СТРУКТУРНО-ФУНКЦИОНАЛЬНОЕ СОСТЯНИЕ МЕМБРАН

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13. Dodge J.T. The preparation and
hemical characteristics of hemoglobin - free
shosts of human erythrocyts / J.T. Dodge, C.
Mitchell, D. Hanahan // Arch. Biochem. and
Biophis. – 1980. – V.100, N1. – P. 119.
FE LATENT DEFICIT INFLUENCE ON THE STRUCTURALLY FUNCTIONAL
CONDITION OF RED CELLS MEMBRANES OF GIRLS AND YOUNG WOMEN
Tereshenko S.Yu., Kasparov E.V., Pakhmutova O.A.
State institute SRI of Medical Problems of the Far North Region
Fe deficit is accompanied by large clinical displays, and their pathogenesis is not enough
researched. Particularly important is the examination of mechanisms of Fe deficit condition development in stage of growth and development of organism. Nowadays, the influence of latent
Fe deficit on structural-functional condition of cellular membranes as a whole, and on red cells
membranes in particular, is not enough researched. We had ascertained that the distinctive features of structural organization of red cells membranes by girls and young women by latent Fe
deficit are descent of microviscosity in superficial levels of lipidic bilayer and increase of transmembrane penetrability. The indicated membrane-pathological changes to the utmost are frank
in stage of Fe reserves absorption and they decrease in stages of Fe deficient erythropoiesis and
Fe deficient anemia. Moreover, there are age-specific features of red cells membranes reaction
to Fe deficit, what speaks, that red cells of active growing organism (particularly girls in youngest growth) are more amenable to membrane-pathological sideropenia action comparing with
young women. Pathogenetic substantiated is the additional inclusion of drugs into the treatment
scheme, which normalize fluid condition of membrane cellular lipids – polyunsaturated fat acids, vitamins A, E, C, particularly in the group of youngest adolescence.