʠʝ ʦʤʦéʡÞåôʢé Þʢʥʤôéçʤ ʝåʢàʧʢéèʥãâçʡéñ ìéʤçʡíãâçʡçãôʤßʢʤßʥʡêãìʢʦäʤæ ʥʡʦèʥʢàʢåʢçãããòèãàʢæãʤåʤßããßʢʝʕʠʝãßʤʝʕʠʝôÞåôóéʦôçʢèʤåçðæãããʦéãççʤʢäʤåãìʢʦéÞʤÝʤåñçðʨʝʕʠʝÞʜʤʦʦããçʢãâÞʢʦéçʤÍãʡßçʤâʝʕʠʝʦéʡÞãéʦôäʥʡʣçʢʥʢàäʤ ãʤëʢçäʡʥʡʦèʥʤʦéʥʡçʢççʤʦéãàʡççʤßʤâʡÝʤåʢÞʡçãôÝʡâãʥʧʢéʦôçʡʥʢâʧåñéʡéʡʨòèãàʢæãʤåʤßãìʢʦäãʨãʦʦåʢàʤÞʡçãʣ èʥʤÞʢàʢççðʨÞàʥʧßãʨʦéʥʡçʡʨ ʒʡä èʥʡÞãåʤ ʧ æʧáìãç ã áʢçîãç ʦ ßʢʝʕʠʝ ã ʧʥʤÞçʢæ ʤÝîʢßʤ ʨʤåʢʦéʢʥãçʡ ąææʤåñåąæßàå ÐÌʝʤÝðìçʤʥʡâÞãÞʡʢéʦôÞą ʣàʢäʡàʢáãâçãʛʥã òéʤæ ʡéʢʥʤʦäåʢʥʤâ äʤʥʤçʡʥçðʨ ʡʥéʢʥãʣ èʥã ßʢʝʕʠʝ ʤÝçʡʥʧáãÞʡʢéʦô ʧ æʧáìãç ʧáʢ Þ Þʤâʥʡʦéʢ åʢé ʧ áʢçîãç ą Þ åʢé ;= ʚàçʡäʤ Þ ʦåʧìʡʢ ʥʡççʢʣ àãʡßçʤʦéãäã ã ʦÞʤʢÞʥʢæʢççʤ çʡìʡéʤßʤ åʢìʢçãô ßʢʝʕʠʝ Þʤâæʤáçʤ èʥʢàʤéÞʥʡîʢçãʢ ʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡãʥʡççʢʣÐÌʝ;=ʛʥãßʤʝʕʠʝʧʥʤÞʢçñʤÝîʢßʤʠʝäʤåʢÝåʢéʦôÞèʥʢàʢåʡʨąææʤåñåąæßàå ÐÌʝʥʡâÞãÞʡʢéʦôÞæʤåʤàʤæ Þʤâʥʡʦéʢ ãÝʢâåʢìʢçãôʥãʦäʥʡâÞãéãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ Þéʤæ ìãʦåʢãêʡéʡåñçðʨ äʥʡʣçʢÞðʦʤä ÒìãéðÞʡôÞðʦʤäʧóʦæʢʥéçʤʦéñʤéʝʕʠʝÞʤÞʦʢææãʥʢ ʦéʡçʤÞãéʦôèʤçôéçʤʣ çʢʤÝʨʤàãæʤʦéñ Þ ʥʡççʢæ ÞðôÞåʢçãã ã åʢìʢçãã òéʤßʤ âʡÝʤåʢÞʡçãô ʔʤ æçʤßãʨ ʦéʥʡçʡʨ ʙãàʢʥåʡçàð ʔʢåãäʤÝʥãéʡçãô ʟʥʡçëãô ʓÞʦéʥʡåãô ʙʤÞʡô Ïʢåʡçàãô àåô ʥʢßãʦéʥʡëãã åãë ʦ ʝʕʠʝ ʦʤâàʡçð çʡëãʤçʡåñçðʢ ʥʢßãʦéʥð Ýåʡßʤàʡʥô äʤéʤʥðæ ʦéʡåʤ Þʤâæʤáçðæ òêêʢäéãÞçʤ ÞðôÞåôéñ ã åʢìãéñ ʝʕʠʝ ʜʡâʥʡÝʤéʡçðàãʡßçʤʦéãìʢʦäãʢäʥãéʢʥããʝʕʠʝą3IMON"ROOMEÞʓçßåããã$UTCH,IPID#LINIC .ETWORKÞʙãàʢʥåʡçàʡʨ ÞäʤéʤʥðʨèʤÝʡååñçʤʣʦãʦéʢæʢʤëʢçãÞʡʢéʦôÞʢʥʤôéçʤʦéñ âʡÝʤåʢÞʡçãô ʧ ʤÝʦåʢàʧʢæʤßʤ åãëʡ ìéʤ àʢåʡʢé ãʨ Þʢʦñæʡ ʧàʤÝçðæã àåô èʥãæʢ- 99 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ çʢçãô Þ äåãçãìʢʦäʤʣ èʥʡäéãäʢ éʡÝå ; = ʝʧîʢʦéÞʧóé ã àʥʧßãʢ èʥʤßʥʡææðàãʡßçʤʦéãäãʝʕʠʝ æʢçʢʢʥʡʦèʥʤʦéʥʡçʢççðʢÞʖÞʥʤèʢ-%$ʜ%$ ÞäʤéʤʥʤʣʤʦçʤÞçðæàãʡßçʤʦéãìʢʦäãæäʥãéʢʥãʢæôÞåôʢéʦôʧʥʤÞʢçñʠʝÑʙʛʧÝʤåñçʤßʤãʢßʤʥʤàʦéÞʢççãäʤÞ;= ãôèʤçʦäʡôíäʡåʡàãʡßçʤâʡʝʕʠʝ èʥʢàèʤåʡßʡóîʡô çʡåãìãʢâʡÝʤåʢÞʡçãôèʥãʧʥʤÞçʢʠʝÑʙʛæßàå ææʤåñå ãçʡåãìããʦʧʨʤáãåñçðʨãäʤáçðʨäʦʡçéʤæ;= ʔʢʥʤôéçʤ ʥʡʦèʥʤʦéʥʡçʢççʤʦéñ ʝʕʠʝ Þ ʜʟ âçʡìãéʢåñçʤ Þðíʢ ìʢæ Þ ʦéʥʡçʡʨ ʦ ʧʦéʡçʤÞåʢççʤʣ ìʡʦéʤéʤʣ ʞʡä Þ ãʦʦåʢàʤÞʡçãã èʥʤÞʢàʢççʤæ Þ Ïʡèʡàçʤæ ʡàæãçãʦéʥʡéãÞçʤæ ʤäʥʧßʢ ß ʘʤʦäÞð ãâ éðʦ åãë ʤÝʥʡéãÞíãʨʦô Þ èʤåãäåãçãäʧ ʧʥʤÞʢçñ ʤÝîʢßʤ ʨʤåʢʦéʢʥãçʡ ʚʠʝ Ýðå ææʤåñå ʧ ʠʝÑʙʛ ææʤåñåąʧ ;=ÚéãàʡççðʢàãäéʧóéçʢʤÝʨʤàãæʤʦéñʦʤâàʡçãô ʥʤʦʦãʣʦäʤßʤ ʥʢßãʦéʥʡ àåô ÞðôÞåʢçãô Ýʤåñçðʨ ʦ ʝʕʠʝ ʦ ëʢåñó ʤʥßʡçãâʡëãã ʥʡççʢʣàãʡßçʤʦéãäããʡàʢäÞʡéçʤʣéʢʥʡèãã ʞʡÝåãëʡ Ìʥãéʡçʦäãʢäʥãéʢʥããàåôàãʡßçʤʦéãäãßʢʝʕʠʝ 3IMON"ROOMECRITERIA ʚèʥʢàʢåʢççʡô$EFINITE ʝʕʠʝ ʔʢʥʤôéçʡô0OSSIBLE ʝʕʠʝ ʕãèʢʥʨʤåʢʦéʢʥãçʢæãô ʔâʥʤʦåðʢąʚʠʝ ææʤåñåãåãʠʝÑʙʛ ææʤåñå Íʢéãæʤåʤáʢåʢéąʚʠʝ ææʤåñåãåãʠʝÑʙʛ ææʤåñå ʛåóʦʨʤéôÝðèʧçäéãâèʢʥʢìãʦåʢççðʨ ą ʦʧʨʤáãåñçðʢäʦʡçéʤæðʧèʡëãʢçéʡãåã ʧʥʤàʦéÞʢççãäʤÞą ʣåãçãã ą çʡʣàʢççðʢæʧéʡëããÑʙʛ ʥʢëʢèéʤʥʡ ʡèʤ"ãåã0#3+ ą ÐʘʧʥʤàʦéÞʢççãäʡ ʣåãçããàʤåʢé ãåãʧʥʤàʦéÞʢççãäʡ ʣåãçããàʤåʢé ą ʦʢæʢʣçðʣʡçʡæçʢâèʤÞðíʢççʤßʤ ʧʥʤÞçôʠʝʚʠʝ ææʤåñåʧÞâʥʤʦåʤßʤ ʥʤàʦéÞʢççãäʡą ʣåãçãããåã ææʤåñåʧʥʢÝʢçäʡãåãÝʥʡéʡʦʢʦéʥð æʤåʤáʢåʢé ʓÑʕʚʜÐʞʘʔØÜʔÑʖʙÐÜʛʓÓÐʖʙʞʚʔʝʝʕʠʝ ʒåãçãìʢʦäãʢíäʡåð ʝʧîʢʦéÞʧʢé ʥôà êʢçʤéãèãìʢʦäãʨ èʥãâçʡäʤÞ ʝʕʠʝ ʧ Þâʥʤʦåðʨ äʤéʤʥðʢ ʤÝʧʦåʤÞåʢçð àåãéʢåñçʤʦéñó òäʦèʤâãëãã Þðʦʤäʤßʤ ʧʥʤÞçô ʨʤåʢʦéʢʥãçʡ ;ą= ʒçãæʤéçʤʦôéʦôèʥʢáàʢÞʦʢßʤäʦʡçéʤæðʦʧʨʤáãåãʣ äʤéʤʥðʢìʡîʢåʤäʡåãâʧóéʦô çʡ ʥʡâßãÝʡéʢåñçʤʣ èʤÞʢʥʨçʤʦéã åʤäéʢÞðʨ äʤåʢççðʨ ʦʧʦéʡÞʤÞ ʡʨãååʤÞðʨ ʦʧʨʤáãåãôʨãʦʧʨʤáãåãôʨʥʡâßãÝʡéʢåʢʣèʡåñëʢÞäãʦéã ʒʥʤæʢʦʧʨʤáãåñçðʨäʦʡçéʤæ ÞðàʢåôóééʡäáʢäʤáçðʢÝʧßʤʥìʡéðʢäʦʡçéʤæð äʤéʤʥðʢåʤäʡåãâʧóéʦôÞéʢʨáʢ 100 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ æʢʦéʡʨ ìéʤãʦʧʨʤáãåñçðʢäʦʡçéʤæðʥãʦ ;=ʠʤéôʦʧʨʤáãåñçðʢäʦʡçéʤæð ʦèʢëãêãìçðàåôʝʕʠʝ ÞʦʢáʢãʨçʢåñâôʦìãéʡéñʦéʤèʥʤëʢçéçðææʡʥäʢʥʤæâʡÝʤåʢÞʡçãô èʤʦäʤåñäʧʤçãæʤßʧéÞʦéʥʢìʡéñʦôãèʥãàʥʧßãʨʦʤʦéʤôçãôʨʦãéʤʦéʢʥʤåʢæãô ã ëʢʥʢÝʥʤéʢçàãçʤâçðʣ äʦʡçéʤæʡéʤâ ;= ʛʤòéʤæʧ àåô Þʢʥãêãäʡëãã àãʡßçʤâʡʥʢäʤæʢçàʧʢéʦôèʥʤÞʢʦéãÍʙʒ àãʡßçʤʦéãäʧãʡçʡåãâʧʥʤÞçôêãéʤʦéʢʥʤåʡÞèåʡâæʢäʥʤÞã; =ÑãèʤãàçʡôàʧßʡʥʤßʤÞãëðæʤáʢéãæʢéñâçʡìʢçãʢàåô àãʡßçʤʦéãäãʝʕʠʝʧåãëæʤåʤáʢåʢéʒʥʤæʢéʤßʤ ʧÝʤåñçðʨʝʕʠʝìʡʦéʤæʤáçʤ çʡÝåóàʡéñäʦʡçéʢåʡâæðąʤéåʤáʢçãôåãèãàʤÞçʡäʤáʢÞʢäʥãʦ ʛʤæãæʤêʢçʤéãèãìʢʦäãʨäʥãéʢʥãʢÞ ãʦèʤåñâʧóéʦôßʢçʤéãèãìʢʦäãʢʔçʡʦéʤôîʢʢÞʥʢæôàåô àãʡßçʤʦéãäãʝʕʠʝíãʥʤäʤãʦèʤåñâʧóéʦôʧáʢʧèʤæôçʧéðʢÝʥãéʡçʦäãʢãßʤååʡçàʦäãʢäʥãéʢʥãã èʥʢàʦéʡÞåʢççðʢÞéʡÝåã;= ʕʢçʢéãìʢʦäʤʢéʢʦéãʥʤÞʡçãʢ ʕʢçʢéãìʢʦäʤʢ ʤÝʦåʢàʤÞʡçãʢ àåô èʤʦéʡçʤÞäã àãʡßçʤâʡ ʝʕʠʝ ãåã äåãçãìʢʦäʤʣ ʤëʢçäã ʤÝðìçʤ çʢ éʥʢÝʧʢéʦô çʤ Þ ʦʤæçãéʢåñçðʨ ʦåʧìʡôʨ ʦéʡçʤÞãéʦô çʢʤÝʨʤàãæðæʚÝîʢèʥãçôéʤ ìéʤʝʕʠʝʥʡâÞãÞʡʢéʦôÞʦåʧìʡôʨæʧéʡëããéʥʢʨßʢçʤÞ Ñʙʛ ʥʢëʢèéʤʥʤÞ,$,2 ʡèʤåãèʤèʥʤéʢãàʡ"!0/" ã0#3+;=ʒʥʤæʢéʤßʤ ʧäʡâðÞʡʢéʦôÞʤâæʤáçʡôʥʤåñæʧéʡëããÝʢåäʡæʤàʧåôéʤʥʡʥʢëʢèéʤʥʤÞÑʙʛʛʡéʤßʢççðʢæʧéʡëããÞʤàçʤæãâòéãʨßʢçʤÞʤèʥʢàʢåôóéʦôèʥãÝåãâãéʢåñçʤʧÝʤåñçðʨ ʦ ʝʕʠʝ ã ʧ ʦ êʢçʤéãèãìʢʦäã ÞʢʥʤôéçðæÞʤâæʤáçðæ àãʡßçʤâʤæ ʝʕʠʝ ;ą=ʝèʤæʤîñóçʤÞðʨæʤåʢäʧåôʥçðʨæʢéʤàʤÞ éʡäãʨäʡäʦʢäÞʢçãʥʤÞʡçãʢ ßʢçʤæʡ ÞʤâæʤáçʡàʢéʢäëãôâçʡìãéʢåñçʤßʤäʤåãìʢʦéÞʡæʧéʡëãʣ; =ʚäʤåʤ æʧéʡëãʣ ãàʢçéãêãëãʥʤÞʡçʤ Þ ßʢçʢ Ñʙʛ ʥʢëʢèéʤʥʡ ą ą Þ ßʢçʢ !0/" ãąÞßʢçʢ0#3+; =ʛʥãçãæʡôÞʤÞçãæʡçãʢÞðʦʤäʧóÞʡʥãʡÝʢåñçʤʦéñæʧéʡëãʣ ʧæçʤßãʨÝʤåñçðʨʦÞʤâæʤáçʤʣʝʕʠʝçʢʧàʡʢéʦôèʤàéÞʢʥàãéñ àãʡßçʤâèʥãèʤæʤîãßʢçʢéãìʢʦäʤßʤãʦʦåʢàʤÞʡçãô; ą=ʔòéãʨʦåʧìʡôʨ èʥã åʢìʢçãã Ýʤåñçðʨ ʤʥãʢçéãʥʧóéʦô çʡ ʧʥʤÞʢçñ åãèãàʤÞ Þ èåʡâæʢ ã ʥãʦä ʥʡâÞãéãô ʝʝÏ ; = ʛʥãæʢʥʤæ òêêʢäéãÞçʤʦéã ßʢçʢéãìʢʦäʤßʤ éʢʦéãʥʤÞʡçãôʝʕʠʝôÞåôʢéʦôãʦʦåʢàʤÞʡçãʢ èʥʤÞʢàʢççʤʢÞÏʡèʡàçʤʣʓÞʦéʥʡåãã Þäʤéʤʥʤæ ʤÝʦåʢàʤÞʡåã ʥʤàʦéÞʢççãäʤÞ èʥʤÝʡçàʤÞ ʦ ßʢçʢéãìʢʦäã ÞʢʥãêãëãʥʤÞʡççðæ àãʡßçʤâʤæʝʕʠʝÐâʥʤàʦéÞʢççãäʤÞ èʥʤéʢʦéãʥʤÞʡççðʨçʡʝʕʠʝ ʧ Ýðåʡ ÞðôÞåʢçʡ èʡéʤßʢççʡô æʧéʡëãô ßʢçʡ Ñʙʛ ʥʢëʢèéʤʥʡ ;= Úéʤ ãʦʦåʢàʤÞʡçãʢèʤäʡâʡåʤ ìéʤäʡʦäʡàçðʣʦäʥãçãçß ÞäåóìʡóîãʣßʢçʢéãìʢʦäʤʢéʢʦéãʥʤÞʡçãʢ ããâæʢʥʢçãʢäʤçëʢçéʥʡëããʠʝ ôÞåôʢéʦôʤèʥʡÞàʡççðæäʡäʦéʤìäãâʥʢçãôèʢʥÞãìçʤʣèʥʤêãåʡäéãäãÞʦʢæñôʨèʥʤÝʡçàʤÞ éʡäãʦéʤìäãâʥʢçãôòäʤçʤæãìʢʦäãʨâʡéʥʡé;=ʞʡäãæʤÝʥʡâʤæ ßʢçʢéãìʢʦäãʢãʦʦåʢàʤÞʡçãôÞʨʤàôéÞʦãʦéʢæʧäʡʦäʡàçʤßʤʦäʥãçãçßʡ äʤéʤʥðʣçʢʤÝʨʤàãæʤèʥʤÞʤàãéñèʥãèʤàʤâʥʢçããçʡʝʕʠʝÞʤÞʦʢʨ ʦåʧìʡôʨ äʤßàʡòéʤéʢʨçãìʢʦäãÞʤâæʤáçʤ; = 101 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʞʡÝåãëʡ ʕʤååʡçàʦäãʢäʥãéʢʥããàåôàãʡßçʤʦéãäãßʢʝʕʠʝ$UTCH,IPID#LINIC .ETWORKCRITERIA ʒʥãéʢʥãʣ Ìʡååð ʜʡççʢʢʥʡâÞãéãʢÐÌʝʧʥʤàʦéÞʢççãäʡ ʣåãçããÞʤâʥʡʦéåʢéàåôæʧáìãç åʢéàåôáʢçîãç 1 ÒʥʤÞʢçñʠʝÑʙʛ ææʤåñåʧʥʤàʦéÞʢççãäʡ ʣåãçãã 1 ʝʧʨʤáãåñçðʢäʦʡçéʤæðããåãåãèʤãàçʡôàʧßʡʥʤßʤÞãëðʧʥʤàʦéÞʢççãäʡ ʣåãçãã 2 ʜʢÝʢçʤäÞÞʤâʥʡʦéʢåʢéʦʧʥʤÞçʢæʠʝÑʙʛ ææʤåñå 2 ʝʢæʢʣçðʣʡçʡæçʢâ ʒåãçãìʢʦäãʣʡçʡæçʢâ ʙʡåãìãʢÐÌʝʧæʧáìãçðÞÞʤâʥʡʦéʢåʢé ʧáʢçîãçðąåʢé 2 ʙʡåãìãʢÓʔÌãåãÝʤåʢâçãèʢʥãêʢʥãìʢʦäãʨʡʥéʢʥãʣʧæʧáìãçðÞÞʤâʥʡʦéʢ åʢé ʧáʢçîãçðÞÞʤâʥʡʦéʢåʢé 1 ʟãâãäʡåñçʤʢʤÝʦåʢàʤÞʡçãʢ ʝʧʨʤáãåñçðʢäʦʡçéʤæð ÑãèʤãàçʡôàʧßʡʥʤßʤÞãëðʧÝʤåñçðʨÞÞʤâʥʡʦéʢåʢé ʓçʡåãâäʥʤÞãçʡʠʝÑʙʛ ææʤåñåæßàå ą ææʤåñåąæßàå ą ææʤåñåąæßàå ą ææʤåñåąæßàå 1 ʘʤåʢäʧåôʥçʤ ßʢçʢéãìʢʦäãʣʡçʡåãâ ʘʧéʡëãôßʢçʡ,$,2 ʘʧéʡëãôßʢçʡ!0/" ʘʧéʡëãôßʢçʡ0#3+GAIN OF FUNCTION ʝʧææʡÝʡååʤÞ ʚèʥʢàʢåʢççʡô$EFINITE ʝʕʠʝ ʔʢʥʤôéçʡô0ROBABLE ʝʕʠʝ ą ʔʤâæʤáçʡô0OSSIBLE ʝʕʠʝ ą ʘʡåʤÞʢʥʤôéçʡô5NLIKELY ʝʕʠʝ 102 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʒʡʦäʡàçðʣʦäʥãçãçß ʚèéãæʡåñçðæ àåô ÞðôÞåʢçãô Ýʤåñçðʨ ʦ ʝʕʠʝ èʥãâçʡç èʤàʨʤà ʤʦçʤÞʡççðʣ çʡ ʤÝʦåʢàʤÞʡçãã ʥʤàʦéÞʢççãäʤÞ èʡëãʢçéʡ ą äʡʦäʡàçðʣ ʦäʥãçãçß ;= ʝʕʠʝ ʦåʢàʧʢéâʡèʤàʤâʥãéñÞʦåʧìʡʢÞðʥʡáʢççʤßʤèʤÞðíʢçãôʧʥʤÞçôʠʝÑʙʛʧÞâʥʤʦåðʨʦéʡʥíʢåʢé ææʤåñåæßàå ʧàʢéʢʣãèʤàʥʤʦéäʤÞą ææʤåñå æßàå ;=ʔʢʥʤôéçʤʦéñʝʕʠʝÞðíʢʧåãë ÞʦʢæñôʨäʤéʤʥðʨçʡÝåóàʡåãʦñ ʦåʧìʡã ßãèʢʥʨʤåʢʦéʢʥãçʢæãã ʡ éʡäáʢ ʥʡççʢʣ ÐÌʝ ʧ æʧáìãç æʤåʤáʢ åʢé ʧáʢçîãçæʤåʤáʢåʢé ʛʥãÞðôÞåʢçããòéãʨèʥãâçʡäʤÞëʢåʢʦʤʤÝʥʡâçʤèʥʤÞʢʦéãäʡʦäʡàçðʣʦäʥãçãçß èʤÞðôÞåʢçãóʝʕʠʝʧʥʤàʦéÞʢççãäʤÞèʥʤÝʡçàʡ; =ʒʡäèʥʡÞãåʤ äʡʦäʡàçðʣ ʦäʥãçãçß ʦʤʦéʤãé ãâ ʤèʥʢàʢåʢçãô æʧéʡëãã ʤèʥʢàʢåʢçãô ʧʥʤÞçô åãèãàʤÞ ã çʡåãìãôÞðôÞåʢççʤʣæʧéʡëããʧʥʤàʦéÞʢççãäʤÞ ʣã ʣåãçããʥʤàʦéÞʡ;ą= ʔʥʡìʧʦåʢàʧʢéʤÝʦʧàãéñʦèʡëãʢçéʤæçʢʤÝʨʤàãæʤʦéñʤèʤÞʢîʢçãôʢßʤʦʢæñãʤÞðôÞåʢççʤæâʡÝʤåʢÞʡçãôãʤèʤʦåʢàʦéÞãôʨàåôãʨâàʤʥʤÞñôÞʦåʧìʡôʨçʢʦÞʤʢÞʥʢæʢççʤʣàãʡßçʤʦéãäããéʢʥʡèãã;= ÍʢéãʦèʤàʤâʥʢçãʢæçʡßʢʝʕʠʝàʤåáçðÝðéñʤÝʦåʢàʤÞʡçðäʡäæʤáçʤʥʡçñíʢ èʥʢàèʤìéãéʢåñçʤÞÞʤâʥʡʦéʢʤéàʤåʢé;ą=ʝëʢåñóʤÝçʡʥʧáʢçãôʝʕʠʝ Þ àʢéʦäʤæ Þʤâʥʡʦéʢ ʧ àʢéʢʣ ʤàãç ãåã àÞʡ ʥʤàãéʢåô äʤéʤʥðʨ ʦéʥʡàʡóé ʝʕʠʝ ʦåʢàʧʢé ʥʡʦʦæʤéʥʢéñ éʥã ʦéʥʡéʢßãã äʡʦäʡàçðʣ ʦäʥãçãçß ʧçãÞʢʥʦʡåñçðʣ ʦäʥãçãçß çʡ ʤʦçʤÞʡçãã êʢçʤéãèãìʢʦäãʨ ãâæʢçʢçãʣ ãåã ʦʢåʢäéãÞçðʣ ʦäʥãçãçß çʡ ʤʦçʤÞʡçãôÞðôÞåʢçãôʧʥʤàʦéÞʢççãäʤÞæʧéʡëãã äʤéʤʥʡôʤÝçʡʥʧáʢçʡʧèʥʤÝʡçàʡ ; =ʔʥʡâçðʨʦéʥʡçʡʨãʦèʤåñâʧóéʦôʥʡâåãìçðʢʦéʥʡéʢßãã ʤʦçʤÞʡççðʢ çʡ ʦéʡçàʡʥéʡʨ æʢàãäʤ ʦʡçãéʡʥçʤʣ èʤæʤîã ã ʥʢäʤæʢçàʡëãôʨ òäʦèʢʥéʤÞ ʔ ʥôàʢ ʢÞʥʤèʢʣʦäãʨʦéʥʡçãʓÞʦéʥʡåããäʡʦäʡàçðʣʦäʥãçãçßèʥʤÞʤàôéçʡʤʦçʤÞʢßʢçʢéãìʢʦäʤßʤéʢʦéãʥʤÞʡçãô; = éʤßàʡäʡäÞʝÕʓʧàʢéʢʣʦ åʢéçʢßʤÞʤâʥʡʦéʡ èʥʤÞʤàãéʦôʦʢåʢäéãÞçðʣʦäʥãçãçß ʡÞÞʤâʥʡʦéʢąåʢéąʧçãÞʢʥʦʡåñçðʣʦäʥãçãçß ; = ÒçãÞʢʥʦʡåñçðʣ ʦäʥãçãçß áʢåʡéʢåñçʤ èʥʤÞʤàãéñ àʤ àʤʦéãáʢçãô èʤåʤÞʤʣâʥʢåʤʦéã ìéʤèʥʡäéãäʧʢéʦô çʡèʥãæʢʥ ÞʝåʤÞʢçãããÞÜèʤçãã çʤʥʢçéʡÝʢåñçʤʦéñàʡççʤʣʦéʥʡéʢßããʤʦéʡʢéʦôçʢãâÞʢʦéçʤʣ;= ʝåʢàʧʢéèʤàìʢʥäçʧéñ ìéʤÞçʡʦéʤôîʢʢÞʥʢæôʤèʥʢàʢåʢçãʢʚʠʝãʢßʤêʥʡäëãʣ çʢÞʨʤàãéÞʦéʡçàʡʥéðʤÝʦåʢàʤÞʡçãôàʢéʢʣ ʨʤéôçʢʤÝʨʤàãæʤʦéñèʥʤÞʢàʢçãôéʡäʤßʤʡçʡåãâʡʤìʢÞãàçʡÌʤåʢʢéʤßʤ ÞʜʤʦʦããàʤçʡʦéʤôîʢßʤÞʥʢæʢçãʤéʦʧéʦéÞʧóé ʦéʡçàʡʥéãâãʥʤÞʡççðʢèʤèʤåʧãÞʤâʥʡʦéʧʥʢêʢʥʢçʦçðʢâçʡìʢçãôʠʝÑʙʛ ÑʖÔʖʙÐʖʝʖʘʖʗʙʚʗʕÐʛʖʜʠʚÑʖʝʞʖʜÐʙʖʘÐÐ Ñʢìʢçãʢ Ýʤåñçðʨ ʦ ʝʕʠʝ åʧìíʢ çʡìãçʡéñ Þ ʦèʢëãʡåãâãʥʤÞʡççðʨ ʦéʡëãʤçʡʥʡʨ ãæʢóîãʨʤèðéÞʢàʢçãôéʡäãʨÝʤåñçðʨʔåóÝʤæʦåʧìʡʢçʢʤÝʨʤàãæʤʤèʥʢàʢåãéñʦô ʦ èʥʤßçʤâʤæ çʡåãìãʢæ àʤèʤåçãéʢåñçðʨ êʡäéʤʥʤÞ ʥãʦäʡ äʧʥʢçãʢ ʤáãʥʢçãʢ ʧʥʤÞʢçñÑèʡ ãʦʤèʧéʦéÞʧóîãʨâʡÝʤåʢÞʡçãʣʓʕ ʝÍ ʠÌʛʛʡëãʢçéð ʦ ʝʕʠʝ àʤåáçð ʦéʥʤßʤ ʦåʢàʤÞʡéñ Þʦʢæ ʥʢäʤæʢçàʡëãôæ èʤ çʢæʢàãäʡæʢçéʤâçʤʣ 103 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ éʢʥʡèããʦʤÝåóàʢçãʢàãʢéð èʥʢäʥʡîʢçãʢäʧʥʢçãô èʤÞðíʢçãʢʧʥʤÞçôêãâãìʢʦäʤʣ ʡäéãÞçʤʦéã èʥã Þʤâæʤáçʤʦéã äʤçéʥʤåñ Þʢʦʡ ʚàçʡäʤ òéãʨ æʢʥʤèʥãôéãʣ çʢàʤʦéʡéʤìçʤ àåô ʦçãáʢçãô ʧʥʤÞçô ʨʤåʢʦéʢʥãçʡ àʤ ëʢåʢÞʤßʤ ʧʥʤÞçô ʛʤòéʤæʧ ÞʦʢæÝʤåñçðæçʡâçʡìʡʢéʦôæʢàãäʡæʢçéʤâçʡôéʢʥʡèãôʦʥʢàçãʢãÞðʦʤäãʢàʤâð ʦéʡéãçʤÞʡéʤʥÞʡʦéʡéãçąąæßʦʧé ʥʤâʧÞʡʦéʡéãçąąæßʦʧé ʖʦåãëʢåʢÞʤʣʧʥʤÞʢçñʠʝÑʙʛçʢʧàʡʢéʦôàʤʦéãßçʧéñ ʦåʢàʧʢéàʤÝʡÞãéñòâʢéãæãÝ ÓʢåʢÞðʢʧʥʤÞçãʠʝÑʙʛàåôÝʤåñçðʨʦʝʕʠʝʦʤʦéʡÞåôóé ææʤåñåàåôåãë ʦÐÌʝãàʥʧßãæãäåãçãìʢʦäãæãèʥʤôÞåʢçãôæãʡéʢʥʤʦäåʢʥʤâʡã ææʤåñåąàåô åãë Ýʢâ äåãçãìʢʦäãʨ èʥʤôÞåʢçãʣ ʡéʢʥʤʦäåʢʥʤâʡ ʖʦåã Þ ʦãåʧ äʡäãʨ åãÝʤ èʥãìãçòéãʧʥʤÞçãçʢæʤßʧéÝðéñàʤʦéãßçʧéð ʦåʢàʧʢéʦéʥʢæãéñʦôʦçãâãéñʧʥʤÞʢçñ ʠʝÑʙʛçʡʤéãʦʨʤàçʤßʤâçʡìʢçãôʔçʡʦéʤôîʢʢÞʥʢæôíãʥʤäãʢÞʤâæʤáçʤʦéã àåô òêêʢäéãÞçʤʣ äʤʥʥʢäëãã ßãèʢʥʨʤåʢʦéʢʥãçʢæãã ʧ òéãʨ Ýʤåñçðʨ èʤôÞãåãʦñ ÞʦÞôâãʦèʤôÞåʢçãʢæèʥʢèʡʥʡéʤÞãçßãÝãéʤʥʤÞ0#3+ ßʤéãèʡ ʘʢàãäʡæʢçéʤâçʧó éʢʥʡèãó ʤʦʤÝʢççʤ ʧ æʧáìãç çʢʤÝʨʤàãæʤ çʡìãçʡéñ äʡä æʤáçʤ ʥʡçñíʢ ʦ àʢéʦäʤßʤ Þʤâʥʡʦéʡ ʞʡäʤʣ èʤàʨʤà Þʢàʢé ä ʦçãáʢçãó Þʥʢæʢçã òäʦèʤâãëããßãèʢʥʨʤåʢʦéʢʥãçʢæããʝßèʥʤÞʤàôéʦôãʦʦåʢàʤÞʡçãôèʤèʥãæʢçʢçãóʦéʡéãçʤÞʧàʢéʢʣʦʝʕʠʝÞÞʤâʥʡʦéʢʤéàʤåʢé ʛʥʤÞʢàʢçʤʥʡçàʤæãâãʥʤÞʡççðʨèåʡëʢÝʤ äʤçéʥʤåãʥʧʢæðʨãʦʦåʢàʤÞʡçãʣ ÞäåóìʡÞíãʨèʡëãʢçéʡʝéʡéãçð âçʡìãéʢåñçʤʦçãáʡåãäʤçëʢçéʥʡëãó ʠʝÑʙʛÒʥʤÞçãʓÑʞ ʓʝʞ ʒʟʒ çʢʤéåãìʡåãʦñæʢáàʧʤÝʦåʢàʧʢæʤʣãäʤçéʥʤåñçʤʣßʥʧèèʡæãʘãʤèʡéãôãàʥʧßãʢ èʤÝʤìçðʢôÞåʢçãôçʡÝåóàʡåãʦñʦçʢÝʤåñíʤʣìʡʦéʤéʤʣ ʤàãçʡäʤÞʤʣÞʤÝʢãʨßʥʧèèʡʨʞʡäãæʤÝʥʡâʤæ ÞäʥʡéäʤʦʥʤìçʤʣèʢʥʦèʢäéãÞʢèʥãæʢçʢçãʢʦéʡéãçʤÞʧàʢéʢʣ ʦìãéʡʢéʦôÝʢâʤèʡʦçðæ;=ʒʥʤæʢéʤßʤ ãæʢóéʦôàʡççðʢʤÝʤéçʤʦãéʢåñçʤʣÝʢâʤèʡʦçʤʦéãàʤåßʤʦʥʤìçʤßʤèʥãæʢçʢçãôʦéʡéãçʤÞʧàʢéʢʣʦßʢʝʕʠʝʦåʢé;= ʔʤʦʤÝðʨʦåʧìʡôʨ çʡèʥãæʢʥʧèʡëãʢçéʤÞʦßʤʝʕʠʝ éʢʥʡèãóʦéʡéãçʡæãʦåʢàʧʢé çʡìãçʡéñÞÝʤåʢʢʥʡççʢæÞʤâʥʡʦéʢ;=&$!ʤàʤÝʥʢçʤʦéʡéãçʤÞʡéʤʥÞʡʦéʡéãç ʥʤâʧÞʡʦéʡéãç ʦãæÞʡʦéʡéãç èʥʡÞʡʦéʡéãç åʤÞʡʦéʡéãç êåʧÞʡʦéʡéãç àåôʦçãáʢçãô èʤÞðíʢççʤßʤʧʥʤÞçôʠʝÑʙʛʧàʢéʢʣåʢéãʦéʡʥíʢ; =ʒʡäèʥʡÞãåʤ ʦéʡéãçð Þʦʥʢàçãʨàʤâʡʨąæß ʦçãáʡóéʧʥʤÞʢçñʠʝÑʙʛçʡą;=ʜôàʡÞéʤʥʤÞ ʥʢäʤæʢçàʧʢéãʦèʤåñâʤÞʡéñʧàʢéʢʣäʤæÝãçãʥʤÞʡççʧóßãèʤåãèãàʢæãìʢʦäʧóéʢʥʡèãóąʦéʡéãçðÞʦʤìʢéʡçããʦʦʢäÞʢʦéʥʡçéʡæãáʢåìçðʨäãʦåʤé; = ʡèʥãçʡåãìããʤéôßʤîʢççʤßʤʦʢæʢʣçʤßʤʡçʡæçʢâʡãàʥʧßãʨêʡäéʤʥʤÞʥãʦäʡąèʥʤÞʤàãéñÝʤåʢʢ ãçéʢçʦãÞçʧóßãèʤåãèãàʢæãìʢʦäʧóéʢʥʡèãó; ą= ʝʢäÞʢʦéʥʡçéðáʢåìçðʨäãʦåʤéäʤåʢʦʢÞʢåʡæ ʨʤåʢʦéãʥʡæãç äʤåʢʦéãèʤå ʦçãáʡóé ʧʥʤÞʢçñ ʠʝÑʙʛ çʡ ą çʤ éʢʥʡèãô ʨʤåʢʦéãʥʡæãçʤæ ã äʤåʢʦéãèʤåʤæ ʦÞôâʡçʡʦèʤÝʤìçðæãôÞåʢçãôæãʦʤʦéʤʥʤçðáʢåʧàʤìçʤ äãíʢìçʤßʤéʥʡäéʡ; =ʞʢʥʡèãôäʤåʢʦʢÞʢåʡæʤæèʢʥʢçʤʦãéʦôåʧìíʢãèʤòéʤæʧæʤáʢéçʡâçʡìʡéñʦô àʢéôæÞäʡìʢʦéÞʢæʤçʤéʢʥʡèãããÞäʤæÝãçʡëããʦʤʦéʡéãçʡæã;=ʛʥãæʢçʢçãʢ òâʢéãæãÝʡʧàʢéʢʣçʢʤàʤÝʥʢçʤ&$!ʙʡʦʢßʤàçôíçãʣàʢçñçʢéʥʡçàʤæãâãʥʤÞʡççðʨ èåʡëʢÝʤ äʤçéʥʤåãʥʧʢæðʨ ãʦʦåʢàʤÞʡçãʣ åʢìʢçãô ßʤʝʕʠʝ ʧ àʢéʢʣ ʚàçʡäʤ 104 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ ʤʦçʤÞðÞʡôʦñçʡʤèðéʢòäʦèʢʥéʤÞ ʧèʡëãʢçéʤÞʦßʤʝʕʠʝʦåʢàʧʢéèʥãæʢçôéñÞðʦʤäãʢàʤâðʦãåñçʤàʢʣʦéÞʧóîãʨʦéʡéãçʤÞãèʥãçʢʤÝʨʤàãæʤʦéãàʤèʤåçôéñæʢàãäʡæʢçéʤâçʧóéʢʥʡèãóòäʦéʥʡäʤʥèʤʥʡåñçðæʡêʢʥʢâʤæÑʙʛ ʔ èʤʦåʢàçãʢ ßʤàð Þ ʦÞôâã ʦ Þðʨʤàʤæ ãçßãÝãéʤʥʤÞ 0#3+ ą ßãèʤåãèãàʢæãìʢʦäãʨèʥʢèʡʥʡéʤÞʦèʥãçëãèãʡåñçʤçʤÞðææʢʨʡçãâæʤæàʢʣʦéÞãôąèʤôÞãåãʦñ çʤÞðʢÞʤâæʤáçʤʦéãàåôòêêʢäéãÞçʤʣéʢʥʡèããèʡëãʢçéʤÞʦʝʕʠʝʛʥʢèʡʥʡéòÞʤåʤäʧæʡÝąèʢʥÞðʣãʢàãçʦéÞʢççðʣâʡʥʢßãʦéʥãʥʤÞʡççðʣçʡʦʢßʤàçôíçãʣæʤæʢçé ÞʜʟãçßãÝãéʤʥ0#3+ąèʤäʡâʡçäèʥãæʢçʢçãóʧÞâʥʤʦåðʨèʡëãʢçéʤÞäʡäʦßʢéʢʥʤâãßʤéçʤʣ éʡäãßʤæʤâãßʤéçʤʣʝʕʠʝÞäʡìʢʦéÞʢàʤèʤåçʢçãôäêʤçʤÞʤʣéʢʥʡèãã ʦéʡéãçʡæãʦòâʢéãæãÝʤæãåãÝʢâçʢßʤ ʡéʡäáʢÞäʡìʢʦéÞʢæʤçʤéʢʥʡèããʧèʡëãʢçéʤÞʦʝʕʠʝʦçʢèʢʥʢçʤʦãæʤʦéñóòêêʢäéãÞçðʨàʤâʦéʡéãçʤÞʔðʦʤäʡôòêêʢäéãÞçʤʦéñòÞʤåʤäʧæʡÝʡÞʦçãáʢçããʠʝÑʙʛʧèʡëãʢçéʤÞʦßʢʝʕʠʝçʡʦʢßʤàçôíçãʣ àʢçñôÞåôʢéʦôçʢàʤʦéãáãæʤʣʦèʤæʤîñóʦéʡçàʡʥéçʤʣéʢʥʡèããʦéʡéãçʡæãòâʢéãæãÝʤæʛʥãòéʤæèʥʤêãåñÝʢâʤèʡʦçʤʦéãòÞʤåʤäʧæʡÝʡèʤåçʤʦéñóʦʥʡÞçãæʦèåʡëʢÝʤ;= ʔʤéçʤíʢçããʢîʢÝʤåʢʢʦåʤáçðʨÞÞʢàʢçããèʡëãʢçéʤÞąʦßʤæʤâãßʤéçʤʣʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣßʤʝʕʠʝ ąòÞʤåʤäʧæʡÝèʤäʡâʡçäçʡâçʡìʢçãóʧáʢ ʦ åʢé Þ àʤâʢ æß èʤàäʤáçʤ ʥʡâ Þ çʢàʢåã ãåã ʥʡâ Þ æʢʦôë ʒåãçãìʢʦäʤʢ ãʦʦåʢàʤÞʡçãʢ 4%3,! " èʥʤÞʤàãæʤʢ ʧ Ýʤåñçðʨ ʦ ßʤʝʕʠʝ èʥʤàʢæʤçʦéʥãʥʤÞʡåʤ ÞðʦʤäʧóòêêʢäéãÞçʤʦéñòÞʤåʤäʧæʡÝʡÞʦçãáʢçããʠʝÑʙʛàʡáʢʧéʡäãʨ çʡãÝʤåʢʢéôáʢåðʨèʡëãʢçéʤÞçʡ èʤʦʥʡÞçʢçãóʦéʢʥʡèãʢʣèåʡëʢÝʤ ;=ʞʡäãæ ʤÝʥʡâʤæ èʥʢèʡʥʡéðçʤÞʤßʤèʤäʤåʢçãôçʡʤʦçʤÞʢæʤçʤäåʤçʡåñçðʨʡçéãéʢåąãçßãÝãéʤʥʤÞ 0#3+ èʥʤôÞåôóé çʡãÝʤåñíʧó òêêʢäéãÞçʤʦéñ Þ ʦçãáʢçãã ʠʝÑʙʛ èʤ ʦʥʡÞçʢçãó ʦ àʥʧßãæã àʤʦéʧèçðæã ʦéʡçàʡʥéçðæã èʥʢèʡʥʡéʡæã ã ôÞåôóéʦô èʢʥʦèʢäéãÞçðæãàʤåßʤáàʡççðæéʢʥʡèʢÞéãìʢʦäãæʥʢíʢçãʢæäʡäàåôèʡëãʢçéʤÞ ʦßʢʝʕʠʝ éʡäãàåôçʡãÝʤåʢʢéôáʢåðʨèʡëãʢçéʤÞʦßʤʝʕʠʝ Îʢçîãçʡæ ʦ ʝʕʠʝ Þ äʡìʢʦéÞʢ æʢéʤàʡ äʤçéʥʡëʢèëãã ʥʢäʤæʢçàʧʢéʦô èʥãæʢçôéñʤʥʡåñçðʢäʤçéʥʡëʢèéãÞð ʦʤàʢʥáʡîãʢòʦéʥʤßʢçÞæʡåðʨàʤâʡʨ; =ʔʤ ÞʥʢæôÝʢʥʢæʢççʤʦéããÞèʢʥãʤàåʡäéʡëããçʢʥʢäʤæʢçàʧʢéʦôèʥãçãæʡéñʦéʡéãçð ãàʥʧßãʢßãèʤåãèãàʢæãìʢʦäãʢʦʥʢàʦéÞʡãâ âʡãʨÞʤâæʤáçʤßʤéʢʥʡéʤßʢççʤßʤàʢʣʦéÞãô;=ʝåʢàʧʢéãæʢéñÞÞãàʧ ìéʤÞéʢìʢçãʢêãâãʤåʤßãìʢʦäãèʥʤéʢäʡóîʢʣ ÝʢʥʢæʢççʤʦéãʧʥʤÞçãʠʝãʞʕèʤÞðíʡóéʦô ìéʤʦÞôâʡçʤʦàʢʣʦéÞãʢæòʦéʥʤßʢçʡ ã èʥʤßʢʦéʢʥʤçʡ çʡ æʢéʡÝʤåãâæ åãèʤèʥʤéʢãçʤÞ ;= ʚàçʡäʤ òéʤ èʤÞðíʢçãʢ ôÞåôʢéʦôêãâãʤåʤßãìʢʦäãæãçʢʦʤèʥôáʢçʤʦʥãʦäʤæʝʝʚʝʤßåʡʦçʤàʡççðæãʦʦåʢàʤÞʡçãô ʧʥʤÞʢçñ ʤÝîʢßʤ ʨʤåʢʦéʢʥãçʡ Þʤ Þʥʢæô Ýʢʥʢæʢççʤʦéã èʤÞðíʡʢéʦô çʡ Ñʙʛąçʡ Ñʔʛąçʡ;= ʕʤʝʕʠʝ ôÞåôʢéʦô âʡÝʤåʢÞʡçãʢæ äʤéʤʥʤʢ èʥʢàʦéʡÞåôʢé ʧßʥʤâʧ àåô æʡéʢʥã ã èåʤàʡ Úäʦèʢʥãæʢçéð çʡ áãÞʤéçðʨ ã ãʦʦåʢàʤÞʡçãô çʡ åóàôʨ èʤäʡâʡåã ìéʤ Þðʦʤäãʣ ʧʥʤÞʢçñ æʡéʢʥãçʦäʤßʤ ʨʤåʢʦéʢʥãçʡ èʥãÞʤàãé ä çʢàʤʦéʡéʤìçʤʦéã æʡéʤìçʤ èåʡëʢçéʡʥçʤßʤäʥʤÞʤʤÝʥʡîʢçãô ìéʤʧÞʢåãìãÞʡʢéʥãʦäéʡäãʨʤʦåʤáçʢçãʣ 105 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ àåô æʡéʢʥã ã èåʤàʡ äʡä âʡàʢʥáäʡ ʥʡâÞãéãô èåʤàʡ èʥʢòäåʡæèʦãô ã èʥʢáàʢÞʥʢæʢççðʢʥʤàð; =ʙʢäʤéʤʥðʢʦèʢëãʡåãʦéðʥʡʦʦæʡéʥãÞʡóéßʤʝʕʠʝäʡä èʥʤéãÞʤèʤäʡâʡçãʢ ä Ýʢʥʢæʢççʤʦéã ;= ʔ çʡʦéʤôîʢʢ Þʥʢæô çʢé äʡäãʨ åãÝʤ ʤèʥʢàʢåʢççðʨʥʢäʤæʢçàʡëãʣèʤÞʢàʢçãóÝʢʥʢæʢççðʨʦʝʕʠʝÌʢʥʢæʢççðæʦåʢàʧʢé ʦäʤʥʥʢäéãʥʤÞʡéñ àãʢéʧ ʤéäʡâʡéñʦô ʤé äʧʥʢçãô Ðâ èʥʢèʡʥʡéʤÞ Þʤâæʤáʢç èʥãʢæ ʦʢäÞʢʦéʥʡçéʤÞ áʢåìçðʨ äãʦåʤé ʨʤéô ʦʧîʢʦéÞʧʢé Þʢʥʤôéçʤʦéñ ʥʡâÞãéãô àʢêãëãéʡ æʡéʢʥãçʦäãʨ áãʥʤʥʡʦéÞʤʥãæðʨ ÞãéʡæãçʤÞ Þ éʤæ ìãʦåʢ Þãéʡæãçʡ ʒ ;= Ìʢâʤèʡʦçðæ èʥʢèʡʥʡéʤæ àåô äʤçéʥʤåô ßãèʢʥʨʤåʢʦéʢʥãçʢæãã Þ èʢʥãʤà ÝʢʥʢæʢççʤʦéããåʡäéʡëããôÞåôʢéʦôʦʢäÞʢʦéʥʡçéáʢåìçðʨäãʦåʤéąäʤåʢʦʢÞʢåʡæ ;=ʔʦåʧìʡôʨÝʢʥʢæʢççʤʦéãÞʦʤìʢéʡçããʦßʤæʤâãßʤéçʤʣʝʕʠʝÞʤâæʤáçʤèʥʤÞʢàʢçãʢʡêʢʥʢâʡÑʙʛÚéʤéÞãàéʢʥʡèããÞçʡãæʢçñíʢʣʦéʢèʢçãʦÞôâʡçʦʥʡâÞãéãʢæèʤÝʤìçðʨôÞåʢçãʣ; ą=ʚèãʦʡçðʢàãçãìçðʢʦåʧìʡãʧàʡìçðʨʥʤàʤÞʧÝʤåñçðʨʦßʤæʤ ãßʢéʢʥʤâãßʤéçðæãêʤʥæʡæãʝʕʠʝ äʤéʤʥðæèʥʤÞʤàãåãʦñ èʥʤëʢàʧʥð ʡêʢʥʢâʡ Ñʙʛ ; = ʓçʡåʤßãìçðʢ àʡççðʢ Ýðåã èʤåʧìʢçð èʥã ãʦʦåʢàʤÞʡçãã æʤàʢåã ʝʕʠʝ çʡ áãÞʤéçðʨ ʦÞãàʢéʢåñʦéÞʧóîãʢ ʤÝ ʧÞʢåãìʢçãã ʡäéãÞçʤʦéãÑʙʛ ʥʢëʢèéʤʥʤÞÞʤÞʥʢæôÝʢʥʢæʢççʤʦéã;=ʔæʢʦéʢʦéʢæçʢåñâô âʡÝðÞʡéñ ìéʤʡêʢʥʢâÑʙʛæʤáʢéʤʦåʤáçãéñʦôÞðʥʡáʢççʤʣßãèʤéʤçãʢʣãʤÝæʤʥʤäʤæ;=ʛʥãçôéãʢʥʢíʢçãôʤèʥʤÞʢàʢçããʡêʢʥʢâʡÑʙʛÞʤÞʥʢæôÝʢʥʢæʢççʤʦéãæʤáʢéÝðéñèʥãçôéʤéʤåñäʤèʤʦåʢèʤåʧìʢçãôãçêʤʥæãʥʤÞʡççʤßʤʦʤßåʡʦãô èʤʦåʢʤÝʦʧáàʢçãôʦʤʦèʢëãʡåãʦéʡæã ãæʢóîãæãʤèðéÞʢàʢçãôéʡäãʨèʡëãʢçéʤä ;=Îʢçîãçðʦʝʕʠʝ èʤ Þãàãæʤæʧ çʢãæʢóéÝʤåʢʢÞðʦʤäʤßʤʥãʦäʡèʥʢáàʢÞʥʢæʢççðʨʥʤàʤÞãåãʥãʦäʡʥʤáàʢçãôàʢéʢʣʦçãâäʤʣæʡʦʦʤʣéʢåʡ ʡéʡäáʢèʤʥʤäʡæãʥʡâÞãéãô ìʢæâàʤʥʤÞðʢáʢçîãçð ÚʒʝʞʜʓʒʚʜʛʚʜʓÑÙʙØʖʘʖʞʚÍØʔʞʖʜʓʛÐÐÍÐʝÑÐʛÐÍʖʘÐʗ ÍåôåʢìʢçãôéôáʢåðʨêʤʥæÍÑʛ ßåʡÞçðæʤÝʥʡâʤæßʤæʤâãßʤéçʤʣêʤʥæðʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãã èʥãæʢçôóéʦôòäʦéʥʡäʤʥèʤʥʡåñçðʢæʢéʤàð éʡäãʢ äʡä ãææʧçʤʦʤʥÝëãô Ñʙʛ äʡʦäʡàçʡô èåʡâæʤêãåñéʥʡëãô èåʡâæʤʦʤʥÝëãô ßʢæʤʦʤʥÝëãô èʥʢëãèãéʡëãôÑʙʛßʢèʡʥãçʤæ ʙʡãÝʤåʢʢʦèʢëãêãìçðæÞãàʤæòäʦéʥʡäʤʥèʤʥʡåñçʤʣéʢʥʡèãã çʡèʥʡÞåʢççðæ éʤåñäʤ çʡ ʧàʡåʢçãʢ ʡéʢʥʤßʢççðʨ Ñʙʛ ôÞåôʢéʦô ãææʧçʤʦʤʥÝëãô ʡêʢʥʢâ Ñʙʛ ;= ʔʤ Þʥʢæô òéʤʣ èʥʤëʢàʧʥð äʥʤÞñ ʥʡâàʢåôʢéʦô Þ ëʢçéʥãêʧßʢ çʡ òʥãéʥʤëãéðãèåʡâæʧʛåʡâæʡèʥʤéʢäʡʢéèʤʤìʢʥʢàçʤìʢʥʢâãææʧçʤʦʤʥÝëãʤççðʢäʤåʤçäã ÞäʤéʤʥðʨèʥʤãʦʨʤàãéʦÞôâðÞʡçãʢÑʙʛʤìãîʢççʡôʤéÑʙʛèåʡâæʡʦʦʤʨʥʡçʢççðæãÞçʢʣÝʢåäʡæã êʢʥæʢçéʡæã ßʤʥæʤçʡæã Þãéʡæãçʡæã ÑʔʛÞʤâÞʥʡîʡʢéʦô èʡëãʢçéʧÞæʢʦéʢʦòʥãéʥʤëãéʡæã ʛʥʤëʢàʧʥðèʥʤÞʤàôéʦãçéʢʥÞʡåʤæʥʡâÞçʢàʢåóʧÝʤåñçðʨʦßʤæʤâãßʤéçʤʣ ʕʠʝãąʥʡâʡÞæʢʦôëąʧÝʤåñçðʨʦßʢéʢʥʤâãßʤéçʤʣʕʠʝÌʤåñçðʢàʤåáçðçʡʨʤàãéñʦôçʡæʡäʦãæʡåñçʤèʢʥʢçʤʦãæʤʣàʤâʢʦéʡéãçʤÞòéʤçʢʤÝʨʤàãæʤʢʧʦåʤÞãʢ 106 ʛʥʤêãåʡäéãäʡãåʢìʢçãʢʡéʢʥʤʦäåʢʥʤâʡãàãʦåãèãàʢæãʣ àåôèʤààʢʥáʡçãôéʥʢÝʧʢæʤßʤʧʥʤÞçôʠʝÑʙʛãçãÞʢåãʥʤÞʡçãôòêêʢäéʡʥãäʤíʢéʡ äʤéʤʥðʣ èʥʤôÞåôʢéʦô ʥʢâäãæ èʤÞðíʢçãʢæ ʧʥʤÞçô ʠʝÑʙʛ Þ Ýåãáʡʣíʢʢ Þʥʢæô èʤʦåʢ âʡÞʢʥíʢçãô ãææʧçʤʦʤʥÝëãã ʚèðé èʤäʡâðÞʡʢé ìéʤ Þ ʥʢâʧåñéʡéʢ àåãéʢåñçʤßʤèʥʤÞʢàʢçãôãææʧçʤʦʤʥÝëããʧʥʤÞʢçñʠʝÑʙʛʦçãáʡʢéʦôçʡą çʡʥôàʧʦòéãæçʤʥæʡåãâʧóéʦôʧʥʤÞçãêãÝʥãçʤßʢçʡãʝʜÌ ʦçãáʡʢéʦôÞôâäʤʦéñ äʥʤÞã Ò Ýʤåñçðʨ äʤéʤʥðæ èʥʤÞʤàãåã ãææʧçʤʦʤʥÝëãó Ñʙʛ çʡÝåóàʡåã ʥʢßʥʢʦʦãó äʤáçðʨ äʦʡçéʤæ ʧæʢçñíʢçãʢ ìãʦåʡ èʥãʦéʧèʤÞ ʦéʢçʤäʡʥàãã èʤÞðíʢçãʢéʤåʢʥʡçéçʤʦéãäêãâãìʢʦäʤʣçʡßʥʧâäʢʛʥʤÞʢàʢççðʢʡçßãʤßʥʡêãìʢʦäãʢ ãʦʦåʢàʤÞʡçãô ʦ èʥãæʢçʢçãʢæ æʢéʤàʡ ʦʢåʢäéãÞçʤʣ äʤʥʤçʡʥʤßʥʡêãã èʤäʡâʡåã ʦéʡÝãåãâʡëãó ʡ Þ ʤéàʢåñçðʨ ʦåʧìʡôʨ ã ʥʢßʥʢʦʦãó ʡéʢʥʤʦäåʢʥʤéãìʢʦäãʨ Ýåôíʢä;= Ìʤåñçðʢ ʨʤʥʤíʤ èʢʥʢçʤʦôé èʥʤëʢàʧʥð ʡêʢʥʢâʡ Ñʙʛ ãâ èʤÝʤìçðʨ ôÞåʢçãʣ ÞʥʢàäãʨʦåʧìʡôʨçʡÝåóàʡåãòèãâʤàðßãèʤéʤçãã ʤâçʤÝð ßãèʢʥʢæãóäʤáçðʨèʤäʥʤÞʤÞ äʤéʤʥðʢåãÝʤèʥʤʨʤàãåãÝʢâÞæʢíʡéʢåñʦéÞʡ åãÝʤäʧèãʥʤÞʡåãʦñçʡâçʡìʢçãʢæʦéʡçàʡʥéçðʨàʤâàʢʦʢçʦãÝãåãâãʥʧóîãʨèʥʢèʡʥʡéʤÞ ʚèðé àåãéʢåñçʤßʤ èʥʤÞʢàʢçãô ãææʧçʤʦʤʥÝëãã Ñʙʛ ʧ àʢéʢʣ ʦ ßʤæʤâãßʤéçʤʣ êʤʥæʤʣ ʝʕʠʝ èʤäʡâðÞʡʢé ʤéʦʧéʦéÞãʢ äʡäãʨ åãÝʤ ʤéäåʤçʢçãʣ Þ ãʨ ʧæʦéÞʢççʤæ ãêãâãìʢʦäʤæʥʡâÞãéãã ãâæʢçʢçãʣÞßʤʥæʤçʡåñçðʨ Ýãʤʨãæãìʢʦäãʨãßʢæʡéʤåʤßãìʢʦäãʨèʤäʡâʡéʢåôʨ;= 107 Ïʡäåóìʢçãʢ ÏʓʒÑÛÔʖʙÐʖ ʔ çʡʦéʤôîʢʢ Þʥʢæô ʤÝîʢãâÞʢʦéçʤ ìéʤ èʥãìãçʤʣ ÝʤåñíãçʦéÞʡ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣôÞåôʢéʦôʡéʢʥʤʦäåʢʥʤâʚàçʡäʤèʤÞåãôéñçʡêʤʥæãʥʤÞʡçãʢ ʥʡâÞãéãʢãéʢìʢçãʢòéãʨâʡÝʤåʢÞʡçãʣçʢåñâô çʢÞʤâàʢʣʦéÞʧôçʡʤʦçʤÞçʤʢ ãʨ èʡéʤßʢçʢéãìʢʦäʤʢ âÞʢçʤ ą àãʦåãèãàʢæãó Ïʡ èʤʦåʢàçãʢ ßʤàð Þ àãʡßçʤʦéãäʢ ãéʢʥʡèããʡéʢʥʤʦäåʢʥʤâʡàʤʦéãßçʧéðâçʡìãéʢåñçðʢʧʦèʢʨãÒʦʤÞʢʥíʢçʦéÞʤÞʡçð Ýãʤʨãæãìʢʦäãʢ ãææʧçʤåʤßãìʢʦäãʢ ãçʦéʥʧæʢçéʡåñçðʢ ã ßʢçʢéãìʢʦäãʢ æʢéʤàð àãʡßçʤʦéãäãʙʡʦéʤôîãʣèʥʤʥðÞèʥʤãâʤíʢåÞʥʡâʥʡÝʤéäʢèʥãçëãèãʡåñçʤçʤÞðʨ åʢäʡʥʦéÞʢççðʨʦʥʢàʦéÞçʡʤʦçʤÞʢæʤçʤäåʤçʡåñçðʨʡçéãéʢå ßʢççʤ ãçáʢçʢʥçðʨ äʤçʦéʥʧäëãʣÚéãèʥʢèʡʥʡéðʤÝʢîʡóéÞçʢʦéãÞäåʡàÞʦçãáʢçãʢʦʢʥàʢìçʤ ʦʤʦʧàãʦéʤʣâʡÝʤåʢÞʡʢæʤʦéããʦæʢʥéçʤʦéã Þéʤæìãʦåʢʥʢâãàʧʡåñçʤʣ äʤéʤʥʡôÞçʡʦéʤôîʢʢÞʥʢæôʦʤʨʥʡçôʢéʦô çʢʦæʤéʥôçʡʤìʢÞãàçðʢʧʦèʢʨãéʢʥʡèããʦéʡéãçʡæã êãÝʥʡéʡæããòâʢéãæãÝʤæ ʚʦçʤÞçʡôèʥʤÝåʢæʡÞåʢìʢçããâʡÝʤåʢÞʡçãʣ ÞðâÞʡççðʨʡéʢʥʤʦäåʢʥʤâʤæ ʦʤʦéʤãéÞéʤæ ìéʤìʡîʢÞʦʢßʤåʢìʢçãʢçʡìãçʡóééʤåñäʤèʥãèʤôÞåʢçããäåãçãìʢʦäãʨ ʦãæèéʤæʤÞʔìʡʦéçʤʦéã äʤʥʥʢäëãôʤʦçʤÞçðʨêʡäéʤʥʤÞʥãʦäʡçʡìãçʡʢéʦôåãíñ èʥãèʤôÞåʢçããʦéʢçʤäʡʥàãããåãʚʒʝ ÞéʤáʢÞʥʢæôèʡëãʢçéðʦçʡìʡåñçðæʡéʢʥʤʦäåʢʥʤâʤæäʤʥʤçʡʥçðʨ ʦʤççðʨ èʢʥãêʢʥãìʢʦäãʨʡʥéʢʥãʣçãáçãʨäʤçʢìçʤʦéʢʣ ÞʤæçʤßãʨʦåʧìʡôʨʤʦéʡóéʦôçʢàʤʤÝʦåʢàʤÞʡççðæããçʢèʤåʧìʡóéʥʢäʤæʢçàʡëãʣ èʤãâæʢçʢçãóʤÝʥʡâʡáãâçããèʥãʢæʧçʢʤÝʨʤàãæðʨèʥʢèʡʥʡéʤÞ ʔ ëʢåʤæ èʥʤÝåʢæʡ èʥʤêãåʡäéãäã ã åʢìʢçãô ʡéʢʥʤʦäåʢʥʤâʡ ʤʦéʡʢéʦô äʥʡʣçʢ ʡäéʧʡåñçʤʣ ã æçʤßãʢ ʡʦèʢäéð òêêʢäéãÞçʤʣ èʥʤêãåʡäéãäã ʡéʢʥʤʦäåʢʥʤâʡ çʢ çʡíåã àʤåáçʤßʤ ʥʡâʥʢíʢçãô èʤ ʦʢßʤàçôíçãʣ àʢçñ ʞʢæ çʢ æʢçʢʢ Þðèʤåçʢçãʢ ʥʢäʤæʢçàʡëãʣ ã ãʦèʤåñâʤÞʡçãʢ Þʦʢʨ ʦʥʢàʦéÞ ʧáʢ ãæʢóîãʨʦô Þ ʡʥʦʢçʡåʢ Þʥʡìʡ èʤâÞʤåôóéâçʡìãéʢåñçʤʦçãâãéñâʡÝʤåʢÞʡʢæʤʦéñãʦæʢʥéçʤʦéñʤéʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨÝʤåʢâçʢʣ ÞʤʦçʤÞʢäʤéʤʥðʨåʢáãéʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʢèʤʥʡáʢçãʢ ʡʥéʢʥãʡåñçʤßʤʥʧʦåʡ ʚʦçʤÞçðʢèʤåʤáʢçãô ą ʛʥãʤëʢçäʢéôáʢʦéãʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʥʤëʢʦʦʡàʡççðʢʤʦéʡÝãåñçʤʦéãʓʝÌ çʢæʢçʢʢÞʡáçð ìʢæàʡççðʢʤÞðʥʡáʢççʤʦéãʦéʢçʤâʤÞʡʥéʢʥãʣ ą ʛʢʥÞðæèʥʤôÞåʢçãʢæÐÌʝæʤáʢéʦéʡéñÐʘãåãäʤʥʤçʡʥçʡôʦæʢʥéñ èʤòéʤæʧåʢìʢçãʢʦåʢàʧʢéèʥʤÞʤàãéñÞâʡÞãʦãæʤʦéãʤéʦéʢèʢçãʥãʦäʡ ʡçʢéʤåñäʤʤéäåãçãìʢʦäʤʣ ʦãæèéʤæʡéãäã ą ʛʢʥÞãìçʡô ßãèʢʥʨʤåʢʦéʢʥãçʢæãô ʦ ʧʥʤÞçʢæ ʚʠʝ ææʤåñå ããåã ʠʝÑʙʛ ææʤåñåæʤáʢéʦÞãàʢéʢåñʦéÞʤÞʡéñʤçʡåãìããʝʕʠʝ 108 Ïʡäåóìʢçãʢ ą ʔʦʢæÝʤåñçðæÐÌʝ ʝÍ))éãèʡ èʢʥʢçʢʦíãæãíʢæãìʢʦäãʣãçʦʧåñé ʦåʢàʧʢéçʡâçʡìʡéñ ʦéʡéãçð èʥã ʤéʦʧéʦéÞãã èʥʤéãÞʤèʤäʡâʡçãʣ ä ãʨ èʥãʢæʧ Þçʢ âʡÞãʦãæʤʦéã ʤéãʦʨʤàçʤßʤʧʥʤÞçôʠʝÑʙʛ ÞéʤæìãʦåʢãèʥãʢßʤçãâäʤæʧʥʤÞçʢ ą ʛʥʢèʡʥʡéʡæã ʦçãáʡóîãæãʚʠʝãʠʝÑʙʛ ôÞåôóéʦôʦéʡéãçð òâʢéãæãÝãʡçéãéʢåʡ ä0#3+ʘãèʤæʢʥʦʢç åʤæãéʡèãàæʤáçʤçʡâçʡìʡéñéʤåñäʤÝʤåñçðæʦßʤæʤâãßʤéçʤʣʝʕʠʝ ą ʛʥãçʡâçʡìʢçããßãèʤåãèãàʢæãìʢʦäʤʣéʢʥʡèããÞʡáçʤàʤʦéãßçʧéñëʢåʢÞʤßʤʧʥʤÞçô ʠʝÑʙʛ ʡçʢèʥʤʦéʤçʡâçʡìãéñʦéʡéãç ą ʚèéãæʡåñçðæãʦéʡéãçʡæãçʡʦʢßʤàçôíçãʣàʢçñôÞåôóéʦôʡéʤʥÞʡʦéʡéãçãʥʤâʧÞʡʦéʡéãçʙʢʦʧîʢʦéÞʧʢéʦéʡéãçʤÞàåôèʢʥÞãìçʤʣãàåôÞéʤʥãìçʤʣèʥʤêãåʡäéãäã ą ʝéʡéãçðçʢèʤäʡâʡçðÝʤåñçðæʦʦʢʥàʢìçʤʣçʢàʤʦéʡéʤìçʤʦéñó äʥʤæʢéʢʨʦåʧìʡʢÞ äʤßàʡʢʢèʥãìãçʡąÐÌʝ ą ʕãèʤåãèãàʢæãìʢʦäʡôéʢʥʡèãôçʡâçʡìʡʢéʦôèʤáãâçʢççʤ 109 ʛʥãåʤáʢçãô ʛʜÐÑʚÎʖʙÐÜ ʒåʢéäã ãʦéʤìçãäã ʒåʢéäã ëʢåã ʚʦçʤÞçʡôêʧçäëãô Úêêʢäé èʥʤ ʡçéãʡéʢʥʤßʢççðʣ ʛʜÐÑʚÎʖʙÐʖʚʝʙʚʔʙØʖʕÒʘʚʜʓÑÙʙØʖʟʓʒʞʚʜØ ʓʞʖʜʚʕʖʙʖÏʓ Óãéʤäãçð ʝʢæʢʣʦéÞʤʟʙʚ ʥʢëʢèéʤʥʤÞ ʟʙʚ ² ʘÓ ʘʟ ʞ " .+ ʕʘʒ Ñãæêʤéʤäʦãç ² ʞH " ʟʙʚ ³ ʚʦéʢʤèʥʤéʢßʢʥãç ʘʟ Úʒ ʕʘʒ /0' #$, ʝʢæʢʣʦéÞʤÐÑ ÐÑ ² ³ 110 ʞÓ ʞ .+ Úʒ ʕʘʒ ʘÓ ʘʟ ÑãÓ Úʒ ʕʘʒ ʘçʤßãʢ ą ʓäéãÞʡëãôʘÓãʙʟ ʦéãæʧåôëãôÞðʥʡÝʤéäã ÐÑ Ðʟ ´ ʘʘʛ ą ʛʥʤʡèʤèéʤéãìʢʦäãʣ êʡäéʤʥ ą ʜʢßʧåôëãôåãæêʤëãéʡʥçʤßʤʤéÞʢéʡ ą ʙʡʥʧíʢçãʢʥʢßʧåôëãã ßʢçʡ32 ! ʘçʤßãʢ ą ʛʥʤʡèʤèéʤéãìʢʦäãʣ êʡäéʤʥ ʚʦéʢʤäåʡʦéð ą ÐçßãÝãʥʧʢéäʡåñëãêãäʡëãóæʢàãã êʡäéʤʥ ÞʤʦèʡåʢçãôãçʢʦéʡÝãåñçʤʦéãÝåôíäã ʘʟ ÑãÓ .+ ą Ïʡèʧʦäʡʢé4H ʤéÞʢé Úʒ ʕʘʒ ãÞðʥʡÝʤéäʧ 4H ëãéʤäãçʤÞ ą ÒʦãåãÞʡʢéÞðʥʡÝʤéäʧ ʘʘʛ ʘçʤßãʢ ʛʥʤʓ ʛʥʤʓ ʛʥʤʓ ąʘʤîçðʣèãʥʤßʢç èʥʤÞʤʦ- ʛʥʤʓ èʡåãéʢåñçðʣéʥãßßʢʥ ąʓäéãÞʡëãô" 4 ąʓäéãÞʡëãôÚʒ ʕʘʒ ąʓäéãÞʡëãô.+ ąʝéãæʧåôëãôÞðʥʡÝʤéäã %4 ÐÑ #!- ʘʘʛ ʛʥãåʤáʢçãô ą ʓçéʡßʤçãʦéʥʢëʢèéʤʥʡ ʓçéãʓ ÐÑ ą ʝéãæʧåãʥʧʢéÞðʥʡÝʤéäʧ ʛʥʤʓ Ðʟ ´ ą ʚèʤʦʥʢàʧʢé àãêêʢʥʢçëãʥʤÞäʧ 4HÞ4H ą ʓäéãÞãâãʥʧʢé.+ ą ÐÑ ʦÞôâðÞʡóîãʣ ʓçéãʓ Ýʢåʤä ÐÑ ʜʓ Úʒ ÐÑ ʘʟ 4 .+ ÐÑ ʞH ʘʟ ʞ ʔ .+ ÐÑ 4 " ʞʒ ʘʟ ą ÒʦãåãÞʡʢéæãßʥʡëãóʙʟ ą ʓäéãÞãʥʧʢéÞðʥʡÝʤéÚʒ äʧÚʒ- #3& '- #3& 6#!- ʦʢåʢäéãçʤÞ ą ʛʥʤåãêʢʥʡëãô" ã4H äåʢéʤä ą ʛʤàʡÞåʢçãʢ4H ʤèʤʦʥʢàʤÞʡççʤßʤʤéÞʢéʡ ą ʝéãæʧåôëãôʥʤʦéʡ 4H ʞʒ Úʒ Bãàãêêʢʥʢçëãʡëãã ʔ äåʢéʤä ą ʓäéãÞʡëãôʦãçéʢâʡʝʜÌ ʘʟ Úʒ ʕʘʒ 4 " ßʢèʡéʤëãéʡæã ʞ ʞʒ ßʢèʡéʤëãéð ą ʝʤâʥʢÞʡçãʢæʢßʡäʡʥãʤÚʒ ʕʘʒ ëãéʤÞ èʥʤàʧäëãôʞÓ ą ʜʤʦéãàãêêʢʥʢçëãʥʤÞäʡʞ " äåʢéʤä ą ʛʥʤåãêʢʥʡëãôʕʘʒ ą ʜʢßʧåôëãôʡäéãÞʡëãã ÐÑ ãʟʙʚ ² ą ʝéãæʧåãʥʧʢéʦãçéʢâÐÑ ʜʓ ą ÐçßãÝãʥʧʢé32 ! æʡäʥʤêʡßʤÞãʥʢëʢèéʤʥðʟʙʚ ÐÑ ʝÌ Óãéʤäãçð)äåʡʦʦʡ ÐÑ ÐÑ 4H ʞʒ ą ʟʡäéʤʥʥʤʦéʡʞ äåʢéʤä ą ʓäéãÞãâʡëãô.+ äåʢéʤä ą ʝéãæʧåôëãô4REG ʛʥʤʓ ʓçéãʓ ʛʥʤʓ ʓçéãʓ ʓçéãʓ ʛʥʤʓ ʓçéãʓ 111 ʛʥãåʤáʢçãô ÐÑ 4H ÐÑ 4H ÐÑ 4H ą ʛʥʤåãêʢʥʡëãô 4 " ʞʒ ãàãêêʢʥʢçëãʡëãôʞʒ òʤâãçʤêãåð ą ʝéãæʧåôëãôèʥʤàʧäëãã ʙʟ )G% ą ʛʤàʡÞåʢçãʢʡäéãÞʡëãã æʤçʤëãéʤÞ ą ʝéãæʧåôëãôÞðʥʡÝʤéäã 4'& ³æʤçʤëãéʡæã ą ʚèʤʦʥʢàʧʢé 4 ʘʟ àãêêʢʥʢçëãʥʤÞäʧ4H Þ4H ą ʝéãæʧåãʥʧʢéʡäéãÞçʤʦéñ.+ ą ʝéãæʧåãʥʧʢéÞðʥʡÝʤéäʧ Ðʟ ´ ą ʝéãæʧåãʥʧʢéʡèʤèéʤâÚʒ ʘçʤßãʢ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡʘÓ ãʙʟ ą ʜʢßʧåôéʤʥèʥʤÞʤʦèʡåãéʢåñçðʨëãéʤäãçʤÞ ą ʝçãáʢçãʢòäʦèʥʢʦʦãã )#!- ʓçéãʓ ʛʥʤʓ ʛʥʤʓ ʓçéãʓ ʓçéãʓ Óãéʤäãçð))äåʡʦʦʡ Ðʟ ´ ʞH .+ äåʢéäã ʞʒ ʘʟ ÑãÓ .+ äåʢéäã Úʒ ʕʘʒ ÐÑ ʘʟ 4H 4REG " ʞʒ ʘʟ ʞ ʔ 112 ą ʝéãæʧåãʥʧʢé4H ʤéÞʢé ʛʥʤʓ ãÞðʥʡÝʤéäʧ 4H ëãéʤäãçʤÞ ą ʛʤàʡÞåôʢéʦãçéʢâʕʘʒ Þçʢäåʢéʤìçʤßʤæʡéʥãäʦʡ ą ʦéãæʧåãʥʧʢéèʥʤàʧäëãó ʘʘʛ ą ʝéãæʧåãʥʧʢéòäʦèʥʢʦʦãóʡçéãßʢçʤÞ-(# äåʡʦʦʡ)) ą ʘʤîçðʣʡäéãÞʡéʤʥ æʡäʥʤêʡßʤÞ ą Ðçàʧëãʥʧʢéòäʦèʥʢʦʦãó #$ ą ʛʤàʡÞåôʢé4H ʤéÞʢé ʓçéãʓ ą ʛʥʤåãêʢʥʡëãô ãàãêêʢʥʢçëãʡëãô4REG ą ʛʤàʡÞåôʢéÞðʥʡÝʤéäʧ Ðʟ ´ ʛʥãåʤáʢçãô ʠʢæʤäãçðʥʢëʢèéʤʥð ), #8#2 -#0 ##, ##2 ʘÓ Úʒ 4 ʘÓ ʘʟ Úʒ ʙʟ ʞ ʘÓ ʘÓ ʙʟ ʟʥʡäéʡåäãç Úʒ ʘÓ #8#, #8#2 ʘÓ ÑÓ ##,2!.4%3 ##2 4 4 ʘÓ .+ -)& ÑÓ Úʒ ʘʟ ʕʘʒ ʘÓ 4 ##,##2 Íʒ ʞ #8#,#8#2 ʕʘʒ Úʒ ÑÓ #8#,#8#2 Íʒ 4 .+ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ ãʡàßʢâããʘÓ ą ÐçßãÝãʥʧʢéʡàßʢâãó çʢʣéʥʤêãåʤÞ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ ãʡàßʢâããʘÓ ʛʥʤʓ ʓçéãʓ ʛʥʤʓ ą ʜʡʦéÞʤʥãæʡôêʥʡäëãô ʛʥʤʓ êʡäéʤʥʨʢæʤéʡäʦãʦʡʘÓ ã4 ą '!' ʦÞôâʡççʡôêʥʡäëãôêʡäéʤʥʡàßʢâããÑÓ äʡäéãÞãʥʤÞʡççʤæʧ òçàʤéʢåãó ą ʔðáãÞʡçãʢ#$C Íʒ ą ʓçéãʡèʤèéʤéãìʢʦäʤʢ ʓçéãʓ ÞåãôçãʢçʡÑÓ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ ʛʥʤʓ ãʡàßʢâãã4 ʘÓ .+ ą ʛʤàʡÞåôʢéæãßʥʡëãó ʘʟ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ ãʡàßʢâãã4 ʘÓ ʙʟ ą ʓäéãÞʡëãôʦãçéʢâʡ-#0 #!- ʟʙʚ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ4 ą ʛʤàʡÞåôʢéßʤæʢʤʦéʡâ 4REG ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ4 ą ʓçßãʤßʢçʢâ ą ʟʡäéʤʥàãêêʢʥʢçëãʡëããèʥʤßʢçãéʤʥçðʨ äåʢéʤäÞʕʘʒʦéʡÝãåãâʡëãôʓʝÌ ą ʟʡäéʤʥʨʢæʤéʡäʦãʦʡ4 ʛʥʤʓ ʛʥʤʓ ʛʥʤʓ ʓçéãʓ ʛʥʤʓ ʓçéãʓ 113 ʛʥãåʤáʢçãô ʓʦʦʤëããʥʤÞʡççðʢʦäʤʦéçʤʣʦãʦéʢæʤʣ ʞ äåʢéäã ą ʚèʤʦʥʢàʧʢé4H ʤéÞʢé ʛʥʤʓ ą ÒÞʢåãìãÞʡʢéèʥʤàʧäëãó ÐÑ ą ʜʢßʧåôëãôäʡåñëãêãäʡëããÝåôíäã ʘʟ Úʒ ʕʘʒ ʚʦéʢʤäåʡʦéð Íʒ Úʒ ą ʜʢßʧåãʥʧʢé ʛʥʤʓ äʡåñëãêãäʡëãóÝåôíäã ą ʝèʤʦʤÝʦéÞʧʢéÞðáãÞʡçãóÍʒ ą ʝéãæʧåôëãôòäʦèʥʢʦʦãã òçàʤéʢåãʢæ#!- ãʦʢåʢäéãçʤÞ ʓäéãÞãçʓ ʕʘʒ Úʒ ʕʘʒ 4'& ³ ʞÓ ʘʟ 4REG ʘçʤßãʢ ą ʜʢàãêêʢʥʢçëãʡëãô ʓçéãʓ çʢʤãçéãæʡåñçðʨʕʘʒ ʦéʡÝãåãâʡëãôÝåôíäã ą ʝéãæʧåãʥʧʢé ʓçéãʓ êʤʥæãʥʤÞʡçãʢ Þçʢäåʢéʤìçʤßʤæʡéʥãäʦʡ ą ʛʤàʡÞåôʢé.+ ą ʛʤàʡÞåôʢé4H ã4H ʤéÞʢé ą ʝéãæʧåãʥʧʢéʡçßãʤßʢçʢâ ãʥʢèʡʥʡëãó ʚʦéʢʤèʤçéãç /0. ʘʟ Úʒ ʕʘʒ ʚʦéʢʤèʥʤéʢßʢʥãç ʝæÞðíʢ 2!.+,åãßʡçà ʥʢëʢèéʤʥʡą ʡäéãÞʡéʤʥʡ .& ʀ" ʝʢæʢʣʦéÞʤ4'&³ " ʕʘʒ Úʒ ʘʡéʥãäʦçðʢæʢéʡååʤèʥʤéʢãçʡâð ʘʘʛ ʘʟ ʕʘʒ ʘçʤßãʢ ą Íʢßʥʡàʡëãô Þçʢäåʢéʤìçʤßʤæʡéʥãäʦʡ ą Òʦãåʢçãʢʡàßʢâãã æʤçʤëãéʤÞ ą ʓäéãÞãʥʧóéʦãçéʢâʟʙʚ ÐÑ ą ʟʡäéʤʥçʢʦéʡÝãåñçʤʦéã Ýåôíäã Íʥʧßãʢêʡäéʤʥðʥʤʦéʡ '- #3& ʘʟ Úʒ ÑÓ - #3& ʘʟ Úʒ ÑãÓ 114 ʕʢæʡéʤèʤ- ą ʜʤʦéãàãêêʢʥʢçëãʡëãô ßʥʡçʧåʤëãéʤÞãʘʟ òéãìʢʦäãʢ ʦéÞʤåʤÞðʢ ą ʜʤʦéãàãêêʢʥʢçëãʡëãô äåʢéäã ʙʟ ʘʟ ʘʟ ʛʥʤʓ ʛʥʤʓ ʛʥãåʤáʢçãô 0$'& ʞÓ ʘʟ Úʒ ʕʘʒ ʟãÝʥʤÝåʡʦéð ʕʘʒ B&'& ʞʒ ʟãÝʥʤÝåʡʦéð ʕʘʒ 6%'& ʞʒãàʥʧßãʢ Úʒ ą ʛʥʤåãêʢʥʡëãô êãÝʥʤÝåʡʦéʤÞãʕʘʒ æãßʥʡëãôãʨÞãçéãæʧ ą ÒÞʢåãìʢçãʢèʥʤàʧäëãã äʤæèʤçʢçéʤÞ ʦʤʢàãçãéʢåñçʤʣéäʡçã '!' äʤååʡßʢçʡ ą ʛʥʤåãêʢʥʡëãôʕʘʒ ą ʙʢʤÞʡʦäʧåôʥãâʡëãô ą ʟʡäéʤʥʥʤʦéʡ ãæãßʥʡëããÚʒ ą ʙʢʤʡçßãʤßʢçʢâ ? ? ? ÌʢåäãéʢèåʤÞʤßʤíʤäʡ (30 Úʒ ʘçʤßãʢ ą ÏʡèʧʦäʡʧéʤʥʢʡäéãÞçʤßʤ 4 äåʢéʤìçʤßʤʤéÞʢéʡ ą ʝéãæʧåôëãôÞðʥʡÝʤéäã ëãéʤäãçʤÞ ʛʥʤʓ ʘʟąæʡäʥʤêʡßÑÓąåʢʣäʤëãéÑãÓąåãæêʤëãé4 " åãæêʤëãéð4REGąʥʢßʧåôéʤʥçðʣ4 åãæêʤëãé .+ąʢʦéʢʦéÞʢççðʣäãååʢʥ.+ åãæêʤëãé Úʒąòçàʤéʢåãʡåñçʡôäåʢéäʡʕʘʒąßåʡàäʤæðíʢìçʡôäåʢé äʡʙʟąçʢʣéʥʤêãåʞʒąéʧìçʡôäåʢéäʡÍʒąàʢçàʥãéçʡôäåʢéäʡʞÓąéʥʤæÝʤëãé 115 ʛʥãåʤáʢçãô ʛʜÐÑʚÎʖʙÐʖ ʒÑÐʙÐÔʖʝʒÐʖÐʝʝÑʖÍʚʔʓʙÐÜʕÐʛʚÑÐʛÐÍʖʘÐÔʖʝʒʚʗʞʖʜʓʛÐÐ ʝèãʦʤäãʦʦåʢàʤÞʡçãʣ àʤäʡâʡÞíãʨçʢʤÝʨʤàãæʤʦéñßãèʤåãèãàʢæãìʢʦäʤʣéʢʥʡèããàåôèʥʢàʤéÞʥʡîʢçãôʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣÍʡççðʢãʦʦåʢàʤÞʡçãôèʤÞåãôåãçʡʥʢäʤæʢçàʡëããèʤàãʡßçʤʦéãäʢãåʢìʢçãóàãʦåãèãàʢæãʣ ʡéʢʥʤʦäåʢʥʤâʡ ÐÌʝ ãçʦʧåñéʡ ʝÍ ʠʛʙ ʝʤäʥçʡâÞ ßʤà ʛʤåçʤʢçʡâÞʡçãʢ ʜʢâóæʢ Ðʦéʤìçãä 3 3CANDINAVIAN 3IMVASTATIN3URVIVAL 3TUDY ʔèʢʥÞðʢèʤäʡâʡçʡçʢʤÝʨʤàãæʤʦéñ çʡâçʡìʢçãôʦéʡéãçʤÞʦãæÞʡʦéʡéãç ÝʤåñçðæʦÐÌʝ ;= 7/3#/03 7ESTOF3COTLAND #ORONARY0REVENTION 3TUDY ʛʥʡÞʡʦéʡéãçʦçãáʡåʥãʦäêʡéʡåñçðʨ ãçʢêʡéʡåñçðʨʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʦʤÝðéãʣçʡʧæʧáìãçʦʥʢàçʢßʤ ÞʤâʥʡʦéʡʦßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣÝʢâ ÐʘÞʡçʡæçʢâʢ ;= #!2% #HOLESTEROLAND 2ECURRENT%VENTS ÒÝʤåñçðʨʦʥʢàçʢʣÞʤâʥʡʦéçʤʣßʥʧèèð èʢʥʢçʢʦíãʨÐʘąæʢʦçʡâʡà èʥʡÞʡʦéʡéãçàʤʦéʤÞʢʥçʤʦçãáʡå äʤåãìʢʦéÞʤçʢÝåʡßʤèʥãôéçðʨ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʦʤÝðéãʣ ʛʤäʡâʡçʡìʢéäʡôÞâʡãæʤʦÞôâñæʢáàʧ ʦçãáʢçãʢæʧʥʤÞçôʠʝÑʙʛ ãʦçãáʢçãʢæʥãʦäʡ ;= ;= !&#!03 4EX#!03 0RIMARY0REVENTION OF!CUTE#ORONARY %VENTS7ITH ,OVASTATININ-ENAND 7OMEN7ITH!VERAGE #HOLESTEROL,EVELS ÑʤÞʡʦéʡéãçʦçãáʡʢé ʦʢʥàʢìçʤ ʦʤʦʧàãʦéʧóʦæʢʥéçʤʦéñ ãçʢêʡéʡåñçðʢʤʦåʤáçʢçãô ʧèʡëãʢçéʤÞÝʢâʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ âʡÝʤåʢÞʡçãʣ ʦʧæʢʥʢççʤèʤÞðíʢççðæ ʧʥʤÞçʢæʠʝãʠʝÑʙʛãʦçãáʢççðæ ʧʥʤÞçʢæʠʝÑʔʛ ,)0)$ 4HE,ONG 4ERM )NTERVENTIONWITH 0RAVASTATININ )SCHAEMIC$ISEASE ʛʤäʡâʡçʤʦçãáʢçãʢêʡéʡåñçðʨ ãçʢêʡéʡåñçðʨʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨ ʤʦåʤáçʢçãʣçʡêʤçʢèʥãʢæʡ èʥʡÞʡʦéʡéãçʡʧÝʤåñçðʨʦÐʘ ãçʢʦéʡÝãåñçʤʣʦéʢçʤäʡʥàãʢʣ 116 ;= ʛʥãåʤáʢçãô -)2!#,% 2001 4HE-YOCARDIAL )SCHEMIA2EDUCTION WITH!CUTE #HOLESTEROL,OWERING ÐçéʢçʦãÞçʡôʦéʡéãçʤéʢʥʡèãôãæʢʢé èʥʢãæʧîʢʦéÞʡèʤʦʥʡÞçʢçãó ʦéʢʥʡèãʢʣʦéʡéãçʡæãÞæʡåðʨàʤâʡʨ ʧÝʤåñçðʨʚʒʝèʥãʥʡççʢæ ʢʢçʡâçʡìʢçãã ;= (03 (EART0ROTECTION 3TUDY ʔèʢʥÞðʢèʤäʡâʡçʡçʢʤÝʨʤàãæʤʦéñ çʡâçʡìʢçãôʦéʡéãçʤÞʦãæÞʡʦéʡéãç ÝʤåñçðæÞðʦʤäʤßʤʥãʦäʡ ;= 02/30%2 2002 0ROSPECTIVE3TUDY OF0RAVASTATININTHE ELDERLYAT2ISK ʞʢʥʡèãôèʥʡÞʡʦéʡéãçʤæèʡëãʢçéʤÞ ʦéʡʥíʢʣÞʤâʥʡʦéçʤʣßʥʧèèðÞéʢìʢçãʢ åʢéʦçãáʡåʡʥãʦä ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ;= '2%!#% 2002 4HE'2%EK !TORVASTATINAND #ORONARY HEART DISEASE%VALUATION ʞʢʥʡèãôʡéʤʥÞʡʦéʡéãçʤæąæßʦʧé àʤàʤʦéãáʢçãôëʢåʢÞʤßʤʧʥʤÞçô ʠʝÑʙʛ ææʤåñåâçʡìãéʢåñçʤ ʦçãáʡåʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéʧó ʦæʢʥéçʤʦéñ ʤʦåʤáçʢçãô Ðʘ ãçʦʧåñéðèʤʦʥʡÞçʢçãóʦÝʤåñçðæã èʤåʧìʡÞíãæãéʢʥʡèãóʦéʡéãçʡæã çʤçʢàʤʦéãßʡÞíãæãëʢåʢÞʤßʤʧʥʤÞçô ʠʝÑʙʛ ;= !3#/4 ,,! !NGLO 3CANDINAVIAN #ARDIAC/UTCOMES 4RIAL ,IPID,OWERING !RM ʛʥãæʢçʢçãʢʡéʤʥÞʡʦéʡéãçʡʧÝʤåñçðʨ ʦʕÌʦçãáʡʢéʥãʦäÞʤâçãäçʤÞʢçãô éÞʢʥàðʨäʤçʢìçðʨéʤìʢä !2-)$! !TORVASTATINFOR 2EDUCTIONOF -9OCARDIAL$AMAGE DURING!NGIOPLASTY !CUTE#ORONARY 3YNDROMES ʛʢʥʢàèʥʤÞʢàʢçãʢæÔʒʔʧÝʤåñçðʨ ʦʚʒʝãʧÝʤåñçðʨʦʤʦéʡÝãåñçʤʣ ÐÌʝçʢʤÝʨʤàãæʤçʡâçʡìãéñʦéʡéãçð ʡéʤʥÞʡʦéʡéãç ÍʡççʤʢãʦʦåʢàʤÞʡçãʢ ʦʤʦéʤãéãâéʥʢʨìʡʦéʢʣ 2%6%23!, 2EVERSALOF !THEROSCLEROSISWITH !GGRESSIVE,IPID ,OWERING ʛʥããçéʢçʦãÞçʤʣʦéʡéãçʤéʢʥʡèãã ʤʦéʡçʡÞåãÞʡʢéʦôʥʤʦéʓʝÌãàʡáʢ çʡÝåóàʡʢéʦôʢʢʥʢßʥʢʦʦãô ʛʥããʦèʤåñâʤÞʡçããʦéʡéãçʤÞÞæʡåðʨ àʤâʡʨèʥʤàʤåáʡʢéʦôʥʤʦéʓʝÌ ;= 02/6% )4 0RAVASTATINOR !TORVASTATIN %VALUATIONAND )NFECTION4HERAPY ÐçéʢçʦãÞçʡôʦéʡéãçʤéʢʥʡèãô ʡéʤʥÞʡʦéʡéãçąæß ãæʢʢé èʥʢãæʧîʢʦéÞʡèʤʦʥʡÞçʢçãóʦéʢʥʡèãʢʣʦéʡéãçʡæãÞæʡåðʨàʤâʡʨʧÝʤåñçðʨ ʚʒʝ ;= ;= ;= 117 ʛʥãåʤáʢçãô $)3#/6%29 $IRECT3TATIN #OMPARISONOF,$, # 6ALUESAN%VALUATION OF2OSUVASTATIN THERAPY ÒèʡëãʢçéʤÞÞðʦʤäʤßʤʥãʦäʡéʢʥʡèãô ʥʤâʧÞʡʦéʡéãçʤæÞàʤâʢæß èʥãÞʢåʡäÝʤåʢʢÞðʥʡáʢççʤæʧ ʦçãáʢçãóʠʝÑʙʛãʞʕ ìʢæʡéʤʥÞʡʦéʡéãçʤæÞàʤâʢæß ;= ,5.!2 ÒÝʤåñçðʨʦʚʒʝʥʤâʧÞʡʦéʡéãçʤäʡâʡå ÝʤåʢʢÞðʥʡáʢççʤʢÞåãôçãʢçʡʠʝÑʙʛ ìʢæʡéʤʥÞʡʦéʡéãçÞòäÞãÞʡåʢçéçðʨ àʤâʡʨʜʤâʧÞʡʦéʡéãçÞàʤâʢæß ÞÝʤåñíʢʣʦéʢèʢçãèʤÞðíʡåʠʝÑʔʛ ìʢæʡéʤʥÞʡʦéʡéãçÞàʤâʢæß ;= -%2#529 ) -EASURING%FFECTIVE 2EDUCTIONSIN #HOLESTEROL5SING 2OSUVASTATINTHERAPY ʛʥʤàʢæʤçʦéʥãʥʤÞʡçðèʥʢãæʧîʢʦéÞʡ èʢʥʢÞʤàʡèʡëãʢçéʤÞʦÐÌʝ ʝÍ ßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣçʡʥʤâʧÞʡʦéʡéãçʦàʥʧßãʨʦéʡéãçʤÞ ;= 34%,,!2 3TATIN4HERAPIES FOR%LEVATED,IPID ,EVELSCOMPARED !CROSSDOSESTO 2OSUVASTATIN ʛʤäʡâʡçʤ ìéʤʥʤâʧÞʡʦéʡéãçÞàʤâʢ æßèʤʦʥʡÞçʢçãóʦàʥʧßãæã ʦéʡéãçʡæãàʤʦéʤÞʢʥçʤìʡîʢèʤâÞʤåôʢéàʤʦéãßʡéñëʢåʢÞʤßʤʧʥʤÞçôʠʝÑʙʛ !TO: %ARLY)NTENSIVEVSA $ELAYED#ONSERVATIVE 3IMVASTATIN3TRATEGY IN0ATIENTS7ITH !CUTE#ORONARY 3YNDROMES ʔèʢʥÞðʢèʤäʡâʡçʡçʢʤÝʨʤàãæʤʦéñ çʡâçʡìʢçãôʦéʡéãçʤÞʦãæÞʡʦéʡéãç ÝʤåñçðæʦʚʒʝÞÝʤåñíãʨàʤâʡʨ Þʥʡççãʢʦʥʤäã ,IMITING 5.DERTREATMENTOF LIPIDSIN!#3WITH 2OSUVASTATIN #!2$3 #OLLABORATIVE ʛʤäʡâʡçʡçʢʤÝʨʤàãæʤʦéñèʥãæʢçʢçãô !TORVASTATIN$IABETES ʦéʡéãçʤÞʡéʤʥÞʡʦéʡéãç ʧÝʤåñçðʨ 3TUDY ʦʝÍ))éãèʡ /2")4!, /PENLABELPRIMARY CARESTUDY 2OSUVASTATIN "ASEDCOMPLIANCE )NITIATIVESLINKED 4O!CHIEVEMENTOF ,$, #GOALS ÍʤâʡʥʤâʧÞʡʦéʡéãçʡãæßÞʦʧéäã ôÞåôʢéʦôàʤʦéʡéʤìçʤʣàåôàʤʦéãáʢçãô ëʢåʢÞʤßʤʧʥʤÞçôʠʝÑʙʛ ææʤåñå !#OMPARATIVESTUDY WITHROSUVASTATIN INSUBJECTSWITH -%4ABOLIC3YNDROME ʔòäÞãÞʡåʢçéçðʨàʤâʡʨʥʤâʧÞʡʦéʡéãç ʤäʡâðÞʡåÝʤåʢʢÞðʥʡáʢççðʣòêêʢäé çʡʠʝÑʙʛ ìʢæʡéʤʥÞʡʦéʡéãç #/-%43 118 ;= ;= ;= ;= ;= ʛʥãåʤáʢçãô #ONTROLLED 2OSUVASTATIN -ULTINATIONAL4RIALIN (EART&AILURE ʞʢʥʡèãôʥʤâʧÞʡʦéʡéãçʤæçʢÞåãôʢé çʡäʤçʢìçðʢéʤìäãʧÝʤåñçðʨ ʦçʢàʤʦéʡéʤìçʤʦéñó äʥʤÞʤʤÝʥʡîʢçãôʙʒ âʡãʦäåóìʢçãʢæ èʤáãåðʨèʡëãʢçéʤÞʦʙʒ ãíʢæãìʢʦäʤßʤßʢçʢâʡ ;= 4REATINGTO.EW 4ARGETS ÐçéʢçʦãÞçʡôʦéʡéãçʤéʢʥʡèãô ʡéʤʥÞʡʦéʡéãç ãæʢʢéèʥʢãæʧîʢʦéÞʡ èʤʦʥʡÞçʢçãóʦéʢʥʡèãʢʣʦéʡéãçʡæã ÞæʡåðʨàʤâʡʨʧÝʤåñçðʨÐÌʝ ;= )NCREMENTAL$ECREASE IN%NDPOINTS4HROUGH !GGRESSIVE,IPID LOWERING ÐçéʢçʦãÞçʡôʦéʡéãçʤéʢʥʡèãô ʡéʤʥÞʡʦéʡéãçæß ãæʢʢé èʥʢãæʧîʢʦéÞʡèʤʦʥʡÞçʢçãó ʦéʢʥʡèãʢʣʦéʡéãçʡæãÞçãâäʤʣàʤâʢ ÞèʥʢàʤéÞʥʡîʢçããÐʘ ;= 30!2#, 4HE3TROKE 0REVENTIONBY !GGRESSIVE2EDUCTION IN#HOLESTEROL,EVELS ÒÝʤåñçðʨ èʢʥʢçʢʦíãʨãíʢæãìʢʦäãʣ ãçʦʧåñé ʡéʤʥÞʡʦéʡéãçÞàʤâʢæß ʦçãáʡʢéʥãʦäÞʤâçãäçʤÞʢçãô èʤÞéʤʥçʤßʤêʡéʡåñçʤßʤ ãçʢêʡéʡåñçʤßʤãçʦʧåñéʡ ;= !34%2/)$ !3TUDY4O EVALUATETHE%FFECT OF2OSUVASTATIN /N)NTRAVASCULAR ULTRASOUNDą$ERIVED CORONARYATHEROMA BURDEN ʜʤâʧÞʡʦéʡéãçÞàʤâʢæßʧæʢçñíʡʢé ʥʡâæʢʥʓʝÌÍʡççðʢòéʤßʤ ãʦʦåʢàʤÞʡçãôçʢãʦèʤåñâʤÞʡçð Þãçʦéʥʧäëããäʤʥãßãçʡåñçʤæʧ ʥʤâʧÞʡʦéʡéãçʧ -%2#529 )) -EASURING%FFECTIVE 2EDUCTIONSIN #HOLESTEROL5SING 2OSUVASTATINTHERAPY ʛʢʥʢÞʤàèʡëãʢçéʤÞçʡãåãæß ʥʤâʧÞʡʦéʡéãçʡʦʦãæÞʡʦéʡéãçʡãåã ʡéʤʥÞʡʦéʡéãçʡèʤâÞʤåôʢéÞÝʤåñíʢæ èʥʤëʢçéʢʦåʧìʡʢÞàʤʦéãßʡéñëʢåʢÞðʨ ʧʥʤÞçʢʣʠʝÑʙʛ -%4%/2 2007 -EASURING%FFECTS ONINTIMAMEDIA 4HICKNESSAN %VALUATIONOF 2OSUVASTATIN ʜʤâʧÞʡʦéʡéãçÞàʤâʢæßàʤʦéʤÞʢʥçʤ ʧæʢçñíʡʢééʤåîãçʧäʤæèåʢäʦʡ ãçéãæʡ æʢàãʡ #/2/.! 4.4 )$%!, ;= ;= ;= 119 ʛʥãåʤáʢçãô #/52!'% 2007 ')33) (& 4HE#LINICAL /UTCOMES5TILIZING 2EVASCULARIZATION AND!GGRESSIVE$RUG %VALUATION ÒÝʤåñçðʨʦéʡÝãåñçʤʣÐÌʝèʥʡÞãåñçʤ èʤàʤÝʥʡççʡôéʢʥʡèãô Þäåóìʡóîʡô éʢʥʡèãóʦéʡéãçʡæãÞʤèéãæʡåñçðʨ àʤâʡʨ çʢʧʦéʧèʡʢéãçÞʡâãÞçʤæʧ åʢìʢçãóʛʥʤÞʢàʢçãʢÔʒʔéʡäãæ ÝʤåñçðæçʢÞåãôʢéçʡʤʦåʤáçʢçãô ãèʥʤßçʤâʔßʤèʧÝåãäʤÞʡçð àʡççðʢ åʢéçʢßʤçʡÝåóàʢçãô âʡòéãæãèʡëãʢçéʡæãʜʢâʧåñéʡéð ʤʦéʡåãʦñéʡäãæãáʢ %FFECTOFROSUVASTATIN ʜʤâʧÞʡʦéʡéãççʢÞåãôʢéçʡäʤçʢìçðʢ INPATIENTSWITH éʤìäãʧÝʤåñçðʨʦʙʒ CHRONICHEARTFAILURE /2)/. /UTCOMEOF 2OSUVASTATIN TREATMENTONCAROTID ARTERYATHEROMAA MAGNETICRESONANCE )MAGING/BSERVATION ÒèʡëãʢçéʤÞʦʧæʢʥʢççʤʣ ßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣʥʤâʧÞʡʦéʡéãç ÞʧæʢʥʢççðʨãÞðʦʤäãʨàʤâʡʨ òêêʢäéãÞçʤʦçãáʡʢéʧʥʤÞʢçñʠʝÑʙʛ ʔéʢìʢçãʢ åʢéçʢʣéʢʥʡèãã èʥʤàʢæʤçʦéʥãʥʤÞʡçʤʧæʢçñíʢçãʢ çʢäʥʤéãìʢʦäʤßʤôàʥʡʓʝÌʤëʢçʢçʤ æʢéʤàʤæʘʜʞ *50)4%2 ÐʦʦåʢàʤÞʡçãʢ àʤäʡâʡÞíʢʢòêêʢäéãÞçʤʦéñéʢʥʡèãã ʦéʡéãçʡæãÞèʢʥÞãìçʤʣèʥʤêãåʡäéãäʢ !52/2! 0,54/ 2010 120 *USTIFICATIONFORTHE 5SEOF3TATINSIN 0RIMARYPREVENTION AN)NTERVENTION 4RIAL%VALUATING 2OSUVASTATIN ʙʢàʤäʡâʡçʡòêêʢäéãÞçʤʦéñ !STUDYEVALUATING ʥʤâʧÞʡʦéʡéãçʡʧÝʤåñçðʨ THE5SEOF çʡʨʤàôîãʨʦôçʡßʢæʤàãʡåãâʢ 2OSUVASTATININ PATIENTSREQUIRING /NGOING2ENAL DIALYSISAN !SSESSMENT OFSURVIVALAND CARDIOVASCULAREVENTS 0EDIATRIC,IPID 2EDUCTION4RIALOF 2OSUVASTATIN Òàʢéʢʣʦʝʕʠʝçʡâçʡìʢçãʢ ʥʤâʧÞʡʦéʡéãçʡÞàʤâʢæßʦçãáʡåʤ ʧʥʤÞʢçñʠʝÑʙʛçʡ ;= ;= ;= ;= ;= ;= ʛʥãåʤáʢçãô !NINDI6IDUALPATIENT DATA META ANALYSIS /FSTATINTHERAP9IN!T RISK'ROUPS%FFECTS OF2OSUVASTATIN ATORVASTATIN AND SIMVASTATIN ʘʢéʡʡçʡåãâãʦʦåʢàʤÞʡçãʣ éðʦ ÝʤåñçðʨʜʤâʧÞʡʦéʡéãçÞÝʤåñíʢʣ ʦéʢèʢçãʦçãáʡʢéʧʥʤÞʢçñʞʕ ìʢæʦãæÞʡʦéʡéãçãʡéʤʥÞʡʦéʡéãç ʜʤâʧÞʡʦéʡéãçÞÝʤåñíʢʣʦéʢèʢçã ʦçãáʡʢéʧʥʤÞʢçñʠʝÑʙʛ ìʢæåóÝʡô àʤâãʥʤÞäʡʦãæÞʡʦéʡéãçʡ ãåãòäÞãÞʡåʢçéçʡôàʤâãʥʤÞäʡ ʡéʤʥÞʡʦéʡéãçʡ ;= 3TUDYOF#ORONARY !THEROMABY )NTRAVASCULAR 5LTRASOUND%FFECTOF 2OSUVASTATIN6ERSUS !TORVASTATIN ʝʥʡÞçãÞʡåãʦñʡéʤʥÞʡʦéʡéãçãʥʤâʧÞʡʦéʡéãçÞòäÞãÞʡåʢçéçðʨàʤâʡʨ ʧÝʤåñçðʨÐÌʝʛʡëãʢçéʡæ èʥʤÞʤàãåʤʦñʔʝÒÏÐäʤʥʤçʡʥçðʨ ʡʥéʢʥãʣãʦʨʤàçʤãçʡêʤçʢéʢʥʡèããʙʢ èʤäʡâʡçʤôÞçðʨèʥʢãæʧîʢʦéÞéʤßʤãåã ãçʤßʤʦéʡéãçʡ ;= 3(!20 3TUDYOF(EARTAND 2ENAL0ROTECTION ʛʤäʡâʡçʤ ìéʤäʤæÝãçʡëãô ʦãæÞʡʦéʡéãçÞàʤâʢæß òâʢéãæãÝ ÞàʤâʢæßʦçãáʡʢéäʤåãìʢʦéÞʤ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ʧÝʤåñçðʨʦʠʛʙą ʣʦéʢèʢçã ;= )-0/6% )4 4HE)MPROVED 2EDUCTIONOF /UTCOMES6YTORIN %FFICACY)NTERNATIONAL 4RIAL ʛʤäʡâʡçʤ ìéʤãʦèʤåñâʤÞʡçãʢ äʤæÝãçãʥʤÞʡççʤʣéʢʥʡèããʦéʡéãç òâʢéãæãÝʧæʢçñíʡʢéäʤåãìʢʦéÞʤ ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨʤʦåʤáçʢçãʣ ÞéʤæìãʦåʢʦæʢʥéãʞʡäʡôäʤæÝãçʡëãô ôÞåôʢéʦôÝʢâʤèʡʦçʤʣʛʤäʡâʡçʤèʥʢãæʧîʢʦéÞʤʦçãáʢçãʢʠʝÑʙʛàʤ èʥʤéãÞ ææʤåñå ;= (EART/UTCOMES 0REVENTION%VALUATION ʞʢʥʡèãôʥʤâʧÞʡʦéʡéãçʤæÞàʤâʢæß ʧåãëʧæʢʥʢççʤßʤʥãʦäʡ èʥʢàʤéÞʥʡîʡʢéʥʡâÞãéãʢ ʝʝ ʤʦåʤáçʢçãʣÝʢâʧìʢéʡãʦʨʤàçʤßʤ ʧʥʤÞçôʠʝÑʙʛ ;= 6/9!'%2 2010 3!452. 2011 (/0% 121 ʛʥãåʤáʢçãô 02/&)#)/ èʥʤàʤåáʡʢéʦô 0ROGRAMTO 2EDUCE,$, #AND #ARDIOVASCULAR /UTCOMES&OLLOWING )NHIBITIONOF0#3+)N $IFFERENT0/PULATIONS ʛʥʤßʥʡææʡ Þäåóìʡóîʡôʥôà ãʦʦåʢàʤÞʡçãʣʦòÞʤåʤäʧæʡÝʤæ $%3#!24% %"").'(!53 &,/2%9 &/52)%2 '!533 '!533 ',!'/6 ,!0,!#% -%.$%, /3,%2 254(%2&/2$ 4!533)' 4%3,! 4(/-!3 4(/-!3 95+!7! ʛʤäʡâʡçʡÞðʦʤäʡô òêêʢäéãÞçʤʦéñòéʤßʤèʥʢèʡʥʡéʡ Þçʤʥæʡåãâʡëããåãèãàçʤßʤʦèʢäéʥʡ êʡäéʤʥʤÞÞʤʦèʡåʢçãôʧÝʤåñçðʨ ʦÐÌʝ ʝʕʠʝ ʝÍÐʦʦåʢàʤÞʡçãʢ èʥʤàʤåáʡʢéʦô /$933%9 èʥʤàʤåáʡʢéʦô /$933%9#LINICAL 4RIAL0ROGRAM ʛʥʤßʥʡææʡ Þäåóìʡóîʡôʥôà ãʦʦåʢàʤÞʡçãʣʦʡåãʥʤäʧæʡÝʤæ #(/)#%) #(/)#%)) /,% ,/.'4%2- #/-"/) #/-"/)) &() &()) ()'( &( /54#/-%3 -/./ !,4%2.!4)6% /04)/.3) /04)/.3)) ʛʤäʡâʡçʡÞðʦʤäʡôòêêʢäéãÞçʤʦéñ òéʤßʤèʥʢèʡʥʡéʡÞçʤʥæʡåãâʡëãã åãèãàçʤßʤʦèʢäéʥʡ êʡäéʤʥʤÞ ÞʤʦèʡåʢçãôʧÝʤåñçðʨʦÐÌʝ ʝʕʠʝ ʝÍ ÐʦʦåʢàʤÞʡçãʢèʥʤàʤåáʡʢéʦô HTTPWWWODYSSEYTRIALSCOMWEB ABOUT?ODYSSEY?PROGRAM 122 ʝèãʦʤäåãéʢʥʡéʧʥð ʝʛÐʝʚʒÑÐʞʖʜʓʞÒʜØ ÐçêʤʥæʡëãʤççðʣÝóååʢéʢçñʔʚÏʋ .ATIONAL)NSTITUTESOF(EALTH.( ,UNG AND"LOOD)NSTITUTE-ORBIDITY-ORTALITY#HART"OOKON#ARDIOVASCULAR ,UNG AND"LOOD$ISEASES"ETHESDA -$.ATIONAL(EART ,UNG AND"LOOD)NSTITUTE 2EIS3% (OLUBKOV2 #ONRAD3MITH!* ETAL#ORONARYMICROVASCULARDYSFUNCTIONISHIGHLYPREVALENTINWOMENWITH CHESTPAININTHEABSENCEOFCORONARYARTERYDISEASERESULTSFROMTHE.(,")7)3%STUDY!M(EART* ą (AN3( "AE*( (OLMES$2 *R ETAL3EXDIFFERENCESINATHEROMABURDENANDENDOTHELIALFUNCTIONINPATIENTSWITH EARLYCORONARYATHEROSCLEROSIS%UR(EART* ą +ITTA9 /BATA*% .AKAMURA4 ETAL0ERSISTENTIMPAIRMENTOFENDOTHELIALVASOMOTORFUNCTIONHASANEGATIVEIMPACT ONOUTCOMEINPATIENTSWITHCORONARYARTERYDISEASE*!M#OLL#ARDIOL ą 'ULATI - #OOPER $E(OFF 2- -C#LURE # ET AL !DVERSE CARDIOVASCULAR OUTCOMES IN WOMEN WITH NONOBSTRUCTIVE CORONARYARTERYDISEASEAREPORTFROMTHE7OMENĈS)SCHEMIA3YNDROME%VALUATION3TUDYANDTHE3T*AMES7OMEN 4AKE(EART0ROJECT!RCH)NTERN-ED ą *ESPERSEN, (VELPLUND! !BILDSTROM3: ETAL3TABLEANGINAPECTORISWITHNOOBSTRUCTIVECORONARYARTERYDISEASEIS ASSOCIATEDWITHINCREASEDRISKSOFMAJORADVERSECARDIOVASCULAREVENTS%UR(EART* ą "ODEN7% /Ĉ2OURKE2! 4EO++ ETAL/PTIMALMEDICALTHERAPYWITHORWITHOUT0#)FORSTABLECORONARYDISEASE. %NGL*-ED ą #HUNG 3# (LATKY -! &AXON $ ET AL 4HE EFFECT OF AGE ON CLINICAL OUTCOMES AND HEALTH STATUS "!2) $ "YPASS !NGIOPLASTY2EVASCULARIZATION)NVESTIGATIONIN4YPE$IABETES *!M#OLL#ARDIOL ą &RYE2, !UGUST0 "ROOKS-- ETAL!RANDOMIZEDTRIALOFTHERAPIESFORTYPEDIABETESANDCORONARYARTERYDISEASE .%NGL*-ED ą (ENDERSON2! 0OCOCK3* #LAYTON4# ETAL3EVEN YEAROUTCOMEINTHE2)4! TRIALCORONARYANGIOPLASTYVERSUS MEDICALTHERAPY*!M#OLL#ARDIOL ą 0OOLE 7ILSON 0! ,UBSEN * +IRWAN "! ET AL %FFECT OF LONG ACTING NIFEDIPINE ON MORTALITY AND CARDIOVASCULAR MORBIDITYINPATIENTSWITHSTABLEANGINAREQUIRINGTREATMENT!#4)/.TRIAL RANDOMISEDCONTROLLEDTRIAL,ANCET ą 3TEG 0' 'REENLAW . 4ARDIF *# ET AL 7OMEN AND MEN WITH STABLE CORONARY ARTERY DISEASE HAVE SIMILAR CLINICAL OUTCOMESINSIGHTSFROMTHEINTERNATIONALPROSPECTIVE#,!2)&9REGISTRY%UR(EART* ą $ALY#! $E3TAVOLA" 3ENDON*, ETAL0REDICTINGPROGNOSISINSTABLEANGINA RESULTSFROMTHE%UROHEARTSURVEYOF STABLEANGINAPROSPECTIVEOBSERVATIONALSTUDY"-* ą 3TEG 0' "HATT $, 7ILSON 07 ET AL /NE YEAR CARDIOVASCULAR EVENT RATES IN OUTPATIENTS WITH ATHEROTHROMBOSIS *!-! ą ÏʡÝʤåʢÞʡʢæʤʦéñçʡʦʢåʢçãôʜʤʦʦããÞßʤàʧʝéʡéãʦéãìʢʦäãʢæʡéʢʥãʡåðʘʤʦäÞʡ ʚßʡçʤÞʜʕ ʒʡåãçãçʡʓʘ ʒʤçëʢÞʡôʓʔÚäʤçʤæãìʢʦäãʣʧîʢʥÝʤéʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣÞʜʤʦʦãʣ ʦäʤʣʟʢàʢʥʡëããʒʡʥàãʤÞʡʦäʧåôʥçʡôéʢʥʡèãôãèʥʤêãåʡäéãäʡą "ERTUCCIO0 ,EVI& ,UCCHINI& ETAL#ORONARYHEARTDISEASEANDCEREBROVASCULARDISEASEMORTALITYINYOUNGADULTS RECENTTRENDSIN%UROPE%UR*#ARDIOVASC0REV2EHABIL ą ʝéʡéãʦéãìʢʦäʡôãçêʤʥæʡëãôâʡßʤàʘãçãʦéʢʥʦéÞʤâàʥʡÞʤʤʨʥʡçʢçãôʜʤʦʦãʣʦäʤʣʟʢàʢʥʡëãã -ONTALESCOT' 3ECHTEM5 !CHENBACH3 ETAL%3#GUIDELINESONTHEMANAGEMENTOFSTABLECORONARYARTERY DISEASETHE4ASK&ORCEONTHEMANAGEMENTOFSTABLECORONARYARTERYDISEASEOFTHE%UROPEAN3OCIETYOF#ARDIOLOGY%UR (EART* ą -ARTIN -* (ULLEY 3" "ROWNER 73 ET AL 3ERUM CHOLESTEROL BLOOD PRESSURE AND MORTALITY IMPLICATIONS FROM A COHORTOF MEN,ANCET ą "AYTURAN/ +APADIA3 .ICHOLLS3* ETAL#LINICALPREDICTORSOFPLAQUEPROGRESSIONDESPITEVERYLOWLEVELSOFLOW DENSITYLIPOPROTEINCHOLESTEROL*!M#OLL#ARDIOL ą .ICHOLLS3* (SU! 7OLSKI+ ETAL)NTRAVASCULARULTRASOUND DERIVEDMEASURESOFCORONARYATHEROSCLEROTICPLAQUE BURDENANDCLINICALOUTCOME*!M#OLL#ARDIOL ą 0ERK* $E"ACKER' 'OHLKE( ETAL%UROPEAN'UIDELINESONCARDIOVASCULARDISEASEPREVENTIONINCLINICALPRACTICE VERSION 4HE&IFTH*OINT4ASK&ORCEOFTHE%UROPEAN3OCIETYOF#ARDIOLOGYAND/THER3OCIETIESON#ARDIOVASCULAR $ISEASE 0REVENTION IN #LINICAL 0RACTICE CONSTITUTED BY REPRESENTATIVES OF NINE SOCIETIES AND BY INVITED EXPERTS %UR (EART* ą .ICHOLLS 3* "ALLANTYNE #- "ARTER 0* ET AL %FFECT OF TWO INTENSIVE STATIN REGIMENS ON PROGRESSION OF CORONARY DISEASE.%NGL*-ED ą -OCK-" 2INGQVIST) &ISHER,$ ETAL3URVIVALOFMEDICALLYTREATEDPATIENTSINTHECORONARYARTERYSURGERYSTUDY #!33 REGISTRY#IRCULATION ą 2OSS2 'LOMSET*!4HEPATHOGENESISOFATHEROSCLEROSISFIRSTOFTWOPARTS .%NGL*-ED ą 123 ʝèãʦʤäåãéʢʥʡéʧʥð ʘôʦçãäʤÞʓÑʕãèʢʥéʤçãìʢʦäʡôÝʤåʢâçñãʡéʢʥʤʦäåʢʥʤâʘʘʢàãëãçʡ 'OLDSTEIN*, "ROWN-34HE,$,RECEPTOR!RTERIOSCLER4HROMB6ASC"IOL ą ʝʢʥßãʢçäʤÐʔÐʦéʤʥãôèʤôÞåʢçãôʦéʡéãçʤÞʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą .ISSEN 3% .ICHOLLS 3* 3IPAHI ) ET AL %FFECT OF VERY HIGH INTENSITY STATIN THERAPY ON REGRESSION OF CORONARY ATHEROSCLEROSISTHE!34%2/)$TRIAL*!-! ą &INN!6 .AKANO- .ARULA* ETAL#ONCEPTOFVULNERABLEUNSTABLEPLAQUE!RTERIOSCLER4HROMB6ASC"IOL ą &ISHBEIN-#4HEVULNERABLEANDUNSTABLEATHEROSCLEROTICPLAQUE#ARDIOVASC0ATHOL ą &ALK%0ATHOGENESISOFATHEROSCLEROSIS*!M#OLL#ARDIOL3UPPL #ą ʜʧäʤÞʤàʦéÞʤ èʤ äʡʥàãʤåʤßãã Þ éʤæʡʨ èʤà ʥʢàʡäëãʢʣ ʖÐ ÔʡâʤÞʡ ʔʔ ʒʧʨʡʥìʧä ʔʙ ʞãéʤÞ ʓéʢʥʤʦäåʢʥʤâ ãàãʦåãèãàʢæããʞ ʦąʘʛʥʡäéãäʡ "ENTZON*& /TSUKA& 6IRMANI2 ETAL-ECHANISMSOFPLAQUEFORMATIONANDRUPTURE#IRC2ES ą #ASSCELLS 7 .AGHAVI - 7ILLERSON *4 6ULNERABLE ATHEROSCLEROTIC PLAQUE A MULTIFOCAL DISEASE #IRCULATION ą 6IRMANI2 +OLODGIE&$ "URKE!0 ETAL!THEROSCLEROTICPLAQUEPROGRESSIONANDVULNERABILITYTORUPTUREANGIOGENESIS ASASOURCEOFINTRAPLAQUEHEMORRHAGE!RTERIOSCLER4HROMB6ASC"IOL ą #ASSCELLS7 (ASSAN+ 6ASEGHI-& ETAL0LAQUEBLUSH BRANCHLOCATION ANDCALCIFICATIONAREANGIOGRAPHICPREDICTORS OFPROGRESSIONOFMILDTOMODERATECORONARYSTENOSES!M(EART* ą ÍãʡßçʤʦéãäʡãäʤʥʥʢäëãôçʡʥʧíʢçãʣåãèãàçʤßʤʤÝæʢçʡʦëʢåñóèʥʤêãåʡäéãäããåʢìʢçãôʡéʢʥʤʦäåʢʥʤâʡʜʤʦ ʦãʣʦäãʢʥʢäʤæʢçàʡëãã6èʢʥʢʦæʤéʥʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą ʒåãæʤÞʓʙ ʙãäʧåñìʢÞʡʙʕʚÝæʢçåãèãàʤÞãåãèʤèʥʤéʢãàʤÞãʢßʤçʡʥʧíʢçãôʜʧäʤÞʤàʦéÞʤàåôÞʥʡìʢʣÐâàʡ çãʢéʥʢéñʢʝʛÝ ʙʤâʡàâʢÍʙ ʝʢʥßãʢçäʤÐʔ ÌʡåʡʨʤçʤÞʡʞʔ ETALʝÞôâñʧʥʤÞçôåãèʤèʥʤéʢãç ʡʦʦʤëããʥʤÞʡççʤʣêʤʦêʤåãèʡâð ʓʦäʡéʢßʤʥãôæãʥãʦäʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣʒʡʥàãʤåʤßãô ą ʙʤâʡàâʢÍʙ ʝʢæEçʤÞʡʓʖ ʒʡæãççʡôʔÐ ETALÑãèʤèʥʤéʢãç ʡʦʦʤëããʥʤÞʡççʡôêʤʦêʤåãèʡâʡʓąçʤÞʡôèʤ âãëãôÞʦãʦéʢæʢʦéʥʡéãêãäʡëããʥãʦäʡʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą ʝʡêʡʥʤÞʡʘʝ ʖáʤÞʘʔÑãèʤèʥʤéʢãàʡ äʡäêʡäéʤʥʥãʦäʡʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣʦʤÞʥʢæʢççʤʢ ʦʤʦéʤôçãʢÞʤèʥʤʦʡʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą .ORDESTGAARD"' #HAPMAN-* 2AY+ ETAL,IPOPROTEINA ASACARDIOVASCULARRISKFACTORCURRENTSTATUS%UR(EART * ą ʒåãæʤÞʓʙʛʥãìãçðãʧʦåʤÞãôʥʡâÞãéãôʡéʢʥʤʦäåʢʥʤâʡʛʥʢÞʢçéãÞçʡôäʡʥàãʤåʤßãôʛʤàʥʢàʕÐʒʤʦãëäʤßʤ ʘʘʢàãëãçʡ 3CHIFFRIN%,4HEENDOTHELIUMOFRESISTANCEARTERIESPHYSIOLOGYANDROLEINHYPERTENSION0ROSTAGLANDINS,EUKOT%SSENT &ATTY!CIDS ą (ALLER(%NDOTHELIALFUNCTION'ENERALCONSIDERATIONS$RUGS3UPPLą ,USCHER 4& %NDOTHELIUM DERIVED VASOACTIVE FACTORSAND REGULATION OF VASCULAR TONE IN HUMAN BLOOD VESSELS ,UNG 3UPPLą -ODENA -' "ONETTI , #OPPI & ET AL 0ROGNOSTIC ROLE OF REVERSIBLE ENDOTHELIAL DYSFUNCTION IN HYPERTENSIVE POSTMENOPAUSALWOMEN*!M#OLL#ARDIOL ą &ARACI&- (EISTAD$$2EGULATIONOFTHECEREBRALCIRCULATIONROLEOFENDOTHELIUMANDPOTASSIUMCHANNELS0HYSIOL 2EV ą (ANSSON'+ (ERMANSSON!4HEIMMUNESYSTEMINATHEROSCLEROSIS.AT)MMUNOL ą 7EVER2- ,USCHER4& #OSENTINO& ETAL!THEROSCLEROSISANDTHETWOFACESOFENDOTHELIALNITRICOXIDESYNTHASE #IRCULATION ą )SHII ( 4EZUKA 4 )SHIKAWA ( ET AL /XIDIZED PHOSPHOLIPIDS IN OXIDIZED LOW DENSITY LIPOPROTEIN DOWN REGULATE THROMBOMODULIN TRANSCRIPTION IN VASCULAR ENDOTHELIAL CELLS THROUGH A DECREASE INTHEBINDING OF 2!2BETA 282ALPHA HETERODIMERSAND3PAND3PTOTHEIRBINDINGSEQUENCESINTHE4-PROMOTER"LOOD ą ʙʤâʡàâʢÍʙ ʜÞʡìʢÞʡʓʔ ʒʡâçʡìʢʢÞʡʖÐ ETALʘʤçʤëãéðÞʥʡâÞãéãããàʢʦéʡÝãåãâʡëããʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣ Ýåôíäãʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą ʝʢʥßãʢçäʤÐʔ ʙʤâʡàâʢÍʙ ʒʡâçʡìʢʢÞʡʖÐʔåãôçãʢʨʢæʤäãçʤÞçʡêʤʥæãʥʤÞʡçãʢʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʤ ʥʡáʢçãôâʡʦìʢéʥʢßʧåãʥʤÞʡçãôêʧçäëããåʢʣäʤëãéʤÞʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą "ORING, 'OSLING* #LEARY- ETAL$ECREASEDLESIONFORMATIONIN##2 MICEREVEALSAROLEFORCHEMOKINESINTHE INITIATIONOFATHEROSCLEROSIS.ATURE ą -OSIG 3 2ENNERT + +RAUSE 3 ET AL $IFFERENT FUNCTIONS OF MONOCYTE SUBSETS IN FAMILIAL HYPERCHOLESTEROLEMIA POTENTIALFUNCTIONOF#$ #$ MONOCYTESINDETOXIFICATIONOFOXIDIZED,$,&!3%"* ą 2OSE$- !LON2 'INSBERG-()NTEGRINMODULATIONANDSIGNALINGINLEUKOCYTEADHESIONANDMIGRATION)MMUNOL2EV ą 124 ʝèãʦʤäåãéʢʥʡéʧʥð 7EBER # .OVEL MECHANISTIC CONCEPTS FOR THE CONTROL OF LEUKOCYTE TRANSMIGRATION SPECIALIZATION OF INTEGRINS CHEMOKINES ANDJUNCTIONALMOLECULES*-OL-ED"ERL ą :HOU : 3UBRAMANIAN 0 3EVILMIS ' ET AL ,IPOPROTEIN DERIVED LYSOPHOSPHATIDIC ACID PROMOTES ATHEROSCLEROSIS BY RELEASING#8#,FROMTHEENDOTHELIUM#ELL-ETAB ą 'ORDON3 4AYLOR02-ONOCYTEANDMACROPHAGEHETEROGENEITY.AT2EV)MMUNOL ą 6ARIN! 'ORDON3!LTERNATIVEACTIVATIONOFMACROPHAGESIMMUNEFUNCTIONANDCELLULARBIOLOGY)MMUNOBIOLOGY ą "ROCHERIOU) -AOUCHE3 $URAND( ETAL!NTAGONISTICREGULATIONOFMACROPHAGEPHENOTYPEBY- #3&AND'- #3& IMPLICATIONINATHEROSCLEROSIS!THEROSCLEROSIS ą 'ORDON 3 -ARTINEZ &/ !LTERNATIVE ACTIVATION OF MACROPHAGES MECHANISM AND FUNCTIONS )MMUNITY ą 'RATCHEV! +ZHYSHKOWSKA* +OTHE+ ETAL-PHIAND-PHICANBERE POLARIZEDBY4HOR4HCYTOKINES RESPECTIVELY ANDRESPONDTOEXOGENOUSDANGERSIGNALS)MMUNOBIOLOGYą ą "UTCHER-* 'ALKINA%60HENOTYPICANDFUNCTIONALHETEROGENEITYOFMACROPHAGESANDDENDRITICCELLSUBSETSINTHE HEALTHYANDATHEROSCLEROSIS PRONEAORTA&RONT0HYSIOL -ERAD- 3ATHE0 (ELFT* ETAL4HEDENDRITICCELLLINEAGEONTOGENYANDFUNCTIONOFDENDRITICCELLSANDTHEIRSUBSETS INTHESTEADYSTATEANDTHEINFLAMEDSETTING!NNU2EV)MMUNOLą #HOI*( $O9 #HEONG# ETAL)DENTIFICATIONOFANTIGEN PRESENTINGDENDRITICCELLSINMOUSEAORTAANDCARDIACVALVES *%XP-ED ą 7EBER# -EILER3 $ORING9 ETAL##, EXPRESSINGDENDRITICCELLSDRIVEATHEROSCLEROSISBYRESTRAININGREGULATORY4 CELLHOMEOSTASISINMICE*#LIN)NVEST ą (ANSSON'+ ,IBBY04HEIMMUNERESPONSEINATHEROSCLEROSISADOUBLE EDGEDSWORD.AT2EV)MMUNOL ą 0RASAD+3 !NDRE0 9AN9 ETAL4HEPLATELET#$,'0))B )))AAXISINATHEROTHROMBOTICDISEASE#URR/PIN(EMATOL ą .GUYEN64 "ENVENISTE%.)NVOLVEMENTOF34!4 ANDETSFAMILYMEMBERSININTERFERON GAMMAINDUCTIONOF#$ TRANSCRIPTIONINMICROGLIAMACROPHAGES*"IOL#HEM ą -ALLAT: (EYMES# /HAN* ETAL%XPRESSIONOFINTERLEUKIN INADVANCEDHUMANATHEROSCLEROTICPLAQUESRELATIONTO INDUCIBLENITRICOXIDESYNTHASEEXPRESSIONANDCELLDEATH!RTERIOSCLER4HROMB6ASC"IOL ą (UBER3! 3AKKINEN0 $AVID# ETAL4HELPER CELLPHENOTYPEREGULATESATHEROSCLEROSISINMICEUNDERCONDITIONSOF MILDHYPERCHOLESTEROLEMIA#IRCULATION ą -ALLAT: !IT /UFELLA( 4EDGUI!2EGULATORY4 CELLIMMUNITYINATHEROSCLEROSIS4RENDS#ARDIOVASC-ED ą .ISHIKAWA( +ATO4 4AWARA) ETAL)&. GAMMACONTROLSTHEGENERATIONACTIVATIONOF#$ #$ REGULATORY4CELLS INANTITUMORIMMUNERESPONSE*)MMUNOL ą :HOU8 #ALIGIURI' (AMSTEN! ETAL,$,IMMUNIZATIONINDUCES4 CELL DEPENDENTANTIBODYFORMATIONANDPROTECTION AGAINSTATHEROSCLEROSIS!RTERIOSCLER4HROMB6ASC"IOL ą $RECHSLER- -EGENS24 VAN:ANDVOORT- ETAL(YPERLIPIDEMIA TRIGGEREDNEUTROPHILIAPROMOTESEARLYATHEROSCLEROSIS #IRCULATION ą 3OEHNLEIN/ :ERNECKE! %RIKSSON%% ETAL.EUTROPHILSECRETIONPRODUCTSPAVETHEWAYFORINFLAMMATORYMONOCYTES "LOOD ą :HANG: #HERRYHOLMES' #HANG& ETAL%VIDENCETHATCATHELICIDINPEPTIDE,, MAYACTASAFUNCTIONALLIGANDFOR #8#2ONHUMANNEUTROPHILS%UR*)MMUNOL ą -ASSBERG3 'RAHL, VON"RUEHL-, ETAL2ECIPROCALCOUPLINGOFCOAGULATIONANDINNATEIMMUNITYVIANEUTROPHIL SERINEPROTEASES.AT-ED ą #OLE*% .AVIN4* #ROSS!* ETAL5NEXPECTEDPROTECTIVEROLEFOR4OLL LIKERECEPTORINTHEARTERIALWALL0ROC.ATL !CAD3CI53! ą +INOSHITA- /KADA- (ARA- ETAL-ASTCELLTRYPTASEINMASTCELLGRANULESENHANCES-#0 ANDINTERLEUKIN PRODUCTION INHUMANENDOTHELIALCELLS!RTERIOSCLER4HROMB6ASC"IOL ą 3UN* 3UKHOVA'+ 7OLTERS0* ETAL-ASTCELLSPROMOTEATHEROSCLEROSISBYRELEASINGPROINFLAMMATORYCYTOKINES .AT-ED ą ,ESKINEN-* +OVANEN04 ,INDSTEDT+!2EGULATIONOFSMOOTHMUSCLECELLGROWTH FUNCTIONANDDEATHINVITROBY ACTIVATED MAST CELLS A POTENTIAL MECHANISM FOR THE WEAKENING AND RUPTURE OF ATHEROSCLEROTIC PLAQUES "IOCHEM 0HARMACOL ą ,INDSTEDT +! +OVANEN 04 -AST CELLS IN VULNERABLE CORONARY PLAQUES POTENTIAL MECHANISMS LINKING MAST CELL ACTIVATIONTOPLAQUEEROSIONANDRUPTURE#URR/PIN,IPIDOL ą 3HI'0 "OT) +OVANEN04-ASTCELLSINHUMANANDEXPERIMENTALCARDIOMETABOLICDISEASES.AT2EV#ARDIOL ą 125 ʝèãʦʤäåãéʢʥʡéʧʥð "OYTCOV 3! 5RAZALINA 3* +UKHARCHUK 66 ET AL 3UBCLINICAL ARTERIAL WALL DAMAGE IN PATIENTS AT LOW TO MODERATE CARDIOVASCULARRISK!CTA#ARDIOL ą 'ALKINA% ,EY+)MMUNEANDINFLAMMATORYMECHANISMSOFATHEROSCLEROSIS !NNU2EV)MMUNOLą 7ILLIAMS +* 4ABAS ) 4HE RESPONSE TO RETENTION HYPOTHESIS OF EARLY ATHEROGENESIS !RTERIOSCLER 4HROMB 6ASC "IOL ą 4ABAS) 7ILLIAMS+* "OREN*3UBENDOTHELIALLIPOPROTEINRETENTIONASTHEINITIATINGPROCESSINATHEROSCLEROSISUPDATE ANDTHERAPEUTICIMPLICATIONS#IRCULATION ą 4ELLIDES' 4EREB$! +IRKILES 3MITH.# ETAL)NTERFERON GAMMAELICITSARTERIOSCLEROSISINTHEABSENCEOFLEUKOCYTES .ATURE ą 7ARD-2 0ASTERKAMP' 9EUNG!# ETAL!RTERIALREMODELING-ECHANISMSANDCLINICALIMPLICATIONS#IRCULATION ą !MENTO %0 %HSANI . 0ALMER ( ET AL #YTOKINES AND GROWTH FACTORS POSITIVELY AND NEGATIVELY REGULATE INTERSTITIAL COLLAGENGENEEXPRESSIONINHUMANVASCULARSMOOTHMUSCLECELLS!RTERIOSCLER4HROMB ą 6AN ,INT 0 ,IBERT # #HEMOKINE AND CYTOKINE PROCESSING BY MATRIX METALLOPROTEINASES AND ITS EFFECT ON LEUKOCYTE MIGRATIONANDINFLAMMATION*,EUKOC"IOL ą *OHNSON *, 'EORGE 3* .EWBY !# ET AL $IVERGENT EFFECTS OF MATRIX METALLOPROTEINASES AND ON ATHEROSCLEROTICPLAQUESTABILITYINMOUSEBRACHIOCEPHALICARTERIES0ROC.ATL!CAD3CI53! ą ÍʤæÝʥʤÞʦäãʣʓÑ ʝʢʥßãʢçäʤÐʔ ʜÞʡìʢÞʡʓʔ ETALʝʤàʢʥáʡçãʢòçàʤéʢåãʡåñçðʨèʥʤßʢçãéʤʥçðʨäåʢéʤäêʢçʤ éãèʡ#$ #$ #$ ʡéʡäáʢêʡäéʤʥʤÞʡçßãʤßʢçʢâʡÞäʥʤÞãʧÝʤåñçðʨÐÌʝʞʢʥʡèʢÞéą ,OLMEDE+ #AMPANA, 6EZZOLI- ETAL)NFLAMMATORYANDALTERNATIVELYACTIVATEDHUMANMACROPHAGESATTRACTVESSEL ASSOCIATEDSTEMCELLS RELYINGONSEPARATE(-'" AND--0 DEPENDENTPATHWAYS*,EUKOC"IOL ą 2OHDE% -ALISCHNIK# 4HALER$ ETAL"LOODMONOCYTESMIMICENDOTHELIALPROGENITORCELLS3TEM#ELLS ą (EISSIG" (ATTORI+ $IAS3 ETAL2ECRUITMENTOFSTEMANDPROGENITORCELLSFROMTHEBONEMARROWNICHEREQUIRES--0 MEDIATEDRELEASEOFKIT LIGAND#ELL ą !BBOTT*$ (UANG9 ,IU$ ETAL3TROMALCELL DERIVEDFACTOR ALPHAPLAYSACRITICALROLEINSTEMCELLRECRUITMENTTO THEHEARTAFTERMYOCARDIALINFARCTIONBUTISNOTSUFFICIENTTOINDUCEHOMINGINTHEABSENCEOFINJURY#IRCULATION ą $ENTELLI 0 2OSSO ! "ALSAMO ! ET AL # +)4 BY INTERACTING WITH THE MEMBRANE BOUND LIGAND RECRUITS ENDOTHELIAL PROGENITORCELLSTOINFLAMEDENDOTHELIUM"LOOD ą ,ATAILLADE** $OMENECH* ,E"OUSSE +ERDILES-#3TROMALCELL DERIVEDFACTOR 3$& <#8#2COUPLEPLAYSMULTIPLE ROLESONHAEMATOPOIETICPROGENITORSATTHEBORDERBETWEENTHEOLDCYTOKINEANDNEWCHEMOKINEWORLDSSURVIVAL CELL CYCLINGANDTRAFFICKING%UR#YTOKINE.ETW ą 0ETIT ) *IN $ 2AFII 3 4HE 3$& #8#2 SIGNALING PATHWAY A MOLECULAR HUB MODULATING NEO ANGIOGENESIS 4RENDS )MMUNOL ą !ICHER! (EESCHEN# -ILDNER 2IHM# ETAL%SSENTIALROLEOFENDOTHELIALNITRICOXIDESYNTHASEFORMOBILIZATIONOFSTEM ANDPROGENITORCELLS.AT-ED ą #ERADINI$* +ULKARNI!2 #ALLAGHAN-* ETAL0ROGENITORCELLTRAFFICKINGISREGULATEDBYHYPOXICGRADIENTSTHROUGH ()& INDUCTIONOF3$& .AT-ED ą :HANG1 9IN( ,IU0 ETAL%SSENTIALROLEOF($,ONENDOTHELIALPROGENITORCELLPROLIFERATIONWITH0)+!KTCYCLIN$AS THESIGNALPATHWAY%XP"IOL-ED-AYWOOD ą :AMPETAKI! +IRTON*0 8U16ASCULARREPAIRBYENDOTHELIALPROGENITORCELLS#ARDIOVASC2ES ą DE"OER(# 6ERSEYDEN# 5LFMAN,( ETAL&IBRINANDACTIVATEDPLATELETSCOOPERATIVELYGUIDESTEMCELLSTOAVASCULAR INJURYANDPROMOTEDIFFERENTIATIONTOWARDSANENDOTHELIALCELLPHENOTYPE!RTERIOSCLER4HROMB6ASC"IOL ą ,ANGER( -AY!% $AUB+ ETAL!DHERENTPLATELETSRECRUITANDINDUCEDIFFERENTIATIONOFMURINEEMBRYONICENDOTHELIAL PROGENITORCELLSTOMATUREENDOTHELIALCELLSINVITRO#IRC2ES Eą ,EV%) %STROV: !BOULFATOVA+ ETAL0OTENTIALROLEOFACTIVATEDPLATELETSINHOMINGOFHUMANENDOTHELIALPROGENITOR CELLSTOSUBENDOTHELIALMATRIX4HROMB(AEMOST ą 8U13TEMCELLSANDTRANSPLANTARTERIOSCLEROSIS#IRC2ES ą :ENG , 8IAO 1 -ARGARITI ! ET AL ($!# IS CRUCIAL IN SHEAR AND 6%'& INDUCED STEM CELL DIFFERENTIATION TOWARD ENDOTHELIALCELLS*#ELL"IOL ą +ULLO )* %DWARDS 7$ 3CHWARTZ 23 6ULNERABLE PLAQUE PATHOBIOLOGY AND CLINICAL IMPLICATIONS !NN )NTERN -ED ą +OLODGIE&$ 'OLD(+ "URKE!0 ETAL)NTRAPLAQUEHEMORRHAGEANDPROGRESSIONOFCORONARYATHEROMA.%NGL*-ED ą 126 ʝèãʦʤäåãéʢʥʡéʧʥð "ODARY 0& 'U 3 3HEN 9 ET AL 2ECOMBINANT LEPTIN PROMOTES ATHEROSCLEROSIS AND THROMBOSIS IN APOLIPOPROTEIN % DEFICIENTMICE!RTERIOSCLER4HROMB6ASC"IOL Eą %PSTEIN3% 3TABILE% +INNAIRD4 ETAL*ANUSPHENOMENONTHEINTERRELATEDTRADEOFFSINHERENTINTHERAPIESDESIGNED TOENHANCECOLLATERALFORMATIONANDTHOSEDESIGNEDTOINHIBITATHEROGENESIS#IRCULATION ą -ALLAT: #ORBAZ! 3COAZEC! ETAL)NTERLEUKIN INTERLEUKIN BINDINGPROTEINSIGNALINGMODULATESATHEROSCLEROTIC LESIONDEVELOPMENTANDSTABILITY#IRC2ES %ą +UHLENCORDT0* #HEN* (AN& ETAL'ENETICDEFICIENCYOFINDUCIBLENITRICOXIDESYNTHASEREDUCESATHEROSCLEROSIS ANDLOWERSPLASMALIPIDPEROXIDESINAPOLIPOPROTEIN% KNOCKOUTMICE#IRCULATION ą $OHERTY4- !SOTRA+ &ITZPATRICK,! ETAL#ALCIFICATIONINATHEROSCLEROSISBONEBIOLOGYANDCHRONICINFLAMMATION ATTHEARTERIALCROSSROADS0ROC.ATL!CAD3CI53! ą /TSUKA& &INN!6 6IRMANI2$OVULNERABLEANDRUPTUREDPLAQUESHIDEINHEAVILYCALCIFIEDARTERIES!THEROSCLEROSIS ą 3HAO *3 #AI * 4OWLER $! -OLECULAR MECHANISMS OF VASCULAR CALCIFICATION LESSONS LEARNED FROM THE AORTA !RTERIOSCLER4HROMB6ASC"IOL ą 7EXLER , "RUNDAGE " #ROUSE * ET AL #ORONARY ARTERY CALCIFICATION PATHOPHYSIOLOGY EPIDEMIOLOGY IMAGING METHODS ANDCLINICALIMPLICATIONS!STATEMENTFORHEALTHPROFESSIONALSFROMTHE!MERICAN(EART!SSOCIATION7RITING 'ROUP#IRCULATION ą !BEDIN- 4INTUT9 $EMER,,6ASCULARCALCIFICATIONMECHANISMSANDCLINICALRAMIFICATIONS!RTERIOSCLER4HROMB 6ASC"IOL ą "OSTROM+ 7ATSON+% (ORN3 ETAL"ONEMORPHOGENETICPROTEINEXPRESSIONINHUMANATHEROSCLEROTICLESIONS* #LIN)NVEST ą $HORE #2 #LEUTJENS *0 ,UTGENS % ET AL $IFFERENTIAL EXPRESSION OF BONE MATRIX REGULATORY PROTEINS IN HUMAN ATHEROSCLEROTICPLAQUES!RTERIOSCLER4HROMB6ASC"IOL ą 'OLLEDGE* -C#ANN- -ANGAN3 ETAL/STEOPROTEGERINANDOSTEOPONTINAREEXPRESSEDATHIGHCONCENTRATIONSWITHIN SYMPTOMATICCAROTIDATHEROSCLEROSIS3TROKE ą +OCKX-- (ERMAN!'!POPTOSISINATHEROSCLEROSISBENEFICIALORDETRIMENTAL#ARDIOVASC2ES ą ,ITTLEWOOD4$ "ENNETT-2!POPTOTICCELLDEATHINATHEROSCLEROSIS#URR/PIN,IPIDOL ą 'ENG9* ,IBBY00ROGRESSIONOFATHEROMAASTRUGGLEBETWEENDEATHANDPROCREATION!RTERIOSCLER4HROMB6ASC"IOL ą +IM9- 4ALANIAN26 ,I* ETAL.ITRICOXIDEPREVENTS), BETAAND)&. GAMMA INDUCINGFACTOR), RELEASEFROM MACROPHAGESBYINHIBITINGCASPASE ), BETA CONVERTINGENZYME *)MMUNOL ą "OYLE** 7EISSBERG0, "ENNETT-24UMORNECROSISFACTOR ALPHAPROMOTESMACROPHAGE INDUCEDVASCULARSMOOTH MUSCLECELLAPOPTOSISBYDIRECTANDAUTOCRINEMECHANISMS!RTERIOSCLER4HROMB6ASC"IOL ą :ERNECKE! "OT) $JALALI 4ALAB9 ETAL0ROTECTIVEROLEOF#8#RECEPTOR#8#LIGANDUNVEILSTHEIMPORTANCEOF NEUTROPHILSINATHEROSCLEROSIS#IRC2ES ą 3OEHNLEIN/ ,INDBOM,0HAGOCYTEPARTNERSHIPDURINGTHEONSETANDRESOLUTIONOFINFLAMMATION.AT2EV)MMUNOL ą %SMON#44HEIMPACTOFTHEINFLAMMATORYRESPONSEONCOAGULATION4HROMB2ESą ą +LEIN.* 3HENNAN') (EYDERMAN23 ETAL!LTERATIONINGLYCOSAMINOGLYCANMETABOLISMANDSURFACECHARGEON HUMANUMBILICALVEINENDOTHELIALCELLSINDUCEDBYCYTOKINES ENDOTOXINANDNEUTROPHILS*#ELL3CI0T ą #ONWAY%- 6ANDE7OUWER- 0OLLEFEYT3 ETAL4HELECTIN LIKEDOMAINOFTHROMBOMODULINCONFERSPROTECTIONFROM NEUTROPHIL MEDIATED TISSUE DAMAGE BY SUPPRESSING ADHESION MOLECULE EXPRESSION VIA NUCLEAR FACTOR KAPPA" AND MITOGEN ACTIVATEDPROTEINKINASEPATHWAYS*%XP-ED ą 3CARPATI%- 3ADLER*%2EGULATIONOFENDOTHELIALCELLCOAGULANTPROPERTIES-ODULATIONOFTISSUEFACTOR PLASMINOGEN ACTIVATORINHIBITORS ANDTHROMBOMODULINBYPHORBOL MYRISTATE ACETATEANDTUMORNECROSISFACTOR*"IOL#HEM ą "URSTEIN3!0LATELETSANDCYTOKINES#URR/PIN(EMATOL ą 3CHUSTER( "ARTER0* 3TENDER3 ETAL%FFECTSOFSWITCHINGSTATINSONACHIEVEMENTOFLIPIDGOALS-EASURING%FFECTIVE 2EDUCTIONSIN#HOLESTEROL5SING2OSUVASTATIN4HERAPY-%2#529) STUDY!M(EART* ą 3CHIFFRIN%, ,IPMAN-, -ANN*&#HRONICKIDNEYDISEASEEFFECTSONTHECARDIOVASCULARSYSTEM#IRCULATION ą ÒʥʡâʡåãçʡʝÎ ʝʢæʢçʤÞʡʓʖ ʝʢʥßãʢçäʤÐʔ ETALʝʧÝäåãçãìʢʦäãʣʡéʢʥʤʦäåʢʥʤâąʥʤåñÞʦéʥʡéãêãäʡëãã ʦʢʥàʢìçʤ ʦʤʦʧàãʦéðʨâʡÝʤåʢÞʡçãʣʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą #ATAPANO !, 'RAHAM ) $E "ACKER ' ET AL %3#%!3 'UIDELINES FOR THE -ANAGEMENT OF $YSLIPIDAEMIAS 4HE 4ASK &ORCE FOR THE -ANAGEMENT OF $YSLIPIDAEMIAS OF THE %UROPEAN 3OCIETY OF #ARDIOLOGY %3# AND %UROPEAN !THEROSCLEROSIS3OCIETY%!3 $EVELOPEDWITHTHESPECIALCONTRIBUTIONOFTHE%UROPEAN!SSOCCIATIONFOR#ARDIOVASCULAR 0REVENTION2EHABILITATION%!#02 %UR(EART* 127 ʝèãʦʤäåãéʢʥʡéʧʥð ÌʤʣëʤÞʝʓ ʒʧʨʡʥìʧäʔʔ ʒʡʥèʤÞÛʓ ETALʝʧÝäåãçãìʢʦäãʣʡéʢʥʤʦäåʢʥʤâäʡäêʡäéʤʥʥãʦäʡʦʢʥàʢìçʤ ʦʤʦʧ àãʦéðʨʤʦåʤáçʢçãʣʒʡʥàãʤÞʡʦäʧåôʥçʡôéʢʥʡèãôãèʥʤêãåʡäéãäʡ ą #ATAPANO!, 2EINER: $E"ACKER' ETAL%3#%!3'UIDELINESFORTHEMANAGEMENTOFDYSLIPIDAEMIAS4HE4ASK&ORCE FORTHEMANAGEMENTOFDYSLIPIDAEMIASOFTHE%UROPEAN3OCIETYOF#ARDIOLOGY%3# ANDTHE%UROPEAN!THEROSCLEROSIS 3OCIETY%!3 !THEROSCLEROSIS ą :ETHELIUS " "ERGLUND , 3UNDSTRǥM * ET AL 5SE OF -ULTIPLE "IOMARKERS TO )MPROVE THE 0REDICTION OF $EATH FROM #ARDIOVASCULAR#AUSES.EW%NGLAND*OURNALOF-EDICINE ą ʙʤâʡàâʢÍʙ Ìʧʥæãʦéʢçäʤʚʝ ʝʢæʢçʤÞʡʓʖ ETALÐçʦéʥʧæʢçéʡåñçðʢãåʡÝʤʥʡéʤʥçðʢæʢéʤàðÞÞðôÞåʢçãã çʢʦéʡÝãåñçðʨʡéʢʥʤʦäåʢʥʤéãìʢʦäãʨÝåôíʢäʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą "URKE !0 %LEVATED # 2EACTIVE 0ROTEIN 6ALUES AND !THEROSCLEROSIS IN 3UDDEN #ORONARY $EATH !SSOCIATION 7ITH $IFFERENT0ATHOLOGIES#IRCULATION ą 6ERMA3 $EVARAJ3 *IALAL))S# REACTIVEPROTEINANINNOCENTBYSTANDERORPROATHEROGENICCULPRIT# REACTIVEPROTEIN PROMOTESATHEROTHROMBOSIS#IRCULATION ąDISCUSSION $ANESH* 7HEELER*' (IRSCHFIELD'- ETAL# 2EACTIVE0ROTEINAND/THER#IRCULATING-ARKERSOF)NFLAMMATIONINTHE 0REDICTIONOF#ORONARY(EART$ISEASE.EW%NGLAND*OURNALOF-EDICINE ą #ASLAKE-* 0ACKARD#* 3UCKLING+% ETAL,IPOPROTEIN ASSOCIATEDPHOSPHOLIPASE! PLATELET ACTIVATINGFACTOR ACETYLHYDROLASEAPOTENTIALNEWRISKFACTORFORCORONARYARTERYDISEASE!THEROSCLEROSIS ą 1UINN-4 0ARTHASARATHY3 3TEINBERG$,YSOPHOSPHATIDYLCHOLINEACHEMOTACTICFACTORFORHUMANMONOCYTESAND ITSPOTENTIALROLEINATHEROGENESIS0ROCEEDINGSOFTHE.ATIONAL!CADEMYOF3CIENCES ą (AKKINEN 4 ,UOMA *3 (ILTUNEN -/ ET AL ,IPOPROTEIN !SSOCIATED 0HOSPHOLIPASE ! 0LATELET !CTIVATING &ACTOR !CETYLHYDROLASE )S %XPRESSED BY -ACROPHAGES IN (UMAN AND 2ABBIT !THEROSCLEROTIC ,ESIONS !RTERIOSCLER 4HROMB 6ASC"IOL ą 3INGH 5 :HONG 3 8IONG - ET AL )NCREASED PLASMA NON ESTERIFIED FATTY ACIDS AND PLATELET ACTIVATING FACTOR ACETYLHYDROLASEAREASSOCIATEDWITHSUSCEPTIBILITYTOATHEROSCLEROSISINMICE#LIN3CI ą -EMON2! &ULLER* -OSER!( ETAL)NVIVOREGULATIONOFPLASMAPLATELET ACTIVATINGFACTORACETYLHYDROLASEDURING THEACUTEPHASERESPONSE!M*0HYSIOL0T 2ą ʙʤâʡàâʢÍʙ ÌʡåʡʨʤçʤÞʡʞʔ ʝʢʥßãʢçäʤÐʔ ETALʝÞôâñæʡʦʦðãʡäéãÞçʤʦéãåãèʤèʥʤéʢãç ʡʦʦʤëããʥʤÞʡççʤʣ êʤʦêʤåãèʡâðʓʦÞðʥʡáʢççʤʦéñóʡéʢʥʤʦäåʢʥʤéãìʢʦäʤßʤèʤʥʡáʢçãôʦʤççðʨʡʥéʢʥãʣʧÝʤåñçðʨʥʡâåãìçðʨ äʡéʢßʤʥãʣʥãʦäʡʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą 'ERBER 9 $UNLAY 3- *AFFE !3 ET AL 0LASMA LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE ! LEVELS IN HEART FAILURE !SSOCIATIONWITHMORTALITYINTHECOMMUNITY!THEROSCLEROSIS ą "RILAKIS%3 +HERA! 3AEED" ETAL!SSOCIATIONOF,IPOPROTEIN !SSOCIATED0HOSPHOLIPASE!-ASSAND!CTIVITYWITH #ORONARYAND!ORTIC!THEROSCLEROSIS&INDINGSFROMTHE$ALLAS(EART3TUDY#LIN#HEM ą 7ASSERTHEIL 3MOLLER3 +OOPERBERG# -C'INN!0 ETAL,IPOPROTEIN !SSOCIATED0HOSPHOLIPASE! (ORMONE5SE ANDTHE2ISKOF)SCHEMIC3TROKEIN0OSTMENOPAUSAL7OMEN(YPERTENSION ą -ǥCKEL- -ǩLLER2 6OLLERT*/ ETAL,IPOPROTEIN ASSOCIATEDPHOSPHOLIPASE!FOREARLYRISKSTRATIFICATIONINPATIENTS WITHSUSPECTEDACUTECORONARYSYNDROMEAMULTI MARKERAPPROACH#LIN2ES#ARDIOL ą 'ARZA#! -ONTORI6- -C#ONNELL*0 ETAL!SSOCIATION"ETWEEN,IPOPROTEIN !SSOCIATED0HOSPHOLIPASE!AND #ARDIOVASCULAR$ISEASE!3YSTEMATIC2EVIEW-AYO#LINIC0ROCEEDINGS ą "ALLANTYNE#-,IPOPROTEIN !SSOCIATED0HOSPHOLIPASE! (IGH 3ENSITIVITY# 2EACTIVE0ROTEIN AND2ISKFOR)NCIDENT #ORONARY(EART$ISEASEIN-IDDLE !GED-ENAND7OMENINTHE!THEROSCLEROSIS2ISKIN#OMMUNITIES!2)# 3TUDY #IRCULATION ą (ASSAN-34!"),)49AND3/,)$ 4)-),IPOPROTEINASSOCIATEDPHOSPHOLIPASE!,P 0,! ASABIOMARKERORRISK FACTORFORCARDIOVASCULARDISEASES'LOB#ARDIOL3CI0RACT 2ATTAZZI- 0UATO- &AGGIN% ETAL# REACTIVEPROTEINANDINTERLEUKIN INVASCULARDISEASE*(YPERTENS ą 3CHIEFFER" 3CHIEFFER% (ILFIKER +LEINER$ ETAL%XPRESSIONOF!NGIOTENSIN))AND)NTERLEUKININ(UMAN#ORONARY !THEROSCLEROTIC0LAQUES0OTENTIAL)MPLICATIONSFOR)NFLAMMATIONAND0LAQUE)NSTABILITY#IRCULATION ą "IASUCCI,- ,IUZZO' &ANTUZZI' ETAL)NCREASING,EVELSOF)NTERLEUKIN), 2AAND), $URINGTHE&IRST$AYSOF (OSPITALIZATIONIN5NSTABLE!NGINA!RE!SSOCIATED7ITH)NCREASED2ISKOF)N (OSPITAL#ORONARY%VENTS#IRCULATION ą ,INDMARK % $IDERHOLM % 7ALLENTIN , ET AL 2ELATIONSHIP "ETWEEN )NTERLEUKIN AND -ORTALITY IN 0ATIENTS 7ITH 5NSTABLE#ORONARY!RTERY$ISEASE*!-! 2IDKER0- 2IFAI. 3TAMPFER-* ETAL0LASMA#ONCENTRATIONOF)NTERLEUKIN ANDTHE2ISKOF&UTURE-YOCARDIAL )NFARCTION!MONG!PPARENTLY(EALTHY-EN#IRCULATION ą 6OLPATO 3 'URALNIK *- &ERRUCCI , ET AL #ARDIOVASCULAR $ISEASE )NTERLEUKIN AND 2ISK OF -ORTALITY IN /LDER 7OMEN4HE7OMENĈS(EALTHAND!GING3TUDY#IRCULATION ą 128 ʝèãʦʤäåãéʢʥʡéʧʥð 4IRET,'ENETIC!NALYSISOFTHE)NTERLEUKIN 3YSTEM(IGHLIGHTSTHE2OLEOFTHE)NTERLEUKIN 'ENEIN#ARDIOVASCULAR $ISEASE#IRCULATION ą "LANKENBERG3 ,UC' $UCIMETIERE0 ETAL)NTERLEUKIN ANDTHERISKOFCORONARYHEARTDISEASEIN%UROPEANMENTHE 0ROSPECTIVE%PIDEMIOLOGICAL3TUDYOF-YOCARDIAL)NFARCTION02)-% #IRCULATION ą +OENIG7 +HUSEYINOVA. "AUMERT* ETAL)NCREASED#ONCENTRATIONSOF# 2EACTIVE0ROTEINAND), BUTNOT), !RE )NDEPENDENTLY!SSOCIATED7ITH)NCIDENT#ORONARY%VENTSIN-IDDLE !GED-ENAND7OMEN2ESULTS&ROMTHE-/.)#! +/2!!UGSBURG#ASE #OHORT3TUDY ą!RTERIOSCLER4HROMB6ASC"IOL ą "ALDUS3-YELOPEROXIDASE3ERUM,EVELS0REDICT2ISKIN0ATIENTS7ITH!CUTE#ORONARY3YNDROMES#IRCULATION ą "RENNAN- , 0ENN-3 6AN,ENTE& ETAL0ROGNOSTIC6ALUEOF-YELOPEROXIDASEIN0ATIENTSWITH#HEST0AIN.EW %NGLAND*OURNALOF-EDICINE ą 'ALIS:3 3UKHOVA'+ ,ARK-7 ETAL)NCREASEDEXPRESSIONOFMATRIXMETALLOPROTEINASESANDMATRIXDEGRADING ACTIVITYINVULNERABLEREGIONSOFHUMANATHEROSCLEROTICPLAQUES*OURNALOF#LINICAL)NVESTIGATION ą *ONES#-ATRIXMETALLOPROTEINASES!REVIEWOFTHEIRSTRUCTUREANDROLEINACUTECORONARYSYNDROME#ARDIOVASC2ES ą "LANKENBERG30LASMA#ONCENTRATIONSAND'ENETIC6ARIATIONOF-ATRIX-ETALLOPROTEINASEAND0ROGNOSISOF0ATIENTS 7ITH#ARDIOVASCULAR$ISEASE#IRCULATION ą (EESCHEN#0ROGNOSTIC6ALUEOF0LACENTAL'ROWTH&ACTORIN0ATIENTS7ITH!CUTE#HEST0AIN*!-! ,ENDERINK4 (EESCHEN# &ICHTLSCHERER3 ETAL%LEVATED0LACENTAL'ROWTH&ACTOR,EVELS!RE!SSOCIATED7ITH!DVERSE /UTCOMESAT&OUR 9EAR&OLLOW 5PIN0ATIENTS7ITH!CUTE#ORONARY3YNDROMES*!M#OLL#ARDIOL ą "LAKE'*3OLUBLE#$,IGAND,EVELS)NDICATE,IPID!CCUMULATIONIN#AROTID!THEROMA!N)N6IVO3TUDY7ITH(IGH 2ESOLUTION-2)!RTERIOSCLER4HROMB6ASC"IOL E (EESCHEN# $IMMELER3 (AMM#7 ETAL3OLUBLE#$,IGANDIN!CUTE#ORONARY3YNDROMES.EW%NGLAND*OURNAL OF-EDICINE ą &ALK% 3HAH0+ &USTER6#ORONARY0LAQUE$ISRUPTION#IRCULATION ą +WEE2- VAN/OSTENBRUGGE2* (OFSTRA, ETAL)DENTIFYINGVULNERABLECAROTIDPLAQUESBYNONINVASIVEIMAGING .EUROLOGY)SSUE 0ART ą "ROTT 4' (ALPERIN *, !BBARA 3 ET AL !3!!##&!(!!!..!!.3!#2!3.2#.33!)03#!)3)23.)3 36-363'UIDELINEONTHE-ANAGEMENTOF0ATIENTS7ITH%XTRACRANIAL#AROTIDAND6ERTEBRAL!RTERY$ISEASE%XECUTIVE 3UMMARY*!M#OLL#ARDIOL ą #OLI3 -AGNONI- 3ANGIORGI' ETAL#ONTRAST %NHANCED5LTRASOUND)MAGINGOF)NTRAPLAQUE.EOVASCULARIZATIONIN #AROTID!RTERIES*!M#OLL#ARDIOL ą /WEN$2 3HALHOUB* -ILLER3 ETAL)NFLAMMATIONWITHIN#AROTID!THEROSCLEROTIC0LAQUE!SSESSMENTWITH,ATE 0HASE#ONTRAST ENHANCED532ADIOLOGY ą ,INDNER*2 #OGGINS-0 +AUL3 ETAL-ICROBUBBLE0ERSISTENCEINTHE-ICROCIRCULATION$URING)SCHEMIA2EPERFUSION AND)NFLAMMATION)S#AUSEDBY)NTEGRIN AND#OMPLEMENT -EDIATED!DHERENCETO!CTIVATED,EUKOCYTES#IRCULATION ą 4SUTSUI*- 8IE& #ANO- ETAL$ETECTIONOFRETAINEDMICROBUBBLESINCAROTIDARTERIESWITHREAL TIMELOWMECHANICAL INDEXIMAGINGINTHESETTINGOFENDOTHELIALDYSFUNCTION*!M#OLL#ARDIOL ą 3TAUB $ 0ATEL -" 4IBREWALA ! ET AL 6ASA 6ASORUM AND 0LAQUE .EOVASCULARIZATION ON #ONTRAST %NHANCED #AROTID5LTRASOUND)MAGING#ORRELATES7ITH#ARDIOVASCULAR$ISEASEAND0AST#ARDIOVASCULAR%VENTS3TROKE ą 8IONG , $ENG 9 " :HU 9 ET AL #ORRELATION OF #AROTID 0LAQUE .EOVASCULARIZATION $ETECTED BY 5SING #ONTRAST ENHANCED53WITH#LINICAL3YMPTOMS2ADIOLOGY ą ,EBER !7 "ECKER ! +NEZ ! ET AL !CCURACY OF 3LICE #OMPUTED 4OMOGRAPHY TO #LASSIFY AND 1UANTIFY 0LAQUE 6OLUMESINTHE0ROXIMAL#ORONARY3YSTEM*!M#OLL#ARDIOL ą /ZAKI9 /KUMURA- )SMAIL4& ETAL#ORONARY#4ANGIOGRAPHICCHARACTERISTICSOFCULPRITLESIONSINACUTECORONARY SYNDROMESNOTRELATEDTOPLAQUERUPTUREASDEFINEDBYOPTICALCOHERENCETOMOGRAPHYANDANGIOSCOPY%UR(EART* ą -OTOYAMA 3 3ARAI - (ARIGAYA ( ET AL #OMPUTED 4OMOGRAPHIC !NGIOGRAPHY #HARACTERISTICS OF !THEROSCLEROTIC 0LAQUES3UBSEQUENTLY2ESULTINGIN!CUTE#ORONARY3YNDROME*!M#OLL#ARDIOL ą -OTOYAMA3 +ONDO4 !NNO( ETAL!THEROSCLEROTIC0LAQUE#HARACTERIZATIONBY MM 3LICE-ULTISLICE#OMPUTED 4OMOGRAPHIC)MAGING#IRCULATION*OURNAL ą +ASHIWAGI - 4ANAKA ! +ITABATA ( ET AL #OMPARISON OF DIAGNOSTIC ACCURACY BETWEEN MULTIDETECTOR COMPUTED TOMOGRAPHY AND VIRTUAL HISTOLOGY INTRAVASCULAR ULTRASOUND FOR DETECTING OPTICAL COHERENCE TOMOGRAPHY DERIVED FIBROATHEROMA#ARDIOVASCULAR)NTERVENTIONAND4HERAPEUTICS ą 129 ʝèãʦʤäåãéʢʥʡéʧʥð (YAFIL& #ORNILY* # &EIG*% ETAL.ONINVASIVEDETECTIONOFMACROPHAGESUSINGANANOPARTICULATECONTRASTAGENT FORCOMPUTEDTOMOGRAPHY.AT-ED ą /TSUKA - "RUINING . 6AN 0ELT .# ET AL 1UANTIFICATION OF #ORONARY 0LAQUE BY SLICE #OMPUTED 4OMOGRAPHY ! #OMPARISONWITH1UANTITATIVE)NTRACORONARY5LTRASOUND)NVEST2ADIOL ą (OFFMANN 5 -OSELEWSKI & .IEMAN + ET AL .ONINVASIVE !SSESSMENT OF 0LAQUE -ORPHOLOGY AND #OMPOSITION IN #ULPRITAND3TABLE,ESIONSIN!CUTE#ORONARY3YNDROMEAND3TABLE,ESIONSIN3TABLE!NGINABY-ULTIDETECTOR#OMPUTED 4OMOGRAPHY*!M#OLL#ARDIOL ą 0UNDZIUTE ' 3CHUIJF *$ *UKEMA *7 ET AL (EAD TO (EAD #OMPARISON OF #ORONARY 0LAQUE %VALUATION "ETWEEN -ULTISLICE#OMPUTED4OMOGRAPHYAND)NTRAVASCULAR5LTRASOUND2ADIOFREQUENCY$ATA!NALYSIS*!###ARDIOVASCULAR )NTERVENTIONS ą 9AMAMOTO ( +ITAGAWA 4 /HASHI . ET AL .ONCALCIFIED ATHEROSCLEROTIC LESIONS WITH VULNERABLE CHARACTERISTICS DETECTEDBYCORONARY#4ANGIOGRAPHYANDFUTURECORONARYEVENTS*OURNALOF#ARDIOVASCULAR#OMPUTED4OMOGRAPHY ą /TSUKA+ &UKUDA3 4ANAKA! ETAL0ROGNOSISOFVULNERABLEPLAQUEONCOMPUTEDTOMOGRAPHICCORONARYANGIOGRAPHY WITHNORMALMYOCARDIALPERFUSIONIMAGE%UROPEAN(EART*OURNAL #ARDIOVASCULAR)MAGING ą +RISTENSEN43 +OFOED+& +ǩHL*4 ETAL0ROGNOSTIC)MPLICATIONSOF.ONOBSTRUCTIVE#ORONARY0LAQUESIN0ATIENTS 7ITH.ONą34 3EGMENT%LEVATION-YOCARDIAL)NFARCTION*!M#OLL#ARDIOL ą &AYAD:! &USTER6 &ALLON*4 ETAL.ONINVASIVE)N6IVO(UMAN#ORONARY!RTERY,UMENAND7ALL)MAGING5SING "LACK "LOOD-AGNETIC2ESONANCE)MAGING#IRCULATION ą "OTNAR 2- 3TUBER - +ISSINGER +6 ET AL .ONINVASIVE #ORONARY 6ESSEL 7ALL AND 0LAQUE )MAGING 7ITH -AGNETIC 2ESONANCE)MAGING#IRCULATION ą &AYAD: &USTER6#HARACTERIZATIONOF!THEROSCLEROTIC0LAQUESBY-AGNETIC2ESONANCE)MAGING!NN.9!CAD3CI ą -ITSUMORI,- (ATSUKAMI43 &ERGUSON-3 ETAL)NVIVOACCURACYOFMULTISEQUENCE-2IMAGINGFORIDENTIFYING UNSTABLEFIBROUSCAPSINADVANCEDHUMANCAROTIDPLAQUES*-AGN2ESON)MAGING ą &AYAD :! #OMPUTED 4OMOGRAPHY AND -AGNETIC 2ESONANCE )MAGING FOR .ONINVASIVE #ORONARY !NGIOGRAPHY AND 0LAQUE)MAGING#URRENTAND0OTENTIAL&UTURE#ONCEPTS#IRCULATION ą .EMIROVSKY$)MAGINGOF(IGH 2ISK0LAQUE#ARDIOLOGY ą 3CHMID- 0FLEDERER4 *ANG) + ETAL2ELATIONSHIPBETWEENDEGREEOFREMODELINGAND#4ATTENUATIONOFPLAQUEIN CORONARYATHEROSCLEROTICLESIONS!NIN VIVOANALYSISBYMULTI DETECTORCOMPUTEDTOMOGRAPHY!THEROSCLEROSIS ą 3AAM4 (ATSUKAMI43 4AKAYA. ETAL4HEVULNERABLE ORHIGH RISK ATHEROSCLEROTICPLAQUENONINVASIVE-2IMAGING FORCHARACTERIZATIONANDASSESSMENT2ADIOLOGY ą *OHNSTONE-4 "OTNAR2- 0EREZ!3 ETAL)N6IVO-AGNETIC2ESONANCE)MAGINGOF%XPERIMENTAL4HROMBOSISINA 2ABBIT-ODEL!RTERIOSCLER4HROMB6ASC"IOL ą 'ERRETSEN3 +ESSELS!' .ELEMANS0* ETAL$ETECTIONOFCORONARYPLAQUESUSING-2CORONARYVESSELWALLIMAGING VALIDATIONOFFINDINGSWITHINTRAVASCULARULTRASOUND%UR2ADIOL ą (E 9 :HANG : $AI 1 ET AL !CCURACY OF -2) TO IDENTIFY THE CORONARY ARTERY PLAQUE ! COMPARATIVE STUDY WITH INTRAVASCULARULTRASOUND*-AGN2ESON)MAGING ą .OGUCHI 4 +AWASAKI 4 4ANAKA ! ET AL (IGH )NTENSITY 3IGNALS IN #ORONARY 0LAQUES ON .ONCONTRAST 4 7EIGHTED -AGNETIC2ESONANCE)MAGINGASA.OVEL$ETERMINANTOF#ORONARY%VENTS*!M#OLL#ARDIOL ą ,IU8 :HAO8 (UANG* ETAL#OMPARISONOF$&REE "REATHING#ORONARY-2!NGIOGRAPHYAND -$#4!NGIOGRAPHY FOR$ETECTIONOF#ORONARY3TENOSISIN0ATIENTSWITH(IGH#ALCIUM3CORES!MERICAN*OURNALOF2OENTGENOLOGY ą -AINTZ$3ELECTIVECORONARYARTERYPLAQUEVISUALIZATIONANDDIFFERENTIATIONBYCONTRAST ENHANCEDINVERSIONPREPARED -2)%UR(EART* ą )BRAHIM 4 -AKOWSKI -2 *ANKAUSKAS ! ET AL 3ERIAL #ONTRAST %NHANCED #ARDIAC -AGNETIC 2ESONANCE )MAGING $EMONSTRATES2EGRESSIONOF(YPERENHANCEMENT7ITHINTHE#ORONARY!RTERY7ALLIN0ATIENTS!FTER!CUTE-YOCARDIAL )NFARCTION*!###ARDIOVASCULAR)MAGING ą -ATTER#- 3TUBER- .AHRENDORF-)MAGINGOFTHEUNSTABLEPLAQUEHOWFARHAVEWEGOT%UR(EART* ą !NDERSON3! 2ADER2+ 7ESTLIN7& ETAL-AGNETICRESONANCECONTRASTENHANCEMENTOFNEOVASCULATUREWITH V TARGETEDNANOPARTICLES-AGNETIC2ESONANCEIN-EDICINE ą (AMILTON!* (UANG3 , 7ARNICK$ ETAL)NTRAVASCULARULTRASOUNDMOLECULARIMAGINGOFATHEROMACOMPONENTSIN VIVO*!M#OLL#ARDIOL ą +ELLY+!$ETECTIONOF6ASCULAR!DHESION-OLECULE %XPRESSION5SINGA.OVEL-ULTIMODAL.ANOPARTICLE#IRC2ES ą 130 ʝèãʦʤäåãéʢʥʡéʧʥð 7INTER 0- -OLECULAR )MAGING OF !NGIOGENESIS IN %ARLY 3TAGE !THEROSCLEROSIS 7ITH V )NTEGRIN 4ARGETED .ANOPARTICLES#IRCULATION ą ʓçíʢåʢʦʓʓ ʝʢʥßãʢçäʤʔÌʞʤæʤßʥʡêãìʢʦäãʢæʢéʤàðàãʡßçʤʦéãäãèʥãʤëʢçäʢèʢʥêʧâããæãʤäʡʥàʡʧÝʤåñçðʨ ʦãíʢæãìʢʦäʤʣÝʤåʢâçñóʦʢʥàëʡʘʢàãëãçʦäʡôʥʡàãʤåʤßãôãʥʡàãʡëãʤççʡôÝʢâʤèʡʦçʤʦéñą ʝʢʥßãʢçäʤʔÌ ʓçíʢåʢʦʓʓʞʤæʤßʥʡêãìʢʦäãʢæʢéʤàðÞʤëʢçäʢèʢʥêʧâããæãʤäʡʥàʡʔʢʦéçãäʥʢçéßʢçʤåʤßãã ãʥʡàãʤåʤßããą ʓçíʢåʢʦʓʓ ʝʢʥßãʢçäʤʔÌʝʤÞʥʢæʢççðʢÞʤâæʤáçʤʦéãʥʡàãʤçʧäåãàçʤʣàãʡßçʤʦéãäãèʥãʡʥéʢʥãʡåñçʤʣßã èʢʥéʢçâããʝãʦéʢæçðʢßãèʢʥéʢçâãã ą ʓçíʢåʢʦʓʓ ÖãßʤåʢÞʡÜʔ ʝʢʥßãʢçäʤÐʔ ETALʚʦʤÝʢççʤʦéãèʢʥêʧâãããʦãæèʡéãìʢʦäʤʣãççʢʥÞʡëããæãʤ äʡʥàʡ èʤ àʡççðæ ʤàçʤêʤéʤççʤʣ òæãʦʦãʤççʤʣ äʤæèñóéʢʥçʤʣ éʤæʤßʥʡêãã ʧ èʡëãʢçéʤÞ ʦ ßãèʢʥéʥʤêãìʢʦäʤʣ äʡʥàãʤæãʤèʡéãʢʣʒʡʥàãʤåʤßãìʢʦäãʣÞʢʦéçãä ą ʓçíʢåʢʦʓʓ ÕʧåñßãçÍʙ ʝʤåʤæôçðʣʔʔ ETALʝʤèʤʦéʡÞåʢçãʢʥʢâʧåñéʡéʤÞçʡßʥʧâʤìçðʨèʥʤÝ àʡççðʨʤà çʤêʤéʤççʤʣ òæãʦʦãʤççʤʣ äʤæèñóéʢʥçʤʣ éʤæʤßʥʡêãã æãʤäʡʥàʡ ã äʤʥʤçʡʥʤßʥʡêãã ʧ Ýʤåñçðʨ ãíʢæãìʢʦäʤʣ ÝʤåʢâçñóʦʢʥàëʡʒʡʥàãʤåʤßãìʢʦäãʣÞʢʦéçãäą ʓçíʢåʢʦʓʓ ÕʧåñßãçÍʙ ʝʤåʤæôçðʣʔʔ ETALʒåãçãìʢʦäʡôâçʡìãæʤʦéñʥʡàãʤçʧäåãàçʤʣàãʡßçʤʦéãäãèʥã ʥʢíʢçããÞʤèʥʤʦʤÞçʡèʥʡÞåʢçãôÝʤåñçðʨÐÌʝçʡäʤʥʤçʡʥʤʡçßãʤßʥʡêãóʞʢʥʡèʢÞéą ʝʢʥßãʢçäʤʔÌ ʓçíʢåʢʦʓʓ ÕʧåñßãçÍʙ ETALʘʢéʤàãìʢʦäãʢʥʢäʤæʢçàʡëããèʢʥêʧâãʤççʡôʦëãçéãßʥʡêãô ãʚÚʒʞæãʤäʡʥàʡʒʡʥàãʤåʤßãìʢʦäãʣÞʢʦéçãäą ʓçíʢåʢʦ ʓʓ ʠʡåãäʤÞʡ ÚÐ ʜðáãäʤÞʡ ʚʓ ʝèʤʦʤÝ äʤåãìʢʦéÞʢççʤʣ ʤëʢçäã çʡʥʧíʢçãʣ èʢʥêʧâãã æãʤäʡʥàʡ èʤàʡççðæʤàçʤêʤéʤççʤʣòæãʦʦãʤççʤʣäʤæèñóéʢʥçʤʣéʤæʤßʥʡêããʘʢàãëãçʦäʡôêãâãäʡ ą ʓçíʢåʢʦʓʓ ʘʡʥéãʥʤʦôçÑʓ ʝʢʥßãʢçäʤÐʔ ETALʙʤÞðʢèʤàʨʤàðääʤåãìʢʦéÞʢççʤʣʤëʢçäʢçʡìʡåñçðʨçʡʥʧ íʢçãʣãçʢʤàçʤʥʤàçʤʦéãèʢʥêʧâããæãʤäʡʥàʡèʤàʡççðæʤàçʤêʤéʤççʤʣòæãʦʦãʤççʤʣäʤæèñóéʢʥçʤʣéʤæʤßʥʡ êããʔʢʦéçãäʥʢçéßʢçʤåʤßãããʥʡàãʤåʤßããą ʓçíʢåʢʦʓʓʚʦʤÝʢççʤʦéããçéʢʥèʥʢéʡëããèʢʥêʧâãʤççʤʣʤàçʤêʤéʤççʤʣòæãʦʦãʤççʤʣäʤæèñóéʢʥçʤʣéʤæʤßʥʡ êããæãʤäʡʥàʡʦäʤæèñóéʢʥçʤ éʤæʤßʥʡêãìʢʦäʤʣäʤʥʥʢäëãʢʣèʤßåʤîʢçãôʔʢʦéçãäʥʢçéßʢçʤåʤßãããʥʡàãʤåʤ ßããą /HTSUKI + (AYASE - !KASHI + ET AL $ETECTION OF MONOCYTE CHEMOATTRACTANT PROTEIN RECEPTOR EXPRESSION IN EXPERIMENTALATHEROSCLEROTICLESIONSANAUTORADIOGRAPHICSTUDY#IRCULATION ą (AUBNER2!LPHAVBETA INTEGRINIMAGINGANEWAPPROACHTOCHARACTERISEANGIOGENESIS%UR*.UCL-ED-OL)MAGING 3UPPLą 6IRGOLINI ) 2AUSCHA & ,UPATTELLI ' ET AL !UTOLOGOUS LOW DENSITY LIPOPROTEIN LABELLING ALLOWS CHARACTERIZATION OF HUMANATHEROSCLEROTICLESIONSINVIVOASTOPRESENCEOFFOAMCELLSANDENDOTHELIALCOVERAGE%UR*.UCL-ED ą #HOUDHARY 3 (IGGINS #, #HEN )9 ET AL 1UANTITATION AND LOCALIZATION OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORSINHUMANCAROTIDENDARTERECTOMYTISSUES!RTERIOSCLER4HROMB6ASC"IOL ą 'RECO # $I ,ORETO - #IAVOLELLA - ET AL )MMUNODETECTION OF HUMAN ATHEROSCLEROTIC PLAQUE WITH ) LABELED MONOCLONALANTIFIBRINANTIBODIES!THEROSCLEROSIS ą 4AWAKOL! -IGRINO21 "ASHIAN'' ETAL)NVIVO& FLUORODEOXYGLUCOSEPOSITRONEMISSIONTOMOGRAPHYIMAGING PROVIDESANONINVASIVEMEASUREOFCAROTIDPLAQUEINFLAMMATIONINPATIENTS*!M#OLL#ARDIOL ą 2UDD*( -YERS+3 "ANSILAL3 ETAL!THEROSCLEROSISINFLAMMATIONIMAGINGWITH& &$'0%4CAROTID ILIAC AND FEMORALUPTAKEREPRODUCIBILITY QUANTIFICATIONMETHODS ANDRECOMMENDATIONS*.UCL-ED ą ,EE3* /N9+ ,EE%* ETAL2EVERSALOFVASCULAR& &$'UPTAKEWITHPLASMAHIGH DENSITYLIPOPROTEINELEVATIONBY ATHEROGENICRISKREDUCTION*.UCL-ED ą 2OGERS)3 .ASIR+ &IGUEROA!, ETAL&EASIBILITYOF&$'IMAGINGOFTHECORONARYARTERIESCOMPARISONBETWEENACUTE CORONARYSYNDROMEANDSTABLEANGINA*!###ARDIOVASC)MAGING ą 2OMINGER ! 3AAM 4 7OLPERS 3 ET AL & &$' 0%4#4 IDENTIFIES PATIENTS AT RISK FOR FUTURE VASCULAR EVENTS IN AN OTHERWISEASYMPTOMATICCOHORTWITHNEOPLASTICDISEASE*.UCL-ED ą ,EE $( ,EE 3* ,EE $* ET AL #AROTID !RTERY &$' 5PTAKE -AY 3ERVE AS A "IOMARKER FOR #ARDIOVASCULAR 2ISK 3TRATIFICATIONIN!SYMPTOMATIC!DULTS.UCL-ED-OL)MAGING ą ʝʢʥßãʢçäʤ ʔÌ ʛʤçìäʤÞʦäʡô ʖʔ ʘʡçʧäʤÞʡ ʔʓ ET AL ʛʤâãéʥʤççʤ òæãʦʦãʤççʡô éʤæʤßʥʡêãô Þ àãʡßçʤʦéãäʢ ʡéʢʥʤʦäåʢʥʤéãìʢʦäãʨÝåôíʢäʧʤçäʤåʤßãìʢʦäãʨÝʤåñçðʨʞʢʥʡèʢÞéãìʢʦäãʣʡʥʨãÞ ą 0ROUDFOOT$ 3HANAHAN#- 7EISSBERG0,6ASCULARCALCIFICATIONNEWINSIGHTSINTOANOLDPROBLEM*0ATHOL ą 2UDD *( .ARULA * 3TRAUSS (7 ET AL )MAGING ATHEROSCLEROTIC PLAQUE INFLAMMATION BY FLUORODEOXYGLUCOSE WITH POSITRONEMISSIONTOMOGRAPHYREADYFORPRIMETIME*!M#OLL#ARDIOL ą 2UDD*( 7ARBURTON%! &RYER4$ ETAL)MAGINGATHEROSCLEROTICPLAQUEINFLAMMATIONWITH;&= FLUORODEOXYGLUCOSE POSITRONEMISSIONTOMOGRAPHY#IRCULATION ą 131 ʝèãʦʤäåãéʢʥʡéʧʥð #HENG 69 3LOMKA 0* ,E -EUNIER , ET AL #ORONARY ARTERIAL & &$' UPTAKE BY FUSION OF 0%4 AND CORONARY #4 ANGIOGRAPHYATSITESOFPERCUTANEOUSSTENTINGFORACUTEMYOCARDIALINFARCTIONANDSTABLECORONARYARTERYDISEASE* .UCL-ED ą -ATTER#- 7YSS-4 -EIER0 ETAL& CHOLINEIMAGESMURINEATHEROSCLEROTICPLAQUESEXVIVO!RTERIOSCLER4HROMB 6ASC"IOL ą "EN (AIM3 +UPZOV% 4AMIR! ETAL%VALUATIONOF& &$'UPTAKEANDARTERIALWALLCALCIFICATIONSUSING& &$' 0%4#4*.UCL-ED ą "ATARSEH! 0APADOPOULOS62EGULATIONOFTRANSLOCATORPROTEINK$A430/ EXPRESSIONINHEALTHANDDISEASESTATES -OL#ELL%NDOCRINOLą ą )MAIZUMI - "RIARD % :OGHBI 33 ET AL "RAIN AND WHOLE BODY IMAGING IN NONHUMAN PRIMATES OF ;#=0"2 A PROMISING0%4RADIOLIGANDFORPERIPHERALBENZODIAZEPINERECEPTORS.EUROIMAGE ą /WEN$2 'UNN2. 2ABINER%! ETAL-IXED AFFINITYBINDINGINHUMANSWITH K$ATRANSLOCATORPROTEINLIGANDS* .UCL-ED ą ,EE3* 0AENG*#.UCLEAR-OLECULAR)MAGINGFOR6ULNERABLE!THEROSCLEROTIC0LAQUES+OREAN*2ADIOL ą 3ANZ* &AYAD:!)MAGINGOFATHEROSCLEROTICCARDIOVASCULARDISEASE.ATURE ą ,AROSE% +INLAY3 3ELWYN!0 ETAL)MPROVEDCHARACTERIZATIONOFATHEROSCLEROTICPLAQUESBYGADOLINIUMCONTRAST DURINGINTRAVASCULARMAGNETICRESONANCEIMAGINGOFHUMANARTERIES!THEROSCLEROSIS ą 7YKRZYKOWSKA ** $ILETTI 2 'UTIERREZ #HICO *, ET AL 0LAQUE SEALING AND PASSIVATION WITH A MECHANICAL SELF EXPANDINGLOWOUTWARDFORCENITINOLV3HIELDDEVICEFORTHETREATMENTOF)653AND/#4 DERIVEDTHINCAPFIBROATHEROMAS 4#&!S INNATIVECORONARYARTERIESREPORTOFTHEPILOTSTUDYV3HIELD%VALUATEDAT#ARDIACHOSPITALIN2OTTERDAMFOR )NVESTIGATIONAND4REATMENTOF4#&!3%#2)44 %URO)NTERVENTION ą %HARA33POTTY#ALCIFICATION4YPIFIESTHE#ULPRIT0LAQUEIN0ATIENTS7ITH!CUTE-YOCARDIAL)NFARCTION!N)NTRAVASCULAR 5LTRASOUND3TUDY#IRCULATION ą .ISSEN3% 'URLEY*# 'RINES#, ETAL)NTRAVASCULARULTRASOUNDASSESSMENTOFLUMENSIZEANDWALLMORPHOLOGYIN NORMALSUBJECTSANDPATIENTSWITHCORONARYARTERYDISEASE#IRCULATION ą .ISHIMURA2! %DWARDS7$ 7ARNES#! ETAL)NTRAVASCULARULTRASOUNDIMAGING)NVITROVALIDATIONANDPATHOLOGIC CORRELATION*!M#OLL#ARDIOL ą 2ASHEED1 $HAWALE0* !NDERSON* ETAL)NTRACORONARYULTRASOUNDĆDEFINEDPLAQUECOMPOSITION#OMPUTER AIDED PLAQUECHARACTERIZATIONANDCORRELATIONWITHHISTOLOGICSAMPLESOBTAINEDDURINGDIRECTIONALCORONARYATHERECTOMY!M (EART* ą +OTANI *I )NTRAVASCULAR 5LTRASOUND !NALYSIS OF )NFARCT 2ELATED AND .ON )NFARCT 2ELATED !RTERIES IN 0ATIENTS 7HO 0RESENTED7ITHAN!CUTE-YOCARDIAL)NFARCTION#IRCULATION ą 9AMAGISHI- 4ERASHIMA- !WANO+ ETAL-ORPHOLOGYOFVULNERABLECORONARYPLAQUEINSIGHTSFROMFOLLOW UPOF PATIENTS EXAMINED BY INTRAVASCULAR ULTRASOUND BEFORE AN ACUTE CORONARY SYNDROME * !M #OLL #ARDIOL ą -OORE-0 3PENCER4 3ALTER$- ETAL#HARACTERISATIONOFCORONARYATHEROSCLEROTICMORPHOLOGYBYSPECTRALANALYSIS OFRADIOFREQUENCYSIGNALINVITROINTRAVASCULARULTRASOUNDSTUDYWITHHISTOLOGICALANDRADIOLOGICALVALIDATION(EART ą .AIR!#ORONARY0LAQUE#LASSIFICATION7ITH)NTRAVASCULAR5LTRASOUND2ADIOFREQUENCY$ATA!NALYSIS#IRCULATION ą ,IZZI&, !STOR- &ELEPPA%* ETAL3TATISTICALFRAMEWORKFORULTRASONICSPECTRALPARAMETERIMAGING5LTRASOUND-ED "IOL ą (ONG- + -INTZ'3 ,EE#7 ETAL!4HREE 6ESSEL6IRTUAL(ISTOLOGY)NTRAVASCULAR5LTRASOUND!NALYSISOF&REQUENCY AND$ISTRIBUTIONOF4HIN #AP&IBROATHEROMASIN0ATIENTS7ITH!CUTE#ORONARY3YNDROMEOR3TABLE!NGINA0ECTORIS!M *#ARDIOL ą #ASCǢN 0ǙREZ *$ DE LA 4ORRE (ERNǑNDEZ *- 2UIZ !BELLǢN -# ET AL #HARACTERISTICS OF CULPRIT ATHEROMATOUS PLAQUESOBTAINEDINVIVOBYINTRAVASCULARULTRASOUNDRADIOFREQUENCYANALYSIS2ESULTSFROMTHE#5,0,!#STUDY!M (EART* ą "RENER3* 7EISZ' -AEHARA! ETAL$OESCLINICALPRESENTATIONAFFECTOUTCOMEAMONGPATIENTSWITHACUTECORONARY SYNDROMES UNDERGOING PERCUTANEOUS CORONARY INTERVENTION )NSIGHTS FROM THE 0ROVIDING 2EGIONAL /BSERVATIONS TO 3TUDY0REDICTORSOF%VENTSINTHE#ORONARY4REESTUDY!M(EART* ą #ALVERT0! /BAID$2 /Ĉ3ULLIVAN- ETAL!SSOCIATION"ETWEEN)653&INDINGSAND!DVERSE/UTCOMESIN0ATIENTS 7ITH#ORONARY!RTERY$ISEASE*!###ARDIOVASCULAR)MAGING ą #HENG*- 'ARCIA 'ARCIA(- DE"OER30- ETAL)NVIVODETECTIONOFHIGH RISKCORONARYPLAQUESBYRADIOFREQUENCY INTRAVASCULAR ULTRASOUND AND CARDIOVASCULAR OUTCOME RESULTS OF THE !4(%2/2%-/ )653 STUDY %UR (EART * ą 132 ʝèãʦʤäåãéʢʥʡéʧʥð 2ODRIGUEZ 'RANILLO'! 'ARCIA 'ARCIA(- 6ALGIMIGLI- ETAL'LOBALCHARACTERIZATIONOFCORONARYPLAQUERUPTURE PHENOTYPE USING THREE VESSEL INTRAVASCULAR ULTRASOUND RADIOFREQUENCY DATA ANALYSIS %UR (EART * ą &UJII+)NTRAVASCULAR5LTRASOUND!SSESSMENTOF5LCERATED2UPTURED0LAQUES!#OMPARISONOF#ULPRITAND.ONCULPRIT ,ESIONS OF 0ATIENTS 7ITH !CUTE #ORONARY 3YNDROMES AND ,ESIONS IN 0ATIENTS 7ITHOUT !CUTE #ORONARY 3YNDROMES #IRCULATION ą (ONG-+#OMPARISONOF#ORONARY0LAQUE2UPTURE"ETWEEN3TABLE!NGINAAND!CUTE-YOCARDIAL)NFARCTION!4HREE 6ESSEL)NTRAVASCULAR5LTRASOUND3TUDYIN0ATIENTS#IRCULATION ą 2IOUFOL' &INET' 'INON) ETAL-ULTIPLE!THEROSCLEROTIC0LAQUE2UPTUREIN!CUTE#ORONARY3YNDROME!4HREE 6ESSEL )NTRAVASCULAR5LTRASOUND3TUDY#IRCULATION ą &UJIMORI 9 -ORIO ( 4ERASAWA + ET AL -ULTIPLE PLAQUE RUPTURES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AN ANGIOSCOPICEVIDENCEOFSYSTEMICCAUSEOFPLAQUEINSTABILITY*!M#OLL#ARDIOL -INTZ'3 -AEHARA! "UI!" ETAL-ULTIPLEVERSUSSINGLECORONARYPLAQUERUPTURESDETECTEDBYINTRAVASCULARULTRASOUND INSTABLEANDUNSTABLEANGINAPECTORISANDINACUTEMYOCARDIALINFARCTION!M*#ARDIOL ą 3TONE 0( #OSKUN !5 9EGHIAZARIANS9 ETAL0REDICTIONOF SITESOF CORONARYATHEROSCLEROSISPROGRESSION)N VIVO PROFILINGOFENDOTHELIALSHEARSTRESS LUMEN ANDOUTERVESSELWALLCHARACTERISTICSTOPREDICTVASCULARBEHAVIOR#URR /PIN#ARDIOL ą -ALEK!-(EMODYNAMIC3HEAR3TRESSAND)TS2OLEIN!THEROSCLEROSIS*!-! 3TONE0( 3AITO3 4AKAHASHI3 ETAL0REDICTIONOF0ROGRESSIONOF#ORONARY!RTERY$ISEASEAND#LINICAL/UTCOMES 5SING 6ASCULAR 0ROFILING OF %NDOTHELIAL 3HEAR 3TRESS AND !RTERIAL 0LAQUE #HARACTERISTICS 4HE 02%$)#4)/. 3TUDY #IRCULATION ą DE+ORTE#, #ESPEDES%) VANDER3TEEN!&7 ETAL)NTRAVASCULARULTRASOUNDELASTOGRAPHYASSESSMENTANDIMAGING OFELASTICPROPERTIESOFDISEASEDARTERIESANDVULNERABLEPLAQUE%UROPEAN*OURNALOF5LTRASOUND ą DE+ORTE#, 0ASTERKAMP' VANDER3TEEN!&7 ETAL#HARACTERIZATIONOF0LAQUE#OMPONENTS7ITH)NTRAVASCULAR 5LTRASOUND%LASTOGRAPHYIN(UMAN&EMORALAND#ORONARY!RTERIES)N6ITRO#IRCULATION ą 3CHAAR *! #HARACTERIZING 6ULNERABLE 0LAQUE &EATURES 7ITH )NTRAVASCULAR %LASTOGRAPHY #IRCULATION ą 9UN+( -INTZ'3 &ARHAT. ETAL2ELATIONBETWEENANGIOGRAPHICLESIONSEVERITY VULNERABLEPLAQUEMORPHOLOGYAND FUTUREADVERSECARDIACEVENTSFROMTHE0ROVIDING2EGIONAL/BSERVATIONSTO3TUDY0REDICTORSOF%VENTSINTHE#ORONARY 4REESTUDY !M*#ARDIOL ą /TAGIRI+ 4SUTSUI( +UMAZAKI3 ETAL%ARLY)NTERVENTION7ITH2OSUVASTATIN$ECREASESTHE,IPID#OMPONENTSOFTHE 0LAQUEIN!CUTE#ORONARY3YNDROME#IRCULATION*OURNAL ą (UANG$ 3WANSON% ,IN# ETAL/PTICALCOHERENCETOMOGRAPHY3CIENCE ą +AWASAKI- "OUMA"% "RESSNER* ETAL$IAGNOSTIC!CCURACYOF/PTICAL#OHERENCE4OMOGRAPHYAND)NTEGRATED "ACKSCATTER )NTRAVASCULAR 5LTRASOUND )MAGES FOR 4ISSUE #HARACTERIZATION OF (UMAN #ORONARY 0LAQUES * !M #OLL #ARDIOL ą "REZINSKI -% 4EARNEY '* "OUMA "% ET AL /PTICAL #OHERENCE 4OMOGRAPHY FOR /PTICAL "IOPSY 0ROPERTIES AND $EMONSTRATIONOF6ASCULAR0ATHOLOGY#IRCULATION ą *ANG )+ )N 6IVO #HARACTERIZATION OF #ORONARY !THEROSCLEROTIC 0LAQUE BY 5SE OF /PTICAL #OHERENCE 4OMOGRAPHY #IRCULATION ą "URKE!0 &ARB! -ALCOM'4 ETAL#ORONARY2ISK&ACTORSAND0LAQUE-ORPHOLOGYIN-ENWITH#ORONARY$ISEASE 7HO$IED3UDDENLY.EW%NGLAND*OURNALOF-EDICINE ą *ANG) + "OUMA"% +ANG$ ( ETAL6ISUALIZATIONOFCORONARYATHEROSCLEROTICPLAQUESINPATIENTSUSINGOPTICAL COHERENCETOMOGRAPHYCOMPARISONWITHINTRAVASCULARULTRASOUND*!M#OLL#ARDIOL ą &UJIMOTO*' "OPPART3! 4EARNEY'* ETAL(IGHRESOLUTIONINVIVOINTRA ARTERIALIMAGINGWITHOPTICALCOHERENCE TOMOGRAPHY(EART ą 2EGAR% ,IGTHART* "RUINING. ETAL4HEDIAGNOSTICVALUEOFINTRACORONARYOPTICALCOHERENCETOMOGRAPHY(ERZ ą 4EARNEY'* *ANG) + +ANG$ ( ETAL0ORCINECORONARYIMAGINGINVIVOBYOPTICALCOHERENCETOMOGRAPHY!CTA #ARDIOL ą +UBO4 )MANISHI4 4AKARADA3 ETAL!SSESSMENTOF#ULPRIT,ESION-ORPHOLOGYIN!CUTE-YOCARDIAL)NFARCTION*!M #OLL#ARDIOL ą -AC.EILL"$ *ANG) + "OUMA"% ETAL&OCALANDMULTI FOCALPLAQUEMACROPHAGEDISTRIBUTIONSINPATIENTSWITH ACUTEANDSTABLEPRESENTATIONSOFCORONARYARTERYDISEASE*!M#OLL#ARDIOL ą -ACNEILL" "OUMA" 9ABUSHITA( ETAL)NTRAVASCULAROPTICALCOHERENCETOMOGRAPHY#ELLULARIMAGING*OURNALOF .UCLEAR#ARDIOLOGY ą 4EARNEY '* 1UANTIFICATION OF -ACROPHAGE #ONTENT IN !THEROSCLEROTIC 0LAQUES BY /PTICAL #OHERENCE 4OMOGRAPHY #IRCULATION ą 133 ʝèãʦʤäåãéʢʥʡéʧʥð +ATO+ 9ONETSU4 +IM3* ETAL.ONCULPRIT0LAQUESIN0ATIENTS7ITH!CUTE#ORONARY3YNDROMES(AVE-ORE6ULNERABLE &EATURES #OMPARED 7ITH 4HOSE 7ITH .ON !CUTE #ORONARY 3YNDROMES ! 6ESSEL /PTICAL #OHERENCE 4OMOGRAPHY 3TUDY#IRCULATION#ARDIOVASCULAR)MAGING ą 2AFFEL /# 4EARNEY '* 'AUTHIER $$ ET AL 2ELATIONSHIP "ETWEEN A 3YSTEMIC )NFLAMMATORY -ARKER 0LAQUE )NFLAMMATION AND0LAQUE#HARACTERISTICS$ETERMINEDBY)NTRAVASCULAR/PTICAL#OHERENCE4OMOGRAPHY!RTERIOSCLER 4HROMB6ASC"IOL ą +ITABATA( 4ANAKA! +UBO4 ETAL2ELATIONOF-ICROCHANNEL3TRUCTURE)DENTIFIEDBY/PTICAL#OHERENCE4OMOGRAPHY TO0LAQUE6ULNERABILITYIN0ATIENTS7ITH#ORONARY!RTERY$ISEASE!M*#ARDIOL ą 5EMURA 3 )SHIGAMI +I 3OEDA 4 ET AL 4HIN CAP FIBROATHEROMA AND MICROCHANNEL FINDINGS IN OPTICAL COHERENCE TOMOGRAPHYCORRELATEWITHSUBSEQUENTPROGRESSIONOFCORONARYATHEROMATOUSPLAQUES%UR(EART* ą +UME4 !KASAKA4 +AWAMOTO4 ETAL6ISUALIZATIONOF.EOINTIMA&ORMATIONBY/PTICAL#OHERENCE4OMOGRAPHY)NT (EART* ą -ATSUMOTO $ 3HITE * 3HINKE 4 ET AL .EOINTIMAL COVERAGE OF SIROLIMUS ELUTING STENTS AT MONTH FOLLOW UP EVALUATEDBYOPTICALCOHERENCETOMOGRAPHY%UR(EART* ą 3UZUKI9 )KENO& +OIZUMI4 ETAL)N6IVO#OMPARISON"ETWEEN/PTICAL#OHERENCE4OMOGRAPHYAND)NTRAVASCULAR 5LTRASOUND FOR $ETECTING 3MALL $EGREES OF )N 3TENT .EOINTIMA !FTER 3TENT )MPLANTATION *!## #ARDIOVASCULAR )NTERVENTIONS ą 2EGAR % !CUTE RECOIL IN SIROLIMUS ELUTING STENT REAL TIME IN VIVO ASSESSMENT WITH OPTICAL COHERENCE TOMOGRAPHY (EART ą /KAMURA 4 /NUMA 9 'ARCIA 'ARCIA ( ET AL &IRST IN MAN EVALUATION OF INTRAVASCULAR OPTICAL FREQUENCY DOMAIN IMAGING /&$) OF 4ERUMO A COMPARISON WITH INTRAVASCULAR ULTRASOUND AND QUANTITATIVE CORONARY ANGIOGRAPHY %URO)NTERVENTION ą 5EDA9 /HTANI4 3HIMIZU- ETAL!SSESSMENTOFPLAQUEVULNERABILITYBYANGIOSCOPICCLASSIFICATIONOFPLAQUECOLOR !M(EART* ą 4AKANO- -IZUNO+ /KAMATSU+ ETAL-ECHANICALANDSTRUCTURALCHARACTERISTICSOFVULNERABLEPLAQUESANALYSISBY CORONARYANGIOSCOPYANDINTRAVASCULARULTRASOUND*!M#OLL#ARDIOL ą +UBO4 )MANISHI4 4AKARADA3 ETAL)MPLICATIONOF0LAQUE#OLOR#LASSIFICATIONFOR!SSESSING0LAQUE6ULNERABILITY *!###ARDIOVASCULAR)NTERVENTIONS ą /HTANI4 5EDA9 -IZOTE) ETAL.UMBEROF9ELLOW0LAQUES$ETECTEDINA#ORONARY!RTERY)S!SSOCIATED7ITH&UTURE 2ISKOF!CUTE#ORONARY3YNDROME*!M#OLL#ARDIOL ą (IGO4 5EDA9 /YABU* ETAL!THEROSCLEROTICAND4HROMBOGENIC.EOINTIMA&ORMED/VER3IROLIMUS$RUG %LUTING 3TENT*!###ARDIOVASCULAR)MAGING ą /KAMATSU+%LEVATED4ROPONIN4,EVELSAND,ESION#HARACTERISTICSIN.ON 34 %LEVATION!CUTE#ORONARY3YNDROMES #IRCULATION ą 7HITE #* 2AMEE 32 #OLLINS 4* ET AL #ORONARY 4HROMBI )NCREASE 04#! 2ISK !NGIOSCOPY AS A #LINICAL 4OOL #IRCULATION ą 7AXMAN3 $IXON32 ,Ĉ!LLIER0 ETAL)N6IVO6ALIDATIONOFA#ATHETER "ASED.EAR )NFRARED3PECTROSCOPY3YSTEMFOR $ETECTIONOF,IPID#ORE#ORONARY0LAQUES*!###ARDIOVASCULAR)MAGING ą +INI!3 "ABER5 +OVACIC*# ETAL#HANGESIN0LAQUE,IPID#ONTENT!FTER3HORT 4ERM)NTENSIVE6ERSUS3TANDARD 3TATIN4HERAPY*!M#OLL#ARDIOL ą "RUGALETTA3 'ARCIA 'ARCIA(- 3ERRUYS07 ETAL$ISTANCEOF,IPID#OREą2ICH0LAQUES&ROMTHE/STIUMBY.)23IN .ONCULPRIT#ORONARY!RTERIES*!###ARDIOVASCULAR)MAGING ą 'ARDNER#- 4AN( (ULL%, ETAL$ETECTIONOF,IPID#ORE#ORONARY0LAQUESIN!UTOPSY3PECIMENS7ITHA.OVEL #ATHETER "ASED.EAR )NFRARED3PECTROSCOPY3YSTEM*!###ARDIOVASCULAR)MAGING ą -ADDER2$ 'OLDSTEIN*! -ADDEN30 ETAL$ETECTIONBY.EAR )NFRARED3PECTROSCOPYOF,ARGE,IPID#ORE0LAQUESAT #ULPRIT3ITESIN0ATIENTS7ITH!CUTE34 3EGMENT%LEVATION-YOCARDIAL)NFARCTION*!###ARDIOVASCULAR)NTERVENTIONS ą 3TEFANADIS # $IAMANTOPOULOS , 6LACHOPOULOS # ET AL 4HERMAL (ETEROGENEITY 7ITHIN (UMAN !THEROSCLEROTIC #ORONARY!RTERIES$ETECTED)N6IVO!.EW-ETHODOF$ETECTIONBY!PPLICATIONOFA3PECIAL4HERMOGRAPHY#ATHETER #IRCULATION ą 3TEFANADIS# 4OUTOUZAS+ 4SIAMIS% ETAL)NCREASEDLOCALTEMPERATUREINHUMANCORONARYATHEROSCLEROTICPLAQUES ANINDEPENDENTPREDICTOROFCLINICALOUTCOMEINPATIENTSUNDERGOINGAPERCUTANEOUSCORONARYINTERVENTION*!M#OLL #ARDIOL ą #UISSET 4 "EAULOYE # -ELIKIAN . ET AL )N VITRO AND IN VIVO STUDIES ON THERMISTOR BASED INTRACORONARY TEMPERATURE MEASUREMENTS%FFECTOFPRESSUREANDFLOW#ATHET#ARDIOVASC)NTERVENT ą ,AROSE % #HARACTERIZATION OF (UMAN !THEROSCLEROTIC 0LAQUES BY )NTRAVASCULAR -AGNETIC 2ESONANCE )MAGING #IRCULATION ą 134 ʝèãʦʤäåãéʢʥʡéʧʥð ʞʡßãʢÞʡʙʜ ÕʡʨçʤÞãìʜʘ ʘãʥʤçʤÞʔʘ ETALÐçÞʡâãÞçðʢæʢéʤàðÞðôÞåʢçãôçʢʦéʡÝãåñçðʨʡéʢʥʤʦäåʢʥʤéã ìʢʦäãʨÝåôíʢäÞäʤʥʤçʡʥçðʨʡʥéʢʥãôʨʒʡʥàãʤåʤßãô ą 0USKA0 ,AATIKAINEN4 +ORPELAINEN6 ETAL#ONTRIBUTIONOFTHE.ORTH+ARELIA0ROJECTTO)NTERNATIONAL7ORKIN#6$AND .#$0REVENTIONAND(EALTH0ROMOTION'LOB(EART ą &ITO- +ONSTANTINIDOU6.UTRITIONAL'ENOMICSANDTHE-EDITERRANEAN$IETĈS%FFECTSON(UMAN#ARDIOVASCULAR(EALTH .UTRIENTS *ONSDOTTIR 3% "RADER , 'UNNARSDOTTIR ) ET AL !DHERENCE TO THE .ORDIC .UTRITION 2ECOMMENDATIONS IN A .ORDIC POPULATIONWITHMETABOLICSYNDROMEHIGHSALTCONSUMPTIONANDLOWDIETARYFIBREINTAKE4HE393$)%4STUDY &OOD .UTR2ES ÌʢåʢçäʤÞÛʙ ʝʢʥßãʢçäʤÐʔ ÑôäãíʢÞʓʓ ETALʝéʡéãçðÞʦʤÞʥʢæʢççʤʣäʡʥàãʤåʤßãìʢʦäʤʣèʥʡäéãäʢʘʤçʤ ßʥʡêãô ʝʢæʢçʤÞʡʓʖ ʝʢʥßãʢçäʤÐʔʟʡʥæʡäʤåʤßãìʢʦäãʢʡʦèʢäéðéʢʥʡèããʦéʡéãçʡæãʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą .ISSEN3%%FFECTOFINTENSIVELIPIDLOWERINGONPROGRESSIONOFCORONARYATHEROSCLEROSISEVIDENCEFORANEARLYBENEFITFROM THE2EVERSALOF!THEROSCLEROSISWITH!GGRESSIVE,IPID,OWERING2%6%23!, TRIAL!M*#ARDIOL! & & 0OOLSUP . 3UKSOMBOON . 7ONGYAOWARAT + ET AL -ETA ANALYSIS OF THE COMPARATIVE EFFICACY AND SAFETY OF PITAVASTATINANDATORVASTATININPATIENTSWITHDYSLIPIDAEMIA*#LIN0HARM4HER ą ʝʢæʢçʤÞʡʓʖ ʝʢʥßãʢçäʤÐʔ ʒʧʨʡʥìʧäʔʔʔʤâæʤáçðʢæʢʨʡçãâæðʦéʡÝãåãâʡëããʡéʢʥʤʦäåʢʥʤéãìʢʦäʤʣÝåôí äãçʡêʤçʢéʢʥʡèããʥʤâʧÞʡʦéʡéãçʤæʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą ÍʤæÝʥʤÞʦäãʣ ʓÑ ʝʢʥßãʢçäʤ Ðʔ ʜÞʡìʢÞʡ ʓʔ ET AL ʔåãôçãʢ éʢʥʡèãã ʡéʤʥÞʡʦéʡéãçʤæ Þ ʥʡâåãìçðʨ àʤâʡʨ çʡòçàʤéʢåãʡåñçðʢèʥʤßʢçãéʤʥçðʢäåʢéäããêʡäéʤʥðʡçßãʤßʢçʢâʡʧÝʤåñçðʨãíʢæãìʢʦäʤʣÝʤåʢâçñóʦʢʥàëʡ ʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæããą ʝʢæʢçʤÞʡʓʖ ʝʢʥßãʢçäʤÐʔ ÍʤæÝʥʤÞʦäãʣʓÑ ETALʜʤåñòçàʤéʢåãʡåñçðʨèʥʤßʢçãéʤʥçðʨäåʢéʤäèʥãʡéʢʥʤ ʦäåʢʥʤâʢʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą ʝʢʥßãʢçäʤÐʔÐçßãÝãʥʤÞʡçãʢÞʦʡʦðÞʡçãôʨʤåʢʦéʢʥãçʡÞòçéʢʥʤëãéʡʨʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą ʜʧäʤÞʤàʦéÞʤèʤäʡʥàãʤåʤßãã ÞéʤæʡʨèʤàʥʢàʡäëãʢʣʖÐÔʡâʤÞʡ ʔʔʒʧʨʡʥìʧä Ðʔʝʢʥßãʢçäʤʕãèʤåãèãàʢ æãìʢʦäãʢʦʥʢàʦéÞʡʞ ʦąʘʛʥʡäéãäʡ 2OBINSON*' &ARNIER- +REMPF- ETAL%FFICACYANDSAFETYOFALIROCUMABINREDUCINGLIPIDSANDCARDIOVASCULAR EVENTS.%NGL*-ED ą 3ABATINE-3 'IUGLIANO20 7IVIOTT3$ ETAL%FFICACYANDSAFETYOFEVOLOCUMABINREDUCINGLIPIDSANDCARDIOVASCULAR EVENTS.%NGL*-ED ą ʒʧʨʡʥìʧäʔʔ Ìʡáʡç ʝʝʛʥʤèʥʤéʢãçäʤçÞʢʥéʡâʡʦʧÝéãåãâãçäʢäʦãçéãèʡ0#3+ ąʥʢßʧåôéʤʥòäʦèʥʢʦʦãã ʥʢëʢèéʤʥʤÞåãèʤèʥʤéʢãçʤÞçãâäʤʣèåʤéçʤʦéãʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą 2OBINSON*' .EDERGAARD"3 2OGERS7* ETAL%FFECTOFEVOLOCUMABOREZETIMIBEADDEDTOMODERATE ORHIGH INTENSITYSTATINTHERAPYON,$, #LOWERINGINPATIENTSWITHHYPERCHOLESTEROLEMIATHE,!0,!#% RANDOMIZEDCLINICAL TRIAL*!-! ą 3TROES% #OLQUHOUN$ 3ULLIVAN$ ETAL!NTI 0#3+ANTIBODYEFFECTIVELYLOWERSCHOLESTEROLINPATIENTSWITHSTATIN INTOLERANCETHE'!533 RANDOMIZED PLACEBO CONTROLLEDPHASECLINICALTRIALOFEVOLOCUMAB*!M#OLL#ARDIOL ą 2AAL &* 3TEIN %! $UFOUR 2 ET AL 0#3+ INHIBITION WITH EVOLOCUMAB !-' IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLAEMIA 254(%2&/2$ A RANDOMISED DOUBLE BLIND PLACEBO CONTROLLED TRIAL ,ANCET ą 2EDDY*+ !ZARNOFF$, (IGNITE#%(YPOLIPIDAEMICHEPATICPEROXISOMEPROLIFERATORSFORMANOVELCLASSOFCHEMICAL CARCINOGENS.ATURE ą "ALENDIRAN'+ 2ATH. +OTHEIMER! ETAL"IOMOLECULARCHEMISTRYOFISOPROPYLFIBRATES*0HARM3CI ą 'INSBERG(. %LAM-" ,OVATO,# ETAL%FFECTSOFCOMBINATIONLIPIDTHERAPYINTYPEDIABETESMELLITUS.%NGL* -ED ą +EECH! 3IMES2* "ARTER0 ETAL%FFECTSOFLONG TERMFENOFIBRATETHERAPYONCARDIOVASCULAREVENTSINPEOPLE WITHTYPEDIABETESMELLITUSTHE&)%,$STUDY RANDOMISEDCONTROLLEDTRIAL,ANCET ą ʓæʢéʤÞʓʝ ʛʥʧàçãäʤÞʡʘʓʙʢåãèãàçðʢòêêʢäéðêʢçʤêãÝʥʡéʡʡäëʢçéçʡʦʡʨʡʥçðʣàãʡÝʢéʝʡʨʡʥçðʣàã ʡÝʢé ą +OCKX- 'ERVOIS00 0OULAIN0 ETAL&IBRATESSUPPRESSFIBRINOGENGENEEXPRESSIONINRODENTSVIAACTIVATIONOFTHE PEROXISOMEPROLIFERATOR ACTIVATEDRECEPTOR ALPHA"LOOD ą 3ALEHI% +HAZAEI- 2ASHIDI"2OLEOFFENOFIBRATEINRESTORINGANGIOGENESISINDIABETICANDCONTROLHINDLIMBISCHEMIC RATS'EN0HYSIOL"IOPHYS ą 135 ʝèãʦʤäåãéʢʥʡéʧʥð #ANNER0, "ERGE+' 7ENGER.+ ETAL&IFTEENYEARMORTALITYIN#ORONARY$RUG0ROJECTPATIENTSLONG TERMBENEFIT WITHNIACIN*!M#OLL#ARDIOL ą .ICHOLLS3*)SNIACININEFFECTIVE/RDID!)- ()'(MISSITSTARGET#LEVE#LIN*-ED ą 4OTH00 -URTHY!- 3IDHU-3 ETAL)S(03 4(2)6%THEDEATHKNELLFORNIACIN*#LIN,IPIDOL ą 2ADER$* +ASTELEIN**,OMITAPIDEANDMIPOMERSENTWOFIRST IN CLASSDRUGSFORREDUCINGLOW DENSITYLIPOPROTEIN CHOLESTEROLINPATIENTSWITHHOMOZYGOUSFAMILIALHYPERCHOLESTEROLEMIA#IRCULATION ą ʚßʡçʤÞʜʕ ʒʧʨʡʥìʧäʔʔ ʓʥʧéóçʤÞʕʛ ETALʝʤʨʥʡçôóîãʢʦôçʡʥʧíʢçãôèʤäʡâʡéʢåʢʣåãèãàçʤßʤʦèʢäéʥʡʧèʡ ëãʢçéʤÞʦàãʦåãèãàʢæãʢʣ èʤåʧìʡóîãʨʦéʡéãçð ÞʥʢʡåñçʤʣäåãçãìʢʦäʤʣèʥʡäéãäʢÞʜʤʦʦãʣʦäʤʣʟʢàʢʥʡëãã ʥʤʦʦãʣʦäʡôìʡʦéñãʦʦåʢàʤÞʡçãô$93)3 ʒʡʥàãʤÞʡʦäʧåôʥçʡôéʢʥʡèãôãèʥʤêãåʡäéãäʡą +OHLI 0 7ATERS $$ .EMR 2 ET AL 2ISK OF NEW ONSET DIABETES AND CARDIOVASCULAR RISK REDUCTION FROM HIGH DOSE STATINTHERAPYINPRE DIABETICSANDNON PRE DIABETICSANANALYSISFROM4.4AND)$%!,*!M#OLL#ARDIOL ą 2IDKER0- -ORA3 2OSE,0ERCENTREDUCTIONIN,$,CHOLESTEROLFOLLOWINGHIGH INTENSITYSTATINTHERAPYPOTENTIAL IMPLICATIONSFORGUIDELINESANDFORTHEPRESCRIPTIONOFEMERGINGLIPID LOWERINGAGENTS%UR(EART* ą 6UPPUTURI3 *OSKI0* +ILPATRICK2 ETAL,$,CHOLESTEROLRESPONSEANDSTATINADHERENCEAMONGHIGH RISKPATIENTS INITIATINGTREATMENT!M*-ANAG#ARE Eą +ATAOKA9 3T*OHN* 7OLSKI+ ETAL!THEROMAPROGRESSIONINHYPORESPONDERSTOSTATINTHERAPY!RTERIOSCLER4HROMB 6ASC"IOL ą 0OSTMUS) 4ROMPET3 $ESHMUKH(! ETAL0HARMACOGENETICMETA ANALYSISOFGENOME WIDEASSOCIATIONSTUDIESOF ,$,CHOLESTEROLRESPONSETOSTATINS.AT#OMMUN &ENG1 7EI71 #HUNG#0 ETAL4HEEFFECTOFGENETICVARIATIONIN0#3+ONTHE,$, CHOLESTEROLRESPONSETOSTATIN THERAPY0HARMACOGENOMICS* 7EI-9 )TO-+ #OHEN*$ ETAL0REDICTORSOFSTATINADHERENCE SWITCHING ANDDISCONTINUATIONINTHE53!'%SURVEY UNDERSTANDINGTHEUSEOFSTATINSIN!MERICAANDGAPSINPATIENTEDUCATION*#LIN,IPIDOL ą "ALLANTYNE#- (OURI* .OTARBARTOLO! ETAL%FFECTOFEZETIMIBECOADMINISTEREDWITHATORVASTATININPATIENTSWITH PRIMARYHYPERCHOLESTEROLEMIAAPROSPECTIVE RANDOMIZED DOUBLE BLINDTRIAL#IRCULATION ą ʝʢʥßãʢçäʤÐʔʞʡäéãäʡåʢìʢçãôèʥãçʢòêêʢäéãÞçʤʦéãæʤçʤéʢʥʡèããʦéʡéãçʡæãʒʡʥàãʤÞʡʦäʧåôʥçʡôéʢʥʡèãô ãèʥʤêãåʡäéãäʡ ą "AIGENT# ,ANDRAY-* 2EITH# ETAL4HEEFFECTSOFLOWERING,$,CHOLESTEROLWITHSIMVASTATINPLUSEZETIMIBEIN PATIENTS WITH CHRONIC KIDNEY DISEASE 3TUDY OF (EART AND 2ENAL 0ROTECTION A RANDOMISED PLACEBO CONTROLLED TRIAL ,ANCET ą #ANNON#0 "LAZING-! 'IUGLIANO20 ETAL%ZETIMIBE!DDEDTO3TATIN4HERAPYAFTER!CUTE#ORONARY3YNDROMES. %NGL*-ED ą -ǩLLER#8ANTHOMATA (YPERCHOLESTEROLEMIA !NGINA0ECTORIS!CTA-ED3CAND3 ą +HACHADURIAN!+4HEINHERITANCEOFESSENTIALFAMILIALHYPERCHOLESTEROLEMIA!M*-ED ą &REDRICKSON$3 ,EES23%DITORIAL!3YSTEMFOR0HENOTYPING(YPERLIPOPROTEINEMIA#IRCULATION ą 'OLDSTEIN*, "ROWN-3&AMILIAL(YPERCHOLESTEROLEMIA)DENTIFICATIONOFA$EFECTINTHE2EGULATIONOF (YDROXY -ETHYLGLUTARYL#OENZYME!2EDUCTASE!CTIVITY!SSOCIATEDWITH/VERPRODUCTIONOF#HOLESTEROL0ROCEEDINGSOFTHE .ATIONAL!CADEMYOF3CIENCES ą +ONTULA+ +OIVISTO5 - +OIVISTO0 ETAL-OLECULAR'ENETICSOF&AMILIAL(YPERCHOLESTEROLAEMIA#OMMONAND2ARE -UTATIONSOFTHE,OW$ENSITY,IPOPROTEIN2ECEPTOR'ENE!NNALSOF-EDICINE ą ,EITERSDORF % 6AN DER 7ESTHUYZEN $2 #OETZEE '! ET AL 4WO COMMON LOW DENSITY LIPOPROTEIN RECEPTOR GENE MUTATIONSCAUSEFAMILIALHYPERCHOLESTEROLEMIAIN!FRIKANERS*OURNALOF#LINICAL)NVESTIGATION ą -OORJANI3 2OY- 'AGNE# ETAL(OMOZYGOUSFAMILIALHYPERCHOLESTEROLEMIAAMONG&RENCH#ANADIANSIN1UEBEC 0ROVINCE!RTERIOSCLER4HROMB6ASC"IOL ą 3EFTEL(# "AKER3' *ENKINS4 ETAL0REVALENCEOFFAMILIALHYPERCHOLESTEROLEMIAIN*OHANNESBURG*EWS!MERICAN *OURNALOF-EDICAL'ENETICS ą 3EFTEL(# "AKER3' 3ANDLER-0 ETAL!HOSTOFHYPERCHOLESTEROLAEMICHOMOZYGOTESIN3OUTH!FRICA"-* ą 3LIMANE - 0OUSSE ( -AATOUG & ET AL 0HENOTYPIC EXPRESSION OF FAMILIAL HYPERCHOLESTEROLAEMIA IN #ENTRAL AND 3OUTHERN4UNISIA!THEROSCLEROSISą ą "ETARD# +ESSLING!- 2OY- ETAL-OLECULARGENETICEVIDENCEFORAFOUNDEREFFECTINFAMILIALHYPERCHOLESTEROLEMIA AMONG&RENCH#ANADIANS(UM'ENET "ENN - 7ATTS '& 4YBJAERG (ANSEN ! ET AL &AMILIAL (YPERCHOLESTEROLEMIA IN THE $ANISH 'ENERAL 0OPULATION 0REVALENCE #ORONARY!RTERY$ISEASE AND#HOLESTEROL ,OWERING-EDICATION4HE*OURNALOF#LINICAL%NDOCRINOLOGY -ETABOLISM ą 136 ʝèãʦʤäåãéʢʥʡéʧʥð -ARKS $ 4HOROGOOD - .EIL (!7 ET AL ! REVIEW ON THE DIAGNOSIS NATURAL HISTORY AND TREATMENT OF FAMILIAL HYPERCHOLESTEROLAEMIA!THEROSCLEROSIS ą .EIL(!7%XTENTOFUNDERDIAGNOSISOFFAMILIALHYPERCHOLESTEROLAEMIAINROUTINEPRACTICEPROSPECTIVEREGISTRYSTUDY "-* ą .ORDESTGAARD "' #HAPMAN -* (UMPHRIES 3% ET AL &AMILIAL HYPERCHOLESTEROLAEMIA IS UNDERDIAGNOSED AND UNDERTREATED IN THE GENERAL POPULATION GUIDANCE FOR CLINICIANS TO PREVENT CORONARY HEART DISEASE #ONSENSUS 3TATEMENTOFTHE%UROPEAN!THEROSCLEROSIS3OCIETY%UR(EART* ą 0IJLMAN!( (UIJGEN2 6ERHAGEN3. ETAL%VALUATIONOFCHOLESTEROLLOWERINGTREATMENTOFPATIENTSWITHFAMILIAL HYPERCHOLESTEROLEMIAALARGECROSS SECTIONALSTUDYIN4HE.ETHERLANDS!THEROSCLEROSIS ą 6UORIO! +UOPPALA* +OVANEN04 ETAL3TATINSFORCHILDRENWITHFAMILIALHYPERCHOLESTEROLEMIA#OCHRANE$ATABASE OF3YSTEMATIC2EVIEWS7ILEY "LACKWELL 6ERSMISSEN* /OSTERVEER$- 9AZDANPANAH- ETAL%FFICACYOFSTATINSINFAMILIALHYPERCHOLESTEROLAEMIAALONG TERMCOHORTSTUDY"-*NOV A A 5MANS %CKENHAUSEN-!7 $EFESCHE*# 3IJBRANDS%*' ETAL2EVIEWOFFIRSTYEARSOFSCREENINGFORFAMILIAL HYPERCHOLESTEROLAEMIAINTHE.ETHERLANDS4HE,ANCET ą 7ILLIAMS22 (UNT3# 3CHUMACHER-# ETAL$IAGNOSINGHETEROZYGOUSFAMILIALHYPERCHOLESTEROLEMIAUSINGNEW PRACTICALCRITERIAVALIDATEDBYMOLECULARGENETICS!M*#ARDIOL ą 4ERAMOTO4 3ASAKI* )SHIBASHI3 ETAL%XECUTIVE3UMMARYOFTHE*APAN!THEROSCLEROSIS3OCIETY*!3 'UIDELINESFOR THE$IAGNOSISAND0REVENTIONOF!THEROSCLEROTIC#ARDIOVASCULAR$ISEASESIN*APAN*!4 ą ʝʡêʡʥʤÞʡʘʝ ʝʢʥßãʢçäʤÐʔ ʖáʤÞʘʔ ETALʜʤʦʦãʣʦäʡôçʡʧìçʤ ãʦʦåʢàʤÞʡéʢåñʦäʡôèʥʤßʥʡææʡèʤʦÞʤʢÞʥʢ æʢççʤʣàãʡßçʤʦéãäʢãåʢìʢçãóÝʤåñçðʨʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæãʢʣʤÝʤʦçʤÞʡçãʢãàãâʡʣçʥʤʦʦãʣʦäʤßʤ ʥʢßãʦéʥʡʦʢæʢʣçʤʣßãèʢʥʨʤåʢʦéʢʥãçʢæããʜʤʝʕʠʝ ʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą #IVEIRA&'UIDELINESFORTHEDIAGNOSISANDMANAGEMENTOFHETEROZYGOUSFAMILIALHYPERCHOLESTEROLEMIA!THEROSCLEROSIS ą 'OLDBERG!# (OPKINS0. 4OTH00 ETAL&AMILIAL(YPERCHOLESTEROLEMIA3CREENING DIAGNOSISANDMANAGEMENTOF PEDIATRICANDADULTPATIENTS*OURNALOF#LINICAL,IPIDOLOGY ą 7ATTS '& 3ULLIVAN $2 0OPLAWSKI . ET AL &AMILIAL HYPERCHOLESTEROLAEMIA ! MODEL OF CARE FOR !USTRALASIA !THEROSCLEROSIS3UPPLEMENTS ą 'HOSH 3+ -AJUMDER " $UTTA ! 4UBEROUS 8ANTHOMA AS A 0RESENTING &EATURE OF &AMILIAL (OMOZYGOUS (YPERCHOLESTEROLEMIAWITH!ORTIC2EGURGITATION*0EDIATR ąE ʒʧʨʡʥìʧäʔʔ ʘʡåðíʢÞʛʛ ʘʢíäʤÞʓʙʝʢæʢʣçʡôßãèʢʥʨʤåʢʦéʢʥãçʢæãôʝʤÞʥʢæʢççðʢʡʦèʢäéðàãʡßçʤʦéã äã èʥʤêãåʡäéãäããéʢʥʡèããʒʡʥàãʤåʤßãô ą (UMPHRIES 3% .ORBURY ' ,EIGH 3 ET AL 7HAT IS THE CLINICAL UTILITY OF $.! TESTING IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLAEMIA#URR/PIN,IPIDOL ą 3OUTAR!+ .AOUMOVA20-ECHANISMSOF$ISEASEGENETICCAUSESOFFAMILIALHYPERCHOLESTEROLEMIA.ATURE#LINICAL 0RACTICE#ARDIOVASCULAR-EDICINE ą 4AYLOR! 7ANG$ 0ATEL+ ETAL-UTATIONDETECTIONRATEANDSPECTRUMINFAMILIALHYPERCHOLESTEROLAEMIAPATIENTSIN THE5+PILOTCASCADEPROJECT#LIN'ENET ą (OOPER!* .GUYEN,4 "URNETT*2 ETAL'ENETICANALYSISOFFAMILIALHYPERCHOLESTEROLAEMIAIN7ESTERN!USTRALIA !THEROSCLEROSIS ą ,OMBARDI-0 2EDEKER%*7 'ENT$(-6 ETAL-OLECULAR'ENETIC4ESTINGFOR&AMILIAL(YPERCHOLESTEROLEMIAIN4HE .ETHERLANDS!3TEPWISE3CREENING3TRATEGY%NHANCESTHE-UTATION$ETECTION2ATE'ENETIC4ESTING ą -OTAZACKER -- 0IRRUCCELLO * (UIJGEN 2 ET AL !DVANCES IN GENETICS SHOW THE NEED FOR EXTENDING SCREENING STRATEGIESFORAUTOSOMALDOMINANTHYPERCHOLESTEROLAEMIA%UR(EART* ą !HMAD : !DAMS (UET " #HEN # ET AL ,OW 0REVALENCE OF -UTATIONS IN +NOWN ,OCI FOR !UTOSOMAL $OMINANT (YPERCHOLESTEROLEMIAINA-ULTIETHNIC0ATIENT#OHORT#IRCULATION#ARDIOVASCULAR'ENETICS ą &AHED!# .EMER'-&AMILIAL(YPERCHOLESTEROLEMIA4HE,IPIDSORTHE'ENES.UTRITION-ETABOLISM 3EIDAH.'0ROPROTEIN#ONVERTASE3UBTILISIN+EXIN0#3+ )NHIBITORSINTHE4REATMENTOF(YPERCHOLESTEROLEMIAAND OTHER0ATHOLOGIES#0$ ą (UIJGEN2 6ISSERS-. +INDT) ETAL!SSESSMENTOF#AROTID!THEROSCLEROSISIN.ORMOCHOLESTEROLEMIC)NDIVIDUALS 7ITH0ROVEN-UTATIONSINTHE,OW $ENSITY,IPOPROTEIN2ECEPTOROR!POLIPOPROTEIN"'ENES#IRCULATION#ARDIOVASCULAR 'ENETICS ą "ELL$! 0ANG* "URROWS3 ETAL%FFECTIVENESSOFGENETICCASCADESCREENINGFORFAMILIALHYPERCHOLESTEROLAEMIA USINGACENTRALLYCO ORDINATEDCLINICALSERVICE!N!USTRALIANEXPERIENCE!THEROSCLEROSIS ą !DEMI : 7ATTS '& 0ANG * ET AL #ASCADE SCREENING BASED ON GENETIC TESTING IS COST EFFECTIVE %VIDENCE FOR THE IMPLEMENTATIONOFMODELSOFCAREFORFAMILIALHYPERCHOLESTEROLEMIA*OURNALOF#LINICAL,IPIDOLOGY ą 'ENETICTESTINGINASYMPTOMATICMINORSRECOMMENDATIONSOFTHE%UROPEAN3OCIETYOF(UMAN'ENETICS%UR*(UM 'ENET ą 137 ʝèãʦʤäåãéʢʥʡéʧʥð 'EORGE2 +OVAK+ #OX3,!LIGNING0OLICYTO0ROMOTE#ASCADE'ENETIC3CREENINGFOR0REVENTIONAND%ARLY$IAGNOSIS OF(ERITABLE$ISEASES*'ENET#OUNS ą $ANIELS32 'IDDING33 DE&ERRANTI3$0EDIATRICASPECTSOF&AMILIAL(YPERCHOLESTEROLEMIAS2ECOMMENDATIONS FROM THE .ATIONAL ,IPID !SSOCIATION %XPERT 0ANEL ON &AMILIAL (YPERCHOLESTEROLEMIA *OURNAL OF #LINICAL ,IPIDOLOGY 3 3 3IJBRANDS %*' -ORTALITY OVER TWO CENTURIES IN LARGE PEDIGREE WITH FAMILIAL HYPERCHOLESTEROLAEMIA FAMILY TREE MORTALITYSTUDY#OMMENTARY2OLEOFOTHERGENESANDENVIRONMENTSHOULDNOTBEOVERLOOKEDINMONOGENICDISEASE "-* ą VAN DER 'RAAF ! !VIS (* +USTERS $- ET AL -OLECULAR "ASIS OF !UTOSOMAL $OMINANT (YPERCHOLESTEROLEMIA !SSESSMENTINA,ARGE#OHORTOF(YPERCHOLESTEROLEMIC#HILDREN#IRCULATION ą 7IEGMAN ! &AMILY (ISTORY AND #ARDIOVASCULAR 2ISK IN &AMILIAL (YPERCHOLESTEROLEMIA $ATA IN -ORE 4HAN #HILDREN#IRCULATION ą +USTERS $- DE "EAUFORT # 7IDHALM + ET AL 0AEDIATRIC SCREENING FOR HYPERCHOLESTEROLAEMIA IN %UROPE 4ABLE !RCHIVESOF$ISEASEIN#HILDHOOD ą -C#RINDLE"7&AMILIALHYPERCHOLESTEROLEMIAINCHILDRENANDADOLESCENTS#URR/PIN,IPIDOL ą $ESCAMPS /3 4ENOUTASSE 3 3TEPHENNE 8 ET AL -ANAGEMENT OF FAMILIAL HYPERCHOLESTEROLEMIA IN CHILDREN AND YOUNG ADULTS #ONSENSUS PAPER DEVELOPED BY A PANEL OF LIPIDOLOGISTS CARDIOLOGISTS PAEDIATRICIANS NUTRITIONISTS GASTROENTEROLOGISTS GENERALPRACTITIONERSANDAPATIENTORGANIZATION!THEROSCLEROSIS ą "RAAMSKAMP -*!- +USTERS $- !VIS (* ET AL ,ONG 4ERM 3TATIN 4REATMENT IN #HILDREN WITH &AMILIAL (YPERCHOLESTEROLEMIA-ORE)NSIGHTINTO4OLERABILITYAND!DHERENCE0EDIATRIC$RUGS ą !VIS (* (UTTEN "! 'AGNǙ # ET AL %FFICACY AND 3AFETY OF 2OSUVASTATIN 4HERAPY FOR #HILDREN 7ITH &AMILIAL (YPERCHOLESTEROLEMIA*!M#OLL#ARDIOL ą 3TEIN%!3TATINSAND#HILDREN7HOM$O7E4REATAND7HEN#IRCULATION ą 6UORIO! +UOPPALA* +OVANEN04 ETAL3TATINSFORCHILDRENWITHFAMILIALHYPERCHOLESTEROLEMIA#OCHRANE$ATABASE OF3YSTEMATIC2EVIEWS7ILEY "LACKWELL -C#RINDLE "7 5RBINA %- $ENNISON "! ET AL $RUG 4HERAPY OF (IGH 2ISK ,IPID !BNORMALITIES IN #HILDREN AND !DOLESCENTS!3CIENTIFIC3TATEMENT&ROMTHE!MERICAN(EART!SSOCIATION!THEROSCLEROSIS (YPERTENSION AND/BESITY IN 9OUTH #OMMITTEE #OUNCIL OF #ARDIOVASCULAR $ISEASE IN THE 9OUNG 7ITH THE #OUNCIL ON #ARDIOVASCULAR .URSING #IRCULATION ą 2ODENBURG* 6ISSERS-. 7IEGMAN! ETAL3TATIN4REATMENTIN#HILDREN7ITH&AMILIAL(YPERCHOLESTEROLEMIA4HE 9OUNGER THE"ETTER#IRCULATION ą !VIS(* 6ISSERS-. 3TEIN%! ETAL!3YSTEMATIC2EVIEWAND-ETA !NALYSISOF3TATIN4HERAPYIN#HILDREN7ITH &AMILIAL(YPERCHOLESTEROLEMIA!RTERIOSCLER4HROMB6ASC"IOL ą *ANSEN!#- !ALST #OHEN%3 4ANCK-7 ETAL4HECONTRIBUTIONOFCLASSICALRISKFACTORSTOCARDIOVASCULARDISEASE INFAMILIALHYPERCHOLESTEROLAEMIADATAINPATIENTS*)NTERN-ED ą /OSTERVEER$- 6ERSMISSEN* 3CHINKEL!&, ETAL#LINICALANDGENETICFACTORSINFLUENCINGCARDIOVASCULARRISKIN PATIENTSWITHFAMILIALHYPERCHOLESTEROLEMIA#LINICAL,IPIDOLOGY ą -C#RINDLE"7 /Ĉ.EILL-" #ULLEN $EAN' ETAL!CCEPTABILITYANDCOMPLIANCEWITHTWOFORMSOFCHOLESTYRAMINEIN THETREATMENTOFHYPERCHOLESTEROLEMIAINCHILDREN!RANDOMIZED CROSSOVERTRIAL*0EDIATR ą 4ONSTAD 3 +NUDTZON * 3IVERTSEN - ET AL %FFICACY AND SAFETY OF CHOLESTYRAMINE THERAPY IN PERIPUBERTAL AND PREPUBERTALCHILDRENWITHFAMILIALHYPERCHOLESTEROLEMIA*0EDIATR ą 0ERRY#-#OLESEVELAM0EDIATRIC$RUGS ą 2AAL &* (ONARPOUR . "LOM $* ET AL )NHIBITION OF 0#3+ WITH EVOLOCUMAB IN HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLAEMIA4%3,!0ART" ARANDOMISED DOUBLE BLIND PLACEBO CONTROLLEDTRIAL,ANCET ą 'OLDBERG !# .OVEL THERAPIES AND NEW TARGETS OF TREATMENT FOR FAMILIAL HYPERCHOLESTEROLEMIA *OURNAL OF #LINICAL ,IPIDOLOGY ą (OPKINS0. 4OTH00 "ALLANTYNE#- ETAL&AMILIAL(YPERCHOLESTEROLEMIAS0REVALENCE GENETICS DIAGNOSISAND SCREENING RECOMMENDATIONS FROM THE .ATIONAL ,IPID !SSOCIATION %XPERT 0ANEL ON &AMILIAL (YPERCHOLESTEROLEMIA *OURNALOF#LINICAL,IPIDOLOGY 3 3 )TO -+ -C'OWAN -0 -ORIARTY 0- -ANAGEMENT OF &AMILIAL (YPERCHOLESTEROLEMIAS IN ADULT PATIENTS 2ECOMMENDATIONS FROM THE .ATIONAL ,IPID !SSOCIATION %XPERT 0ANEL ON &AMILIAL (YPERCHOLESTEROLEMIA *OURNAL OF #LINICAL,IPIDOLOGY 3 3 +LINGEL 2 'OHLEN " 3CHWARTING ! ET AL $IFFERENTIAL )NDICATION OF ,IPOPROTEIN !PHERESIS $URING 0REGNANCY 4HERAPEUTIC!PHERESISAND$IALYSIS ą "ASARAN!0REGNANCY INDUCEDHYPERLIPOPROTEINEMIAREVIEWOFTHELITERATURE2EPROD3CI ą $E!SSIS3- 3EGURO!# (ELOU#-%FFECTSOFMATERNALHYPERCHOLESTEROLEMIAONPREGNANCYANDDEVELOPMENTOF OFFSPRING0EDIATR.EPHROL ą 138 ʝèãʦʤäåãéʢʥʡéʧʥð 4HADHANI 2 3TAMPFER -* (UNTER $* ET AL (IGH "ODY -ASS )NDEX AND (YPERCHOLESTEROLEMIA /BSTETRICS 'YNECOLOGY ą (AMEED!" 4UMMALA00 'OODWIN4- ETAL5NSTABLEANGINADURINGPREGNANCYINTWOPATIENTSWITHPREMATURE CORONARYATHEROSCLEROSISANDAORTICSTENOSISINASSOCIATIONWITHFAMILIALHYPERCHOLESTEROLEMIA!M*/BSTET'YNECOL ą 9OUNGBLOM% +NOWLES*7&AMILIAL(YPERCHOLESTEROLEMIA)N0AGON2! !DAM-0 !RDINGER(( 7ALLACE3% !MEMIYA! "EAN,*( ETAL EDITORS'ENE2EVIEWS2 3EATTLE7! (ARADA 3HIBA- !RAI( /IKAWA3 ETAL'UIDELINESFORTHE-ANAGEMENTOF&AMILIAL(YPERCHOLESTEROLEMIA*!4 ą !NEDDA3 -URA3 -ARCELLO# ETAL(%,0,$, APHERESISINTWOCASESOFFAMILIALHYPERCHOLESTEROLEMICPREGNANT WOMEN4RANSFUSIONAND!PHERESIS3CIENCE ą #ASHIN (EMPHILL, .OONE- !BBOTT*& ETAL,OW DENSITYLIPOPROTEINAPHERESISTHERAPYDURINGPREGNANCY!M* #ARDIOL %RTORER-% 'UVENC" (AYDARDEDEOGLU" ETAL!#ASE2EPORTOFTHE#ASCADE&ILTRATION3YSTEM!3AFEAND%FFECTIVE -ETHOD FOR ,OW DENSITY ,IPOPROTEIN !PHERESIS $URING 0REGNANCY 4HERAPEUTIC !PHERESIS AND $IALYSIS ą &AHED ! .ASSAR ! 0REGNANCY IN A 7OMAN WITH (OMOZYGOUS &AMILIAL (YPERCHOLESTEROLEMIA .OT ON ,OW $ENSITY ,IPOPROTEIN!PHERESIS!M*0ERINATOL2EP ą -ABUCHI ( 3AKAI 9 7ATANABE ! ET AL .ORMALIZATION OF LOW DENSITY LIPOPROTEIN LEVELS AND DISAPPEARANCE OF XANTHOMASDURINGPREGNANCYINAWOMANWITHHETEROZYGOUSFAMILIALHYPERCHOLESTEROLEMIA-ETABOLISM ą 3HIOMI - )TO 4 7ATANABE 9 )NCREASE IN HEPATIC LOW DENSITY LIPOPROTEIN RECEPTOR ACTIVITY DURING PREGNANCY IN 7ATANABE HERITABLE HYPERLIPIDEMIC RABBITS AN ANIMAL MODEL FOR FAMILIAL HYPERCHOLESTEROLEMIA "IOCHIMICA ET "IOPHYSICA!CTA""! ,IPIDSAND,IPID-ETABOLISM ą "EIGEL9 "AR* #OHEN- ETAL0REGNANCYOUTCOMEINFAMILIALHOMOZYGOUSHYPERCHOLESTEROLEMICFEMALESTREATED WITHLONG TERMPLASMAEXCHANGE!CTA/BSTETRICIAET'YNECOLOGICA3CANDINAVICA ą ʛʤäʥʤÞʦäãʣʝʙ ʒʧʨʡʥìʧäʔʔ ʓêʡçʡʦñʢÞʡʚÐ ETALʝʤʥÝëãʤççðʢéʢʨçʤåʤßããÞåʢìʢçããʦʢʥàʢìçʤ ʦʤʦʧàã ʦéðʨâʡÝʤåʢÞʡçãʣʒʡʥàãʤåʤßãìʢʦäãʣÞʢʦéçãäą *ANSEN- 'ABRIEL( "ANYAI3 ETAL2EGRESSIONOFCORONARYATHEROSCLEROSISANDAMELIORATIONOFRENALFUNCTIONDURING ,$, IMMUNOADSORPTIONTHERAPYINARENALTRANSPLANTRECIPIENT7IEN+LIN7OCHENSCHR ą ʒʤçʤÞʡåʤÞʕʓ ʒʧʨʡʥìʧäʔʔ ʛʤäʥʤÞʦäãʣʝʙÚäʦéʥʡäʤʥèʤʥʡåñçðʢæʢéʤàðåʢìʢçãôʥʢêʥʡäéʢʥçðʨàãʦåãèã àʢæãʣʓéʢʥʤʦäåʢʥʤâãàãʦåãèãàʢæãã ą 2ANDOMISEDTRIALOFCHOLESTEROLLOWERINGINPATIENTSWITHCORONARYHEARTDISEASETHE3CANDINAVIAN3IMVASTATIN 3URVIVAL3TUDY3 ,ANCET ą 3HEPHERD * #OBBE 3- &ORD ) ET AL 0REVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA7ESTOF3COTLAND#ORONARY0REVENTION3TUDY'ROUP.%NGL*-ED ą 3ACKS&- 0FEFFER-! -OYE,! ETAL4HEEFFECTOFPRAVASTATINONCORONARYEVENTSAFTERMYOCARDIALINFARCTIONIN PATIENTS WITH AVERAGE CHOLESTEROL LEVELS #HOLESTEROL AND 2ECURRENT %VENTS 4RIAL INVESTIGATORS . %NGL * -ED ą $OWNS*2 #LEARFIELD- 7EIS3 ETAL0RIMARYPREVENTIONOFACUTECORONARYEVENTSWITHLOVASTATININMENANDWOMEN WITH AVERAGE CHOLESTEROL LEVELS RESULTS OF !&#!034EX#!03 !IR &ORCE4EXAS #ORONARY !THEROSCLEROSIS 0REVENTION 3TUDY*!-! ą 0REVENTIONOFCARDIOVASCULAREVENTSANDDEATHWITHPRAVASTATININPATIENTSWITHCORONARYHEARTDISEASEANDABROAD RANGE OF INITIAL CHOLESTEROL LEVELS 4HE ,ONG 4ERM )NTERVENTION WITH 0RAVASTATIN IN )SCHAEMIC $ISEASE ,)0)$ 3TUDY 'ROUP.%NGL*-ED ą 7ATERS$ 3CHWARTZ'' /LSSON!'4HE-YOCARDIAL)SCHEMIA2EDUCTIONWITH!CUTE#HOLESTEROL,OWERING-)2!#, TRIALANEWFRONTIERFORSTATINS#URR#ONTROL4RIALS#ARDIOVASC-ED ą -2#"(&(EART0ROTECTION3TUDYOFCHOLESTEROLLOWERINGWITHSIMVASTATININ HIGH RISKINDIVIDUALSARANDOMISED PLACEBO CONTROLLEDTRIAL,ANCET ą 3HEPHERD* "LAUW'* -URPHY-" ETAL0RAVASTATININELDERLYINDIVIDUALSATRISKOFVASCULARDISEASE02/30%2 A RANDOMISEDCONTROLLEDTRIAL,ANCET ą !THYROS 6' 0APAGEORGIOU !! -ERCOURIS "2 ET AL 4REATMENT WITH ATORVASTATIN TO THE .ATIONAL #HOLESTEROL %DUCATIONAL0ROGRAMGOALVERSUSćUSUALĈCAREINSECONDARYCORONARYHEARTDISEASEPREVENTION4HE'2%EK!TORVASTATIN AND#ORONARY HEART DISEASE%VALUATION'2%!#% STUDY#URR-ED2ES/PIN ą 3EVER03 $AHLOF" 0OULTER.2 ETAL0REVENTIONOFCORONARYANDSTROKEEVENTSWITHATORVASTATININHYPERTENSIVEPATIENTS WHOHAVEAVERAGEORLOWER THAN AVERAGECHOLESTEROLCONCENTRATIONS INTHE!NGLO 3CANDINAVIAN#ARDIAC/UTCOMES4RIAL ,IPID,OWERING!RM!3#/4 ,,! AMULTICENTRERANDOMISEDCONTROLLEDTRIAL,ANCET ą 139 ʝèãʦʤäåãéʢʥʡéʧʥð 0ASCERI 6 0ATTI ' .USCA ! ET AL 2ANDOMIZED TRIAL OF ATORVASTATIN FOR REDUCTION OF MYOCARDIAL DAMAGE DURING CORONARYINTERVENTIONRESULTSFROMTHE!2-9$!!TORVASTATINFOR2EDUCTIONOF-9OCARDIAL$AMAGEDURING!NGIOPLASTY STUDY#IRCULATION ą .ISSEN3% 4UZCU%- 3CHOENHAGEN0 ETAL%FFECTOFINTENSIVECOMPAREDWITHMODERATELIPID LOWERINGTHERAPYON PROGRESSIONOFCORONARYATHEROSCLEROSISARANDOMIZEDCONTROLLEDTRIAL*!-! ą #ANNON #0 "RAUNWALD % -C#ABE #( ET AL )NTENSIVE VERSUS MODERATE LIPID LOWERING WITH STATINS AFTER ACUTE CORONARYSYNDROMES.%NGL*-ED ą 3TRANDBERG4% &EELY* 3IGURDSSON%,4WELVE WEEK MULTICENTER RANDOMIZED OPEN LABELCOMPARISONOFTHEEFFECTS OF ROSUVASTATIN MGD AND ATORVASTATIN MGD IN HIGH RISK ADULTS A $)3#/6%29 STUDY #LIN 4HER ą 0ITT" ,OSCALZO* 9CAS* ETAL,IPIDLEVELSAFTERACUTECORONARYSYNDROMES*!M#OLL#ARDIOL ą *ONES 0( (UNNINGHAKE $" &ERDINAND +# ET AL %FFECTS OF ROSUVASTATIN VERSUS ATORVASTATIN SIMVASTATIN AND PRAVASTATIN ON NON HIGH DENSITY LIPOPROTEIN CHOLESTEROL APOLIPOPROTEINS AND LIPID RATIOS IN PATIENTS WITH HYPERCHOLESTEROLEMIAADDITIONALRESULTSFROMTHE34%,,!2TRIAL#LIN4HER ą DE ,EMOS *! "LAZING -! 7IVIOTT 3$ ET AL %ARLY INTENSIVE VS A DELAYED CONSERVATIVE SIMVASTATIN STRATEGY IN PATIENTSWITHACUTECORONARYSYNDROMESPHASE:OFTHE!TO:TRIAL*!-! ą #OLHOUN(- "ETTERIDGE$* $URRINGTON0. ETAL0RIMARYPREVENTIONOFCARDIOVASCULARDISEASEWITHATORVASTATININ TYPEDIABETESINTHE#OLLABORATIVE!TORVASTATIN$IABETES3TUDY#!2$3 MULTICENTRERANDOMISEDPLACEBO CONTROLLED TRIAL,ANCET ą 7ILLICH3. -ULLER .ORDHORN* 3ONNTAG& ETAL%CONOMICEVALUATIONOFACOMPLIANCE ENHANCINGINTERVENTIONIN PATIENTSWITHHYPERCHOLESTEROLEMIADESIGNANDBASELINERESULTSOFTHE/PEN,ABEL0RIMARY#ARE3TUDY2OSUVASTATIN "ASED#OMPLIANCE)NITIATIVES4O!CHIEVEMENTSOF,$,'OALS/2")4!, STUDY!M(EART* ą 3TALENHOEF !& "ALLANTYNE #- 3ARTI # ET AL ! COMPARATIVE STUDY WITH ROSUVASTATIN IN SUBJECTS WITH METABOLIC SYNDROMERESULTSOFTHE#/-%43STUDY%UR(EART* ą +JEKSHUS * $UNSELMAN 0 "LIDESKOG - ET AL ! STATIN IN THE TREATMENT OF HEART FAILURE #ONTROLLED ROSUVASTATIN MULTINATIONALSTUDYINHEARTFAILURE#/2/.! STUDYDESIGNANDBASELINECHARACTERISTICS%UR*(EART&AIL ą ,A2OSA*# 'RUNDY3- 7ATERS$$ ETAL)NTENSIVELIPIDLOWERINGWITHATORVASTATININPATIENTSWITHSTABLECORONARY DISEASE.%NGL*-ED ą 0EDERSEN 42 &AERGEMAN / +ASTELEIN ** ET AL (IGH DOSE ATORVASTATIN VS USUAL DOSE SIMVASTATIN FOR SECONDARY PREVENTIONAFTERMYOCARDIALINFARCTIONTHE)$%!,STUDYARANDOMIZEDCONTROLLEDTRIAL*!-! ą !MARENCO 0 "OGOUSSLAVSKY * #ALLAHAN ! RD ET AL (IGH DOSE ATORVASTATIN AFTER STROKE OR TRANSIENT ISCHEMIC ATTACK.%NGL*-ED ą "ALLANTYNE #- "ERTOLAMI - (ERNANDEZ 'ARCIA (2 ET AL !CHIEVING ,$, CHOLESTEROL NON ($, CHOLESTEROL AND APOLIPOPROTEIN"TARGETLEVELSINHIGH RISKPATIENTS-EASURING%FFECTIVE2EDUCTIONSIN#HOLESTEROL5SING2OSUVASTATIN THERAP9-%2#529 ))!M(EART* Eą #ROUSE*2 RD 2AICHLEN*3 2ILEY7! ETAL%FFECTOFROSUVASTATINONPROGRESSIONOFCAROTIDINTIMA MEDIATHICKNESS INLOW RISKINDIVIDUALSWITHSUBCLINICALATHEROSCLEROSISTHE-%4%/24RIAL*!-! ą 4AVAZZI, -AGGIONI!0 -ARCHIOLI2 ETAL%FFECTOFROSUVASTATININPATIENTSWITHCHRONICHEARTFAILURETHE')33) (& TRIAL ARANDOMISED DOUBLE BLIND PLACEBO CONTROLLEDTRIAL,ANCET ą 5NDERHILL(2 9UAN# :HAO81 ETAL%FFECTOFROSUVASTATINTHERAPYONCAROTIDPLAQUEMORPHOLOGYANDCOMPOSITION INMODERATELYHYPERCHOLESTEROLEMICPATIENTSAHIGH RESOLUTIONMAGNETICRESONANCEIMAGINGTRIAL!M(EART* Eą 2IDKER0- $ANIELSON% &ONSECA&! ETAL2OSUVASTATINTOPREVENTVASCULAREVENTSINMENANDWOMENWITHELEVATED # REACTIVEPROTEIN.%NGL*-ED ą &ELLSTROM "# *ARDINE !' 3CHMIEDER 2% ET AL 2OSUVASTATIN AND CARDIOVASCULAR EVENTS IN PATIENTS UNDERGOING HEMODIALYSIS.%NGL*-ED ą !VIS (* (UTTEN "! 'AGNE # ET AL %FFICACY AND SAFETY OF ROSUVASTATIN THERAPY FOR CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA*!M#OLL#ARDIOL ą .ICHOLLS 3* "RANDRUP 7OGNSEN ' 0ALMER - ET AL -ETA ANALYSIS OF COMPARATIVE EFFICACY OF INCREASING DOSE OF !TORVASTATINVERSUS2OSUVASTATINVERSUS3IMVASTATINONLOWERINGLEVELSOFATHEROGENICLIPIDSFROM6/9!'%2 !M* #ARDIOL ą 9USUF 3 "OSCH * $AGENAIS ' ET AL #HOLESTEROL ,OWERING IN )NTERMEDIATE 2ISK 0ERSONS WITHOUT #ARDIOVASCULAR $ISEASE.%NGL*-ED ą 140