, 4, 2013 544.18/577.29:577.17 . ,

Реклама
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4, 2013
544.18/577.29:577.17
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Protein Data Base
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A new mechanism of interaction of thyroid gland hormones with biotargets is offered on
the basis of X-ray structural data from Protein Data Base and quantum-chemical computation of 3,3',5'-triiodothyronine (T 3) interaction with the active center of thyroidal receptor
as well as with oxygen molecules and ATP. The nature of the mechanism is that when T3
and T4 interact with biotargets, a transportation of electron occurs, and T3 and T4 can act as
donors and acceptors of electron. Being electron carriers, T3 and T4 can interact with molecules that are in triplet state (O2, ATP, thyroidal receptor).
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–
:
humbio.ru/humbio/01122001/tr_sv2/00023140. –
.
.
2
TR (
c-erbA) [
]. –
: www.medbiol.ru/medbiol/
01122001/tr _sv2/00023140. .
.
3
–
.doc [
]. –
: gendocs.ru/v1658/?cc=5. –
.
.
c-erbA) [
,
4,
.
183
,
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4 Discovery Studio Client v2.5.0.9164
]. –
:
http//www.accelrys.com/. –
.
.
5 Protein Data Base [
]. : www.rcsb.org/pdb/
home/home.do. .
.
6 Hyper Chem Release 7 for Windows
]. - HyperCube, 2002. - 860 p.
7 Brent, G.A Mechanisms of thyroid hormone action [Text] / GA Brent // The Journal of
Clinical Investigation. - 2012. 9. - V. 122. –
P. 3035-3043.
REFERENCES
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[Text]. - HyperCube, 2002. - 860 p.
7 Brent, G.A Mechanisms of thyroid hormone action [Text] / GA Brent // The Journal of
Clinical Investigation. - 2012. 9. - V. 122. –
P. 3035-3043.
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