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модельные системы перекисного окисления липидов и их

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.
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)
A
HP
CS
CSHP
CA
CAHP
X
0,809212
0,273196
0,258608
0,720845
0,466287
X
0,135105
0,125195
0,445276
0,454228
X
0,961776
0,120343
0,454676
X
0,106637
0,429891
X
0,598788
HP
CS
CSHP
CA
X
CAHP
#
/ / / &!
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HP
CS
CSHP
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CAHP
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0,231931
0,019024
0,025648
0,000003
0,000018
X
0,138616
0,127319
0,000048
0,002704
X
0,796009
0,000176
0,003202
X
0,000798
0,010910
X
0,406779
CSHP
CA
X
CAHP
129
#
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0,363595
0,562546
0,558155
0,406021
0,023176
X
0,338716
0,327023
0,001569
0,004267
X
0,977225
0,000996
0,006124
X
0,000694
0,005954
X
0,010894
HP
CS
CSHP
CA
X
CAHP
#
1/
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48 /
72 /
96 /
X
0,043627
0,000039
2,29⋅⋅10–21
3,98⋅⋅10–20
< 1⋅⋅10–30
3,18⋅⋅10–21
X
0,015953
3,65⋅⋅10–18
3,08⋅⋅10–17 2,97⋅⋅10–28 1,34⋅⋅10–17
X
1,09⋅⋅10–14
3,61⋅⋅10–14 2,48⋅⋅10–22 6,12⋅⋅10–14
X
48 /
72 /
96 /
0,001076
2,02⋅⋅10–7
0,001180
X
0,036159
0,043618
X
0,645026
X
130
#
/ / / &!
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24 /
48 /
72 /
96 /
X
0,186647
0,002891
0,000020
0,000010
1,21⋅⋅10–8
8,48⋅⋅10–8
X
0,029785
0,000168
0,000098
4,27⋅⋅10–7
0,000002
X
0,000627
0,000285
0,000003
0,000009
X
0,194536
0,007993
0,010948
X
0,057742
0,082679
X
0,755408
1/
3/
6/
24 /
48 /
72 /
96 /
X
.
#
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+ /
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!
$
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1/
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48 /
X
0,04270
0,000790
4,07⋅⋅10–10
1,23⋅⋅10–9
4,80⋅⋅10–13 3,74⋅⋅10–12
X
0,016192
1,12⋅⋅10–9
2,82⋅⋅10–9
7,29⋅⋅10–12 9,68⋅⋅10–11
X
5,20⋅⋅10–8
7,47⋅⋅10–8
2,22⋅⋅10–8
2,76⋅⋅10–7
X
0,088523
0,049088
0,104437
X
0,985001
0,885371
X
0,687528
48 /
72 /
96 /
72 /
96 /
X
131
.
#
/ / / &!
#0!#/ 0 "
" 3# & + /
. #
!# 5
%#1
/ /
$
3/
X
0,020257
3/
X
& " 1.
!$ #!# "
2,5 +
!
6/
&#1
!$#
!#3
0,8 +
CuSO4
/! %# /
1/
1/
/
+,
!
!# -
24 /
48 /
+ /
72 /
96 /
0,066612 6,30⋅⋅10–10
7,24⋅⋅10–9
2,94⋅⋅10–7
2,45⋅⋅10–8
8,26⋅⋅10–8
4,17⋅⋅10–7
0,000006
0,000006
X
0,188072
0,248382
0,253217
X
0,873099
0,849486
X
0,933262
X
24 /
48 /
72 /
96 /
X
.
#
/ / / &!
#0!#/ 0 "
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. #
/ /
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6/
24 /
/
& " 1.
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6/
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+,
Cu(CH3COO)2, 3
2,5 +
!
3/
/
0,001423 3,12⋅⋅10–12 5,49⋅⋅10–11 1,02⋅⋅10–11 5,32⋅⋅10–12
6/
1/
& #
$ ! ,# /1
H2O2, 3
$
0 ).1.11.
$
+ /
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0 ).1.12.
& #
$ ! ,# /1
/$
/! %# /
72 /
96 /
!# -
1/
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X
1,47⋅⋅10–7
7,83⋅⋅10–17 8,52⋅⋅10–26 3,56⋅⋅10–23 1,74⋅⋅10–20 1,97⋅⋅10–20
X
2,71⋅⋅10–11 9,11⋅⋅10–25 2,39⋅⋅10–22 2,63⋅⋅10–18 2,47⋅⋅10–18
X
24 /
48 /
3,12⋅⋅10–20 2,41⋅⋅10–18 5,36⋅⋅10–13 4,02⋅⋅10–13
X
48 /
72 /
96 /
0,685642
0,588435
0,703352
X
0,411625
0,505665
X
0,645568
X
132
.
#
/ / / &!
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/ /
1/
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X
3/
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/
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Cu(CH3COO)2
/! %# /
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24 /
48 /
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0 ).1.13.
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72 /
+ /
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96 /
5,27⋅⋅10–10 2,85⋅⋅10–18
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X
3,48⋅⋅10–15
1,30⋅⋅10–10
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0,004322
X
0,647726
0,116336
0,000520
X
0,200961
0,009509
X
0,036457
X
48 /
72 /
96 /
X
133
&*" 3 $* 2. .!,*%*4 % # % + &3!$*- !&' $*"#$(7 % +*$ $*8 , % %2 $0**
"*2 % 4, 2 +, &9$
$! &*- , *$
(7 *$+ 1*& ,!$$ 4
*%" $*;,
$1 $ &!1** !1 ! !
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.
$! 6 # !
$ ! ,# /1
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%#1
1
3
6
24
48
## + 2,5 +
#0!#/ 0
0!/ / # /
!# 5, 3
-
## "
# . 0
-
# . 0
$ /+ ),
+ /
/
!$!
## "
!$!, +
/ / / !/
0,2
1
2,5
5
0,111
0,099
0,122
0,120
0,147
± 0,012
± 0,005
± 0,009
± 0,008
± 0,015
p = 0,1144
p = 0,1928
p = 0,2585
p = 0,0095
0,173
0,172
0,212
0,203
0,277
± 0,019
± 0,015
± 0,011
± 0,008
± 0,023
p = 0,9368
p = 0,0120
p = 0,0270
p = 0,0004
0,308
0,462
0,764
0,944
1,254
± 0,024
± 0,038
± 0,087
± 0,146
± 0,315
p = 0,0005
p = 0,0001
p = 0,0001
p = 0,0010
1,210
1,328
1,368
1,366
1,514
± 0,037
± 0,057
± 0,062
± 0,029
± 0,035
p = 0,0133
p = 0,0047
p = 0,0006
p < 0,0001
1,379
1,383
1,356
1,336
1,266
± 0,053
± 0,052
± 0,062
± 0,040
± 0,097
p = 0,9177
p = 0,5932
p = 0,2429
p = 0,0869
#- / / / &!
!# - 0!/ / # /
+ (2,38 +,
CuSO4
#0!#/ 0 - 0!/ / # /
!$#!# ! !3 %/ /
# !+
!#3
#$ 0
/! %# /%
!# -, &
!$ #!# "
0 ).2.1
-
48
!
+!#/ .
" 3# & + /
# . 0
## "
##1!
/
!$!).
134
& " /#
!$!#1
/! %#
$! M ± SD
#/
3 -
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.
$! 6 # !
. #
$ ! ,# /1
3
%#1
#$ 0
+ /
/
/! %# /%
!# -, &
1
3
6
24
48
## + 2,5 +
#0!#/ 0
+ (2,38 +,
CuSO4 + 0,8 +
0!/ / # /
-
!# 5,
H2O2
# . 0
# . 0
$ /+ ),
## "
## "
!$!
!$!, +
/ / / !/
0,2
1
2,5
5
0,158
0,160
0,163
0,230
0,340
± 0,021
± 0,010
± 0,011
± 0,028
± 0,035
p = 0,8691
p = 0,6878
p = 0,0063
p = 0,0001
0,273
0,309
0,406
0,471
0,609
± 0,029
± 0,018
± 0,037
± 0,048
± 0,123
p = 0,0794
p = 0,0013
p = 0,0004
p = 0,0018
0,409
0,512
0,882
1,133
1,468
± 0,041
± 0,047
± 0,117
± 0,102
± 0,209
p = 0,0163
p = 0,0003
p < 0,0001
p = 0,0001
1,279
1,275
1,311
1,350
1,438
± 0,042
± 0,021
± 0,028
± 0,058
± 0,071
p = 0,8703
p = 0,2518
p = 0,0946
p = 0,0084
1,388
1,380
1,327
1,305
1,408
± 0,041
± 0,066
± 0,055
± 0,085
± 0,052
p = 0,8437
p = 0,1257
p = 0,1291
p = 0,5679
#- / / / &!
!# - 0!/ / # /
!#3
#0!#/ 0 - 0!/ / # /
!$#!# ! !3 %/ /
# !+
!$ #!# "
0 ).2.2
-
48
!
+!#/ .
" 3# & + /
# . 0
## "
##1!
/
!$!).
135
& " /#
!$!#1
/! %#
$! M ± SD
#/
3 -
- (.!3 $ . -
&*" 3 $* 3.
<::*1* $ ( "*$ 8$ 8
$1 $ &!1* 8 !&' $*"#$(7 2& +
,,7 +
: %:! *+*"7 "*$ ,(7 "*2 % 4 *
8** 0 !#/1
#1
#!"# "
!$ #!# "
H2O2- #$ 0
## +
+,
!# 5
#!" $ / ,# / " / / / &!
*&% $! 4 3+
*%" $*-
$1 $ &!1* 8 "*2*+!.
! -0
!#3
&& "-1**
)
# r +!6$
$ ! ,# /1
37
,
$! 6 # !+
#/ ## +
#0!#/ 0 !"
. #
Cu(CH3COO)2 +
$
3 # !+
" 3# & + / p.
.
/! %# /%
!# -, &
%-
/
!# !
#$ 0
0 ).3.1
## ! )
1
r = 0,9801 (p = 0,020)
r = 0,9898 (p = 0,010)
3
r = 0,9825 (p = 0,017)
r = 0,9960 (p = 0,004)
24
r = 0,9752 (p = 0,025)
r = 0,9590 (p = 0,041)
48
r = 0,9796 (p = 0,020)
r = 0,9849 (p = 0,015)
96
r = 0,9819 (p = 0,018)
r = 0,9778 (p = 0,022)
136
&*" 3 $* 4. "*-$* ' : &$ 9 &!% , &! $! %$ , MES – NaOH $!
% + &3!$*
!&' $*"#$(7 % +*$ $*8 , % %2 $0** "*2 % 4, 2 +, &9$
%2 $ !$$ 4 *$+ 1*& ,!$$ 4
(7
*%" $*;.
.
$! 6 # !
, /
. #
%#1
!$ #!# "
!##1 # $ /
## "
+ (2,38 +,
$! (– MES)
NaOH (20 + , pH 6,8) (+ MES), 3
# 0 0 -
!#3
+ /
/
.
/! %# /% !
)
1
# . *! # +
0 ).4.1
$ /+ ),
/
! MES–
# 0 0
$
!# -
!# -, &
3
6
24
– MES + MES – MES + MES – MES + MES – MES + MES
/
!# !
0,121
0,152
0,144
0,272
0,180
0,279
0,889
1,082
± 0,024
± 0,016
± 0,011
± 0,023
± 0,017
± 0,029
± 0,034
± 0,077
p = 0,0752
2,5 +
CuSO4
p = 0,0001
+ 0,8 +
CuSO4
H2O2
0,188
0,182
0,340
0,298
0,417
1,217
1,658
± 0,023
± 0,022
± 0,025
± 0,042
± 0,015
± 0,031
± 0,033
± 0,106
p = 0,0006
Cu(CH3COO)2
Cu(CH3COO)2
+ 0,8 +
H2O2
0,271
0,452
0,402
0,764
1,277
1,542
± 0,012
± 0,023
± 0,024
± 0,051
± 0,051
± 0,083
± 0,054
± 0,062
p = 0,0007
p = 0,0003
p = 0,0007
0,160
0,183
0,302
0,399
0,569
0,624
1,238
1,261
± 0,033
± 0,032
± 0,011
± 0,024
± 0,040
± 0,039
± 0,023
± 0,038
p = 0,0965
p = 0,0003
p = 0,3403
0,322
0,328
0,551
0,478
0,789
0,817
1,281
1,223
± 0,020
± 0,030
± 0,032
± 0,044
± 0,045
± 0,049
± 0,056
± 0,040
p = 0,3236
!$#!# ! !3 %/ /
# !+
p = 0,0002
0,215
p = 0,3556
2,5 +
p = 0,0005
0,165
p = 0,0084
2,5 +
p = 0,0037
0,118
p = 0,0046
2,5 +
p = 0,0011
#- / / / &!
48
p = 0,0364
!
+!#/ .
" 3# & + /
##1!
/
& "
p = 0,4322
p = 0,1429
$! M ± SD
!$!#1
$! 6 # -
. #
%#1
3 !$ -
#!# "
!#3
+,
, /
!## " # MES–NaOH-. *! ! (+ MES), / / -
,
!#3
+,
, /
!## " # $ /
137
## "
$! (– MES).
&*" 3 $* 5. "*-$* ' : &$(7 &!% , & , (&
*%"
$! % + &3!$*
2 +, &9$
6,0) $! %$ ,
!&' $ ,(7
!&' $*"#$(7 % +*$ $*8 , % %2 $0** "*2 % 4,
(7 *$+ 1*& ,!$$ 4
*%" $*;.
.
$! 6 # !
. #
$ ! ,# /1
#
# !
/! %# /% !
0!/ /#1", 10 +
0 # /#1",
2+
0 # /#1",
10 +
/ /#1", 2 +
/ /#1", 10 +
!/ .
. # 1
/
!# -, &
3
6
24
0,176 ± 0,021
0,259 ± 0,030
0,421 ± 0,022
1,261 ± 0,049
0,190 ± 0,018
0,446 ± 0,088
1,045 ± 0,201
1,719 ± 0,033
p = 0,3504
p = 0,0069
p = 0,0008
p < 0,0001
0,252 ± 0,019
0,820 ± 0,041
1,518 ± 0,082
1,818 ± 0,099
p = 0,0017
p < 0,0001
p < 0,0001
p = 0,0001
0,198 ± 0,043
0,373 ± 0,070
0,375 ± 0,042
1,090 ± 0,066
p = 0,3933
p = 0,0242
p = 0,1004
p = 0,0059
0,198 ± 0,016
0,318 ± 0,022
0,407 ± 0,026
0,962 ± 0,083
p = 0,1466
p = 0,0193
p = 0,4425
p = 0,0008
0,185 ± 0,034
0,308 ± 0,036
0,342 ± 0,026
1,060 ± 0,044
p = 0,6682
p = 0,0815
p = 0,0035
p = 0,0009
0,125 ± 0,019
0,221 ± 0,015
0,270 ± 0,021
0,152 ± 0,031
p = 0,0113
p = 0,0640
p = 0,0001
p < 0,0001
#- / / / &!
!#3
!# 5
H2O2
$
$ /+ ),
1
!$#!# ! !3 %/ /
54!" /
+ (2,38 +,
CuSO4 + 0,8 +
/
/
0!/ /#1", 2 +
!$ #!# "
!#3
## + 2,5 +
. *! #1
#!/
# !+
!$ #!# "
#$ 0
/ /
2 *! #1"
%#1
0 ).5.1
48
!
+!#/ .
##1!
" $ / ! # /
+,
0! . *! # ,
, /
/
/
& "
$! 6 # -
!## " #
, //
+.
138
$! M ± SD
!$!#1
# !
,
. #
3 ## ,
#!3 . *! !## "
3 -
%#1
-
/ !/ /!#3
.
$! 6 # !
. #
$ ! ,# /1
#$ 0
/ /
2 *! #1"
%#1
+ (2,38 +,
#
# !
/! %# /% !
0!/ /#1", 10 +
0 # /#1",
2+
0 # /#1",
10 +
/ /#1", 2 +
/ /#1", 10 +
!/ .
/
!# -, &
3
6
24
0,314 ± 0,019
0,569 ± 0,036
0,769 ± 0,018
1,254 ± 0,044
0,395 ± 0,029
0,662 ± 0,033
0,835 ± 0,043
1,281 ± 0,026
p = 0,0034
p = 0,0089
p = 0,0299
p = 0,3314
0,422 ± 0,023
1,093 ± 0,045
1,089 ± 0,029
1,258 ± 0,030
p = 0,0004
p < 0,0001
p < 0,0001
p = 0,8855
0,280 ± 0,017
0,230 ± 0,039
0,218 ± 0,020
1,299 ± 0,038
p = 0,0372
p < 0,0001
p < 0,0001
p = 0,1726
0,303 ± 0,024
0,317 ± 0,023
0,301 ± 0,025
1,108 ± 0,040
p = 0,4993
p < 0,0001
p < 0,0001
p = 0,0027
0,238 ± 0,019
0,253 ± 0,051
0,278 ± 0,012
1,144 ± 0,076
p = 0,0013
p = 0,0001
p < 0,0001
p = 0,0462
0,272 ± 0,024
0,188 ± 0,022
0,164 ± 0,024
0,173 ± 0,037
p = 0,0336
p < 0,0001
p < 0,0001
p < 0,0001
#- / / / &!
!#3
!# 5
H2O2
. # 1
$
$ /+ ),
1
!$#!# ! !3 %/ /
54!" /
/
/
0!/ /#1", 2 +
!$ #!# "
!#3
Cu(CH3COO)2 + 0,8 +
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